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91. 发明申请

WO00005566A1 FLOW CYTOMETER DROPLET BREAK-OFF LOCATION ADJUSTMENT MECHANISM 审中-公开
标题翻译：流量计流量计突破位置调整机制
公开(公告)号：WO00005566A1
公开(公告)日：2000-02-03
申请号：PCT/US1999/014284
申请日：1999-06-25
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N2015/1406
摘要： A droplet travel path monitoring mechanism for a flow cytometer is operative to adjust the droplet break-off point back to an initially calibrated spatial location, in the event of the departure from calibrated timing of gaps in the unsorted fluid droplet stream that have been created by the deflection of charged droplets. In addition, the flow cytometer is operative to monitor prescribed characteristics of deflected droplet streams, and to controllably adjust drop sorting deflection parameters, so as to maintain the deflected travel path of sorted droplets coincident with the opening into a sorted droplet collection container, thereby maximizing collection of all sorted droplets.
摘要翻译：在流式细胞计数器的液滴行进路径监测机制可操作以将液滴分离点调回到初始校准的空间位置，在偏离由未分配的流体液滴流中的间隙的校准定时的情况下，已经由带电液滴的偏转。此外，流式细胞计数器可操作以监测偏转的液滴流的规定特性，并且可控地调整液滴分选偏转参数，以便将经分选的液滴的偏转的行进路径保持与开口进入分选的液滴收集容器，从而最大化收集所有排序的液滴。

92. 发明申请

WO1996012172A1 FLOW CYTOMETER JET MONITOR SYSTEM 审中-公开
标题翻译：流量计流量监测系统
公开(公告)号：WO1996012172A1
公开(公告)日：1996-04-25
申请号：PCT/US1995013502
申请日：1995-10-13
申请人： UNIVERSITY OF WASHINGTON , VAN DEN ENGH, Ger
发明人： UNIVERSITY OF WASHINGTON
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/149
摘要： A direct jet monitor (66) illuminates the jet of a flow cytometer in a monitor wavelength band which is substantially separate from the substance wavelengthband. When a laser is used to cause fluorescence of the substance, it may be appropriate to use an infrared source (67) to illuminate the jet and thus optically monitor the conditions within the jet through a CCD camera (68) or the like. This optical monitoring may be provided to some type of controller or feedback system (34) which automatically changes either the horizontal location of the jet, the point at which droplet separation occurs, or some other condition within the jet in order to maintain optimum conditions. The direct jet monitor (66) may be operated simultaneously with the substance property sensing and analysis system so that continuous monitoring may be achieved without interfering with the substance data gathering and may be configured so as to allow the front of the analysis or free fall area (7) to be unobstructed during processing.
摘要翻译：直接喷射监视器（66）照射基本上与物质波长带分离的监测波长带中的流式细胞仪的射流。当使用激光来引起物质的荧光时，使用红外光源（67）来照射射流并因此通过CCD照相机（68）等光学地监测射流内的状况可能是合适的。这种光学监视可以被提供给某种类型的控制器或反馈系统（34），其自动地改变射流的水平位置，发生液滴分离的点或射流内的某些其他状态，以保持最佳条件。直接喷射监视器（66）可以与物质性质感测和分析系统同时操作，使得可以在不干扰物质数据收集的情况下实现连续监测，并且可以配置为允许分析前沿或自由落体区域（7）在加工过程中不受阻碍。

93. 发明申请

WO9612171A2 HIGH SPEED FLOW CYTOMETER DROPLET FORMATION SYSTEM 审中-公开
标题翻译：高速流量计流量计形成系统
公开(公告)号：WO9612171A2
公开(公告)日：1996-04-25
申请号：PCT/US9513308
申请日：1995-10-13
申请人： UNIV WASHINGTON , DEN ENGH GER VAN
发明人： VAN DEN ENGH GER
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/1409 , Y10T436/117497 , Y10T436/118339 , Y10T436/25375 , Y10T436/2575
摘要： A droplet forming flow cytometer system (1) allows high speed processing without the need for high oscillator drive powers through the inclusion of an oscillator or piezoelectric crystal (10) within the nozzle volume (3) and directly coupled to the sheath fluid. The nozzle container (27) continuously converges so as to amplify unidirectional oscillations (11) which are transmitted as pressure waves through the nozzle volume (3) to the nozzle exit so as to form droplets from the fluid jet. The oscillator is directionally isolated so as to avoid moving the entire nozzle container so as to create only pressure waves within the sheath fluid. A variation in substance concentration is achieved through a movable substance introduction port (9) which is positioned within a convergence zone (32) to vary the relative concentration of substance to sheath fluid while still maintaining optimal laminar flow conditions. This variation may be automatically controlled through a sensor and controller configuration. A replaceable tip design is also provided whereby the ceramic nozzle tip is positioned within an edge insert (29) in the nozzle body (24) so as to smoothly transition from nozzle body (24) to nozzle tip (25). The nozzle tip is sealed against its outer surface to the nozzle body so it may be removable for cleaning or replacement.
摘要翻译：液滴形成流式细胞仪系统（1）允许高速处理，而不需要通过在喷嘴体积（3）内包含振荡器或压电晶体（10）并直接耦合到鞘液的高振荡器驱动功率。喷嘴容器（27）连续地会聚，以便放大单向振荡（11），其作为压力波通过喷嘴容积（3）传递到喷嘴出口，以便从流体射流形成液滴。振荡器是方向隔离的，以避免移动整个喷嘴容器，从而仅在护套液体内产生压力波。通过位于会聚区（32）内的可移动物质引入口（9）来实现物质浓度的变化，以改变物质与鞘液的相对浓度，同时仍保持最佳的层流条件。该变化可以通过传感器和控制器配置自动控制。还提供了可替换的尖端设计，其中陶瓷喷嘴尖端位于喷嘴主体（24）中的边缘插入件（29）内，以便从喷嘴体（24）到喷嘴尖端（25）平滑过渡。喷嘴尖端与其外表面密封到喷嘴体，因此其可以是可移除的用于清洁或更换。

94. 发明公开

EP2984468A4 AUTOMATED SET-UP FOR CELL SORTING 有权
标题翻译：自动设置FOR细胞分选
公开(公告)号：EP2984468A4
公开(公告)日：2016-12-07
申请号：EP14782993
申请日：2014-04-11
申请人： BECTON DICKINSON CO
发明人： NORTON PIERCE O , AZERSKY VLADIMIR
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01F1/661 , G01N15/14 , G01N15/1404 , G01N15/1459 , G01N2015/1006 , G01N2015/1406 , G01N2015/1481 , G01N2015/149 , G05D7/0617 , G06T7/0012
摘要： Apparatus and methods are described for automatically performing set-up steps for flow cytometry operations. The invention provides for the spatial determination of a flow stream and the subsequent automatic alignment of analysis devices and/or collection vessels. The automatic determination of flow stream properties provides for the automatic configuration flow cytometer parameters.

95. 发明公开

EP2984468A1 AUTOMATED SET-UP FOR CELL SORTING 有权
标题翻译：自动设置细胞分选
公开(公告)号：EP2984468A1
公开(公告)日：2016-02-17
申请号：EP14782993.1
申请日：2014-04-11
申请人： Becton, Dickinson and Company
发明人： Norton, Pierce O. , Azersky, Vladimir
IPC分类号： G01N15/14 , G01N21/47 , G01N33/487 , B01L3/00
CPC分类号： G01F1/661 , G01N15/14 , G01N15/1404 , G01N15/1459 , G01N2015/1006 , G01N2015/1406 , G01N2015/1481 , G01N2015/149 , G05D7/0617 , G06T7/0012
摘要： Apparatus and methods are described for automatically performing set-up steps for flow cytometry operations. The invention provides for the spatial determination of a flow stream and the subsequent automatic alignment of analysis devices and/or collection vessels. The automatic determination of flow stream properties provides for the automatic configuration flow cytometer parameters.
摘要翻译：描述了用于自动执行流式细胞术操作的设置步骤的设备和方法。本发明提供了流动流的空间确定以及随后的分析装置和/或收集容器的自动对准。流体流特性的自动确定提供了自动配置流式细胞仪参数。

96. 发明公开

EP2923758A3 MICROCHIP AND CHANNEL STRUCTURE FOR THE SAME 有权
标题翻译：迈克尔·肯·卡拉斯哥大学DAFÜR
公开(公告)号：EP2923758A3
公开(公告)日：2015-12-30
申请号：EP15001193.0
申请日：2009-04-22
申请人： Sony Corporation
发明人： Shinoda, Masataka , Takashimizu, Toru
IPC分类号： B01L3/00 , G01N1/40 , G01N15/14
CPC分类号： B01L3/502776 , B01J19/0093 , B01J2219/00853 , B01J2219/00889 , B01J2219/00891 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0645 , B01L2300/0861 , B01L2400/02 , G01N15/1404 , G01N35/10 , G01N2015/1037 , G01N2015/1406 , G01N2015/149 , Y10T137/0324 , Y10T137/2191
摘要： A microchip includes a channel permitting a sheath liquid to flow therethrough; and a microtube for introducing a sample liquid into a laminar flow of the sheath liquid flowing through the channel; wherein liquid feeding is performed in the condition where a laminar flow of the sample liquid introduced through the microtube is surrounded by the laminar flow of the sheath liquid. The channel has a narrow-down section in which its area in a section orthogonal to the liquid feed direction decreases gradually or stepwise along the liquid feed direction; and said sheath liquid laminar flow and said sample liquid laminar flow are made to pass while the laminar flow widths of said laminar flows are narrowed down in said narrow-down section.
摘要翻译：微芯片包括允许鞘液流过其中的通道; 以及用于将样品液体引入流过所述通道的鞘液的层流的微管; 其中在通过微管引入的样品液体的层流被鞘液的层流包围的条件下进行液体进料。

97. 发明授权

EP1236992B1 Procedure for controlling the enumeration of the absolute count of cells or other particles present in a sample 有权
标题翻译：样品在控制细胞或其它颗粒的绝对数量的方法
公开(公告)号：EP1236992B1
公开(公告)日：2004-07-14
申请号：EP02380032.9
申请日：2002-02-11
申请人： Universidad De Salamanca
发明人： Orfao De Matos Correia E Vale, José Alberto
IPC分类号： G01N15/10
CPC分类号： G01N15/1012 , G01N2015/1406

98. 发明授权

EP0786079B1 FLOW CYTOMETER JET MONITOR SYSTEM 失效
标题翻译： MONITOR DEVICE FOR流式细胞仪的光束
公开(公告)号：EP0786079B1
公开(公告)日：2003-05-21
申请号：EP95937545.2
申请日：1995-10-13
申请人： University of Washington
发明人： VAN DEN ENGH, Ger
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/149
摘要： A direct jet monitor (66) illuminates the jet of a flow cytometer in a monitor wavelength band which is substantially separate from the substance wavelengthband. When a laser is used to cause fluorescence of the substance, it may be appropriate to use an infrared source (67) to illuminate the jet and thus optically monitor the conditions within the jet through a CCD camera (68) or the like. This optical monitoring may be provided to some type of controller or feedback system (34) which automatically changes either the horizontal location of the jet, the point at which droplet separation occurs, or some other condition within the jet in order to maintain optimum conditions. The direct jet monitor (66) may be operated simultaneously with the substance property sensing and analysis system so that continuous monitoring may be achieved without interfering with the substance data gathering and may be configured so as to allow the front of the analysis or free fall area (7) to be unobstructed during processing.

99. 发明授权

EP1037713B1 METHOD OF PRODUCING HOLLOW DROPLETS 有权
标题翻译：工艺用于产生在空心液滴
公开(公告)号：EP1037713B1
公开(公告)日：2002-07-10
申请号：EP98960047.3
申请日：1998-12-16
申请人： Universidad de Sevilla
发明人： GANAN CALVO, Alfonso
IPC分类号： B05B7/06 , A61M15/00 , B01J2/04 , B01D1/18
CPC分类号： B82Y30/00 , A61M11/001 , A61M15/0065 , A61M15/025 , A61M2202/064 , B01F3/0446 , B01F5/04 , B01J2219/00378 , B05B1/02 , B05B7/0475 , B05B7/061 , B05B7/065 , B05B7/066 , B05B7/0884 , C40B60/14 , F02M43/04 , F02M67/10 , F02M69/047 , F02M69/08 , F23D11/106 , G01N21/01 , G01N2015/1406 , G01N2015/1409

100. 发明授权

EP0781985B1 Verfahren und Anordnung zur Überwachung eines abreissenden Flüssigkeitsstrahls 失效
标题翻译：方法和装置用于监测液体喷射结束
公开(公告)号：EP0781985B1
公开(公告)日：2001-04-04
申请号：EP96118854.7
申请日：1996-11-25
申请人： SIEMENS AKTIENGESELLSCHAFT , GSF-Forschungszentrum für Umwelt und Gesundheit GmbH
发明人： Karls, Ingolf, Dr. , Ellwart, Joachim, Dr.
IPC分类号： G01N13/02 , G01N15/14
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/149 , Y10S209/906

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