专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明公开

EP2316925A1 Séquences de circovirus associé à la maladie de l'amaigrissement du porcelet (MAP) 有权
公开(公告)号：EP2316925A1
公开(公告)日：2011-05-04
申请号：EP10184556.8
申请日：1998-12-04
申请人： Wyeth LLC
发明人： Jestin, André , Albina, Emmanuel , Le Cann, Pierre , Blanchard, Philippe , Hutet, Evelyne , Arnault, Claire , Truong, Catherine , Mahe, Dominique , Cariolet, Roland , Madec, François
IPC分类号： C12N7/00 , C12N7/04 , C07K14/01 , C12N5/10 , A01K67/027 , C12Q1/68 , C07K16/08 , G01N33/569 , A61K39/12
CPC分类号： A61K39/12 , A01K2217/05 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/55522 , A61K2039/55566 , A61K2039/58 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2710/14143 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10061 , G01N33/56983 , G01N2333/01 , G01N2469/20 , Y10T428/13
摘要： L'invention a pour objet la séquence génomique et des séquences nucléotidiques codant pour des polypeptides de circovirus MAP, tels que les polypeptides structuraux et non structuraux dudit circovirus, ainsi que des vecteurs incluant lesdites séquences et cellules ou animaux transformés par ces vecteurs. L'invention concerne également des procédés de détection de ces acides nucléiques ou polypeptides et des kits de diagnostic d'infection par un circovirus MAP. L'invention vise aussi une méthode de sélection de composés capables de moduler l'infection virale. L'invention comprend enfin des compositions pharmaceutiques, notamment vaccinales, pour la prévention et/ou le traitement d'infections virales par circovirus MAP ainsi que l'utilisation de vecteur selon l'invention pour la prévention et/ou le traitement de maladies par thérapie génique.

92. 发明公开

EP2275130A2 PCV2 ORF2 immunogenic composition 审中-公开
标题翻译： PCV2ORF2免疫原性组合物
公开(公告)号：EP2275130A2
公开(公告)日：2011-01-19
申请号：EP10174456.3
申请日：2006-12-28
申请人： BOEHRINGER INGELHEIM VETMEDICA, INC.
发明人： Roof, Michael B. , Eichmeyer, Marc Allan , Nitzel, Greg , Hayes, Phillip Wayne , Schaeffer, Merrill Lynn
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
摘要翻译：本发明涉及包含用于治疗几种临床表现（疾病）的2型猪圆环病毒（PCV2）抗原的免疫原性组合物。优选地，临床表现与PCV2感染有关。优选地，它们包括淋巴结病，淋巴耗竭和/或多核/巨组织细胞。此外，临床症状包括淋巴结病和猪中的一种或多种以下症状：（1）伴有小叶间水肿的间质性肺炎，（2）皮肤苍白或黄疸，（3）斑驳萎缩肝，（4）胃溃疡，（5）肾炎和（6）生殖障碍，例如流产，死胎，木乃伊等。此外，临床症状包括Pia类病变，通常已知其与细胞内劳索尼亚菌感染相关。

93. 发明公开

EP1036180A2 SEQUENCES DE CIRCOVIRUS ASSOCIE A LA MALADIE DE L'AMAIGRISSEMENT DU PORCELET (MAP), 有权
标题翻译：随着乙仔猪ASSOCIATED圆环病毒类型ABMAGERUNGSKRANKHEIT PREPARED疫苗
公开(公告)号：EP1036180A2
公开(公告)日：2000-09-20
申请号：EP98958957.7
申请日：1998-12-04
申请人： Agence Française de Sécurité Sanitaires des Aliments
发明人： JESTIN, André , ALBINA, Emmanuel , LE CANN, Pierre , BLANCHARD, Philippe , HUTET, Evelyne , ARNAULD, Claire , TRUONG, Catherine , MAHE, Dominique , CARIOLET, Roland , MADEC, François
IPC分类号： C12N15/34 , C12N15/86 , C07K14/01 , C12N7/04 , C12N5/10 , C12N7/00 , A01K67/027 , C12Q1/68 , C07K16/08 , G01N33/569
CPC分类号： A61K39/12 , A01K2217/05 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/55522 , A61K2039/55566 , A61K2039/58 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2710/14143 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10061 , G01N33/56983 , G01N2333/01 , G01N2469/20 , Y10T428/13
摘要： The invention concerns the genome sequence and the nucleotide sequences coding for the PWD circovirus polypeptides, such as said circovirus structural and non-structural polypeptides, and vectors including said sequences and cells or animals transformed by said vectors. The invention also concerns methods for detecting said nucleic acids or polypeptides and kits for diagnosing infection by a PWD circovirus. The invention further concerns a method for selecting compounds capable modulating the viral infection. Finally the invention concerns pharmaceutical, in particular vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of said vector for preventing and/or treating diseases by gene therapy.

94. 发明公开

KR1020130024978A ＰＣＶ2 면역 조성물 및 이들 조성물의 생산 방법 无效
标题翻译： PCV2免疫组合物及其制备方法
公开(公告)号：KR1020130024978A
公开(公告)日：2013-03-08
申请号：KR1020137003087
申请日：2005-12-29
申请人： 베링거잉겔하임베트메디카인코퍼레이티드
发明人： 에크메리어,마크 , 닛젤,그레그 , 샤에페르,메릴
IPC分类号： A61K38/00 , C12N15/12 , C12N15/33 , C07K16/00
CPC分类号： A61K39/12 , A61K33/00 , A61K45/06 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55505 , A61K2039/55555 , C07K14/005 , C12N2710/14143 , C12N2710/14163 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2770/10034
摘要： 돼지 서코바이러스(porcine circovirus) 2형으로부터 오픈 리딩 프레임 2에 의해 발현되는 단백질을 회수하는 개선된 방법이 제시된다. 상기 방법은 전반적으로, 성장 배지 내에 내포된 세포 내로, 오픈 리딩 프레임 2 코딩 서열을 보유하는 재조합 바이러스를 형질감염시키고, 상기 바이러스가 오픈 리딩 프레임 2를 발현하도록 유도하고, 상층액 내에서 발현된 단백질을 회수하는 단계를 포함한다. 이러한 회수는 충분한 양의 재조합 단백질이 발현되고 상기 세포로부터 성장 배지 내로 분비되도록 하기 위하여, 이들 세포의 감염이후 대략 5일 시점부터 시작된다. 이들 방법은 세포 내로부터 재조합 단백질을 분리하고 회수하는데 요구되는, 비용과 시간이 많이 소모되는 추출 절차를 회피한다.

95. 发明公开

KR1020080093112A 돼지에서 임상 증상을 경감시키기 위한 ＰＣＶ2 면역원성조성물의 용도 无效
标题翻译：使用PCV2免疫组合物治疗小便中的临床症状
公开(公告)号：KR1020080093112A
公开(公告)日：2008-10-20
申请号：KR1020087018597
申请日：2006-12-28
申请人： 베링거잉겔하임베트메디카인코퍼레이티드
发明人： 루프마이클비 , 헤이스필립웨인 , 아이흐마이어마르크 , 니첼그레그 , 쉐퍼메릴
IPC分类号： A61K39/12 , A61K39/125
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopalhy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (51 nephritis and (6) reproductive disorders, e.g. abortion, stillbirths. mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
摘要翻译：本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物的用途。优选地，临床表现与PCV2感染相关。优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结肿大：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡，（51）肾炎和（6）生殖障碍，例如堕胎，死胎，木乃伊等。此外，临床症状包括通常已知与细胞内劳森氏菌感染相关的Pia样病变。

96. 发明公开

KR1020040021988A 바이러스 증식용 돼지 신장 상피 세포주, 및 이의 용도 无效
标题翻译：用于复制病毒的PORCINE KIDNEY上皮细胞系及其用途
公开(公告)号：KR1020040021988A
公开(公告)日：2004-03-11
申请号：KR1020020053792
申请日：2002-09-06
申请人： 서상희
发明人： 서상희
IPC分类号： C12N5/07
CPC分类号： C12N5/0686 , C12N7/02 , C12N2510/02 , C12N2750/10051 , C12N2760/16151 , C12N2770/24051
摘要： PURPOSE: A porcine kidney epithelial cell line for replication of virus and the use thereof are provided. The porcine kidney epithelial cell line has improved infectivity titer and the influenza virus produced from the porcine kidney epithelial cell line does not induce antigenic change of the HA1 region of hemagglutin molecule. Therefore, it can be useful for production of influenza virus vaccine for human and animals. CONSTITUTION: A porcine kidney epithelial cell line(VL-PKEC)(KCTC 10299BP) for replication of virus is free of HA antigenic change. The virus is Japanese encephalitis virus, porcine circovirus or influenza virus, and the influenza virus comprises all subtypes of influenza viruses. A method for replication of virus without HA antigenic change comprises the steps of: (a) infecting a virus to be replicated with the porcine kidney epithelial cell line(VL-PKEC)(KCTC 10299BP); (b) culturing the infected virus; and (c) isolating and purifying the virus when the virus shows high titer.
摘要翻译：目的：提供用于病毒复制的猪肾上皮细胞系及其用途。猪肾上皮细胞系具有改善的感染效价，并且由猪肾上皮细胞系产生的流感病毒不诱导血凝素分子的HA1区域的抗原性变化。因此，它可用于生产用于人和动物的流感病毒疫苗。构成：用于病毒复制的猪肾上皮细胞系（VL-PKEC）（KCTC 10299BP）不具有HA抗原性变化。病毒是日本脑炎病毒，猪圆环病毒或流感病毒，流感病毒包括流感病毒的所有亚型。用于复制没有HA抗原变化的病毒的方法包括以下步骤：（a）感染用猪肾上皮细胞系（VL-PKEC）（KCTC 10299BP）复制的病毒; （b）培养感染病毒; 和（c）当病毒显示高滴度时分离和纯化病毒。

97. 发明公开

KR1020170122262A 특히 바큘로바이러스-발현 아단위 항원을 위한 마커 시스템 审中-实审
标题翻译：特别是杆状病毒表达的亚基抗原的标记系统
公开(公告)号：KR1020170122262A
公开(公告)日：2017-11-03
申请号：KR1020177028087
申请日：2016-03-04
申请人： 베링거잉겔하임베트메디카인코퍼레이티드
发明人： 아이어에이런브이. , 헤르만조셉랄프 , 루프마이클비. , 본에릭마틴 , 쉐퍼메릴린
IPC分类号： G01N33/68 , G01N33/50 , C07K14/005 , C12Q1/70 , A61K39/12 , A61K39/145 , A61K39/00
CPC分类号： G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07K14/005 , C07K2319/21 , C07K2319/50 , C12N7/00 , C12N2710/14021 , C12N2710/14022 , C12N2710/14043 , C12N2710/14051 , C12N2710/14143 , C12N2750/10034 , C12N2750/10051 , C12N2760/16134 , C12N2760/16151 , C12N2760/20022 , C12N2760/20034 , C12N2760/20051 , C12P21/00 , C12Q1/701 , G01N33/5091 , G01N33/6854 , G01N2333/01
摘要： 본발명은감염된개체와백신접종된개체사이의구별을위한순응마커 (compliance marker) 및마커백신분야에속한다. 특히, 본발명은개체가배양된곤충세포에서바큘로바이러스발현시스템에의해생산된재조합단백질을포함하는면역원성조성물을투여받았는지여부를결정하는방법을제공한다.
摘要翻译：本发明属于依从性标记和标记疫苗领域，用于区分感染和接种疫苗的个体。具体而言，本发明提供了一种用于确定个体是否已施用了包含由杆状病毒表达系统产生的重组蛋白在培养的昆虫细胞中的免疫原性组合物的方法。

98. 发明公开

KR1020140019479A 돼지에서 임상 증상을 경감시키기 위한 ＰＣＶ2 면역원성 조성물의 용도 无效
标题翻译：使用PCV2免疫组合物治疗小便中的临床症状
公开(公告)号：KR1020140019479A
公开(公告)日：2014-02-14
申请号：KR1020147001544
申请日：2006-12-28
申请人： 베링거잉겔하임베트메디카인코퍼레이티드
发明人： 루프마이클비 , 헤이스필립웨인 , 아이흐마이어마르크 , 니첼그레그 , 쉐퍼메릴
IPC分类号： A61K39/12 , A61K39/125 , A61P11/00 , A61P17/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： 본 발명은 여러 임상적 증상(질환)을 치료하기 위한, 돼지 시르코바이러스 2형(PCV2) 항원을 포함하는 면역원성 조성물의 용도에 관한 것이다. 바람직하게, 임상적 증상은 PCV2 감염과 관련된다. 바람직하게, 이들은 림프선병증, 림프계 고갈 및/또는 다핵화된/거대 조직구를 포함한다. 더욱이, 임상적 증상은 돼지에서 하기의 하나 또는 다중의 증상과 복합된 림프선병증을 포함한다: (1) 소엽사이 부종을 갖는 간질성 폐렴, (2) 피부 창백 또는 황달, (3) 반점 위축성 간, (4) 위궤양, (5) 신염 및 (6) 생식 장애(예를 들어, 유산, 사산, 미이라) 등. 추가로, 임상적 증상은 로소니아 세포내 감염과 관련된 것으로 공지된 연막형 병변을 포함한다.
摘要翻译：本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物。优选地，临床表现与PCV2感染相关。优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡，（5）肾炎和（6）生殖障碍，例如流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。

99. 发明公开

KR1020020020260A 서코바이러스를 생장시키거나 생물학적 물질로부터제거하는 방법 无效
标题翻译：从生物材料中生长或去除线粒体的方法
公开(公告)号：KR1020020020260A
公开(公告)日：2002-03-14
申请号：KR1020010055061
申请日：2001-09-07
申请人： 체에스엘 베링 게엠베하
发明人： 베른하르트디터 , 바이머토마스 , 그뢰너알브레흐트
IPC分类号： C12N7/08
CPC分类号： G01N33/56983 , A61K39/12 , A61K2039/525 , A61K2039/5254 , C12N7/00 , C12N2750/10034 , C12N2750/10051 , C12N2750/10064
摘要： PURPOSE: Provided are methods for growing and quantifying the infectious or antigenic amount and determining antibodies against circoviruses, in particular porcine circoviruses (PCV). Also provided are methods for detecting the reduction in circoviruses and circovirus-like viruses of humans through the method for manufacturing pharmaceuticals from biological material. CONSTITUTION: The method for growing circoviruses, in particular porcine circoviruses (PCV), comprises circoviruses obtained from an infected cell culture being, after one or more passages in cultures of porcine, bovine or human cells, developed in these cell cultures and a cytopathogenic effect occurring thereby. The method for neutralizing or removing circoviruses from biological material, comprises treating it with an antibody-containing substrate such as porcine serum or human immunoglobulin or subjecting it to a pasteurization method.
摘要翻译：目的：提供生长和定量感染或抗原量的方法，并确定抗圆环病毒，特别是猪圆环病毒（PCV）的抗体。还提供了通过生物材料制造药物的方法来检测人类的圆环病毒和圆环病毒样病毒的减少的方法。构成：生长圆环病毒，特别是猪圆环病毒（PCV）的方法包括从感染细胞培养物获得的圆环病毒，在这些细胞培养物中发育的猪，牛或人细胞培养物中的一种或多种传代后，产生细胞致病作用由此发生。用于从生物材料中和或去除圆环病毒的方法包括用含抗体的底物如猪血清或人免疫球蛋白处理，或使其进行巴氏消毒法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式