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91. 发明申请

US20220315860A1 METHOD FOR TRANSFORMING AN ESSENTIAL OIL 有权
公开(公告)号：US20220315860A1
公开(公告)日：2022-10-06
申请号：US17781958
申请日：2020-12-04
申请人： PRANAROM INTERNATIONAL S.A. , UNIVERSITE LIBRE DE BRUXELLES , UNIVERSITE GRENOBLE ALPES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： Abdesselam ZHIRI , Sofia OLIVEIRA RIBEIRO , Caroline STEVIGNY , Florence SOUARD , Dominique BAUDOUX
IPC分类号： C11B9/02 , A61K36/28 , A61K45/06
摘要： The invention relates to a method for transforming an essential oil, an essential oil fraction obtained in said manner, combinations comprising the essential fraction obtained in said manner and an antibiotic or an antifungal and the use thereof as a medicament in particular the use thereof in the prevention or treatment of infectious bacterial or fungal diseases.

92. 发明申请

US20210196106A1 DEVICES, SYSTEMS, AND METHODS FOR LOCATING A BODY LUMEN 有权
公开(公告)号：US20210196106A1
公开(公告)日：2021-07-01
申请号：US17034026
申请日：2020-09-28
申请人： Boston Scientific Scimed Inc. , Universite Libre de Bruxelles , Brussels Medical Device Center
发明人： Peter L. Dayton , Nicolas Cauche , Cecilia Delattre , Marc A. Barthet , Jean-Michel Gonzalez , Louis J. Barbato , Eric F. Brown , John Nguyen , John T. Favreau , Marcia Nardone
IPC分类号： A61B1/01 , A61B1/06 , A61B1/00 , A61B1/273 , A61B1/31
摘要： This disclosure relates generally to medical devices, systems, and methods for locating devices and/or anatomy during medical procedures. More particularly, in some embodiments, the disclosure relates to medical device and/or anatomy locating devices, access devices, and systems and methods thereof, for use during, e.g., gastrojejunostomy procedures. In an aspect, a medical device locator may include an elongate member (such as sheath or guidewire) having a proximal end, a distal end, a longitudinal axis, and a length extending along the longitudinal axis. A location device may be disposed along the length of the elongate member.

93. 发明申请

US20210068708A1 ENDOSCOPIC NON-CONTACT MEASUREMENT DEVICE 有权
公开(公告)号：US20210068708A1
公开(公告)日：2021-03-11
申请号：US16960257
申请日：2019-01-09
申请人： UNIVERSITE LIBRE DE BRUXELLES
发明人： Benjamin MERTENS , Alain DELCHAMBRE , Maxime PETRE , Jacques DEVIERE , Dimitri LEDUC
IPC分类号： A61B5/107 , G02B27/10 , A61B1/00 , A61B1/05 , A61B1/06 , A61B5/00 , A61B1/267 , A61B1/07 , G06T7/00 , G06T7/62 , H04N5/225 , G06T7/70 , G01B11/25
摘要： A device for non-contact measurement includes a light source and a light pattern projector having a diffractive optical element. An imaging system images a target site illuminated by the light pattern projector. The light pattern projector and the imaging system are attached to a support in fixed relative positions. The support has a longitudinal axis parallel to an optical axis of the projector, and the projector and the imaging system are spaced apart along the longitudinal axis. The light source emits a plurality of light beams of different colors, each one being a coherent beam optically coupled to the diffractive optical element. The diffractive optical element diffracts the plurality of light beams according to different diffraction angles resulting in separate patterns. The processing unit determines a measurement based on at least two positions automatically recognized in data acquired from a single one of the separate patterns.

94. 发明授权

US10022190B2 Optical force transducer 有权
公开(公告)号：US10022190B2
公开(公告)日：2018-07-17
申请号：US14377443
申请日：2013-04-02
申请人： UNIVERSITE LIBRE DE BRUXELLES , UNIVERSITE DE MONS
发明人： Jean-Baptiste Valsamis , Nicolas Cauche , Jacques Deviere , Christophe Caucheteur , Valérie Voisin
IPC分类号： A61B19/00 , A61B5/22 , G01L5/16 , G01L1/24 , A61B5/00 , G01B11/16 , A61B34/20 , G01D5/353 , A61B90/00
摘要： Force transducer (10) include two structural members (11, 12) spaced apart to define a gap (101) and being linked to each other. Optical fibers (13) are to the members and are freely suspended in the gap. The optical fibers are configured to provide a change in a detectable optical property responsive to a change in relative position between the two members in one or more predetermined degrees of freedom. Each of the optical fibers (13) is fixed to both structural members and continuous between the members to link the two structural members to each other. The optical fibers are substantially the only structure forming a link between the two structural members (11, 12), such that the arrangement of the optical fibers defines substantially the stiffness of the link between the two structural members in the one or more predetermined degrees of freedom, which stiffness is mainly, such as for at least 95%, determined by the optical fibers.

95. 发明授权

US09309518B2 Reversible, parallel and multitask cloning method and kit 有权
标题翻译：可逆，并行和多任务克隆方法和试剂盒
公开(公告)号：US09309518B2
公开(公告)日：2016-04-12
申请号：US13660907
申请日：2012-10-25
申请人： Cédric Szpirer , Michel C. Milinkovitch , Philippe Gabant
发明人： Cédric Szpirer , Michel C. Milinkovitch , Philippe Gabant
IPC分类号： C12N15/66 , C12N15/63 , C12N15/10 , C12N15/65 , C12N15/70
CPC分类号： C12N15/63 , C12N15/10 , C12N15/65 , C12N15/66 , C12N15/70
摘要： The present invention is related to integrated method and tools to construct recombinant DNA molecules (to be used as DNA vaccine or gene therapy) without requiring the use of antibiotic(s) resistance gene(s) and without requiring the addition of one or more antibiotic(s) to the culture medium of cells submitted to this recombinant DNA method. The present invention allows to obtain the selection of recombinant host cell(s) transformed by a (exogenous) nucleic acid sequence of interest (extra-chromosomal vector containing the insert) and simultaneously stabilization (stable inheritance) of this (exogenous) nucleic acid sequence of interest into the transformed host cell(s) descendants (maintenance of the nucleic acid sequence of interest in the host cells population).
摘要翻译：本发明涉及构建重组DNA分子（用作DNA疫苗或基因治疗）而不需要使用抗生素抗性基因并且不需要添加一种或多种抗生素的综合方法和工具到细胞的培养基中进行该重组DNA方法。本发明允许获得通过（外源）感兴趣的核酸序列（含有插入片段的染色体外载体）转化的重组宿主细胞的选择，并同时稳定（稳定的遗传）该（外源）核酸序列对转化的宿主细胞后代感兴趣（维持宿主细胞群体中感兴趣的核酸序列）。

96. 发明授权

US09211338B2 Composition and method for treating HPV 有权
标题翻译：用于治疗HPV的组合物和方法
公开(公告)号：US09211338B2
公开(公告)日：2015-12-15
申请号：US14232529
申请日：2012-07-13
申请人： Marie Piette , Brigitte Evrard , Isabelle Coïa
发明人： Marie Piette , Brigitte Evrard , Isabelle Coïa
IPC分类号： A61K9/14 , A61K47/38 , A61K9/00 , A61K9/19 , A61K31/675 , A61K9/06 , A61K9/70
CPC分类号： A61K47/38 , A61K9/0014 , A61K9/0034 , A61K9/006 , A61K9/06 , A61K9/19 , A61K9/7007 , A61K31/675
摘要： Described are lyophilized compositions comprising cidofovir, hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and, optionally, a plasticizer. In particular, described are such compositions that form a sheet-shaped porous solid matrix. Also described are methods for producing such compositions and their use in treating human papillomavirus (HPV) infections and HPV-associated malignancies, in particular, HPV lesions and cervical cancer.
摘要翻译：描述了包含西多福韦，羟丙基甲基纤维素（HPMC）或羟乙基纤维素（HEC）和任选的增塑剂的冻干组合物。特别地，描述了形成片状多孔固体基质的这种组合物。还描述了生产这种组合物的方法及其在治疗人乳头状瘤病毒（HPV）感染和HPV相关恶性肿瘤，特别是HPV病变和子宫颈癌中的用途。

97. 发明申请

US20140363828A1 METHOD AND DEVICE FOR ASSAYING AN ANTIGEN PRESENT ON ERYTHROCYTES OR AN ANTIBODY BINDING TO AN ANTIGEN PRESENT ON ERYTHROCYTES 审中-公开
标题翻译：用于测定抗原蛋白的抗原蛋白或抗体结合抗原存在于抗凝血剂上的方法和装置
公开(公告)号：US20140363828A1
公开(公告)日：2014-12-11
申请号：US14363554
申请日：2012-12-05
申请人： UNIVERSITE LIBRE DE BRUXELLES
发明人： Francis Corazza , Hanane El Kenz
IPC分类号： G01N33/80
CPC分类号： G01N33/80
摘要： An assaying kit is for pre-transfusion blood group matching between two blood samples. The kit includes at least two assemblies (101,201) corresponding to the first and the second blood sample, each assembly has at least two test units (1). Each test unit (1) includes a reagent containing an antigen present on erythrocytes or an antibody able to bind to an antigen present on erythrocytes. Each test unit (1) also includes a membrane (2) permeable to free erythrocytes (6) and impermeable to hemagglutinated erythrocytes. The antibody contained in the first test unit for both the first assembly (101) and the second assembly (201) corresponds to a first blood group and the antibody contained in the second test units for both the first assembly (101) and the second assembly (201) corresponds to a second blood group.
摘要翻译：测定试剂盒用于两个血液样本之间的输血前血型匹配。该套件包括对应于第一和第二血液样本的至少两个组件（101,201），每个组件具有至少两个测试单元（1）。每个测试单元（1）包括含有存在于红细胞上的抗原或能够结合存在于红细胞上的抗原的抗体的试剂。每个测试单元（1）还包括可透过游离红细胞（6）的膜（2），并且对血细胞凝集的红细胞是不可渗透的。包含在第一组件（101）和第二组件（201）中的第一测试单元中的抗体对应于第一血型，并且包含在第一测试单元中的用于第一组件（101）和第二组件（201）对应于第二血型。

98. 发明授权

US08877504B2 Method for the selection of recombinant clones comprising a sequence encoding an antidote protein to toxic molecule 有权
标题翻译：用于选择重组克隆的方法，其包含编码毒性分子的解毒剂蛋白的序列
公开(公告)号：US08877504B2
公开(公告)日：2014-11-04
申请号：US13919952
申请日：2013-06-17
申请人： Universite Libre de Bruxelles
发明人： Philippe Gabant , Laurence Van Melderen , Cedric Yves Szpirer
IPC分类号： C12N15/70 , C07K14/245 , C12N15/10 , C12N15/65 , C12N15/66 , C07H21/04
CPC分类号： C12N15/70 , C07K14/245 , C12N15/10 , C12N15/1034 , C12N15/65 , C12N15/66
摘要： The present invention is related to a method for the selection of recombinant clones having integrated a gene of interest and a nucleotide sequence encoding a functional antidote protein to a toxic molecule, wherein said recombinant clones are the ones which survive following their integration into a host cell comprising in its genome a nucleotide sequence encoding said toxic molecule. The present invention is also related to a nucleic acid construct, a vector comprising said nucleic acid construct, a host cell and a cloning and/or sequencing kit for performing said method.
摘要翻译：本发明涉及用于选择具有将感兴趣的基因与编码功能性解毒剂蛋白质的核苷酸序列集成到毒性分子的重组克隆的方法，其中所述重组克隆是在其整合入宿主细胞后能够存活的克隆在其基因组中包含编码所述毒性分子的核苷酸序列。本发明还涉及核酸构建体，包含所述核酸构建体的载体，宿主细胞和用于进行所述方法的克隆和/或测序试剂盒。

99. 发明授权

US08772265B2 Water soluble curcumin compositions for use in anti-cancer and anti-inflammatory therapy 有权
标题翻译：用于抗癌和抗炎治疗的水溶性姜黄素组合物
公开(公告)号：US08772265B2
公开(公告)日：2014-07-08
申请号：US12995126
申请日：2009-05-26
申请人： Philippe Neven , Didier Serteyn , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks , Eva Scheer
发明人： Philippe Neven , Didier Serteyn , Jacques Delarge , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： B82Y5/00 , A61K31/724 , A61K45/06 , A61K47/6951 , A61K2300/00
摘要： The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumor and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases. In a fifth aspect, the present invention relates to the use of a pharmaceutical composition comprising said water soluble curcumin derivatives in the treatment of cancer and inflammatory diseases and to a new pharmaceutical composition comprising said water soluble curcumin derivatives.
摘要翻译：本发明涉及医疗领域。在第一方面，本发明涉及具有药理活性，特别是抗肿瘤和/或抗炎活性以及改善的物理化学性质的新的水溶性环糊精 - 姜黄素复合物。在第二方面，本发明涉及一种制备所述水溶性姜黄素衍生物的方法。本发明在第三方面进一步涉及包含有效量的所述水溶性姜黄素衍生物的药物组合物。在第四方面，本发明涉及所述水溶性姜黄素衍生物作为药物的用途，以及所述水溶性姜黄素衍生物在制备用于治疗癌症和炎性疾病的药物中的用途。在第五方面，本发明涉及包含所述水溶性姜黄素衍生物的药物组合物在治疗癌症和炎性疾病中的用途以及包含所述水溶性姜黄素衍生物的新药物组合物的用途。

100. 发明申请

US20140170219A1 COMPOSITION AND METHOD FOR TREATING HPV 有权
标题翻译：用于治疗HPV的组合物和方法
公开(公告)号：US20140170219A1
公开(公告)日：2014-06-19
申请号：US14232529
申请日：2012-07-13
申请人： Marie Piette , Brigitte Evrard , Isabelle Coïaée
发明人： Marie Piette , Brigitte Evrard , Isabelle Coïaée
IPC分类号： A61K47/38 , A61K31/675 , A61K9/70
CPC分类号： A61K47/38 , A61K9/0014 , A61K9/0034 , A61K9/006 , A61K9/06 , A61K9/19 , A61K9/7007 , A61K31/675
摘要： Described are lyophilized compositions comprising cidofovir, hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and, optionally, a plasticizer. In particular, described are such compositions that form a sheet-shaped porous solid matrix. Also described are methods for producing such compositions and their use in treating human papillomavirus (HPV) infections and HPV-associated malignancies, in particular, HPV lesions and cervical cancer.
摘要翻译：描述了包含西多福韦，羟丙基甲基纤维素（HPMC）或羟乙基纤维素（HEC）和任选的增塑剂的冻干组合物。特别地，描述了形成片状多孔固体基质的这种组合物。还描述了生产这种组合物的方法及其在治疗人乳头状瘤病毒（HPV）感染和HPV相关恶性肿瘤，特别是HPV病变和子宫颈癌中的用途。

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