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91. 发明专利

AU2006215084B2 Cyclohepta(b)pyridine-3-carbonylguanidine derivative and pharmaceutical product containing same 未知
公开(公告)号：AU2006215084B2
公开(公告)日：2011-03-24
申请号：AU2006215084
申请日：2006-02-16
申请人： TOA EIYO LTD
发明人： UEMOTO KAZUHIRO , KAZAYAMA SHIN-ICHI , TAKAYANAGI KOICHI
IPC分类号： C07D221/04 , A61K31/435 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/06 , A61P9/10 , A61P9/12 , A61P35/00 , A61P43/00
摘要： The present invention relates to a medicine, particularly a medicine comprising a novel cyclohepta[b]pyridine-3-carbonylguanidine derivative having an inhibitory effect on an Na + /H + exchanger (NHE). There is provided a cyclohepta[b]pyridine-3-carbonylguanidine derivative represented by Formula (1): wherein R 1 is a group selected from a sulfo group, a sulfoxy group, -OCONH-(CH 2 CH 2 O) n -SO 3 H and the following formulas: R 2 represents a halogen atom, a lower alkyl group or a lower alkoxy group; and n represents an integer from 1 to 10, or a pharmaceutically acceptable salt thereof.

92. 发明专利

NZ566494A Adhesive preparation containing bisoprolol 未知
公开(公告)号：NZ566494A
公开(公告)日：2010-10-29
申请号：NZ56649406
申请日：2006-09-07
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： IWAO YOSHIHIRO , OOKUBO KATSUYUKI , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12
摘要： Disclosed is an adhesive pharmaceutical preparation containing bisoprolol, which comprises a support and an adhesive layer on one side of the support, wherein the adhesive layer contains bisoprolol, polyisobutylene, a tackifier, and an organic liquid ingredient compatible with polyisobutylene and the tackifier selected from a fatty acid alkyl ester, a long-chain alcohol selected from saturated or unsaturated alcohols having from 12 to 28 carbon atoms, or a combination thereof; and wherein the content of bisoprolol per the total weight of the adhesive layer is 0.5 to 5% by weight.

93. 发明专利

DE60333351D1 N-SUBSTITUIERTES BENZOTHIOPHENSULFONAMIDDERIVAT 未知
公开(公告)号：DE60333351D1
公开(公告)日：2010-08-26
申请号：DE60333351
申请日：2003-03-13
申请人： TOA EIYO LTD
发明人： SATOH SHOJI , MIZUNO YUSUKE , MASAKI HIDEKAZU
IPC分类号： C07D333/62 , A61K31/381 , A61K31/422 , A61K31/427 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D413/12 , C07D417/12 , C07D417/14

94. 发明专利

IL200378D0 PERCUTANEOUS ADMINISTRATION DEVICE OF DISOPROLOL 未知
公开(公告)号：IL200378D0
公开(公告)日：2010-04-29
申请号：IL20037809
申请日：2009-08-13
申请人： NITTO DENKO CORP , TOA EIYO LTD
IPC分类号： A61K20100101
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 µg/cm 2 /hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 µg/cm 2 /hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.

95. 发明专利

CA2626011A1 S1P3 RECEPTOR ANTAGONIST 未知
公开(公告)号：CA2626011A1
公开(公告)日：2007-04-19
申请号：CA2626011
申请日：2006-10-11
申请人： TOA EIYO LTD
发明人： SADA TOMOYUKI , OHNUMA SHIN-YA , HASEGAWA TAKESHI
IPC分类号： C07C257/22 , A61K31/155 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/4453 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P11/00 , A61P13/12 , A61P27/02 , A61P35/00 , A61P43/00 , C07C317/36 , C07D295/18 , C07D307/46 , C07D333/22
摘要： The present invention relates to a medicine, and more particularly to novel arylamidrazone derivatives having an antagonistic action against S1P 3 receptors and a medicine containing thereof as an active ingredient. The present invention provides an arylamidrazone derivative represented by' the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R 1 represents a C 2 -C 8 alkyl group which maybe substituted, a phenyl group which maybe substituted, an aromatic heterocyclic group which may be substituted, a C 2 -C 8 alkoxy group which may be substituted, or -NR 4 R 5 (wherein R 4 and R 5 , which are identical or different, each represent a hydrogen atom or a lower alkyl group which may be substituted, or R 4 and R 5 may be joined with the adjacent nitrogen atom to form a nitrogen-containing heterocyclic ring which may be substituted); R 2 and R 3 , which are identical or different, each represent a hydrogen atom, a halogen atom, a halo-lower alkyl group, a lower alkyl group, a lower alkynyl group, a lower alkoxy group, a cyano group, a lower alkanoyl group or a lower alkylsulfonyl group; A represents a benzene ring or a heterocyclic ring; D represents a single bond or methylene; m represents an integer from 1 to 3, and n represents an integer from 1 to 5 (with the proviso that the case where R 1 is an ethoxy group, R 2 is a 2,4-dichloro group, R 3 is a hydrogen atom, A is a benzene ring, and D is methylene; and the case where R 1 is an ethoxy group, R 2 is a 2,4-dichloro group, R 3 is a hydrogen atom, a 2-methyl group, a 4-methyl group, a 4-methoxy group or a 4-ethoxy group, A is a benzene ring, and D is a single bond, are excluded).

96. 发明专利

AU2006288260A1 Adhesive preparation containing bisoprolol 未知
公开(公告)号：AU2006288260A1
公开(公告)日：2007-03-15
申请号：AU2006288260
申请日：2006-09-07
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： IWAO YOSHIHIRO , OHKUBO KATSUYUKI , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12
摘要： An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparation 10 comprises a support 1, an adhesive layer 2 laminated on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisprolol can be administered continuously into the living body through the skin surface.

97. 发明专利

DE69930271T8 未知
公开(公告)号：DE69930271T8
公开(公告)日：2006-12-28
申请号：DE69930271
申请日：1999-08-31
申请人： YAMASA CORP , TOA EIYO LTD
发明人： ENDO KAZUKI , ABIRU TOICHI , HOSOKAWA TOMOKAZU , MISAWA MIWA , KONNO TAKASHI
IPC分类号： A61K31/70 , A61K9/00 , A61K9/06 , A61K9/08 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P27/02 , C07H19/16 , C07H19/167
摘要： Medicinal compositions for treating eye diseases which contain as the active ingredient 2-alkynyladenosine derivatives having an acetylene union at the 2-position of adenine base. Having a long-lasting and remarkable effect of lowering ocular tension, these compositions are useful as remedies for eye diseases accompanying increased ocular tension or optic nerve failures, such as glaucoma and hypertonia oculi.

98. 发明专利

AT281464T 未知
公开(公告)号：AT281464T
公开(公告)日：2004-11-15
申请号：AT01963522
申请日：2001-09-07
申请人： TOA EIYO LTD , YAMASA CORP
发明人： KONNO TAKASHI , YUNO IIZAKAMACHI , UEMOTO KAZUHIRO , ONUMA SHINYA , KATO YOSHIKAZU
IPC分类号： A61K9/00 , A61K31/7076 , A61P27/06 , C07H19/16 , C07H19/20 , C07H19/167 , A61K31/70
摘要： 2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5'-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent effects of lowering ocular tension, promoting blood flow in retina, and protecting optic nerve failure and are highly soluble in water. Owing to these characteristics, the compounds are useful as drugs such as remedies for glaucoma and ocular hypertension.

99. 发明专利

CA2421067A1 ADENOSINE DERIVATIVES AND USE THEREOF 未知
公开(公告)号：CA2421067A1
公开(公告)日：2003-02-28
申请号：CA2421067
申请日：2001-09-07
申请人： TOA EIYO LTD , YAMASA CORP
发明人： ONUMA SHINYA , UEMOTO KAZUHIRO , KATO YOSHIKAZU , KONNO TAKASHI
IPC分类号： A61K9/00 , A61P27/06 , C07H19/16 , C07H19/20 , C07H19/167 , A61K9/08 , A61K31/7076
摘要： 2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5'- monophosphate or salts thereof and drugs containing the same as the active ingredient. The above compounds have excellent effects of lowering ocular tension, promoting blood flow in the retina and protecting optic nerve failu re and are highly soluble in water. Owing to these characteristics, the above compounds are useful as drugs such as remedies for glaucoma and ocular hypertension.

100. 发明专利

ES2139806T3 未知
公开(公告)号：ES2139806T3
公开(公告)日：2000-02-16
申请号：ES95114128
申请日：1995-09-08
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： AKEMI HITOSHI , MURAOKA TAKATERU , HIGASHIO KAZUHIRO , OTSUKA SABURO , KINOSHITA TAKASHI
IPC分类号： A61K9/70 , A61K31/34 , A61K47/14 , A61P9/08 , A61P9/10 , A61K47/32

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