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    • 96. 发明公开
    • T cell epitopes of the major allergens from ambrosia artemisiifolia
    • 来自苦楝的主要过敏原的T细胞表位
    • EP0770681A3
    • 1997-06-04
    • EP96202492.3
    • 1993-04-06
    • IMMULOGIC PHARMACEUTICAL CORPORATION
    • Kuo, Mei-ChangGarman, Richard D.Greenstein, Julia L.
    • C12N15/29C07K14/415A61K39/36G01N33/68
    • C07K14/415A61K39/00G01N33/68
    • The present invention provides isolated peptides of the major protein allergens of Ambrosia artemisiifolia, or short ragweed pollen. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Amb a I.1, Amb a I.2, Amb a I.3, Amb a I.4 and Amb a II. Modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects are disclosed. The invention also provides nucleic acids having sequences encoding peptides of the invention. Methods of treatment or of diagnosis of sensitivity to ragweed pollen allergens in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.
    • 本发明提供了豚草(Ambrosia artemisiifolia)或短豚草花粉的主要蛋白质过敏原的分离肽。 本发明范围内的肽包含至少一个T细胞表位,或优选至少两个选自过敏原Amb a I.1,Amb a I.2,Amb a I.3,Amb II的蛋白质过敏原的T细胞表位 一个I.4和一个Amb II II。 披露了具有与相应的天然存在的过敏原或其部分相似或增强的治疗性质但具有减少的副作用的修饰的肽。 本发明还提供了具有编码本发明肽的序列的核酸。 还提供了在个体中治疗或诊断对豚草花粉变应原敏感的方法和包含一种或多种本发明肽的治疗性组合物。