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91. 发明申请

US20120232109A1 3-SUBSTITUTED SULFONYL PIPERIDINE DERIVATIVE 有权
标题翻译： 3-取代的噻吩哌啶衍生物
公开(公告)号：US20120232109A1
公开(公告)日：2012-09-13
申请号：US13478680
申请日：2012-05-23
申请人： Tsuyoshi Nagase , Takahide Sasaki , Toshiyuki Takahashi
发明人： Tsuyoshi Nagase , Takahide Sasaki , Toshiyuki Takahashi
IPC分类号： A61K31/439 , A61K31/444 , C07D401/12 , A61K31/4545 , A61K31/454 , C07D401/14 , A61K31/445 , C07D451/02 , A61K31/46 , A61P3/10 , A61P3/04 , A61P1/16 , C07D471/08 , C07D211/96
CPC分类号： C07D211/26 , C07D401/04 , C07D401/14 , C07D453/06
摘要： [Problem] There is provided a compound useful as a preventive or remedy for cardiovascular disease, neurologic disease, metabolic disease, reproductive disease, and digestive disease.[Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I) wherein Z represents wherein n1, n2, and n3 are 0, 1, or 2, respectively; R1 represents C1-6 alkyl, C3-8 cycloalkyl, or the like; R2 represents aryl or heteroaryl; R3 represents a hydrogen atom, C1-6 alkyl, or the like; and M1, M2, M3, and M4 independently represent a hydrogen atom, C1-6 alkyl, or the like, or M1, together with M2, M3, or M4, forms —CH2— or the like.
摘要翻译： [问题]提供了用作心血管疾病，神经疾病，代谢疾病，生殖疾病和消化疾病的预防或补救的化合物。 [解决方法]由下式（I）表示的化合物或其药学上可接受的盐，其中Z表示其中n1，n2和n3分别为0,1或2; R 1表示C 1-6烷基，C 3-8环烷基等; R2表示芳基或杂芳基; R3表示氢原子，C1-6烷基等; 并且M1，M2，M3和M4独立地表示氢原子，C1-6烷基等，或M1与M2，M3或M4一起形成-CH 2 - 等。

92. 发明授权

US08188280B2 3-substituted sulfonyl piperidine derivative 有权
标题翻译： 3-取代的磺酰哌啶衍生物
公开(公告)号：US08188280B2
公开(公告)日：2012-05-29
申请号：US12865878
申请日：2009-02-04
申请人： Tsuyoshi Nagase , Takahide Sasaki , Toshiyuki Takahashi
发明人： Tsuyoshi Nagase , Takahide Sasaki , Toshiyuki Takahashi
IPC分类号： A61K31/439 , A61K31/46 , A61K31/451 , A61K31/4545 , A61K31/454 , C07D401/12 , C07D417/12 , C07D451/02 , C07D211/96 , C07D221/21
CPC分类号： C07D211/26 , C07D401/04 , C07D401/14 , C07D453/06
摘要： [Problem] There is provided a compound useful as a preventive or remedy for cardiovascular disease, neurologic disease, metabolic disease, reproductive disease, and digestive disease.[Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I) wherein Z represents wherein n1, n2, and n3 are 0, 1, or 2, respectively; R1 represents C1-6 alkyl, C3-8 cycloalkyl, or the like; R2 represents aryl or heteroaryl; R3 represents a hydrogen atom, C1-6 alkyl, or the like; and M1, M2, M3, and M4 independently represent a hydrogen atom, C1-6 alkyl, or the like, or M1, together with M2, M3, or M4, forms —CH2— or the like.
摘要翻译： [问题]提供了用作心血管疾病，神经疾病，代谢疾病，生殖疾病和消化疾病的预防或补救的化合物。 [解决方法]由下式（I）表示的化合物或其药学上可接受的盐，其中Z表示其中n1，n2和n3分别为0,1或2; R 1表示C 1-6烷基，C 3-8环烷基等; R2表示芳基或杂芳基; R3表示氢原子，C1-6烷基等; 并且M1，M2，M3和M4独立地表示氢原子，C1-6烷基等，或M1与M2，M3或M4一起形成-CH 2 - 等。

93. 发明授权

US08163898B2 4-sulfonylpiperidine derivatives 有权
标题翻译： 4-磺酰基哌啶衍生物
公开(公告)号：US08163898B2
公开(公告)日：2012-04-24
申请号：US12674999
申请日：2008-09-12
申请人： Tsuyoshi Nagase , Takahide Sasaki , Toshiyuki Takahashi
发明人： Tsuyoshi Nagase , Takahide Sasaki , Toshiyuki Takahashi
IPC分类号： C07D345/00 , C07D517/00 , C07D295/00 , C07D211/60
CPC分类号： C07D451/04 , C07D487/08
摘要： [PROBLEMS]To provide compounds useful as preventives or remedies for circulatory diseases, nervous diseases, metabolic diseases, reproductive system diseases, and digestive diseases.[MEANS FOR SOLVING PROBLEMS]Compounds represented by the general formula (I) or pharmaceutically acceptable salts thereof: wherein R1 is C1-6 alkyl, C3-8 cycloalkyl, or the like; R2 is phenyl, heteroaryl, or the like; Q is N or CH; and M1, M2, M3 and M4 are each independently hydrogen or C1-6 alkyl, or alternatively M1 together with M2 or M3 forms —CH2-CH2- or the like, or M4 together with M2 or M3 forms —CH2-CH2- or the like, with the proviso that M1, M2, M3, and M4 are such that one —CH2- or —CH2-CH2- group is formed thereamong.
摘要翻译： [问题]提供可用作循环系统疾病，神经疾病，代谢疾病，生殖系统疾病和消化系统疾病的预防措施或补救措施的化合物。用于解决问题的方法由通式（I）表示的化合物或其药学上可接受的盐：其中R 1是C 1-6烷基，C 3-8环烷基等; R2是苯基，杂芳基等; Q是N或CH; 并且M1，M2，M3和M4各自独立地为氢或C 1-6烷基，或者M1与M2或M3一起形成-CH 2 -CH 2 - 等，或者M4与M2或M3一起形成-CH 2 -CH 2 - 或其中，M1，M2，M3和M4是这样形成的，其中形成一个-CH 2 - 或-CH 2 -CH 2 - 基团。

94. 发明申请

US20120085220A1 BRASS INSTRUMENT PRACTICE DEVICE 有权
标题翻译：黄铜仪器实践装置
公开(公告)号：US20120085220A1
公开(公告)日：2012-04-12
申请号：US13377570
申请日：2010-05-10
申请人： Toshiyuki Takahashi
发明人： Toshiyuki Takahashi
IPC分类号： G09B15/06
CPC分类号： G09B15/06
摘要： A brass instrument practice device (1) is used for practicing while holding a lip state for playing a brass instrument and has a tubular body (10) and a mouth piece portion (20). The tubular body (10) has a through hole (11) formed inside. The mouth piece portion (20) is secured on one end side of the tubular body (10), has a cross-sectional shape relatively long in one direction so as to fit the shape between the upper and lower lips, and has an opening portion (22) communicating with the through hole (11) and constituting a flow path through which air from the lips flows.
摘要翻译：铜管乐器练习装置（1）用于练习用于演奏铜管乐器的唇状态，并具有管状体（10）和口部（20）。管状体（10）具有内部形成的通孔（11）。嘴部分（20）固定在管状体（10）的一端侧，具有在一个方向上相对较长的横截面形状，以适应上下唇之间的形状，并且具有开口部（22）与所述通孔（11）连通并构成来自所述嘴唇的空气流过的流路。

95. 发明申请

US20120004319A1 PROCESS FOR PRODUCING CAROTENOID 有权
标题翻译：生产CAROTENOID的方法
公开(公告)号：US20120004319A1
公开(公告)日：2012-01-05
申请号：US13203324
申请日：2010-03-01
申请人： Kentaro Shimizu , Tomoyuki Ishizaki , Toshiyuki Takahashi , Shotaro Uchizawa
发明人： Kentaro Shimizu , Tomoyuki Ishizaki , Toshiyuki Takahashi , Shotaro Uchizawa
IPC分类号： A61K31/122 , C07C49/573 , A61K8/35 , A61P43/00 , A61Q90/00 , C12P7/26 , C07C49/557
CPC分类号： C12R1/01 , A23L5/44 , A23L33/105 , A61K31/122 , C12P23/00
摘要： The present invention provides a method for producing a carotenoid-containing composition, comprising the steps of: subjecting a culture of a carotenoid-producing microorganism to an extraction treatment using a water-soluble organic solvent; dispersing the resulting extract solution in water for micellization; heat stirring the resulting micellized solution in a solvent break the micelles and precipitate the carotenoid component of interest to obtain the precipitate; collecting and heat washing the precipitate with ethanol; and further subjecting the precipitate to pulverization/drying; and food, a pharmaceutical composition and a cosmetic product comprising the carotenoid-containing composition.
摘要翻译：本发明提供一种含有类胡萝卜素的组合物的制造方法，包括以下步骤：使用水溶性有机溶剂对产生类胡萝卜素的微生物的培养物进行萃取处理; 将得到的提取液分散在水中进行胶束化; 在溶剂中加热搅拌得到的胶束化溶液使胶束破裂并沉淀出目的类胡萝卜素成分，得到沉淀物; 用乙醇收集和洗涤沉淀物; 并进一步对沉淀物进行粉碎/干燥; 食品，药物组合物和含有类胡萝卜素的组合物的化妆品。

96. 发明申请

US20100331360A1 3-SUBSTITUTED SULFONYL PIPERIDINE DERIVATIVE 有权
标题翻译： 3-取代的噻吩哌啶衍生物
公开(公告)号：US20100331360A1
公开(公告)日：2010-12-30
申请号：US12865878
申请日：2009-02-04
申请人： Tsuyoshi Nagase , Takahide Sasaki , Toshiyuki Takahashi
发明人： Tsuyoshi Nagase , Takahide Sasaki , Toshiyuki Takahashi
IPC分类号： A61K31/439 , C07D221/22 , C07D401/12 , A61K31/444 , C07D417/12 , A61K31/4439 , C07D451/02 , A61K31/46 , C07D211/96 , A61K31/451 , A61K31/4545 , A61K31/454 , A61P3/10 , A61P3/04 , A61P1/16
CPC分类号： C07D211/26 , C07D401/04 , C07D401/14 , C07D453/06
摘要： [Problem] There is provided a compound useful as a preventive or remedy for cardiovascular disease, neurologic disease, metabolic disease, reproductive disease, and digestive disease.[Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I) wherein Z represents wherein n1, n2, and n3 are 0, 1, or 2, respectively; R1 represents C1-6 alkyl, C3-8 cycloalkyl, or the like; R2 represents aryl or heteroaryl; R3 represents a hydrogen atom, C1-6 alkyl, or the like; and M1, M2, M3, and M4 independently represent a hydrogen atom, C1-6 alkyl, or the like, or M1, together with M2, M3, or M4, forms —CH2— or the like.
摘要翻译： [问题]提供了用作心血管疾病，神经疾病，代谢疾病，生殖疾病和消化疾病的预防或补救的化合物。 [解决方法]由下式（I）表示的化合物或其药学上可接受的盐，其中Z表示其中n1，n2和n3分别为0,1或2; R 1表示C 1-6烷基，C 3-8环烷基等; R2表示芳基或杂芳基; R3表示氢原子，C1-6烷基等; 并且M1，M2，M3和M4独立地表示氢原子，C1-6烷基等，或M1与M2，M3或M4一起形成-CH 2 - 等。

97. 发明申请

US20100168156A1 Novel Benzoxathiine Derivative 失效
标题翻译：新型苯并噻嗪衍生物
公开(公告)号：US20100168156A1
公开(公告)日：2010-07-01
申请号：US12084017
申请日：2006-10-25
申请人： Takashi Mizutani , Nagaaki Sato , Takahide Sasaki , Toshiyuki Takahashi
发明人： Takashi Mizutani , Nagaaki Sato , Takahide Sasaki , Toshiyuki Takahashi
IPC分类号： A61K31/4365 , A61K31/4523 , A61K31/4436 , A61K31/39 , C07D497/04 , C07D401/12 , C07D411/04 , C07D411/12 , A61P25/30 , A61P3/06 , A61P19/06 , A61P1/16 , A61P9/10 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/32 , A61P25/08
CPC分类号： C07D327/06 , C07D497/04
摘要： Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent —CH—, a nitrogen atom or the like.
摘要翻译：公开了由下式（I）表示的化合物及其药学上可接受的盐。该化合物可用于治疗肥胖症，糖尿病等。 [式（I）中，Ar表示苯环等， X1表示氮原子，硫原子等; R1表示芳基等; X2表示由下式（II）表示的基团：（其中R4和R5分别表示低级烷基等，m表示2-4的数）等; X和Y中的一个表示氧原子，另一个表示硫烷基等; X3-X6分别表示-CH-，氮原子等。

98. 发明授权

US07745506B2 UV-curable ink-jet ink, electronic circuit board, electronic component and display device 有权
标题翻译： UV固化型喷墨油墨，电子电路板，电子元件及显示装置
公开(公告)号：US07745506B2
公开(公告)日：2010-06-29
申请号：US11776091
申请日：2007-07-11
申请人： Hiroyuki Satou , Setsuo Itami , Fumitaka Ooizumi , Toshiyuki Takahashi
发明人： Hiroyuki Satou , Setsuo Itami , Fumitaka Ooizumi , Toshiyuki Takahashi
IPC分类号： C09D11/02 , C08F2/50 , G03F7/004
CPC分类号： C08F2/48 , C09D4/00 , C09D11/101 , C09D11/30 , Y10T428/31797 , C08F220/26
摘要： A UV-curable ink-jet ink is provided, which has a high sensitivity and allows soft and highly fine patterns to be formed. The UV-curable ink-jet ink includes a mono-functional polymerizable monomer (A) having a hydroxyl group, a di(meth)acrylate ester (B) and a photo-polymerization initiator (C).
摘要翻译：提供了一种UV固化喷墨油墨，其具有高灵敏度并且可以形成柔软且高度精细的图案。 UV固化型喷墨油墨包括具有羟基的单官能聚合单体（A），二（甲基）丙烯酸酯（B）和光聚合引发剂（C）。

99. 发明授权

US07737523B2 Semiconductor device 有权
标题翻译：半导体器件
公开(公告)号：US07737523B2
公开(公告)日：2010-06-15
申请号：US11395599
申请日：2006-03-30
申请人： Shuichi Kikuchi , Shigeaki Okawa , Kiyofumi Nakaya , Toshiyuki Takahashi
发明人： Shuichi Kikuchi , Shigeaki Okawa , Kiyofumi Nakaya , Toshiyuki Takahashi
IPC分类号： H01L29/93
CPC分类号： H01L29/872 , H01L29/866
摘要： In a semiconductor device of the present invention, a protection diode for protecting a device is formed on an epitaxial layer formed on a substrate. A Schottky barrier metal layer is formed on a surface of the epitaxial layer and a P-type diffusion layer is formed at a lower portion of an end portion of the Schottky barrier metal layer. Then, a P-type diffusion layer is formed to be connected to a P-type diffusion layer and is extended to a cathode region. A metal layer to which an anode electrode is applied is formed above the P-type diffusion layer, thereby making it possible to obtain a field plate effect. This structure reduces a large change in a curvature of a depletion layer, thereby improving a withstand voltage characteristic of the protection diode.
摘要翻译：在本发明的半导体器件中，在形成在基板上的外延层上形成用于保护器件的保护二极管。在外延层的表面上形成肖特基势垒金属层，在肖特基势垒金属层的端部的下部形成P型扩散层。然后，形成P型扩散层以连接到P型扩散层并延伸到阴极区。在P型扩散层的上方形成有施加了阳极电极的金属层，能够得到场板效应。这种结构减小了耗尽层的曲率的大的变化，从而提高了保护二极管的耐电压特性。

100. 发明授权

US07645756B2 Nitrogenous fused heteroaromatic ring derivative 失效
标题翻译：含氮稠合杂芳环衍生物
公开(公告)号：US07645756B2
公开(公告)日：2010-01-12
申请号：US10589832
申请日：2005-02-17
申请人： Toshiyuki Takahashi , Akio Kanatani , Shigeru Tokita , Ryo Yoshimoto
发明人： Toshiyuki Takahashi , Akio Kanatani , Shigeru Tokita , Ryo Yoshimoto
IPC分类号： C07D487/04 , A61K31/5025 , A61K31/53 , A61P3/04 , A61P3/10 , A61P9/10
CPC分类号： C07D487/04
摘要： The invention provides a compound or its pharmaceutically-acceptable salt of formula wherein A1 is a hydrogen, etc.; j and k are 0 or 1; is a double bond, etc.; is a double bond, etc.; one of W1 and W2 is E—O—W, etc., and the other is a hydrogen atom, etc.; E is a divalent group derived from a benzene ring, etc., by removing two hydrogen atoms therefrom; W is a group of formula (II-1): which has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for prevention or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.
摘要翻译：本发明提供了下式的化合物或其药学上可接受的盐：其中A1是氢等; j和k为0或1; “img id =”CUSTOM-CHARACTER-00001“he =”3.13mm“wi =”9.14mm“file =”US07645756-20100112-P00001.TIF“alt =”custom character“img-content =”character“img-format =“tif”/>是双键等; “img id =”CUSTOM-CHARACTER-00002“he =”3.13mm“wi =”9.48mm“file =”US07645756-20100112-P00002.TIF“alt =”custom character“img-content =”character“img-format =“tif”/>是双键等; W1和W2之一是E-O-W等，另一个是氢原子等; E是通过从其中除去两个氢原子而衍生自苯环等的二价基团; W是一组式（II-1）：其具有组胺H3受体拮抗作用或组胺H3受体反向激动作用，并且可用于预防或治疗代谢系统疾病，循环系统疾病或神经系统疾病。

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