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91. 发明授权

US07396687B2 Mass spectrometric immunoassay analysis of specific proteins and variants present in various biological fluids 失效
标题翻译：对各种生物液体中存在的特定蛋白质和变体的质谱免疫分析
公开(公告)号：US07396687B2
公开(公告)日：2008-07-08
申请号：US10958867
申请日：2004-10-04
申请人： Randall W. Nelson , Peter Williams , Jennifer Reeve Krone
发明人： Randall W. Nelson , Peter Williams , Jennifer Reeve Krone
IPC分类号： G01N24/00
CPC分类号： C12Q1/6816 , C12Q1/6872 , G01N33/5302 , G01N33/54373 , Y10T436/24
摘要： Presented herein is the construction of pipettor tips (termed MSIA-Tips) containing porous solid supports that are constructed, covalently derivatized with affinity ligand, and used to extract specific proteins and their variants from various biological fluids by repeatedly flowing the fluids through the MSIA-Tips. A second protein species (a mass-shifted variant of the targeted protein doped into the samples at a constant concentration) is co-extracted with the endogenous protein and variants and is used as a quantitative internal reference standard (IRS). Nonspecifcally bound compounds are rinsed from the MSIA-Tip using a series of buffer and water rinses, after which the wild type protein, protein variants and the IRS are eluted from the MSIA-Tips directly onto a target in preparation for analysis such as MALDI-TOF. Mass spectrometry of the eluted sample then follows with the retained proteins identified via accurate molecular mass determination. Protein and variant levels are determined via a quantitative method in which the protein/variant signals are normalized to the signal of the IRS and the values compared to a working curve constructed from samples containing known concentrations of the protein or variants.
摘要翻译：这里提出的是构建含有多孔固体支持物的移液器尖端（称为MSIA-Tips），其构建为用亲和配体共价衍生，并且用于通过重复地使流体流过MSIA-DNA来从各种生物流体提取特定蛋白质及其变体，提示。将第二种蛋白质物种（以恒定浓度掺入样品中的靶向蛋白质的质量转移变体）与内源蛋白质和变体共萃取并用作定量内部参照标准品（IRS）。使用一系列缓冲液和水冲洗从MSIA-Tip中冲洗非特异性结合的化合物，之后将野生型蛋白质，蛋白质变体和IRS直接从MSIA-Tip中洗脱到靶上用于分析，如MALDI- TOF。洗脱的样品的质谱随后通过精确的分子量测定鉴定的保留的蛋白质。通过定量方法测定蛋白质和变体水平，其中将蛋白质/变体信号归一化为IRS的信号，并且该值与由含有已知浓度的蛋白质或变体的样品构建的工作曲线相比较。

92. 发明申请

US20080048441A1 TUBE FITTING WITH SEPARABLE TUBE GRIPPING DEVICE 失效
标题翻译：具有可分离管道装置的管子接头
公开(公告)号：US20080048441A1
公开(公告)日：2008-02-28
申请号：US11928104
申请日：2007-10-30
申请人： Mark Bennett , Peter Williams
发明人： Mark Bennett , Peter Williams
IPC分类号： F16L35/00
CPC分类号： F16L19/14 , F16L19/10
摘要： A tube fitting for a tube end has a female member that cooperates with a male member. A tube gripping device in the form of a gripping ring or ferrule is retained with the female member. Upon a partial pull-up, the tube gripping device separates from the female member.
摘要翻译：用于管端的管配件具有与阳构件配合的阴构件。夹紧环或套圈形式的管夹持装置与母构件一起保持。在部分上拉时，管夹持装置与阴构件分离。

93. 发明申请

US20080023110A1 Metal article with high interstitial content 审中-公开
标题翻译：具有高间隙含量的金属制品
公开(公告)号：US20080023110A1
公开(公告)日：2008-01-31
申请号：US11880597
申请日：2007-07-23
申请人： Peter Williams , Sunniva Collins , Steven Marx
发明人： Peter Williams , Sunniva Collins , Steven Marx
IPC分类号： C23C8/00
CPC分类号： C23C8/22 , C23C8/00 , C23C8/20
摘要： A thin metal workpiece is subjected to a low temperature diffusion-based surface treatment to produce a thin metal product in which at least one property of the thin metal product, as a whole, is enhanced by at least 10% as compared with an otherwise identical product not subjected to such surface treatment.
摘要翻译：对薄金属工件进行低温扩散型表面处理，以制造薄金属制品，其中与其他相同的材料相比，薄金属制品整体的至少一种性能比其他相同增强了至少10％产品不经过这种表面处理。

94. 发明申请

US20070170662A1 Seal assembly for fluid components 审中-公开
标题翻译：流体组件的密封组件
公开(公告)号：US20070170662A1
公开(公告)日：2007-07-26
申请号：US10590646
申请日：2005-02-28
申请人： Peter Williams , Mark Bennett , George Carlson , Theodore Gausman , Joseph Jagielo , Timothy Maruna , Douglas Nordstrom
发明人： Peter Williams , Mark Bennett , George Carlson , Theodore Gausman , Joseph Jagielo , Timothy Maruna , Douglas Nordstrom
IPC分类号： F16J15/08 , H02G15/013
CPC分类号： F16J15/0881 , F16J15/0825 , F16J15/0887 , F16J2015/0862
摘要： A seal (10) includes a seal structure (130) for engagement with first (24) and second fluid components (26) in first (84) and second counterbores (88). The seal also includes a holding plate (20, 30) structure for engagement with first (81) and second surfaces (85) of the components. The holding plate structure includes one or more layers that are preferably formed with the outer layers of the seal structure (30). The seal structure preferably includes at least three abutting layers of metal, the inner layer (70) having a hardness that is selected to be greater than the hardness of the first and second outer layers (20, 30). The invention also relates to a method of achieving a metal to metal seal between two relatively hard metal components in a fluid System.
摘要翻译：密封件（10）包括用于与第一（84）和第二沉孔（88）中的第一（24）和第二流体部件（26）接合的密封结构（130）。密封件还包括用于与部件的第一（81）和第二表面（85）接合的保持板（20,30）结构。保持板结构包括优选地形成有密封结构（30）的外层的一个或多个层。密封结构优选地包括至少三个金属邻接层，内层（70）的硬度被选择为大于第一和第二外层（20,30）的硬度。本发明还涉及在流体系统中实现两个相对硬的金属组分之间的金属 - 金属密封的方法。

95. 发明申请

US20070144021A1 Intrinsic gauging for tube fittings 失效
公开(公告)号：US20070144021A1
公开(公告)日：2007-06-28
申请号：US11708739
申请日：2007-02-21
申请人： Peter Williams , Lonnie Johnston , John Karkosiak , Gerald Babuder , Sanjeev Moghe
发明人： Peter Williams , Lonnie Johnston , John Karkosiak , Gerald Babuder , Sanjeev Moghe
IPC分类号： G01B3/50
CPC分类号： F16L19/103 , F16L19/00 , F16L19/065 , F16L2201/10 , F16L2201/60
摘要： An intrinsic gauging device for a ferrule type tube fitting of the type having a coupling nut, a coupling body and at least one ferrule, includes a precisely formed marking on the coupling nut that is visually perceptible that indicates the pull-up position of the tube fitting assembly.

96. 发明授权

US07182278B2 Spray valve 有权
标题翻译：喷雾阀
公开(公告)号：US07182278B2
公开(公告)日：2007-02-27
申请号：US10715027
申请日：2003-11-17
申请人： Geoff Haviland , Sean Haviland , Peter Williams
发明人： Geoff Haviland , Sean Haviland , Peter Williams
IPC分类号： B05B1/32 , B05B1/00 , F16K31/00
CPC分类号： B05B1/3013
摘要： Accordingly, the invention provides a spray valve comprising: (a) an upper valve body including a hydraulic chamber for receiving an incompressible hydraulic fluid through a piston port and a piston slidable within said hydraulic chamber; (b) a lower valve body including a fluid conduit for receiving fluid into the spray valve, a lower valve seating surface, an annular fluid chamber around the lower valve seating surface and a fluid outlet; and (c) a seating member between the upper valve body and lower valve body including: (i) an upper seat for the piston within the hydraulic chamber of the upper valve body; (ii) a diaphragm of resilient material extending between the upper valve body and lower valve body; and (iii) a valve seat for bearing against the lower valve seating surface and closing the fluid conduit when pressurised incompressible hydraulic fluid is received through the piston port and displacing the piston within the hydraulic chamber.
摘要翻译：因此，本发明提供一种喷雾阀，包括：（a）上阀体，其包括用于通过活塞端口接收不可压缩液压流体的液压室和可在所述液压室内滑动的活塞; （b）下阀体，其包括用于将流体接收到喷射阀中的流体导管，下阀座表面，围绕下阀座表面的环形流体室和流体出口; （c）上阀体和下阀体之间的座部件，其包括：（i）活塞在上阀体的液压室内的上座; （ii）在上阀体和下阀体之间延伸的弹性材料隔膜; 以及（iii）阀座，用于当加压的不可压缩液压流体通过活塞端口接收并使活塞在液压室内移动时，该阀座用于抵靠下阀座表面并关闭流体导管。

97. 发明申请

US20060273581A1 TUBE FITTING WITH FERRULE HAVING RECESS 审中-公开
标题翻译：管子接头与FERRULE有回收
公开(公告)号：US20060273581A1
公开(公告)日：2006-12-07
申请号：US11463024
申请日：2006-08-08
申请人： Peter Williams , Howard Kuhns
发明人： Peter Williams , Howard Kuhns
IPC分类号： F16L47/00
CPC分类号： F16L19/103 , F16L19/10
摘要： High localized loading, galling, and high torque forces have been generally eliminated or greatly reduced in a two ferrule tube fitting assembly through suitable modification of the rear ferrule so as to redirect the reaction forces acting between the front ferrule and the drive nut. The rear ferrule has a cylindrical interior wall that closely surrounds the tube end and is provided on the interior cylindrical wall with a circumferentially continuous radial recess that is located between the nose and rear wall of the rear ferrule. The rear ferrule also has a radially external wall that is substantially conical and additionally shaped to extend radially outward toward the enlarged diameter portion or flange of the rear ferrule. The rear ferrule further includes a contoured face on the rear driven surface of the ferrule that engages the drive surface of the drive nut.
摘要翻译：通过对后套圈的适当改进，两个套圈管接头组件通常消除或大大降低了高局部负载，磨损和高扭矩力，以便重定向作用在前套圈和驱动螺母之间的反作用力。后套圈具有紧密围绕管端的圆柱形内壁，并且在内圆柱形壁上设置有周向连续的径向凹部，其位于后套圈的前后壁之间。后套圈还具有径向外壁，其基本上为圆锥形并且另外成形为朝向后套圈的扩大直径部分或凸缘径向向外延伸。后套圈还包括在套圈的后驱动表面上的与驱动螺母的驱动表面接合的轮廓面。

98. 发明申请

US20060010565A1 Double-donnable glove 有权
标题翻译：双重戴手套
公开(公告)号：US20060010565A1
公开(公告)日：2006-01-19
申请号：US10514020
申请日：2003-05-14
申请人： Seng Teoh , Peter Williams
发明人： Seng Teoh , Peter Williams
IPC分类号： A41D19/00
CPC分类号： C08J7/126 , A41D19/0055 , A41D2400/44 , B29C41/003 , B29C41/14 , B29C71/0009 , B29K2009/06 , B29K2011/00 , B29K2995/0073 , B29L2031/4864 , B29L2031/7546 , C08J2311/00 , C08L11/02 , C08L13/00 , C08L13/02 , C08L21/00 , Y10T428/13 , Y10T428/1352 , C08L2666/08
摘要： A polychloroprene article comprises a polymer which is more readily chlorinatable that polychloroprene. A method of making the article comprises forming the article from an aqueous dispersion or solution of polychloroprene, chracterised in that one or more polymers which are more readily chlorinatable than polychloroprene are included in said dispersion or solution. Preferably, the article is a polychloroprene glove containing carboxylated nitrile rubber, carboxylated styrene butadiene or polyisoprene.
摘要翻译：聚氯丁二烯制品包括聚氯丁烯更容易可氯化的聚合物。制备该制品的方法包括由聚氯丁二烯的水性分散体或溶液形成制品，其特征在于，所述分散液或溶液中包含比聚氯丁二烯更易氯化的一种或多种聚合物。优选地，制品是含有羧化丁腈橡胶，羧化苯乙烯丁二烯或聚异戊二烯的聚氯丁二烯手套。

99. 发明申请

US20050192871A1 Electronic music/media distribution system 有权
标题翻译：电子音乐/媒体分发系统
公开(公告)号：US20050192871A1
公开(公告)日：2005-09-01
申请号：US11058910
申请日：2005-02-15
申请人： Albhy Galuten , Dmitry Radbel , Peter Williams
发明人： Albhy Galuten , Dmitry Radbel , Peter Williams
IPC分类号： G06Q30/00 , G07F17/16 , G06F17/60
CPC分类号： G06Q20/123 , G06Q30/06 , G06Q30/0601 , G06Q30/0633
摘要： A method for distributing content over a network by providing a predetermined electronic contract for distributing the content between a retailer and a distributor, wherein terms of the contract are independent of the content and the retailer distributes the content to a consumer and the distributor has rights in the content. A step of presenting a candidate retail offer for the distribution of the content to the consumer and receiving a request from the consumer to exercise the candidate retail offer. Finally, validating the candidate retail offer for the distribution of the content by accessing the electronic contract and determining if the candidate retail offer is consistent with the electronic contract. Upon successful validation, providing the content to the consumer, receiving compensation information from the consumer indicating at least the amount of compensation for the content provided and allocating the compensation according to the electronic contract.
摘要翻译：一种通过提供在零售商和分销商之间分发内容的预定电子合同来分发内容的方法，其中合同条款独立于内容，零售商将内容分发给消费者，并且分销商具有内容。向消费者呈现分配内容的候选零售报价并接收消费者行使候选零售报价的请求的步骤。最后，通过访问电子合同，确定候选零售报价是否与电子合同一致，验证候选零售报价的内容分配。验证成功后，向消费者提供内容，从消费者处接收补偿信息，至少指出所提供内容的赔偿金额，并根据电子合同分配补偿。

100. 发明申请

US20050055281A1 Method and system for interactively providing product related information on demand and providing personalized transactional benefits at a point of purchase 有权
标题翻译：方法和系统，用于根据需要交互地提供产品相关信息，并在购买点提供个性化的交易收益
公开(公告)号：US20050055281A1
公开(公告)日：2005-03-10
申请号：US10866648
申请日：2004-06-11
申请人： Peter Williams
发明人： Peter Williams
IPC分类号： G06Q10/00 , G06Q20/20 , G06Q30/02 , G06Q30/06 , G06F17/60
CPC分类号： G06Q30/02 , G06Q10/00 , G06Q20/20 , G06Q30/0207 , G06Q30/0222 , G06Q30/0224 , G06Q30/06 , G06Q30/0601 , G06Q30/0609 , G06Q30/0623
摘要： The present invention provides a system and method for interactively providing product and related information to a user based upon product identification information, such as a UPC code, and enabling the user to engage in various transactions related to the product. According to one aspect of the present invention, the system informs and educates the user about a particular product or service which the user is interested in and enables the user to efficiently purchase the product or service. The system is also configured to offer personalized transactional benefits to the user based on the amount and/or type of personal information that is provided by the user. According to one aspect, a mobile device with a camera can be used as the means for reading and processing product and service identifying indicia.
摘要翻译：本发明提供了一种用于基于诸如UPC代码的产品识别信息向用户交互地提供产品和相关信息的系统和方法，并且使得用户能够参与与产品相关的各种交易。根据本发明的一个方面，系统通知并教育用户关于用户感兴趣的特定产品或服务，并使用户有效地购买产品或服务。该系统还被配置为基于由用户提供的个人信息的数量和/或类型向用户提供个性化的交易益处。根据一个方面，具有相机的移动设备可以用作读取和处理产品和服务识别标记的手段。

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