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91. 发明授权

US06551836B1 Microfluidic devices, systems and methods for performing integrated reactions and separations 失效
标题翻译：用于执行集成反应和分离的微流体装置，系统和方法
公开(公告)号：US06551836B1
公开(公告)日：2003-04-22
申请号：US09442073
申请日：1999-11-15
申请人： Andrea W. Chow , Anne R. Kopf-Sill , J. Wallace Parce , Steven A. Sundberg
发明人： Andrea W. Chow , Anne R. Kopf-Sill , J. Wallace Parce , Steven A. Sundberg
IPC分类号： G01N27447
CPC分类号： B01L3/50273 , B01F13/0059 , B01L3/502753 , B01L3/502784 , B01L2200/0605 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44743 , G01N27/44791 , G01N2001/4038 , Y10T436/117497 , Y10T436/25375 , Y10T436/2575
摘要： Microfluidic devices for performing integrated reaction and separation operations. The devices have a planar substrate having a first surface with an integrated channel network disposed therein. The reaction region in the integrated microscale channel network has a mixture of at least first and second reactants located therein, wherein the mixture interacts to produce one or more products. The reaction region is configured to maintain contact between the first and second reactants contained within it. The device also includes a separation region in the integrated channel network, where the separation region is configured to separate the first reactant from the product, when the first reactant and product are flowing through the separation region.
摘要翻译：用于进行集成反应和分离操作的微流体装置。这些装置具有平面基板，其具有设置在其中的集成通道网络的第一表面。集成微量通道网络中的反应区域具有位于其中的至少第一和第二反应物的混合物，其中混合物相互作用以产生一种或多种产物。反应区域被配置为保持包含在其中的第一和第二反应物之间的接触。该装置还包括在集成通道网络中的分离区域，其中当第一反应物和产物流过分离区域时，分离区域被配置为将第一反应物与产物分离。

92. 发明授权

US06547942B1 Electropipettor and compensation means for electrophoretic bias 有权
公开(公告)号：US06547942B1
公开(公告)日：2003-04-15
申请号：US09202993
申请日：1999-07-23
申请人： J. Wallace Parce , Michael R. Knapp
发明人： J. Wallace Parce , Michael R. Knapp
IPC分类号： G01N2726
CPC分类号： B01F13/0071 , B01F13/0084 , B01F13/0086 , B01J19/0093 , B01J2219/00891 , B01L3/021 , B01L3/502715 , B01L3/50273 , B01L3/502784 , B01L2200/027 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44743 , G01N27/44791 , H02N11/006 , Y10S366/02 , Y10T436/113332 , Y10T436/2575
摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.

93. 发明授权

US06413782B1 Methods of manufacturing high-throughput screening systems 失效
标题翻译：制造高通量筛选系统的方法
公开(公告)号：US06413782B1
公开(公告)日：2002-07-02
申请号：US09044587
申请日：1998-03-19
申请人： J. Wallace Parce , Anne R. Kopf-Sill , Luc J. Bousse
发明人： J. Wallace Parce , Anne R. Kopf-Sill , Luc J. Bousse
IPC分类号： G01N33558
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： Microfluidic devices for analyzing a plurality of compounds are manufactured for performing high throughput screening assays. The methods are used to manufacture devices that screen large numbers of different compounds for their effects on a variety of chemical and biochemical systems.
摘要翻译：制造用于分析多种化合物的微流控装置用于进行高通量筛选测定。这些方法用于制造显示大量不同化合物的装置，用于对各种化学和生化系统的影响。

94. 发明授权

US06322683B1 Alignment of multicomponent microfabricated structures 有权
标题翻译：多组分微制造结构的对齐
公开(公告)号：US06322683B1
公开(公告)日：2001-11-27
申请号：US09291808
申请日：1999-04-14
申请人： Jeffrey A. Wolk , Richard J. McReynolds , J. Wallace Parce
发明人： Jeffrey A. Wolk , Richard J. McReynolds , J. Wallace Parce
IPC分类号： G01N2726
CPC分类号： B01L3/502707 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487
摘要： Microfluidic devices are fabricated by fabricating structures that are used to align elements that are to be attached to the devices or tools that are to be used in further fabrication steps on those devices. Elements to be attached include additional substrate layers, external sampling elements, e.g. capillaries, and the like. Preferred alignment structures include wells over which reservoirs are positioned, notches for use with alignment keys to align substrate layers or for receiving additional structural elements, and targets or guide holes for receiving tooling in further fabrication steps.
摘要翻译：微流体装置通过制造用于对准要附接到在这些装置上的进一步制造步骤中使用的装置或工具的元件的结构来制造。待连接的元件包括附加的基底层，外部取样元件，毛细血管等。优选的对准结构包括在其上定位储存器的孔，用于对齐键以对准衬底层或用于接收附加结构元件的凹口，以及用于在进一步制造步骤中接收工具的靶或引导孔。

95. 发明授权

US6042709A Microfluidic sampling system and methods 有权
标题翻译：微流体采样系统及方法
公开(公告)号：US6042709A
公开(公告)日：2000-03-28
申请号：US199225
申请日：1998-11-24
申请人： J. Wallace Parce , Michael R. Knapp
发明人： J. Wallace Parce , Michael R. Knapp
IPC分类号： G01N31/20 , B01F13/00 , B01J19/00 , B01L3/00 , B01L3/02 , F04B17/00 , F04B19/00 , G01N27/26 , G01N27/447 , G01N37/00 , H02N11/00 , G01N27/473
CPC分类号： B01F13/0071 , B01J19/0093 , B01L3/502715 , B01L3/50273 , B01L3/502784 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44743 , G01N27/44791 , H02N11/006 , B01F13/0084 , B01F13/0086 , B01J2219/00891 , B01L2200/027 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L3/021 , Y10S366/02 , Y10T436/113332 , Y10T436/2575
摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.
摘要翻译：本发明提供了使用电动力通过微流体系统的通道输送材料的技术。主体材料在高离子浓度的区域运输，靠近高离子浓度的间隔物材料区域，其由具有低离子浓度的间隔物材料区域分离。这种布置允许材料在运输通过时间内保持局部化，以避免混合材料。使用这些技术，产生与微流体系统相容的电吸移器，使得材料可以容易地引入到微流体系统中。本发明还补偿电泳偏压，因为材料通过将通道分成具有正表面电荷和负表面电荷的部分，以及两部分之间的第三电极，或者通过在运输之后通过电泳材料的扩散而传输通过微流体系统的通道一个频道

96. 发明授权

US5852495A Fourier detection of species migrating in a microchannel 失效
标题翻译：傅立叶检测在微通道中迁移的物种
公开(公告)号：US5852495A
公开(公告)日：1998-12-22
申请号：US941679
申请日：1997-09-30
申请人： J. Wallace Parce
发明人： J. Wallace Parce
IPC分类号： G01N27/447 , G01N21/00
CPC分类号： G01N27/44791 , G01N27/44721 , Y10S366/02
摘要： The present invention provides a microfluidic system for fast, accurate and low cost electrophoretic analysis of materials in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields. Light from periodically spaced regions along a channel in the microfluidic system are received by a photodetector. The intensity of light received by the photodetector is modulated by the movement of species bands through the channel under electrophoretic forces. By Fourier analysis, the velocity of each species band is determined and the identification of the species is made by its electrophoretic mobility in the channel.
摘要翻译：本发明提供了一种用于在化学，生物化学，生物技术，分子生物学等许多领域中快速，准确和低成本电泳分析材料的微流体系统。沿着微流体系统中的通道的周期性间隔的区域的光由光电检测器接收。由光电探测器接收的光的强度通过电泳力通过通道的物种带的移动来调制。通过傅立叶分析，确定每个物种带的速度，并通过其在通道中的电泳迁移率来确定物种的鉴定。

97. 发明授权

US5800690A Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces 失效
公开(公告)号：US5800690A
公开(公告)日：1998-09-01
申请号：US678436
申请日：1996-07-03
申请人： Calvin Y. H. Chow , J. Wallace Parce
发明人： Calvin Y. H. Chow , J. Wallace Parce
IPC分类号： G01N27/26 , G01N27/447 , G01N37/00
CPC分类号： G01N27/44791 , G01N27/44713 , G01N27/44752 , G01N27/44773 , Y10S366/02 , Y10T29/49002
摘要： In a microfluidic system using electrokinetic forces, the present invention uses electrical current or electrical parameters, other than voltage, to control the movement of fluids through the channels of the system. Time-multiplexed power supplies also provide further control over fluid movement by varying the voltage on an electrode connected to a fluid reservoir of the microfluidic system, by varying the duty cycle during which the voltage is applied to the electrode, or by a combination of both. A time-multiplexed power supply can also be connected to more than one electrode for a savings in cost.

98. 发明授权

US08563133B2 Compositions and methods for modulation of nanostructure energy levels 有权
公开(公告)号：US08563133B2
公开(公告)日：2013-10-22
申请号：US11299299
申请日：2005-12-09
申请人： Jeffery A. Whiteford , Mihai A. Buretea , Jian Chen , William P. Freeman , Andreas Meisel , Linh Nguyen , J. Wallace Parce , Erik Scher
发明人： Jeffery A. Whiteford , Mihai A. Buretea , Jian Chen , William P. Freeman , Andreas Meisel , Linh Nguyen , J. Wallace Parce , Erik Scher
IPC分类号： B32B5/16
CPC分类号： B05D5/12 , C07F5/025 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998
摘要： Ligand compositions for use in preparing discrete coated nanostructures are provided, as well as the coated nanostructures themselves and devices incorporating same. Methods for post-deposition shell formation on a nanostructure, for reversibly modifying nanostructures, and for manipulating the electronic properties of nanostructures are also provided. The ligands and coated nanostructures of the present invention are particularly useful for close packed nanostructure compositions, which can have improved quantum confinement and/or reduced cross-talk between nanostructures. Ligands of the present invention are also useful for manipulating the electronic properties of nanostructure compositions (e.g., by modulating energy levels, creating internal bias fields, reducing charge transfer or leakage, etc.).

99. 发明授权

US08357475B2 Nanowire-based membrane electrode assemblies for fuel cells 有权
标题翻译：用于燃料电池的纳米线基膜电极组件
公开(公告)号：US08357475B2
公开(公告)日：2013-01-22
申请号：US13149527
申请日：2011-05-31
申请人： Chunming Niu , Calvin Y. H. Chow , Stephen A. Empedocles , J. Wallace Parce
发明人： Chunming Niu , Calvin Y. H. Chow , Stephen A. Empedocles , J. Wallace Parce
IPC分类号： H01M4/86
CPC分类号： H01M4/8605 , B82Y30/00 , H01M4/881 , H01M4/8846 , H01M4/8853 , H01M4/8867 , H01M4/90 , H01M4/9075 , H01M4/921 , H01M4/925 , H01M4/926 , H01M8/023 , H01M8/0232 , H01M8/0234 , H01M8/0236 , H01M8/0241 , H01M8/1004 , H01M8/1007 , H01M8/1011 , H01M8/1086 , Y02E60/523 , Y02P70/56 , Y10S977/762 , Y10S977/948
摘要： The present invention discloses nanowires for use in a fuel cell comprising a metal catalyst deposited on a surface of the nanowires. A membrane electrode assembly for a fuel cell is disclosed which generally comprises a proton exchange membrane, an anode electrode, and a cathode electrode, wherein at least one or more of the anode electrode and cathode electrode comprise an interconnected network of the catalyst supported nanowires. Methods are also disclosed for preparing a membrane electrode assembly and fuel cell based upon an interconnected network of nanowires.
摘要翻译：本发明公开了一种用于燃料电池的纳米线，其包括沉积在纳米线表面上的金属催化剂。公开了一种用于燃料电池的膜电极组件，其通常包括质子交换膜，阳极电极和阴极电极，其中阳极电极和阴极电极中的至少一个或多个包括催化剂负载的纳米线的互连网络。还公开了基于互连的纳米线网络来制备膜电极组件和燃料电池的方法。

100. 发明申请

US20120031486A1 Nanoparticle Plasmon Scattering Layer for Photovoltaic Cells 审中-公开
标题翻译：用于光伏电池的纳米粒子等离子体散射层
公开(公告)号：US20120031486A1
公开(公告)日：2012-02-09
申请号：US13264020
申请日：2010-04-14
申请人： J. Wallace Parce , Jian Chen
发明人： J. Wallace Parce , Jian Chen
IPC分类号： H01L31/0216 , B05D5/12 , H01L31/18 , B82Y99/00
CPC分类号： H01L31/055 , H01L31/02168 , H01L31/0384 , Y02E10/52
摘要： The present invention relates to nanoparticle compositions for use in photovoltaic cells. Nanoparticles are utilized to provide increased scattering and also wavelength shifting to increase the efficiency of the photovoltaic cells. Exemplary nanoparticles include colloidal metal and fluorescent nanoparticles.
摘要翻译：本发明涉及用于光伏电池的纳米颗粒组合物。纳米颗粒用于提供增加的散射和波长移位以提高光伏电池的效率。示例性纳米颗粒包括胶体金属和荧光纳米颗粒。

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