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91. 发明申请

US20110136264A1 METHOD FOR DETECTING TARGET SUBSTANCE AND TARGET-SUBSTANCE DETECTION KIT 审中-公开
标题翻译：检测目标物质和目标物质检测试剂盒的方法
公开(公告)号：US20110136264A1
公开(公告)日：2011-06-09
申请号：US13030089
申请日：2011-02-17
申请人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
发明人： Miki Ogawa , Masato Minami , Takeshi Imamura , Takashi Ikeda , Kazumichi Nakahama
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , Y10S436/807
摘要： The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ1 of the magnetic label in the sample solution, the surface potential ψ2 of the detecting part, and the surface potential ψ3 of the non-detecting part satisfy any one of the following relationships i) to iv): ψ1ψ3>0 and ψ2=0, i) ψ1ψ2 0, and |ψ2|>|ψ3|, and iii) ψ1ψ2
摘要翻译：本发明提供了一种通过使样品溶液与包括检测部分和非检测部分的检测元件接触来检测样品溶液中目标物质的存在或浓度来检测目标物质的方法，或存在于检测部件表面附近的磁性标签（磁性标记）的数量，并提供目标物质检测试剂盒。样品溶液中的磁性标记的表面电位ψ1，检测部分的表面电位ψ2和非检测部分的表面电位ψ3满足以下关系式i）至iv）中的任何一个：ψ1ψ3> 0和 ψ2= 0，i）ψ1ψ2<0和ψ3= 0，ii）ψ1ψ2<0，ψ2ψ3> 0和|ψ2|> |ψ3|，以及iii）ψ1ψ2<0和ψ2ψ3<0; iv）并且由磁性标签承载的目标物质被由检测部分承载的主要捕获体捕获，或者由被检测部分承载的主捕获体捕获的目标物质被由磁体承载的二次捕获体捕获标签。

92. 发明授权

US07871614B2 Gold-binding protein and use thereof 有权
标题翻译：金结合蛋白及其用途
公开(公告)号：US07871614B2
公开(公告)日：2011-01-18
申请号：US12473199
申请日：2009-05-27
申请人： Hidenori Shiotsuka , Takeshi Imamura , Izumi Kumagai
发明人： Hidenori Shiotsuka , Takeshi Imamura , Izumi Kumagai
IPC分类号： G01N33/53 , A61K39/395
CPC分类号： G01N33/532 , C07K16/44 , C07K2317/21 , C07K2317/56 , C07K2317/622 , C07K2317/92
摘要： A protein utilizing an anti-gold antibody and a gold-binding side which is a part of the anti-gold antibody is constructed. This protein is capable of specifically binding to gold. This protein or a complex protein containing such a protein can be used for the detection of a target substance.
摘要翻译：构建了使用抗金抗体和作为抗金抗体的一部分的金结合侧的蛋白质。该蛋白质能够特异性结合金。该蛋白质或含有这种蛋白质的复合蛋白质可用于检测目标物质。

93. 发明授权

US07868142B2 Protein, method for immobilizing protein, structure, biosensor, nucleic acid, vector and kit for detecting target substance 有权
标题翻译：蛋白质，固定蛋白质的方法，结构，生物传感器，核酸，用于检测目标物质的载体和试剂盒
公开(公告)号：US07868142B2
公开(公告)日：2011-01-11
申请号：US11869711
申请日：2007-10-09
申请人： Satoru Hatakeyama , Takeshi Imamura , Hidenori Shiotsuka
发明人： Satoru Hatakeyama , Takeshi Imamura , Hidenori Shiotsuka
IPC分类号： C07K16/00 , G01N33/53 , C12M1/34 , C12N5/16 , C12N15/00
CPC分类号： C07K16/44 , C07K16/40 , C07K2317/31 , C07K2317/56 , G01N33/54306 , G01N33/54393
摘要： It is intended to provide an anti-photocrosslinking group antibody capable of specifically binding to a photocrosslinking group and available in the binding of a substrate and a substance of interest in a microstructure, a complex protein including at least the antibody or at least a portion thereof, and a technique for use thereof in the detection of a target substance. The present invention provides a protein having at least the structure of an antibody that recognizes a photocrosslinking group.
摘要翻译：旨在提供能够特异性结合光交联基团并且可用于在微结构中结合底物和目标物质的抗光连接性抗体，至少包含抗体或其至少一部分的复合蛋白质，以及用于检测目标物质的技术。本发明提供至少具有识别光交联基团的抗体结构的蛋白质。

94. 发明授权

US07811829B2 Measuring probe and production process thereof 有权
标题翻译：测量探头及其生产工艺
公开(公告)号：US07811829B2
公开(公告)日：2010-10-12
申请号：US11808139
申请日：2007-06-07
申请人： Yoshihiko Kikuchi , Hiroshi Suzuki , Takeshi Imamura
发明人： Yoshihiko Kikuchi , Hiroshi Suzuki , Takeshi Imamura
IPC分类号： G01N33/543
CPC分类号： G01N33/54353 , G01N33/54393
摘要： To provide a measuring probe excellent in sensitivity and reproducibility, simple operation in the protein immobilization onto a support can prevent peeling or damage. A layer containing a protein is adsorbed onto a support surface to fully encircle the long axis of the support, and the adsorbed layer is treated for cross-linking with a cross-linking agent in a concentration of 1 to 5 moles to 1 mole of the protein.
摘要翻译：为了提供灵敏度和重复性优异的测量探针，将蛋白质固定在载体上的简单操作可以防止剥离或损伤。将含有蛋白质的层吸附到支撑体表面上以完全环绕支撑体的长轴，并且将吸附层处理为与交联剂交联，该交联剂的浓度为1至5摩尔至1摩尔蛋白。

95. 发明授权

US07774450B2 Method for creating and processing a soap message, and method, apparatus and program for processing information 有权
标题翻译：用于创建和处理肥皂消息的方法，以及用于处理信息的方法，装置和程序
公开(公告)号：US07774450B2
公开(公告)日：2010-08-10
申请号：US12052297
申请日：2008-03-20
申请人： Takeshi Imamura , James Andrew Clark , Hiroshi Maruyama , Yumi Yamaguchi , Masayoshi Teraguchi , Takayuki Itoh , Fumiko Satoh
发明人： Takeshi Imamura , James Andrew Clark , Hiroshi Maruyama , Yumi Yamaguchi , Masayoshi Teraguchi , Takayuki Itoh , Fumiko Satoh
IPC分类号： G06F15/173
CPC分类号： H04L63/0823 , G06F21/64 , H04L63/0428
摘要： The present invention creates a SOAP message without using DOM by generating a body part by sequentially performing such a process of a message as encryption or signing for each piece of the message, generating a header part by using information acquired during the process, and by combining the body part and the header part. The present invention also breaks a SOAP message without using DOM by acquiring header information with parsing a received SOAP message and sequentially performing decode or verification of a signature of a body part according to the header information.
摘要翻译：本发明通过以下步骤生成身体部位来生成SOAP消息：通过依次对消息的每一片段进行消息的加密或签名的处理，通过使用在该处理中获取的信息来生成头部部分，并通过组合身体部位和头部。本发明还通过解析接收到的SOAP消息并且根据标题信息顺序地执行身体部位的签名的解码或验证，而不使用DOM来中断SOAP消息。

96. 发明授权

US07660099B2 Case molded capacitor 有权
标题翻译：表壳电容器
公开(公告)号：US07660099B2
公开(公告)日：2010-02-09
申请号：US11856361
申请日：2007-09-17
申请人： Takeshi Imamura , Toshiharu Saito , Satoshi Hosokawa , Toshihisa Miura , Yoshinari Nagata
发明人： Takeshi Imamura , Toshiharu Saito , Satoshi Hosokawa , Toshihisa Miura , Yoshinari Nagata
IPC分类号： H01G4/32 , H01G4/015
CPC分类号： H01G4/224 , H01G2/106 , H01G9/008 , Y02T10/7022
摘要： A case molded capacitor has a metallized film capacitor, a pair of bus bars, a resin-made internal case, molding resin, a metal external case, and a buffer material layer. The bus bars are each connected to respective one of electrodes of the metallized film capacitor. The internal case contains the metallized film capacitor. The metallized film capacitor is submerged with molding resin in the internal case so as to expose parts of the bus bars. The external case contains the internal case and both cases are connected at a connecting part. A buffer material layer is put in a gap made at least at a part between the internal case and the external case.
摘要翻译：壳体电容器具有金属化膜电容器，一对母线，树脂制内部壳体，模制树脂，金属外壳和缓冲材料层。汇流条各自连接到金属化薄膜电容器的相应电极之一。内部壳体包含金属化薄膜电容器。金属化膜电容器在内部壳体中浸入模制树脂，以暴露母线的部分。外壳包含内部外壳，两个外壳均连接在连接部分。将缓冲材料层放置在至少在内部壳体和外部壳体之间的部分处形成的间隙中。

97. 发明申请

US20090130776A1 BINDING PROTEIN MOLECULE 审中-公开
标题翻译：结合蛋白分子
公开(公告)号：US20090130776A1
公开(公告)日：2009-05-21
申请号：US11995911
申请日：2006-09-01
申请人： Takeshi Imamura , Hidenori Shiotsuka , Kazuhiro Ban , Takahisa Ibii
发明人： Takeshi Imamura , Hidenori Shiotsuka , Kazuhiro Ban , Takahisa Ibii
IPC分类号： G01N33/543 , C07K16/18 , B01J19/00
CPC分类号： C07K16/44 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C07K16/00 , C07K16/40 , C07K2317/565 , C07K2317/622 , C07K2317/626 , G01N33/543 , G01N33/54366 , G01N33/68 , G01N33/6845
摘要： A binding protein molecule, characterized in that it has a first domain having a binding site to an inhibitor of non-specific adsorption in which the domain comprises a part of the variable region of an antibody as the binding site and a second domain having a binding site to a target substance in which the domain comprises a part of the variable region of an antibody as the binding site, wherein the first and second domains are bound via a linker.
摘要翻译：一种结合蛋白质分子，其特征在于其具有与非特异性吸附抑制剂的结合位点的第一结构域，其中所述结构域包含作为结合位点的抗体的可变区的一部分和具有结合位点的第二结构域其中所述结构域包含作为结合位点的抗体的可变区的一部分的靶物质，其中所述第一和第二结构域经由接头结合。

98. 发明申请

US20080187461A1 PROTEIN, METHOD FOR IMMOBILIZING PROTEIN, STRUCTURE, BIOSENSOR, NUCLEIC ACID, VECTOR AND KIT FOR DETECTING TARGET SUBSTANCE 有权
标题翻译：蛋白质，用于固定蛋白质，结构，生物传感器，核酸，载体和用于检测目标物质的试剂盒的方法
公开(公告)号：US20080187461A1
公开(公告)日：2008-08-07
申请号：US11869711
申请日：2007-10-09
申请人： Satoru Hatakeyama , Takeshi Imamura , Hidenori Shiotsuka
发明人： Satoru Hatakeyama , Takeshi Imamura , Hidenori Shiotsuka
IPC分类号： B01J19/00 , C07K16/18 , C07H21/00 , C12N15/00 , C07K1/00
CPC分类号： C07K16/44 , C07K16/40 , C07K2317/31 , C07K2317/56 , G01N33/54306 , G01N33/54393
摘要： It is intended to provide an anti-photocrosslinking group antibody capable of specifically binding to a photocrosslinking group and available in the binding of a substrate and a substance of interest in a microstructure, a complex protein including at least the antibody or at least a portion thereof, and a technique for use thereof in the detection of a target substance. The present invention provides a protein having at least the structure of an antibody that recognizes a photocrosslinking group.
摘要翻译：旨在提供能够特异性结合光交联基团并且可用于在微结构中结合底物和目标物质的抗光连接性抗体，至少包含抗体或其至少一部分的复合蛋白质，以及用于检测目标物质的技术。本发明提供至少具有识别光交联基团的抗体结构的蛋白质。

99. 发明申请

US20080108132A1 Kit for Immobilizing Organic Substance, Organic Substance-Immobilized Structure, and Manufacturing Methods Therefor 失效
标题翻译：固定化有机物，有机物固定化结构用试剂盒及其制造方法
公开(公告)号：US20080108132A1
公开(公告)日：2008-05-08
申请号：US10555383
申请日：2005-01-25
申请人： Kazuhiro Ban , Hidenori Shiotsuka , Takeshi Imamura
发明人： Kazuhiro Ban , Hidenori Shiotsuka , Takeshi Imamura
IPC分类号： C12N15/63 , C07K7/08 , C07K7/64 , C07H21/04
CPC分类号： G01N33/54353 , G01N33/551
摘要： To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic substance, particularly a biological substance is immobilized on the surface of a substrate, the organic substance, particularly the biological substance can be stably immobilized on the surface of the substrate through orientation of the organic substance, particularly the biological substance suitable for exerting physiological functions thereof. At least part of the substrate's surface is constructed of one or more substrates containing aluminum oxide. The immobilization of the organic substance to the surface of the substrate is carried out by binding at least part of the binding domain to the surface of the substrate through a binding domain containing a peptide having an affinity to aluminum oxide and composed of at least one or more amino acids, which is coupled with the organic substance.
摘要翻译：为了提供采用新型固定化技术的有机物质固定化结构及其制造方法，其中，当将有机物质，特别是生物物质固定在基材表面上时，有机物质，特别是生物物质可以通过有机物质，特别是适于发挥其生理功能的生物物质的取向，稳定地固定在基材的表面上。衬底表面的至少一部分由含有氧化铝的一个或多个衬底构成。有机物质固定到底物的表面是通过结合结构域与底物的表面结合而进行的，所述结合结构域含有与氧化铝具有亲和性的肽，并且由至少一个或多个更多的氨基酸，其与有机物质偶联。

100. 发明授权

US07294310B2 Liquid transport device and liquid transporting method 失效
标题翻译：液体输送装置和液体输送方法
公开(公告)号：US07294310B2
公开(公告)日：2007-11-13
申请号：US10480040
申请日：2003-08-05
申请人： Takeo Yamazaki , Takeshi Imamura
发明人： Takeo Yamazaki , Takeshi Imamura
IPC分类号： B01L3/02
CPC分类号： B01F15/0255 , B01F13/0059 , B01F15/0203 , B01L3/0241 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/0605 , B01L2300/0816 , B01L2400/0439 , B01L2400/0442 , Y10T436/2575
摘要： A liquid transport device capable of introducing and transporting a liquid and preventing a backward flow of the liquid in a small-sized analysis system is provided. The liquid transport device has a substrate 201, an ejection orifice 205, which is formed integrally with the substrate 201 and through which a liquid is ejected, a space portion 210, which is formed so as to communicate with the ejection orifice 205 and through which the liquid ejected from the ejection orifice flies, and a flow channel 204, which communicates with the space portion 210 and which is positioned within such a distance range that the flying liquid can reach the flow channel.
摘要翻译：提供一种能够引入和输送液体并防止液体在小型分析系统中反向流动的液体输送装置。液体输送装置具有衬底201，与衬底201一体形成并且液体被喷射的喷射孔205，形成为与喷射孔205连通的空间部分210，从喷射口喷出的液体飞行，流路204与空间部210连通，位于与飞行液体到达流路的距离范围内。

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