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91. 发明授权

US5550121A Aminoalkylpyrrolidinylthiocarbapenem derivatives 失效
标题翻译：氨基烷基吡咯烷基硫代碳青霉烯衍生物
公开(公告)号：US5550121A
公开(公告)日：1996-08-27
申请号：US312619
申请日：1994-09-27
申请人： Susumu Nakagawa , Shinji Kato , Satoshi Murase , Osamu Okamoto , Ryuji Mitomo , Katsumi Yamamoto , Koji Yamada , Hiroshi Fukatsu
发明人： Susumu Nakagawa , Shinji Kato , Satoshi Murase , Osamu Okamoto , Ryuji Mitomo , Katsumi Yamamoto , Koji Yamada , Hiroshi Fukatsu
IPC分类号： C07D207/12 , C07D477/20 , C07D487/04 , A61K31/40
CPC分类号： C07D477/20 , C07D207/12
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or a negative charge, R.sup.3 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkanoyloxy group, an amino group, an N-lower alkylamino group, an N,N-di-lower alkylamino group, a lower alkanoylamino group, an aroylamino group, a (lower alkylsulfonyl)amino group, a sulfamoylamino group, a cyano group, a nitro group, a group of --COOR.sup.4 (wherein R.sup.4 is a hydrogen atom or a lower alkyl group) or a group of --CON(R.sup.5)R.sup.6 (wherein each of R.sup.5 and R.sup.6 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R.sup.5 and R.sup.6 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidyl group, a piperazinyl group, a 4-lower alkyl piperazinyl group and a morpholino group), A is a linear or branched lower alkylene group, X is a group of --N(R.sup.7)R.sup.8 (wherein each of R.sup.7 and R.sup.8 which may be the same or different, is a hydrogen atom or a lower alkyl group) or a group of --N.sup.+ (R.sup.9)(R.sup.10)R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 which may be the same or different, is a lower alkyl group), provided that when A is a linear lower alkylene group, R.sup.3 is other than a hydrogen atom; or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：下式的化合物：其中R1是氢原子或甲基，R2是氢原子或负电荷，R3是氢原子，卤素原子，羟基，低级烷氧基低级烷酰氧基，氨基，N-低级烷基氨基，N，N-二低级烷基氨基，低级烷酰基氨基，芳酰氨基，（低级烷基磺酰基）氨基，氨磺酰氨基，氰基，硝基，-COOR 4（其中R 4是氢原子或低级烷基）或-CON（R 5）R 6（其中R 5和R 6可以相同或不同）的基团是氢原子或低级烷基，或者R 5和R 6与相邻的氮原子一起形成选自氮丙啶基，氮杂环丁烷基，吡咯烷基，哌啶基，哌嗪基的杂环基，4-低级烷基哌嗪基和吗啉代基），A为直链或支链低级亚烷基，X为杂环 -N（R 7）R 8（其中可以相同或不同的R7和R8各自为氢原子或低级烷基）或-N +（R 9）（R 10）R 11（其中每个 R 9，R 10和R 11可以相同或不同，为低级烷基），条件是当A为直链低级亚烷基时，R 3不是氢原子; 或其药学上可接受的盐或酯。

92. 发明授权

US5478840A Tricyclic compounds 失效
标题翻译：三环化合物
公开(公告)号：US5478840A
公开(公告)日：1995-12-26
申请号：US294978
申请日：1994-08-24
申请人： Etsuo Ohshima , Fumihiko Kanai , Hideyuki Sato , Hiroyuki Obase , Toshiaki Kumazawa , Shiho Takahara , Tetsuji Ohno , Tomoko Ishikawa , Koji Yamada
发明人： Etsuo Ohshima , Fumihiko Kanai , Hideyuki Sato , Hiroyuki Obase , Toshiaki Kumazawa , Shiho Takahara , Tetsuji Ohno , Tomoko Ishikawa , Koji Yamada
IPC分类号： C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D471/04 , C07D521/00 , A61K31/44
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D471/04
摘要： A tricyclic compound represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen, halogen or lower alkyl; A represents cyano, carboxyl, tetrazolyl, cyano-substituted phenyl, carboxyl-substituted phenyl or tetrazolyl-substituted phenyl; V represents --(CH.sub.2).sub.m --(wherein m is an integer of 0 to 2); W represents ##STR2## (wherein R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, halogen, lower alkyl, cycloalkyl, halogenated lower alkyl, hydroxy, lower alkoxy, amino, lower alkylamino, carboxyl or lower alkoxycarbonyl; and Q.sup.1 --Q.sup.2 --Q.sup.3 --Q.sup.4 represents N.dbd.CH--CH.dbd.CH; X.sup.1 --X.sup.2 --X.sup.3 represents CH.dbd.CH--CH.dbd.CH, S--CH.dbd.CH or CH.dbd.CH--S; Y represents a single bond, CH.sub.2, O, S, CH.sub.2 O, OCH.sub.2, CH.sub.2 S, SCH.sub.2, CH.sub.2 CH.sub.2 or CH.dbd.CH; and Z.sup.1 --Z.sup.2 represents C.dbd.CH, CH--CH.sub.2 or CH--CH(COOH)-- or a pharmaceutically acceptable salt thereof. The compound of the present invention exhibits antagonism to angiotensin II receptors.
摘要翻译：由下式（I）表示的三环化合物：其中R 1表示氢，卤素或低级烷基; A代表氰基，羧基，四唑基，氰基取代的苯基，羧基取代的苯基或四唑基取代的苯基; V表示 - （CH 2）m - （其中m为0〜2的整数）; W表示（其中R2，R3和R4独立地表示氢，卤素，低级烷基，环烷基，卤代低级烷基，羟基，低级烷氧基，氨基，低级烷基氨基，羧基或低级烷氧基羰基;以及Q1-Q2-Q3-Q4 表示N = CH-CH = CH; X 1 -X 2 -X 3表示CH = CH-CH = CH，S-CH = CH或CH = CH-S; Y表示单键，CH 2，O，S，CH 2 O，OCH 2 ，CH2S，SCH2，CH2CH2或CH = CH; Z1-Z2表示C = CH，CH-CH2或CH-CH（COOH） - 或其药学上可接受的盐。本发明化合物显示对血管紧张素II受体的拮抗作用。

93. 发明授权

US5340807A Tricyclic compounds and intermediates thereof 失效
标题翻译：三环化合物及其中间体
公开(公告)号：US5340807A
公开(公告)日：1994-08-23
申请号：US989906
申请日：1992-12-11
申请人： Toshiaki Kumazawa , Masashi Yanase , Hiroyuki Harakawa , Hiroyuki Obase , Shoji Oda , Shiro Shirakura , Koji Yamada , Kazuhiro Kubo
发明人： Toshiaki Kumazawa , Masashi Yanase , Hiroyuki Harakawa , Hiroyuki Obase , Shoji Oda , Shiro Shirakura , Koji Yamada , Kazuhiro Kubo
IPC分类号： A61K31/335 , A61K31/165 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/235 , A61K31/275 , A61K31/38 , A61K31/435 , A61K31/44 , A61K31/55 , A61P3/06 , A61P9/10 , A61P43/00 , C07C233/65 , C07C235/46 , C07C235/48 , C07C237/40 , C07C323/40 , C07C323/62 , C07C327/26 , C07C331/08 , C07D221/16 , C07D223/20 , C07D233/58 , C07D313/12 , C07D337/12 , C07D471/04 , C07D491/04 , C07D491/044 , C07D495/04 , A01N43/46 , C07D273/02 , C07D313/06
CPC分类号： C07D491/04 , C07C233/65 , C07D223/20 , C07D313/12 , C07D337/12 , C07C2103/32 , Y10S514/824
摘要： Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halogenated C1-6 alkoxy, halogen, nitro, cyano, carboxy, C1-6 alkoxycarbonyl, hydroxymethyl, CR.sup.9 R.sup.10 CO.sub.2 R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 independently represents hydrogen or C1-6 alkyl) or CONR.sup.12 R.sup.13 (wherein each of R.sup.12 and R.sup.13 independently represents hydrogen or C1-6 alkyl); R.sup.5 represents hydrogen or C1-6 alkyl; each of R.sup.6, R.sup.7 and R.sup.8 independently represents hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkanoyloxy, C1-6 alkylthio, thiocyanato or halogen; X represents CH or N; Y.sup.1 -Y.sup.2 represents CH.sub.2 --O, CH.sub.2 --(O).sub.n, (wherein n represents 0, 1, or 2), CH.sub.2 CH.sub.2, CH.dbd.CH or CON(R.sup.14) (wherein R.sup.14 represents hydrogen or C1-6 alkyl) and Z represents oxygen or sulfur, or a pharmaceutically acceptable salt thereof. The compound possesses an acyl coenzyme A: cholesterol acyltransferase-inhibiting activity, and thus are expected to have preventive and therapeutic effects on hyperlipemia and arteriosclerosis.
摘要翻译：公开了由式（I）表示的三环化合物：其中R 1，R 2，R 3和R 4各自独立地表示氢，C 1-6烷基，C 1-6烷氧基，C 1-6烷硫基，氨基， C 1-6烷基氨基，卤代C 1-6烷基，卤代C 1-6烷氧基，卤素，硝基，氰基，羧基，C 1-6烷氧基羰基，羟甲基，CR 9 R 10 CO 2 R 11（其中R 9，R 10和R 11各自独立地表示氢或C 1-6烷基）或CONR 12 R 13（其中R 12和R 13各自独立地表示氢或C 1-6烷基）; R5表示氢或C1-6烷基; R 6，R 7和R 8各自独立地表示氢，C 1-6烷基，羟基，C 1-6烷氧基，C 1-6烷酰氧基，C 1-6烷硫基，氰硫基或卤素; X表示CH或N; Y1-Y2表示CH2-O，CH2-（O）n，（其中n表示0,1或2），CH2CH2，CH = CH或CON（R14）（其中R14表示氢或C1-6烷基）和Z 表示氧或硫，或其药学上可接受的盐。该化合物具有酰基辅酶A：胆固醇酰基转移酶抑制活性，因此预期对高脂血症和动脉硬化具有预防和治疗作用。

94. 发明授权

US5247140A Brake control system in elevator control apparatus 失效
标题翻译：电梯控制装置制动控制系统
公开(公告)号：US5247140A
公开(公告)日：1993-09-21
申请号：US741273
申请日：1991-08-07
申请人： Masao Iwasa , Koji Yamada , Hirofumi Sugiura
发明人： Masao Iwasa , Koji Yamada , Hirofumi Sugiura
IPC分类号： B66B1/30 , B66B1/32 , B66B1/34 , H02P3/04
CPC分类号： H02P3/04
摘要： The current an inverter is used as a power source for a brake circuit. The brake circuit includes a current detector, a comparator for comparing the detected value with a dictated brake current pattern, and a switch which switches the brake current in accordance with the magnitude of the difference between the detected current value and the dictated value. The brake current is selected to smoothly increase and decrease the brake current to prevent vibration and noise.
摘要翻译：当前的逆变器用作制动电路的电源。制动电路包括电流检测器，用于将检测值与规定的制动电流模式进行比较的比较器，以及根据检测到的电流值与规定值之间的差值的大小来切换制动电流的开关。选择制动电流以平滑地增加和减少制动电流，以防止振动和噪音。

95. 发明授权

US5223637A KS-506 compounds 失效
标题翻译： KS-506化合物
公开(公告)号：US5223637A
公开(公告)日：1993-06-29
申请号：US889388
申请日：1992-05-28
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C323/20 , C07C327/26 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
摘要翻译：通过培养属于被孢霉属属的微生物来产生具有抑制环核苷酸磷酸二酯酶的活性的KS-506a，KS-506x和KS-506g以及具有抑制组胺释放活性的KS-506m和KS-506h。

96. 发明授权

US5084453A 1-carboxy-1-vinyloxyimino aminothiazole cephalosporin derivatives 失效
标题翻译： 1-羧基-1-乙烯氧基亚氨基氨基噻唑头孢菌素衍生物
公开(公告)号：US5084453A
公开(公告)日：1992-01-28
申请号：US265458
申请日：1988-10-13
申请人： Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
发明人： Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
IPC分类号： A61K31/545 , C07D235/28 , C07D263/46 , C07D263/58 , C07D271/10 , C07D271/113 , C07D277/20 , C07D277/36 , C07D277/40 , C07D277/56 , C07D285/12 , C07D285/125 , C07D501/22 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46
CPC分类号： C07D263/58 , C07D235/28 , C07D263/46 , C07D271/113 , C07D277/36 , C07D277/56 , C07D277/587 , C07D285/125 , Y02P20/55
摘要： The present invention relates to a compound having the formula: ##STR1## wherein R is a hydrogen atom, a carboxyl-protecting group or a negative charge and Q is a hydrogen atom, a halogen atom, a hydroxyl group, an acetoxy group, a carbamoyl group, an azide group, a substituted or unsubstituted quarternary ammonio group or a substituted or unsubstituted heterocyclic thio group having at least one hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or a non-toxic salt or physiologically hydrolyzable non-toxic ester thereof; a process for producing it; and an antibacterial agent comprising it as an active ingredient.Further, the present invention also relates to a compound having the formula: ##STR2## wherein R.sup.3 is a hydrogen atom or an amino-protecting group, and each of R.sup.4 and R.sup.5 which may be the same or different is a hydrogen atom or a carboxyl-protecting group, or a salt thereof; and a process for producing it.

97. 发明授权

US4990693A Novel substances KS-504a, KS-504b, KS-504d and KS-504e and process for their preparation 失效
公开(公告)号：US4990693A
公开(公告)日：1991-02-05
申请号：US465892
申请日：1990-01-16
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
IPC分类号： C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P7/02 , C12P7/24 , C12P17/02
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

98. 发明授权

US4977994A Fare adjustment machine for prepaid card type tickets 失效
标题翻译：票价调整机用于预付卡型票
公开(公告)号：US4977994A
公开(公告)日：1990-12-18
申请号：US327871
申请日：1989-03-23
申请人： Masaharu Adachi , Yoshiaki Uematsu , Haruo Nagano , Koji Yamada
发明人： Masaharu Adachi , Yoshiaki Uematsu , Haruo Nagano , Koji Yamada
IPC分类号： G07B11/00 , G07G5/00
CPC分类号： G07G5/00 , G07B11/00
摘要： A fare adjustment machine, wherein a card conveyor for carrying a fare-adjusted card and a receipt conveyor for carrying a printed receipt are disposed with their passages intersecting each other so that the surfaces of the card and the receipt cross each other perpendicularly. The receipt is held at one-side at the intersection by a clamp mechanism and released from the receipt conveyor by a release mechanism. The receipt thus held is pushed at its lower side by the card carried by the card conveyor so that it falls down flat on top of the card, and the card and receipt are then then simultaneously discharged from the machine.

99. 发明授权

US4923986A Derivatives of physiologically active substance K-252 失效
标题翻译：生理活性物质K-252的衍生物
公开(公告)号：US4923986A
公开(公告)日：1990-05-08
申请号：US273519
申请日：1988-11-08
申请人： Chikara Murakata , Akira Sato , Mitsuru Takahashi , Eiji Kobayashi , Makoto Morimoto , Shiro Akinaga , Tadashi Hirata , Kenichi Mochida , Hiroshi Kase , Koji Yamada , Kazuyuki Iwashashi
发明人： Chikara Murakata , Akira Sato , Mitsuru Takahashi , Eiji Kobayashi , Makoto Morimoto , Shiro Akinaga , Tadashi Hirata , Kenichi Mochida , Hiroshi Kase , Koji Yamada , Kazuyuki Iwashashi
IPC分类号： A61K31/55 , C07D20060101 , C07D498/22
CPC分类号： C07D498/22
摘要： The present invention relates to novel derivatives of K-252, (8R*, 9S*, 11S*)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epoxy-1H,8H, 11H-2,7b,11a-triazadibenzo[a,g]cycloocta-[c,d,e,]trinden-1-one, and the compounds are represented by formula (I): ##STR1## wherein W.sub.1, W.sub.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y represent various substituents. The compounds are physiologically active substances that inhibit protein kinase C and exhibit an antitumor activity, and are useful as medicines.

100. 发明授权

US4883868A 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives 失效
标题翻译： 7-氨基-3-（取代的异二氢吲哚鎓）甲基-3-头孢烯衍生物
公开(公告)号：US4883868A
公开(公告)日：1989-11-28
申请号：US64462
申请日：1987-06-22
申请人： Susumu Nakagawa , Ryosuke Ushijima , Fumio Nakano , Koji Yamada , Eiichi Mano
发明人： Susumu Nakagawa , Ryosuke Ushijima , Fumio Nakano , Koji Yamada , Eiichi Mano
IPC分类号： A61K31/545 , C07D501/46
CPC分类号： C07D501/46 , C07D501/18 , C07D501/38 , Y02P20/55
摘要： A compound having the formula: ##STR1## wherein R.sup.1 is an amino group or a protected amino group, R.sup.2 is a hydrogen atom or a protecting group for a hydroxyl group, R.sup.3 represents negative charge, a hydrogen atom or a protecting group for a carboxyl group, and n is 0 or 1, and a salt thereof.
摘要翻译：具有下式的化合物：其中R1是氨基或被保护的氨基，R2是氢原子或羟基的保护基，R3代表负电荷，氢原子或保护基羧基，n为0或1，及其盐。

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