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91. 发明申请

US20090087072A1 Method and system for diaphragm segmentation in chest X-ray radiographs 有权
标题翻译：胸部X光片检查的隔膜分割方法及系统
公开(公告)号：US20090087072A1
公开(公告)日：2009-04-02
申请号：US12284136
申请日：2008-09-18
申请人： Lin Hong , Ying Li , Hong Shen
发明人： Lin Hong , Ying Li , Hong Shen
IPC分类号： G06K9/00
CPC分类号： G06T7/149 , G06T7/12 , G06T2207/10116 , G06T2207/20012 , G06T2207/20036 , G06T2207/30061
摘要： A method and system for segmenting diaphragm regions in a chest X-ray radiograph is disclosed. The diaphragm regions are segmented based on left and right lung lobe regions and a heart region in the chest X-ray radiograph. A right diaphragm region is segmented in the chest X-ray radiograph based a boundary of the right lung lobe. A left diaphragm region is segmented in the chest X-ray radiograph based on the heart region and a boundary of the left lung lobe.
摘要翻译：公开了一种用于分割胸部X线片的隔膜区域的方法和系统。基于左肺和右肺叶区域以及胸部X线片中的心脏区域分隔隔膜区域。基于右肺叶的边界，在胸部X射线照片中分割右侧隔膜区域。基于心脏区域和左肺叶的边界在胸部X射线照片中分割左隔膜区域。

92. 发明授权

US07480401B2 Method for local surface smoothing with application to chest wall nodule segmentation in lung CT data 失效
标题翻译：方法用于局部表面平滑应用于胸壁结节分段的肺CT数据
公开(公告)号：US07480401B2
公开(公告)日：2009-01-20
申请号：US10870304
申请日：2004-06-17
申请人： Hong Shen , Bernhard Göbel , Benjamin Odry
发明人： Hong Shen , Bernhard Göbel , Benjamin Odry
IPC分类号： G06K9/00
CPC分类号： G06T5/002 , G06T2200/04 , G06T2207/30032 , G06T2207/30064
摘要： We present an algorithm for local surface smoothing in a defined Volume of Interest (“VOI”) cropped from three-dimensional (“3D”) volume data, such as lung computer tomography (“CT”) data. Because the VOI is generally a smooth and piecewise linear surface, the inclusion of one or more bumps may suggest an abnormality. In lung CT data, for example, such bumps can be nodules that are grown from the chest wall. The nodules may represent a possibility of lung cancer. Through surface smoothing, potential pathologies are separated from the surrounding anatomical structures. For example, nodules may be segmented from the chest wall. The separated pathologies can be analyzed as diagnostic evidence.
摘要翻译：我们提出了一个定义的兴趣感兴趣体系（“VOI”）中的局部表面平滑算法，从三维（“3D”）体数据裁剪，如肺部计算机断层扫描（“CT”）数据。因为VOI通常是平滑和分段的线性表面，所以包含一个或多个凸块可能表示异常。在肺CT数据中，例如，这种颠簸可以是从胸壁生长的结节。结节可能代表肺癌的可能性。通过表面平滑，潜在的病理与周围的解剖结构分离。例如，可以从胸壁分割结节。分离的病理学可以作为诊断证据进行分析。

93. 发明申请

US20070281969A1 Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment 审中-公开
标题翻译：烟酸受体激动剂，包含这些化合物的组合物和治疗方法
公开(公告)号：US20070281969A1
公开(公告)日：2007-12-06
申请号：US11791183
申请日：2005-11-18
申请人： Steven Colletti , James Tata , Hong Shen , Fa-Xiang Ding , Jessica Frie , Jason Imbriglio , Weichun Chen
发明人： Steven Colletti , James Tata , Hong Shen , Fa-Xiang Ding , Jessica Frie , Jason Imbriglio , Weichun Chen
IPC分类号： A61K31/192 , A61K31/47 , A61P3/00 , A61P9/10 , C07C229/40 , C07D215/12
CPC分类号： C07D217/02 , C07C233/55 , C07C235/38 , C07C317/44 , C07D209/08 , C07D209/88 , C07D209/94 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/80 , C07D215/12 , C07D231/12 , C07D231/56 , C07D239/26 , C07D261/08 , C07D271/113 , C07D277/30 , C07D307/54 , C07D307/79 , C07D317/60 , C07D333/24 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/14
摘要： The present invention encompasses compounds of Formula (I); as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating dyslipidemias. Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明包括式（I）的化合物; 以及其药学上可接受的盐和水合物，其可用于治疗血脂异常。还包括药物组合物和使用方法。

94. 发明申请

US20070265272A1 TRIAZOLOPYRAZINE DERIVATIVES 失效
标题翻译：三唑并吡啶衍生物
公开(公告)号：US20070265272A1
公开(公告)日：2007-11-15
申请号：US11745921
申请日：2007-05-08
申请人： Hengmiao Cheng , Jingrong Jean Cui , Jacqui Elizabeth Hoffman , Lei Jia , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Bich Tran-Dube
发明人： Hengmiao Cheng , Jingrong Jean Cui , Jacqui Elizabeth Hoffman , Lei Jia , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Bich Tran-Dube
IPC分类号： A61K31/495 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3和R 2 > 4 如本文所定义。本发明还涉及含有式I化合物的药物组合物和通过施用式I化合物来治疗哺乳动物中过度增殖性疾病的方法。

95. 发明申请

US20070223795A1 System and Method For Tracing Rib Posterior In Chest CT Volumes 有权
标题翻译：胸部跟踪肋后胸CT系统及方法
公开(公告)号：US20070223795A1
公开(公告)日：2007-09-27
申请号：US11549723
申请日：2006-10-16
申请人： Shuping Qing , Hong Shen
发明人： Shuping Qing , Hong Shen
IPC分类号： G06K9/00 , G01C17/00
CPC分类号： G06T7/0012 , G06T7/155
摘要： A method for tracing, rib posteriors includes providing an incomplete rib tracing comprising a digitized 3-dimensional representation of a rib and a digital image from which said rib tracing was extracted, initializing, a tracing direction for a remainder of said rib, detecting a plurality of ridge points in a sub-volume of said digital image about said initial tracing direction, and deforming a closed curve in a plane perpendicular to said tracing direction until a rib-edge contour is obtained, using said ridge points as constraints.
摘要翻译：一种用于跟踪的方法，肋部后部包括提供不完整的肋跟踪，其包括肋的数字化3维表示和从其提取所述肋跟踪的数字图像，初始化，所述肋的剩余部分的跟踪方向，检测多个在所述数字图像的子体积中的关于所述初始跟踪方向的脊点的脊点，并且使垂直于所述跟踪方向的平面中的闭合曲线变形，直到获得肋边缘轮廓，使用所述脊点作为约束。

96. 发明申请

US20060047195A1 Combinational computer aided diagnosis 有权
标题翻译：组合计算机辅助诊断
公开(公告)号：US20060047195A1
公开(公告)日：2006-03-02
申请号：US11188366
申请日：2005-07-25
申请人： Hong Shen
发明人： Hong Shen
IPC分类号： A61B5/05
CPC分类号： G16H50/20 , G06F19/00 , G06F19/321 , G16H15/00
摘要： A computer-implemented method for combinational computer aided diagnosis (C-CAD) includes providing volume data of tissue, providing a database of disease and pathologies, and providing action items for processing the volume data. The method further comprises selecting at least two diseases of interest for the volume data, selecting at least one action item to be performed for each selected disease, determining a set of decision rules based on an output of a selected action item, and producing a combinational report predicting of the tissue of the volume data.
摘要翻译：用于组合计算机辅助诊断（C-CAD）的计算机实现方法包括提供组织体积数据，提供疾病和病理数据库，并提供用于处理体积数据的动作项目。所述方法还包括选择所述体积数据的至少两种感兴趣的疾病，选择要为每个所选疾病执行的至少一个动作项目，基于所选动作项目的输出确定一组决策规则，以及产生组合报告预测体数据的组织。

97. 发明授权

US06932611B2 Conducting remote instructor-controlled experimentation 有权
标题翻译：进行远程讲师控制实验
公开(公告)号：US06932611B2
公开(公告)日：2005-08-23
申请号：US10343516
申请日：2001-07-31
申请人： Hong Shen , Michael Shur , Tor Fjeldly
发明人： Hong Shen , Michael Shur , Tor Fjeldly
IPC分类号： G09B5/00 , G09B7/00 , G09B23/00 , G09B23/18
CPC分类号： G09B7/00 , G09B5/00 , G09B23/00 , G09B23/183
摘要： The invention includes a method for a client to remotely conduct a laboratory experiment using a remote computer communicating with a host computer in a computer network. The experiment is stimulated by a set of input variable and provides a set of dependent output variables. The method includes the steps of an instructor setting up the experiment at a central location, determining a tolerance band for each input variable of the experiment, and restricting a range of each tolerance band. The instructor enters into the host computer a program to run the experiment. The client remotely access the experiment using the remote computer. The instructor enables the client to conduct the experiment and simultaneously limits the client to the range of each tolerance band.
摘要翻译：本发明包括一种用于客户端使用在计算机网络中与主计算机通信的远程计算机进行实验室实验的方法。实验由一组输入变量刺激，并提供一组相关的输出变量。该方法包括以下步骤：在中心位置设置实验的指导者，确定实验的每个输入变量的公差带，并限制每个公差带的范围。导师进入主机运行实验的程序。客户端使用远程计算机远程访问实验。教练使客户端进行实验，同时将客户端限制在每个公差带的范围内。

98. 发明申请

US20050158856A1 Methods for producing functional antigen presenting dendritic cells using biodegradable microparticles for delivery of antigenic materials 审中-公开
标题翻译：使用可生物降解的微粒产生功能性抗原呈递树突细胞的方法用于递送抗原性材料
公开(公告)号：US20050158856A1
公开(公告)日：2005-07-21
申请号：US10884519
申请日：2004-07-01
申请人： Richard Edelson , Carole Berger , Douglas Hanlon , Hong Shen
发明人： Richard Edelson , Carole Berger , Douglas Hanlon , Hong Shen
IPC分类号： A61K9/16 , A61K9/50 , C12N5/0784 , C12N5/08
CPC分类号： C12N5/0639 , A61K39/0011 , A61K2035/128 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55555 , C12N2533/40
摘要： Methods are provided for producing functional antigen presenting dendritic cells. The dendritic cells are produced by treating an extracorporeal quantity of a subject's blood to induce differentiation of blood monocytes into dendritic cells. The dendritic cells may be exposed to cellular material encapsulated within a biodegradable polymer material to produce the antigen presenting dendritic cells.
摘要翻译：提供用于产生呈递树突细胞的功能性抗原的方法。通过治疗体外数量的受试者的血液以诱导血液单核细胞分化成树突细胞来产生树突状细胞。树突细胞可以暴露于包封在可生物降解的聚合物材料内的细胞材料以产生呈递树突状细胞的抗原。

99. 发明授权

US09505730B2 Mineralocorticoid receptor antagonists 有权
标题翻译：盐皮质激素受体拮抗剂
公开(公告)号：US09505730B2
公开(公告)日：2016-11-29
申请号：US14351006
申请日：2012-10-08
申请人： Hong Shen , Jason M. Cox , Christine Yang , Zhicai Wu
发明人： Hong Shen , Jason M. Cox , Christine Yang , Zhicai Wu
IPC分类号： C07D263/44 , C07D413/12 , C07D413/06 , A61K31/422 , A61K31/4439 , A61K31/4725 , C07D401/06 , A61K31/421
CPC分类号： C07D263/44 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/4725 , C07D401/06 , C07D413/06 , C07D413/12
摘要： The present invention is directed to compounds of the Formula I as well as pharmaceutically acceptable salts thereof, that are potentially useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula I, to their possible use in the treatment of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula I.

100. 发明授权

US09487506B2 Mineralocorticoid receptor antagonists 有权
公开(公告)号：US09487506B2
公开(公告)日：2016-11-08
申请号：US14110441
申请日：2012-04-11
申请人： Ping Lan , Kun Liu , Anthony Ogawa , Hong Shen , Christine Yang , Yuguang Wang , Richard Beresis , Changhe Qi
发明人： Ping Lan , Kun Liu , Anthony Ogawa , Hong Shen , Christine Yang , Yuguang Wang , Richard Beresis , Changhe Qi
IPC分类号： C07D413/06 , A61K31/4245 , C07D401/04 , A61K31/4439 , C07D231/56 , A61K31/416
CPC分类号： C07D413/06 , A61K31/416 , A61K31/4245 , A61K31/4439 , C07D231/56 , C07D401/04
摘要： Compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that may be useful for treating aldosterone-mediated diseases are disclosed. Processes for preparing compounds of the Formula (I), use of the compounds for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and pharmaceutical compositions which comprise compounds of the Formula (I) are disclosed.

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