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91. 发明授权

US5882890A Nucleic acids encoding novel regulators of G-protein signaling 失效
标题翻译：核酸编码G蛋白信号传导的新型调控因子
公开(公告)号：US5882890A
公开(公告)日：1999-03-16
申请号：US829110
申请日：1997-03-31
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides two regulators of G-protein signaling (designated individually as RGPS-1 and RGPS-2, and collectively as RGPS) and polynucleotides which identify and encode RGPS. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing RGPS and for treating or preventing disorders associated with expression of RGPS.
摘要翻译：本发明提供了两种G蛋白信号调控因子（分别称为RGPS-1和RGPS-2，统称为RGPS）以及鉴定和编码RGPS的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。此外，本发明还提供了用于产生RGPS并用于治疗或预防与RGPS表达相关的疾病的方法。

92. 发明授权

US5863735A Human transmembrane 4 superfamily protein 失效
标题翻译：人类跨膜4超家族蛋白
公开(公告)号：US5863735A
公开(公告)日：1999-01-26
申请号：US807044
申请日：1997-02-24
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P35/04 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/70596 , A61K38/00
摘要： The present invention provides a novel human integral membrane (TMP-1) and polynucleotides which identify and encode TMP-1. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TMP-1 and a method for producing TMP-1. The invention also provides for agonists, antibodies, or antagonists specifically binding TMP-1, and their use, in the prevention and treatment of diseases associated with expression of TMP-1. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TMP-1 for the treatment of diseases associated with the expression of TMP-1. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TMP-1.
摘要翻译：本发明提供一种新型人体内膜（TMP-1）和识别和编码TMP-1的多核苷酸。本发明还提供了包含编码TMP-1的核酸序列的基因工程表达载体和宿主细胞以及产生TMP-1的方法。本发明还提供了特异性结合TMP-1的激动剂，抗体或拮抗剂及其在预防和治疗与TMP-1表达相关的疾病中的用途。此外，本发明提供了将反义分子用于编码TMP-1的多核苷酸用于治疗与TMP-1表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合TMP-1的抗体的诊断测定法。

93. 发明授权

US5854414A Human mitochondrial membrane protein 失效
标题翻译：人线粒体膜蛋白
公开(公告)号：US5854414A
公开(公告)日：1998-12-29
申请号：US812645
申请日：1997-03-07
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , C07H21/04 , C12N15/63
CPC分类号： C07K14/47
摘要： The present invention provides a human mitochondrial membrane protein (HuTIM17) and polynucleotides which identify and encode HuTIM17. The invention also provides expression vectors and host cells and a method for producing HuTIM17. The invention also provides for antibodies or antagonists specifically binding HuTIM17, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of HuTIM17 in identifying antifungal and antiprotozoal therapeutics.
摘要翻译：本发明提供了人线粒体膜蛋白（HuTIM17）和识别和编码HuTIM17的多核苷酸。本发明还提供了表达载体和宿主细胞以及生产HuTIM17的方法。本发明还提供了特异性结合HuTIM17的抗体或拮抗剂及其在预防和治疗癌症中的用途。本发明还提供诊断测定。本发明还提供了使用HuTIM17鉴定抗真菌和抗原虫治疗药物。

94. 发明授权

US5840871A Prostate-associated kallikrein 失效
标题翻译：前列腺相关激肽释放酶
公开(公告)号：US5840871A
公开(公告)日：1998-11-24
申请号：US790137
申请日：1997-01-29
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P13/08 , A61P35/00 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/57 , C12P21/02 , C12Q1/68 , C07H21/04 , C12N15/00 , C12P21/06
CPC分类号： C12N9/6445 , A61K38/00
摘要： The present invention provides a human prostate-associated kallikrein (HPAK) and polynucleotides which identify and encode HPAK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPAK and a method for producing HPAK. The invention also provides for antibodies or antagonists specifically binding HPAK, and their use, in the prevention and treatment of diseases associated with expression of HPAK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPAK for the treatment of diseases associated with the expression of HPAK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPAK.
摘要翻译：本发明提供了人前列腺相关的激肽释放酶（HPAK）和识别和编码HPAK的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码HPAK的核酸序列的宿主细胞和用于产生HPAK的方法。本发明还提供了特异性结合HPAK的抗体或拮抗剂及其在预防和治疗与HPAK表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码HPAK的多核苷酸用于治疗与HPAK表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HPAK的抗体的诊断测定法。

95. 发明授权

US5840866A Human ubiquitin-conjugating enzyme 失效
公开(公告)号：US5840866A
公开(公告)日：1998-11-24
申请号：US679765
申请日：1996-07-10
申请人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N15/09 , C07K16/40 , C12N1/21 , C12N9/00 , C12Q1/68 , C12R1/19 , C07H21/04 , C12N1/20 , C12N9/10 , C12N15/00
CPC分类号： C12N9/93 , C07K16/40
摘要： The present invention provides a polynucleotide (ubcp) which identifies and encodes a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding UBCP. The invention also provides for the use of substantially purified UBCP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of UBCP. Additionally, the invention provides for the use of antisense molecules to ubcp in pharmaceutical compositions for treatment of diseases associated with the expression of UBCP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ubcp or anti-UBCP antibodies which specifically bind to UBCP.

96. 发明授权

US5830660A Tumorigenesis protein 失效
标题翻译：肿瘤发生蛋白
公开(公告)号：US5830660A
公开(公告)日：1998-11-03
申请号：US822260
申请日：1997-03-20
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P29/00 , A61P35/00 , C07K14/82 , C07K16/32 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07K14/82 , A61K38/00
摘要： The present invention provides a human tumorigenesis protein (HTAP) and polynucleotides which identify and encode HTAP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for producing HTAP and for treating or preventing disorders associated with the expression of HTAP.
摘要翻译：本发明提供了人类肿瘤发生蛋白（HTAP）和识别和编码HTAP的多核苷酸。此外，本发明提供表达载体和宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了用于产生HTAP并用于治疗或预防与HTAP表达相关的障碍的方法。

97. 发明授权

US5786150A F.sub.0 ATP synthase subunit 失效
公开(公告)号：US5786150A
公开(公告)日：1998-07-28
申请号：US815177
申请日：1997-03-11
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N9/14 , C12N15/60 , C12N9/88
CPC分类号： C12N9/14
摘要： The present invention provides a human ATP synthase subunit (ASYS) and polynucleotides which encode ASYS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYS and for treating disorders associated with expression of ASYS.

98. 发明授权

US5776698A Regulation of gene transcription 失效
标题翻译：基因转录调控
公开(公告)号：US5776698A
公开(公告)日：1998-07-07
申请号：US839710
申请日：1997-04-14
申请人： Jennifer L. Hillman , Surya K. Goli , David G. Streeter
发明人： Jennifer L. Hillman , Surya K. Goli , David G. Streeter
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12P21/06 , C07H21/02 , C12N5/00 , C12N15/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a human regulator of gene transcription (HRGT) and polynucleotides which encode HRGT. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HRGT.
摘要翻译：本发明提供编码HRGT的人基因转录调节子（HRGT）和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了治疗与HRGT表达相关的疾病的方法。

99. 发明授权

US06492499B1 Human pancreatitis-associated protein 失效
标题翻译：人胰腺炎相关蛋白
公开(公告)号：US06492499B1
公开(公告)日：2002-12-10
申请号：US09226852
申请日：1999-01-07
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C07K100
CPC分类号： C07K14/4733 , A61K38/00
摘要： The present invention provides a novel human C-type lectin (human PAP-2) and polynucleotides which identify and encode human PAP-2. The invention also provides expression vectors, host cells, agonists, antibodies or antagonists. The invention also provides methods for treating or preventing diseases associated with expression of human PAP-2.
摘要翻译：本发明提供了一种鉴定和编码人PAP-2的新型人C型凝集素（人PAP-2）和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体或拮抗剂。本发明还提供了治疗或预防与人PAP-2表达相关的疾病的方法。

100. 发明授权

US06281190B1 Human LEA-motif developmental protein 失效
标题翻译：人类LEA主题发育蛋白
公开(公告)号：US06281190B1
公开(公告)日：2001-08-28
申请号：US09213391
申请日：1998-12-15
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C07K1400
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a human LEA motif protein (HuLEAP) and polynucleotides which identify and encode HuLEAP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HuLEAP and a method for producing HuLEAP. The invention also provides for agonists, antibodies, or antagonists specifically binding HuLEAP, and their use, in the prevention and treatment of diseases associated with expression of HuLEAP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HuLEAP for the treatment of diseases associated with the expression of HuLEAP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HuLEAP.
摘要翻译：本发明提供了人LEA基序蛋白（HuLEAP）和识别和编码HuLEAP的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HuLEAP的核酸序列和生产HuLEAP的方法。本发明还提供了特异性结合HuLEAP的激动剂，抗体或拮抗剂及其在预防和治疗与HuLEAP表达相关的疾病中的用途。另外，本发明提供反义分子用于编码HuLEAP的多核苷酸用于治疗与HuLEAP表达相关的疾病。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合HuLEAP的抗体的诊断测定法。

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