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91. 发明申请

US20110004111A1 ISCHEMIA DETECTION USING INTRA-CARDIAC SIGNALS 有权
标题翻译： ISCHEMIA检测使用内部信号
公开(公告)号：US20110004111A1
公开(公告)日：2011-01-06
申请号：US12846387
申请日：2010-07-29
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/7203 , A61B5/7264 , Y10S128/92
摘要： An implanted cardiac rhythm management device is disclosed that is operative to detect myocardial ischemia. This is done by evaluating electrogram features to detect an electrocardiographic change; specifically, changes in electrogram segment during the early part of an ST segment. The early part of the ST segment is chosen to avoid the T-wave.
摘要翻译：公开了可用于检测心肌缺血的植入式心律管理装置。这通过评估电描记图特征来检测心电图变化来完成; 具体来说，在ST段的早期部分的电描绘片段的变化。选择ST段的早期部分以避免T波。

92. 发明授权

US09415226B1 Method and apparatus with anodal capture monitoring 有权
标题翻译：具有阳极捕获监测的方法和装置
公开(公告)号：US09415226B1
公开(公告)日：2016-08-16
申请号：US11961720
申请日：2007-12-20
申请人： Jeffery D. Snell , Gene A. Bornzin , Laurence S. Sloman , Jong Gill
发明人： Jeffery D. Snell , Gene A. Bornzin , Laurence S. Sloman , Jong Gill
IPC分类号： A61N1/00 , A61N1/362
CPC分类号： A61N1/3622 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： During cross-chamber pacing, where anodal capture may not be desirable, pulses are applied between a cathode electrode in a first chamber and an anode electrode in a second chamber. A capture detector detects for capture of the second chamber by the pacing pulses. If capture of the second chamber persists, another electrode is selected as the anodal electrode. During single-chamber pacing, where anodal capture may be desirable, pulses are applied between a cathode electrode and an anode electrode associated with the same chamber. A capture detector detects for capture at both electrodes. If anodal capture is not detected, the energy of the pacing pulse is increased, until anodal capture is detected.
摘要翻译：在跨室起搏期间，可能不需要阳极捕获，脉冲施加在第一室中的阴极和第二室中的阳极之间。捕获检测器通过起搏脉冲检测第二腔室的捕获。如果第二室的捕获持续，则选择另一电极作为阳极电极。在可以期望阳极捕获的单室起搏期间，在与相同的室相关联的阴极和阳极之间施加脉冲。捕获检测器检测两个电极的捕获。如果没有检测到阳极捕获，则起搏脉冲的能量增加，直到检测到阳极捕获。

93. 发明授权

US08180439B2 Ischemia detection using intra-cardiac signals 有权
标题翻译：使用心脏内信号的缺血检测
公开(公告)号：US08180439B2
公开(公告)日：2012-05-15
申请号：US12846387
申请日：2010-07-29
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/7203 , A61B5/7264 , Y10S128/92
摘要： An implanted cardiac rhythm management device is disclosed that is operative to detect myocardial ischemia. This is done by evaluating electrogram features to detect an electrocardiographic change; specifically, changes in electrogram segment during the early part of an ST segment. The early part of the ST segment is chosen to avoid the T-wave.
摘要翻译：公开了可用于检测心肌缺血的植入式心律管理装置。这通过评估电描记图特征来检测心电图变化来完成; 具体来说，在ST段的早期部分，电描绘片段的变化。选择ST段的早期部分以避免T波。

94. 发明申请

US20110125206A1 SINGLE CHAMBER IMPLANTABLE MEDICAL DEVICE FOR CONFIRMING ARRHYTHMIA THROUGH RETROSPECTIVE CARDIAC SIGNALS 审中-公开
标题翻译：通过回顾性心脏病信号确认ARRHYTHMIA的单室可植入医疗器械
公开(公告)号：US20110125206A1
公开(公告)日：2011-05-26
申请号：US12625416
申请日：2009-11-24
申请人： Gene A. Bornzin , Jong Gill , Jeffery D. Snell
发明人： Gene A. Bornzin , Jong Gill , Jeffery D. Snell
IPC分类号： A61N1/39 , A61B5/0452 , A61B5/046
CPC分类号： A61N1/36507 , A61B5/0031 , A61B5/0422 , A61B5/0452 , A61N1/3956
摘要： An implantable medical device is provided that comprises a housing, sensors configured to be located to proximate a heart, and a sensing module to sense cardiac signals originating from the heart over a channel defined by the sensors. The cardiac signals include intrinsic R-wave events and associated intrinsic confirmation events when the heart exhibits normal sinus rhythm. The device further includes memory to store the cardiac signals sensed over a channel, and a detection module. The detection module identifies an R-wave event within the cardiac signals. The detection module captures, in the memory, a segment of the cardiac signals that precedes the R-wave event as a retrospective segment. The detection module determines whether the retrospective segment includes an intrinsic confirmation event that is associated with and occurs before the R-wave event. The detection module declares an arrhythmia based at least in part on the determination of whether the retrospective segment includes the intrinsic confirmation event is absent from the retrospective segment.
摘要翻译：提供了一种植入式医疗装置，其包括壳体，被配置为邻近心脏定位的传感器，以及感测模块，用于感测通过由传感器限定的通道的来自心脏的心脏信号。当心脏呈现正常窦性心律时，心脏信号包括固有的R波事件和相关的固有确认事件。该装置还包括用于存储通过信道感测的心脏信号的存储器和检测模块。检测模块识别心脏信号内的R波事件。检测模块在存储器中捕获在作为回顾段的R波事件之前的心脏信号的一部分。检测模块确定回溯段是否包括与R波事件相关联并发生的固有确认事件。检测模块至少部分地基于回顾段中是否包含内在确认事件的确定来声明心律失常。

95. 发明申请

US20100121396A1 ENHANCED HEMODYNAMICS THROUGH ENERGY-EFFICIENT ANODAL PACING 审中-公开
标题翻译：通过高能量阳极加强增强血液动力学
公开(公告)号：US20100121396A1
公开(公告)日：2010-05-13
申请号：US12267941
申请日：2008-11-10
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61B5/0452 , A61B5/053 , A61B5/6846 , A61N1/3627 , A61N1/36535 , A61N1/36557 , A61N1/36564 , A61N1/37252 , A61N2001/083
摘要： An implantable device may employ anodal-based cardiac stimulation to improve hemodynamics. Anodal pacing may be provided on a conditional basis (e.g., upon detection of a defined condition). An implantable device may provide anodal pacing or cathodal pacing according to a defined ratio. An implantable device may use automatic capture detection to determine a pacing energy level that provides effective anodal pacing while attempting to minimize the power consumption associated with the anodal pacing.
摘要翻译：可植入装置可采用基于阳极的心脏刺激来改善血液动力学。可以在有条件的基础上（例如，在检测到定义的条件时）提供定型起搏。可植入装置可以根据规定的比例提供阳极起搏或阴极起搏。可植入装置可以使用自动捕获检测来确定提供有效的阳极起搏的起搏能量水平，同时尝试最小化与阳极起搏相关联的功率消耗。

96. 发明申请

US20100121394A1 System and Method for Setting Atrioventricular Pacing Delays Based on Far-Field Atrial Signals 审中-公开
公开(公告)号：US20100121394A1
公开(公告)日：2010-05-13
申请号：US12267476
申请日：2008-11-07
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B5/0452
摘要： An intrinsic inter-atrial conduction delay is determined by a pacemaker or implantable cardioverter-defibrillator based, at least in part, on far-field atrial events sensed using ventricular pacing/sensing leads. An atrioventricular pacing delay is then set based on the inter-atrial conduction delay. By detecting atrial events using ventricular leads, rather than using atrial leads, a more useful measurement of the intrinsic inter-atrial conduction delay can be obtained. In this regard, since atrial electrodes detect atrial activity locally around the electrodes, a near-field atrial event sensed using an atrial electrode might not properly represent the actual timing of the atrial event across both the right and left atria. Far-field atrial events sensed using ventricular leads thus allow for a more useful measurement of inter-atrial conduction delays for use in setting atrioventricular pacing delays. The delivery of individual V-pulses to the heart of the patient may be timed relative to the ends of individual far-field atrial events.

97. 发明授权

US07505813B1 System and method for determining preferred atrioventricular pacing delay values based on intracardiac electrogram signals 有权
标题翻译：基于心内电图信号确定优选房室起搏延迟值的系统和方法
公开(公告)号：US07505813B1
公开(公告)日：2009-03-17
申请号：US11199619
申请日：2005-08-08
申请人： Jong Gill , Alexander Huemmer , Gene A. Bornzin , Euljoon Park
发明人： Jong Gill , Alexander Huemmer , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3682
摘要： Techniques are provided for use by an implantable medical device for determining optimal or preferred atrioventricular (AV) pacing delay values for use in pacing the heart. Briefly, the atria and ventricles are paced using an initial AV pacing delay set to a value less than an intrinsic AV conduction delay so that intrinsic ventricular depolarizations are avoided. An internal electrical cardiac signal is sensed and atrial evoked responses and subsequent ventricular evoked responses are identified therein. Time delays between the atrial and ventricular evoked responses are measured and then a preferred or optimal AV pacing delay value is determined based on: the initial AV pacing delay; the measured time delays between the atrial and ventricular evoked responses; and on a predetermined preferred time delay to be achieved between atrial and ventricular evoked responses. Similar procedures are employed in connection with atrial sensed events. A calibration procedure is also described.
摘要翻译：技术被提供用于由可植入医疗装置用于确定用于起搏心脏的最佳或优选房室（AV）起搏延迟值。简而言之，心房和心室使用初始AV起搏延迟设定为小于固有AV传导延迟的值来进行起搏，从而避免内在的心室去极化。感测到内部电气心脏信号，并在其中识别心房诱发反应和随后的心室诱发反应。测量心房和心室诱发反应之间的时间延迟，然后基于：初始AV起搏延迟确定优选的或最佳的AV起搏延迟值; 测量心房和心室诱发反应之间的时间延迟; 并且在心房和心室诱发反应之间达到预定的优选时间延迟。与心房感觉事件有关的类似手术。还描述了校准过程。

98. 发明授权

US07460900B1 Method and apparatus for detecting ischemia using changes in QRS morphology 有权
标题翻译：使用QRS形态变化检测缺血的方法和装置
公开(公告)号：US07460900B1
公开(公告)日：2008-12-02
申请号：US11227856
申请日：2005-09-14
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/024 , A61N1/3627 , A61N1/36507
摘要： A method for operating an implantable medical device includes determining the difference of the absolute value of the voltage of a test QRS complex and the voltage of a baseline QRS template at a plurality of corresponding sample points and detecting ischemia if the sum of the differences at the plurality of sample points is greater than an ischemia detection threshold.
摘要翻译：一种用于操作可植入医疗装置的方法包括确定测试QRS复合物的电压的绝对值与基准QRS模板在多个对应采样点的电压之间的差异，并检测缺血，如果在多个采样点大于缺血检测阈值。

99. 发明授权

US07289847B1 Implantable cardiac device and method of treating atrial fibrillation 有权
标题翻译：植入式心脏装置及治疗心房颤动的方法
公开(公告)号：US07289847B1
公开(公告)日：2007-10-30
申请号：US11038553
申请日：2005-01-18
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/05
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/395
摘要： An apparatus and method of treating atrial fibrillation (AF) are provided. The apparatus includes means for detecting AF in a heart of a patient, means for classifying the AF as one of a plurality of AF types, means for selecting a therapy for delivery to the heart, from a plurality of therapies, based on AF type, and means for delivering the selected therapy to the heart. The plurality of therapies includes ATP therapy, a hybrid therapy including a combination of ATP therapy and drug therapy, and shock therapy. The method includes sensing an electrogram signal from the heart, analyzing the electrogram signal to detect AF in the heart, classifying the AF as one of a plurality of AF types, selecting a therapy for delivery to the heart, from a plurality of therapies, based on the AF type, and delivering the selected therapy to the heart.
摘要翻译：提供了一种治疗心房颤动（AF）的装置和方法。该装置包括用于检测患者心脏中的AF的装置，用于将AF分类为多个AF类型之一的装置，用于基于AF类型从多种治疗中选择用于递送至心脏的治疗的装置，以及用于将所选择的治疗递送至心脏的装置。多种疗法包括ATP疗法，包括ATP疗法和药物治疗组合的混合疗法以及休克疗法。该方法包括感测来自心脏的电描记图信号，分析电描记图信号以检测心脏中的AF，将AF分类为多个AF类型之一，从多个疗法中选择用于递送至心脏的治疗，基于在AF类型上，并将所选择的治疗递送到心脏。

100. 发明授权

US08131361B2 System and method for setting atrioventricular pacing delays based on far-field atrial signals 有权
标题翻译：基于远场心房信号设置房室起搏延迟的系统和方法
公开(公告)号：US08131361B2
公开(公告)日：2012-03-06
申请号：US12267483
申请日：2008-11-07
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B5/0452 , A61N1/3704
摘要： An intrinsic inter-atrial conduction delay is determined by a pacemaker or implantable cardioverter-defibrillator based, at least in part, on far-field atrial events sensed using ventricular pacing/sensing leads. An atrioventricular pacing delay is then set based on the inter-atrial conduction delay. By detecting atrial events using ventricular leads, rather than using atrial leads, a more useful measurement of the intrinsic inter-atrial conduction delay can be obtained. In this regard, since atrial electrodes detect atrial activity locally around the electrodes, a near-field atrial event sensed using an atrial electrode might not properly represent the actual timing of the atrial event across both the right and left atria. Far-field atrial events sensed using ventricular leads thus allow for a more useful measurement of inter-atrial conduction delays for use in setting atrioventricular pacing delays. The delivery of individual V-pulses to the heart of the patient may be timed relative to the ends of individual far-field atrial events.
摘要翻译：至少部分地基于使用心室起搏/感测引线感测的远场心房事件，起搏器或植入式心律转复除颤器确定内在的心房间传导延迟。然后基于心房间传导延迟来设置房室起搏延迟。通过使用心室导联检测心房事件，而不是使用心房线，可以获得更有用的内在心房传导延迟的测量。在这方面，由于心房电极在电极周围局部地检测心房活动，使用心房电极感测到的近场心房事件可能不能正确地表示在右心房和左心房两侧的心房事件的实际时间。使用心室引线检测的远场心房事件因此允许更有用的测量心房间传导延迟，用于设置房室起搏延迟。单个V脉冲到患者心脏的传送可以相对于单个远场心房事件的结束而定时。

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