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91. 发明申请

US20080114410A1 CLOSED LOOP IMPEDANCE-BASED CARDIAC RESYNCHRONIZATION THERAPY SYSTEMS, DEVICES, AND METHODS 有权
标题翻译：基于闭环阻塞的心脏再生治疗系统，装置和方法
公开(公告)号：US20080114410A1
公开(公告)日：2008-05-15
申请号：US12016830
申请日：2008-01-18
申请人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
发明人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

92. 发明授权

US07310554B2 Method and apparatus for adjustment of sequential biventricular pacing parameters 有权
标题翻译：用于调整顺序性双心室起搏参数的方法和装置
公开(公告)号：US07310554B2
公开(公告)日：2007-12-18
申请号：US10742630
申请日：2003-12-19
申请人： Andrew P. Kramer , Jiang Ding
发明人： Andrew P. Kramer , Jiang Ding
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and system are disclosed for setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The system may, in different embodiments, be implemented in programming of the implantable device and an external programmer in communication therewith or in the programming of the implantable device by itself. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way are the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes and the biventricular offset interval.
摘要翻译：公开了一种用于设置由可植入心脏装置用于输送心脏再同步治疗的起搏参数的方法和系统。在不同的实施例中，该系统可以在可植入装置和与之通信的外部编程器的编程中或在可植入装置自身的编程中实现。起搏参数的选择至少部分地基于固有心脏传导参数的测量。可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式和双心室偏移间隔中使用的心房延迟间隔。

93. 发明申请

US20070125703A1 Method for providing resistance to biofouling in a porous support 有权
标题翻译：在多孔载体中提供抗生物污损的方法
公开(公告)号：US20070125703A1
公开(公告)日：2007-06-07
申请号：US11400428
申请日：2006-04-06
申请人： John Chapman , Jiang Ding , Yu-Ling Hsiao , Christian Lenges , Yanhui Niu , Stefan Reinartz , Cheryl Stancik , Judith Van Gorp
发明人： John Chapman , Jiang Ding , Yu-Ling Hsiao , Christian Lenges , Yanhui Niu , Stefan Reinartz , Cheryl Stancik , Judith Van Gorp
IPC分类号： B01D29/00
CPC分类号： B01D39/1607 , B01D39/083 , B01D39/086 , B01D39/2017 , B01D39/2041 , B01D39/2082 , B01D46/546 , B01D2239/0225 , B01D2239/0233 , B01D2239/025 , B01D2239/0478 , B01D2239/0492 , B01D2239/0622 , B01D2239/0627 , B01D2239/0631 , B01D2239/065 , B01D2239/0654 , B01D2239/10 , B01D2239/1216 , B01D2239/1233 , Y10T428/249921
摘要： The invention is a process useful for providing a treated support comprising a porous nanoweb coating wherein the treated support is characterized by a biofilm cell count of less than 50% that of an untreated porous support control. The process is useful for modifying porous materials, such as filter media and barrier fabrics to provide resistance to biofouling. The porous nanoweb coating is comprised of fibrous structures derived from gelation and drying of supramolecular assemblies of non-covalently bonded organogelators. Typical organogelators useful in the invention include those that assemble via hydrogen bonding and π-stacking.
摘要翻译：本发明是一种可用于提供包含多孔纳米网涂层的经处理的载体的方法，其中经处理的载体的特征在于生物膜细胞计数小于未处理的多孔支持物对照的50％。该方法可用于改性多孔材料，例如过滤介质和阻隔织物以提供抵抗生物污垢。多孔纳米网涂层由衍生自非共价键合的有机凝胶的超分子组装的凝胶化和干燥的纤维结构组成。用于本发明的典型有机凝胶包括通过氢键和π-叠层组装的有机凝胶。

94. 发明申请

US20060259086A1 Apparatus and method for optimizing atrioventricular delay 有权
标题翻译：用于优化房室延迟的装置和方法
公开(公告)号：US20060259086A1
公开(公告)日：2006-11-16
申请号：US11126490
申请日：2005-05-11
申请人： Yinghong Yu , Jiang Ding , Jeffrey Stahmann
发明人： Yinghong Yu , Jiang Ding , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/3706
摘要： Systems and methods to optimize atrioventricular delay during sensing or pacing of the atrium and for a plurality of sensed rates or pacing rates. In one example, a paced atrioventricular delay is calculated using a sensed atrioventricular interval and a paced atrioventricular interval. In another example, a plurality of paced atrioventricular delays for different pacing rates can be calculated. In another example embodiment, a plurality of sensed atrioventricular delays for different sensing rates can be calculated. Combinations of the various systems and methods are also possible.
摘要翻译：在心房的感测或起搏期间以及多个感测速率或起搏速率下优化房室延迟的系统和方法。在一个示例中，使用感测的房室间隔和起搏房室间隔来计算起搏房室延迟。在另一个示例中，可以计算用于不同起搏速率的多个起搏房室延迟。在另一示例性实施例中，可以计算用于不同感测速率的多个感测的房室延迟。各种系统和方法的组合也是可能的。

95. 发明申请

US20060241703A1 Method and system for treatment of mechanical cardiac asynchrony 有权
公开(公告)号：US20060241703A1
公开(公告)日：2006-10-26
申请号：US11113827
申请日：2005-04-25
申请人： Jiang Ding , Yinghong Yu , Milton Morris
发明人： Jiang Ding , Yinghong Yu , Milton Morris
IPC分类号： A61N1/362
CPC分类号： A61N1/36528 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A system and method for identifying patients with asynchronous ventricular contractions due to abnormal electro-mechanical coupling and computing optimal pacing parameters for restoring synchronous contractions is disclosed. Such patients may have normal intra-ventricular and inter-ventricular conduction and cannot be identified from intrinsic conduction data alone such as QRS width. Techniques for computing optimal resynchronization pacing in order to compensate for abnormal electro-mechanical coupling are also described.

96. 发明授权

US07123960B2 Method and system for delivering cardiac resynchronization therapy with variable atrio-ventricular delay 有权
标题翻译：用心脏再同步治疗可变心房延迟的方法和系统
公开(公告)号：US07123960B2
公开(公告)日：2006-10-17
申请号：US10744944
申请日：2003-12-22
申请人： Jiang Ding , Yinghong Yu , Milton M. Morris
发明人： Jiang Ding , Yinghong Yu , Milton M. Morris
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method is presented by which an implantable cardiac rhythm management device may vary the atrio-ventricular delay or AVD interval used for delivering cardiac resynchronization therapy in an atrial tracking or AV sequential pacing mode in accordance with the sensed or paced atrial rate. Optimal values for the AVD parameter associated with a particular atrial rate are computed as linear functions of an intrinsic conduction measurement taken when the particular rate is present.
摘要翻译：提出一种方法，通过该方法，可植入的心律管理装置可以根据感测或起搏的心房率改变用于在心房跟踪或AV顺序起搏模式中递送心脏再同步治疗的心房延迟或AVD间隔。与特定心房率相关的AVD参数的最佳值被计算为当存在特定速率时所进行的本征传导测量的线性函数。

97. 发明申请

US20060155020A1 Rheology control agents for coating compositions 有权
标题翻译：用于涂料组合物的流变控制剂
公开(公告)号：US20060155020A1
公开(公告)日：2006-07-13
申请号：US11330933
申请日：2006-01-12
申请人： Christian Lenges , Yanhui Niu , Yu-Ling Hsiao , Jiang Ding , Robert Barsotti , Renee Kelly , Robert Butera , Young Kim
发明人： Christian Lenges , Yanhui Niu , Yu-Ling Hsiao , Jiang Ding , Robert Barsotti , Renee Kelly , Robert Butera , Young Kim
IPC分类号： C08K5/16 , C08G73/00 , B05D1/00
CPC分类号： C08G18/3228 , C08G18/3271 , C08G18/3829 , C08G18/71 , C08G18/73 , C08G18/78 , C08K5/20 , C08K5/21 , C09D7/43 , C09D175/04
摘要： The present invention is directed to a rheology control agent for coating compositions. The rheology control agent includes a compound having the Formula (I) including isomers or mixtures of isomers thereof: wherein p is 0, 1, 2, or 3; and R2, R3, R4, X and Y groups are described in the specification. The solvent-borne coating compositions containing the rheology control agent have improved rheology control on application and are useful for OEM, refinishing or repainting the exterior of automobile and truck bodies and parts thereof.
摘要翻译：本发明涉及用于涂料组合物的流变控制剂。流变控制剂包括具有式（I）的化合物，其包含异构体或其异构体的混合物：其中p为0,1,2或3; R 2，R 3，R 4，X和Y基团在说明书中描述。含有流变控制剂的溶剂型涂料组合物在应用上具有改进的流变学控制，并且可用于OEM，修补或重新涂漆汽车和卡车车身及其部件的外部。

98. 发明申请

US20050038480A1 Ventricular conduction delay trending system and method 有权
标题翻译：心室传导延迟趋势系统及方法
公开(公告)号：US20050038480A1
公开(公告)日：2005-02-17
申请号：US10889354
申请日：2004-07-12
申请人： Jiang Ding
发明人： Jiang Ding
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/365
摘要： A method and system for ascertaining the condition of the heart's conduction system in a patient treated for congestive heart failure with pacing therapy. In accordance with the invention, changes in ventricular activation patterns are monitored over time in order to detect changes in the heart's conduction system that may occur due to physiological regeneration of conduction pathways. The activation patterns are reflected by electrogram signals detected from different ventricular locations. By measuring the difference in conduction times of an excitation impulse traveling from the AV node to the different ventricular locations, a parameter representative of the heart's conduction system is obtained that may be used to adjust the pacing therapy in accordance therewith.
摘要翻译：一种确定心脏传导系统状态的方法和系统，用于采用起搏治疗充血性心力衰竭治疗的患者。根据本发明，随着时间的推移监测心室激活模式的变化，以便检测由于传导途径的生理再生而可能发生的心脏传导系统的变化。激活模式由从不同心室位置检测到的电描记图信号反映。通过测量从AV节点行进到不同心室位置的激励脉冲的传导时间的差异，可以获得代表心脏传导系统的参数，其可用于根据其调节起搏疗法。

99. 发明授权

US06766189B2 Method and apparatus for predicting acute response to cardiac resynchronization therapy 有权
公开(公告)号：US06766189B2
公开(公告)日：2004-07-20
申请号：US09822790
申请日：2001-03-30
申请人： Yinghong Yu , Jiang Ding , Julio Spinelli , Angelo Auricchio
发明人： Yinghong Yu , Jiang Ding , Julio Spinelli , Angelo Auricchio
IPC分类号： A61B106
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.

100. 发明授权

US06622040B2 Automatic selection of stimulation chamber for ventricular resynchronization therapy 有权
公开(公告)号：US06622040B2
公开(公告)日：2003-09-16
申请号：US09738407
申请日：2000-12-15
申请人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
IPC分类号： A61N1362
CPC分类号： A61N1/36592 , A61B5/0472 , A61N1/3627 , A61N1/3684
摘要： A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.

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