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91. 发明申请

US20060116325A1 Methods and compositions for inhibiting hiv-coreceptor interactions 审中-公开
标题翻译：用于抑制HIV感受器相互作用的方法和组合物
公开(公告)号：US20060116325A1
公开(公告)日：2006-06-01
申请号：US10468182
申请日：2002-02-15
申请人： Oleg Chertov , Joost Oppenheim , Xin Chen , Connor McGrath , Raymond Sowder , Jacek Lubkowski , Michele Wetzel , Thomas Rogers
发明人： Oleg Chertov , Joost Oppenheim , Xin Chen , Connor McGrath , Raymond Sowder , Jacek Lubkowski , Michele Wetzel , Thomas Rogers
IPC分类号： A61K38/10
CPC分类号： A61K38/162 , A61K39/12 , A61K39/21 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： Novel methods and compositions are provided for inhibiting interactions between human immunodeficiency viruses (HIVs) and viral coreceptors, including CXCR4 and/or CCR5 coreceptors. The anti-coreceptor binding agent includes a novel peptide portion of the gp120 envelope protein of HIV-1, as well as peptide analogs and mimetics of this peptide, that specifically binds to, or modulates activity of, the coreceptors(s). The anti-coreceptor binding agent is useful as a prophylactic or therapeutic treatment to prevent or inhibit HIV binding to a susceptible cell and thereby reduces infection and/or moderates or treats related diseases. In alternative embodiments, the peptides, analogs and mimetics are effective to inhibit direct co-receptor binding by HIV virus, coreceptor binding by HIV gp120 proteins or peptides, HIV fusion with target host cells, HIV virion entry into host cells, HIV replication, and HIV transmission between cells and hosts. In more detailed embodiments, the anti-coreceptor binding agents of the invention are multi-tropic by exhibiting activity against HIV interactions with multiple, CXCR4 and CCR5, coreceptors.
摘要翻译：提供新的方法和组合物用于抑制人免疫缺陷病毒（HIV）和病毒共同受体（包括CXCR4和/或CCR5共受体）之间的相互作用。抗感受器结合剂包括HIV-1的gp120包膜蛋白的新肽部分，以及该肽的肽类似物和模拟物，其特异性结合或调节共受体的活性。抗感受器结合剂可用作预防或治疗性治疗以预防或抑制HIV与敏感细胞的结合，从而降低感染和/或调节或治疗相关疾病。在替代实施方案中，肽，类似物和模拟物有效抑制HIV病毒的直接共受体结合，HIV gp120蛋白或肽的共受体结合，与靶宿主细胞的HIV融合，进入宿主细胞的HIV病毒体，HIV复制和细胞和宿主之间的HIV传播。在更详细的实施方案中，本发明的抗共感受体结合剂通过展现针对HIV与多种CXCR4和CCR5共受体的相互作用的活性而呈多向性。

92. 发明申请

US20060088261A1 Rare earth doped single polarization double clad optical fiber and a method for making such fiber 有权
标题翻译：稀土掺杂单极化双包层光纤及其制造方法
公开(公告)号：US20060088261A1
公开(公告)日：2006-04-27
申请号：US11058309
申请日：2005-02-14
申请人： George Berkey , Xin Chen , Joohyun Koh , Ming-Jun Li , Daniel Nolan , Donnell Walton , Ji Wang , Luis Zenteno
发明人： George Berkey , Xin Chen , Joohyun Koh , Ming-Jun Li , Daniel Nolan , Donnell Walton , Ji Wang , Luis Zenteno
IPC分类号： G02B6/02
CPC分类号： G02B6/03666 , C03B37/01234 , C03B37/01245 , C03B37/01413 , C03B37/01446 , C03B2201/12 , C03B2201/14 , C03B2201/28 , C03B2201/31 , C03B2201/36 , C03B2203/12 , C03B2203/23 , C03B2207/90 , G02B6/023 , G02B6/024 , G02B6/03611 , G02B6/03661 , H01S3/06716 , H01S3/0672 , H01S3/06729 , H01S3/1618 , H01S3/1695
摘要： An optical fiber, comprising: (i) a rare earth doped silica based elongated core with a first refractive index (n1) with an aspect ratio of 1:5 to 1; (ii) a silica based moat abutting and at least substantially surrounding the core, the moat having a refractive index n2, wherein n2 n3; and n3>n2; (iv) a silica based outer cladding surrounding said inner cladding, the outer cladding having a fourth refractive index (n4), such that n4
摘要翻译：一种光纤，包括：（i）具有长宽比为1:5至1的第一折射率（n <1> 1）的稀土掺杂二氧化硅基细长芯; （ii）邻接并且至少基本上围绕所述芯的基于二氧化硅的护城河，所述护城河具有折射率n 2 N 2，其中n 2 ; （iii）围绕所述护城河的基于二氧化硅的内包层，所述内包层具有第三折射率（n 3/3），其中n 1 <3> n 3 < SUB>; 和n 3 3 n 2; （iv）围绕所述内包层的基于二氧化硅的外包层，所述外包层具有第四折射率（n≥4），使得n 4 光纤在工作波长带表现出单极化。

93. 发明申请

US20060069788A1 Interface method, system, and program product for facilitating layering of a data communications protocol over an active message layer protocol 失效
公开(公告)号：US20060069788A1
公开(公告)日：2006-03-30
申请号：US10875471
申请日：2004-06-24
申请人： Robert Blackmore , Xin Chen , Scott Epter , Chulho Kim , Rajeev Sivaram , Hanhong Xue
发明人： Robert Blackmore , Xin Chen , Scott Epter , Chulho Kim , Rajeev Sivaram , Hanhong Xue
IPC分类号： G06F15/16
CPC分类号： H04L51/18 , H04L69/22
摘要： A protocol interface is provided for an active message protocol of a computing environment and a client process employing the active message protocol. The protocol interface includes an interface to a header handler function associated with the client process. The interface to the header handler function has parameters to be passed by and a parameter to be returned to the active message protocol when processing a message received through the active message protocol. The parameters to be passed include current message state information and current message type information for the received message. These parameters facilitate message-specific decisions by the header handler function about processing data of the message by the active message protocol. The parameter to be returned to the active message protocol instructs the active message protocol how to process the received message other than just where to store the message.

94. 发明申请

US20050244118A1 SOLID TYPE SINGLE POLARIZATION FIBER AND APPARATUS 失效
标题翻译：固体类型单极化光纤和装置
公开(公告)号：US20050244118A1
公开(公告)日：2005-11-03
申请号：US10837861
申请日：2004-05-03
申请人： George Berkey , Xin Chen
发明人： George Berkey , Xin Chen
IPC分类号： G02B6/024 , G02B6/036 , G02B6/17
CPC分类号： G02B6/03627 , G02B6/024 , G02B6/0281 , G02B6/03694
摘要： Disclosed is an optical fiber (20) having a centermost laterally-elongated core (30) having a short dimension (a), a long dimension (b) and a first refractive index (n1), a moat (40) surrounding the central laterally-elongated core, the moat (40) having a second refractive index (n2), an outer dimension (c) and an outer dimension (d), and a cladding (50) surrounding the moat (40), the cladding (50) having a third refractive index (n3), wherein n1>n3>n2, a ratio of b/a is between 1.5 and 5.0, and a ratio of d/a is between 2.0 and 7.0. The fiber supports a single (one and only one) polarization within a Single Polarization Band (SPB). The fiber (20) may be coupled to optical components in apparatus where single polarization properties are desired.
摘要翻译：公开了一种光纤（20），其具有具有短尺寸（a），长尺寸（b）和第一折射率（n <1> 1）的中心横向细长芯部（30），围绕中央横向细长的芯的护城河（40），护城河（40）具有第二折射率（n 2/2），外部尺寸（c）和外部尺寸（d），以及围绕护城河（40）的包层（50），包层（50）具有第三折射率（n 3/3），其中n 1 n 3 < / SUB >> n 2，b / a的比例在1.5和5.0之间，d / a的比率在2.0和7.0之间。光纤支持在单极化带（SPB）内的单一（仅一个）极化。纤维（20）可以耦合到需要单极化性质的设备中的光学部件。

95. 发明授权

US06876804B2 Method of making a spun optical fiber with low polarization mode dispersion 有权
标题翻译：制造具有低偏振模色散的纺丝光纤的方法
公开(公告)号：US06876804B2
公开(公告)日：2005-04-05
申请号：US10392652
申请日：2003-03-20
申请人： Xin Chen , Ming-Jun Li , Jesse C. Meyer , Oscar Palmer
发明人： Xin Chen , Ming-Jun Li , Jesse C. Meyer , Oscar Palmer
IPC分类号： C03B37/027 , C03B37/03 , C03B37/02 , C03B37/022 , C03B37/075
CPC分类号： G02B6/02285 , C03B37/02745 , C03B37/032 , C03B2203/19 , C03B2203/20 , C03B2203/36 , C03B2205/06
摘要： An optical fiber, and a method of making such optical fiber, wherein the optical fiber exhibits a beatlength greater than about 5 meters, and the fiber is spun to provide a polarization mode dispersion in the spun state of said fiber which is less than 0.05 ps/km1/2. The fiber is spun by employing a spin having a spin repeat distance of at least 10 meters. The spin preferably alternates between clockwise and counterclockwise directions.
摘要翻译：一种光纤，以及制造这种光纤的方法，其中光纤表现出大于约5米的拍子长度，并且纺丝纤维以在所述光纤的纺丝状态下提供小于0.05ps的偏振模色散 / km <1/2>。通过采用具有至少10米的自旋重复距离的纺丝来纺丝纤维。旋转优选地在顺时针和逆时针方向之间交替。

96. 发明授权

US06459008B1 Selective hydrogenation catalyst system and process for preparing the same and its use 有权
标题翻译：选择性氢化催化剂体系及其制备方法及其应用
公开(公告)号：US06459008B1
公开(公告)日：2002-10-01
申请号：US09599612
申请日：2000-06-23
申请人： Wei Dai , Jing Zhu , Helong Li , Yanlai Guo , Wei Mu , Hui Peng , Xin Chen
发明人： Wei Dai , Jing Zhu , Helong Li , Yanlai Guo , Wei Mu , Hui Peng , Xin Chen
IPC分类号： C07C402
CPC分类号： C10G45/40 , B01J23/6447
摘要： A selective hydrogenation catalyst system, and a process for its preparation and its use. The catalyst system of the invention comprises a support material, a Pd-containing catalyst component and a Bi-containing cocatalyst component. The catalyst system of the invention is manufactured by impregnating the support material simultaneously or separately with Pd-containing solution, Bi-containing solution or/and one or more other cocatalyst solutions, and then drying and calcining. The activity and selectivity of the catalyst system of the invention, in selective hydrogenation of acetylenic and diolefmic compounds in hydrocarbon feeds, are significantly improved, while the green oil formation and carbon deposit on the catalyst reduced, and the service life increased and production costs decreased.
摘要翻译：选择性氢化催化剂体系及其制备方法及其应用。本发明的催化剂体系包括载体材料，含Pd催化剂组分和含Bi助催化剂组分。本发明的催化剂体系是通过与含Pd溶液，含Bi的溶液或一种或多种其它助催化剂溶液同时或分开地浸渍载体材料，然后干燥和煅烧来制造的。本发明的催化剂体系在烃类进料中炔属和二烯化合物的选择性氢化中的活性和选择性得到显着提高，而催化剂上的绿色油形成和碳沉积减少，使用寿命增加，生产成本降低。

97. 发明授权

US06389478B1 Efficient non-contiguous I/O vector and strided data transfer in one sided communication on multiprocessor computers 失效
标题翻译：在多处理器计算机上的单面通信中有效的非连续I / O向量和跨数据传输
公开(公告)号：US06389478B1
公开(公告)日：2002-05-14
申请号：US09365696
申请日：1999-08-02
申请人： Robert Sidney Blackmore , Xin Chen , Rama Krishna Govindaraju , Anan Vishwanath Hudli
发明人： Robert Sidney Blackmore , Xin Chen , Rama Krishna Govindaraju , Anan Vishwanath Hudli
IPC分类号： G06F1500
CPC分类号： H04L29/06 , H04L67/10 , H04L69/22 , H04L69/329
摘要： A method for grouping I/O vectors to be transferred across a distributed computing environment comprising a plurality of processing nodes coupled together over a network. The method reduces the number of packets transmitted over a network between two or more nodes. The method includes the grouping of two or more I/O vectors into a single message, consisting of one packet with a predetermined maximum size, provided the sizes of the vectors are small enough to be placed into a single packet. The grouping method finds an efficient collection of vectors to form groups that fit inside a single packet. If two or more of the vectors can be combined so that the resulting single packet size does not exceed the predetermined maximum size, the vectors are grouped accordingly. Vectors whose size approach the predetermined maximum packet size are sent as a separate message.
摘要翻译：一种用于分组要在分布式计算环境中传送的I / O向量的方法，包括通过网络耦合在一起的多个处理节点。该方法减少了两个或多个节点之间通过网络传输的数据包数量。该方法包括将两个或更多个I / O向量分组为单个消息，由具有预定最大大小的一个分组组成，只要向量的大小足够小以便放置在单个分组中。分组方法找到有效的向量集合以形成适合单个数据包内的组。如果可以组合两个或更多个向量，使得所得到的单个分组大小不超过预定的最大大小，则矢量被相应地分组。大小接近预定最大数据包大小的向量作为单独消息发送。

98. 发明授权

US06365711B1 Methods and reagents for modulating TGF-&bgr; superfamily signalling 失效
标题翻译：用于调节TGF-β超家族信号传导的方法和试剂
公开(公告)号：US06365711B1
公开(公告)日：2002-04-02
申请号：US09087134
申请日：1998-05-28
申请人： Malcolm Whitman , Xin Chen
发明人： Malcolm Whitman , Xin Chen
IPC分类号： C07K1447
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/463 , C07K2319/00 , C12Q1/6897 , G01N2333/495
摘要： FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF-&bgr; superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF-&bgr; superfamily signalling.
摘要翻译： FAST-1和Smad2或Smad3形成由TGF-β超家族成员产生的信号特异性诱导的复合物。我们已经表明，FAST-1的结构域与Smad2或Smad3直接相互作用，并且这种相互作用由两个相互作用的分子的特定结构域介导，即Smad2或Smad3的MH2结构域和Smad2的Smad相互作用域（SID） FAST-1。该结果允许开发用于分离参与和/或调节TGF-β超家族信号传导的化合物的方法和试剂。

99. 发明授权

US10285429B2 Automated fruit and vegetable calyx or stem removal machine 有权
公开(公告)号：US10285429B2
公开(公告)日：2019-05-14
申请号：US15152400
申请日：2016-05-11
申请人： Yang Tao , John Lin , Xin Chen , Gary E. Seibel
发明人： Yang Tao , John Lin , Xin Chen , Gary E. Seibel
IPC分类号： A23N15/02 , B26D7/06 , B26F3/00 , B26D5/00 , B26D5/34 , A23L19/00
摘要： A system and methods are provided for removal of undesired portions of a fruit or vegetable, such as removal of calyxes from strawberries before they are flash frozen. An automated process for high-throughput fruit or vegetable calyx removal includes a loading system, an identification system, and a removal system. The loading system is configured to transport the fruit or vegetable through the automated process. The loading system may also orient the fruits or vegetables along an axis of the fruit and or align the fruit or vegetables in a desired pattern, orientation, and/or arrangement. The identification system is configured to locate the calyx and determines calyx position data and an optimal cutting path for individual fruit. The removal system uses data received from the identification system to separate the calyx from the fruit or vegetable.

100. 发明授权

US10143630B2 Device and method for guiding latch-on 有权
公开(公告)号：US10143630B2
公开(公告)日：2018-12-04
申请号：US13996566
申请日：2011-12-19
申请人： Aizhi Yang , Renjun Yu , Xin Chen , Axelle Stephanie Maud Ducos
发明人： Aizhi Yang , Renjun Yu , Xin Chen , Axelle Stephanie Maud Ducos
IPC分类号： A61J13/00 , A61J11/00
摘要： The invention proposes a device (1) and a corresponding method, wherein the device (1) comprises: a first element (10) to be attached to a breast of a breastfeeding mother; and a first marker (11) located on the outer surface (100) of the first element (10), wherein the first marker (11) is used for indicating a position of a mother's breast that the baby's lip is expected to contact in order to correctly hold the mother's breast. With the device (1) attached to the mother's breast, the first marker (11) indicates a position that the baby's lip is expected to contact, and the breastfeeding mother can have a clear view of whether the baby correctly holds the mother's breast according to the distance between the first marker (11) and the baby's lip.

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