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91. 发明申请

US20100113832A1 PALLADIUM CATALYSTS 失效
标题翻译：钯催化剂
公开(公告)号：US20100113832A1
公开(公告)日：2010-05-06
申请号：US12532820
申请日：2007-03-23
申请人： Jackie Y. Ying , Nandanan Erathidiyil
发明人： Jackie Y. Ying , Nandanan Erathidiyil
IPC分类号： C07C209/78 , B01J23/44 , B01J21/08 , B01J31/20 , B01J31/02 , C07C13/28 , C07C6/00 , C07C5/03 , C07C29/153 , C07C1/00
CPC分类号： B01J23/44 , B01J21/18 , B01J31/1608 , B01J31/1616 , B01J31/1625 , B01J31/1805 , B01J35/04 , B01J35/1019 , B01J35/1047 , B01J35/1061 , B01J2231/4211 , B01J2231/4261 , B01J2231/643 , B01J2231/645 , B01J2531/824 , C07B37/04 , Y02P20/588
摘要： The invention relates to a particulate substance comprising a particulate porous support coupled to a palladium species. The palladium species may comprise palladium nanoclusters. The particulate substance may be used as a catalyst for conducting a carbon-carbon coupling reaction or a reduction.
摘要翻译：本发明涉及包含与钯物质偶联的颗粒状多孔载体的颗粒物质。钯物质可以包括钯纳米团簇。颗粒物质可以用作进行碳 - 碳偶联反应或还原的催化剂。

92. 发明申请

US20100092383A1 Mesostructured Zeolitic Materials and Methods of Making and Using the Same 有权
标题翻译：中等结构的沸石材料及其制备和使用方法
公开(公告)号：US20100092383A1
公开(公告)日：2010-04-15
申请号：US12565351
申请日：2009-09-23
申请人： Jackie Y. Ying , Javier Garcia-Martinez
发明人： Jackie Y. Ying , Javier Garcia-Martinez
IPC分类号： C01B39/00
CPC分类号： B01J29/40 , B01J20/18 , B01J20/186 , B01J29/005 , B01J29/0308 , B01J29/041 , B01J29/084 , B01J29/106 , B01J29/18 , B01J29/80 , B01J2229/62 , B82Y30/00 , C01B39/02 , C01B39/023 , C01B39/026 , C01B39/04 , C10G1/086 , C10G11/02 , C10G11/05 , C10G11/18 , C10G45/04 , C10G47/02 , C10G2300/1033 , C10G2300/1074 , C10G2300/1096 , C10G2400/02 , C10G2400/20 , Y10T428/26
摘要： One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for organic compounds and degradation catalysts for polymers.
摘要翻译：本发明的一个方面涉及介孔结构的沸石。本发明还涉及一种制备介孔结构的沸石的方法，以及它们用作有机化合物的裂化催化剂和聚合物的降解催化剂。

93. 发明申请

US20090186077A1 THERMO-RESPONSIVE MATERIALS 审中-公开
标题翻译：热响应材料
公开(公告)号：US20090186077A1
公开(公告)日：2009-07-23
申请号：US12279461
申请日：2007-02-14
申请人： Jackie Y. Ying , Cindy Ren
发明人： Jackie Y. Ying , Cindy Ren
IPC分类号： A61K9/127 , A61K35/00
CPC分类号： A61L27/54 , A61K9/0024 , A61K47/36 , A61L26/0047 , A61L26/008 , A61L27/20 , A61L27/22 , A61L27/50 , A61L2300/414 , A61L2300/602 , A61L2300/626 , A61L2400/06
摘要： The invention is directed to, inter alia, injectable materials, which comprise a a zero-length cross-linking agent encapsulated in a thermo-responsive liposome dispersed in a polymer solution where the polymer and cross-linking agent are segregated at a first temperature, and non-segregated at a second temperature, and the material is injectable at the first temperature. The invention is directed to, inter alia, processes for producing the material and use of the material for tissue repair and regeneration and controlled delivery of an agent are also described.
摘要翻译：本发明特别涉及可注射材料，其包含包封在分散在聚合物溶液中的热响应性脂质体中的零长度交联剂，其中聚合物和交联剂在第一温度下分离，以及在第二温度下不分离，并且材料在第一温度下可注射。本发明特别涉及用于生产材料的方法和用于组织修复和再生以及受控制剂递送的材料的使用。

94. 发明申请

US20080241877A1 Immobilised Enzymes 失效
标题翻译：固定化酶
公开(公告)号：US20080241877A1
公开(公告)日：2008-10-02
申请号：US11885983
申请日：2005-03-08
申请人： Jackie Y. Ying , Su Seong Lee , Yu Han
发明人： Jackie Y. Ying , Su Seong Lee , Yu Han
IPC分类号： C12P1/00 , C12N11/00 , C12M1/00
CPC分类号： C07K17/14 , C12N11/14 , C12P1/00 , Y02P20/588
摘要： The present invention relates to a method for immobilizing enzymes in a solid porous support, and to enzymes immobilized in solid porous supports. Specifically, the present invention uses a fluid containing the enzyme under high pressure (such as 25 to 50 Mpa) to immobilize the enzyme (such as CALB) on the porous support (such as silica). The resulting porous support contain more immobilized enzyme than would otherwise have been obtained by a process carried out at atmospheric pressures.
摘要翻译：本发明涉及固定在固体多孔载体中的酶的固定方法和固定在固体多孔载体中的酶。具体地说，本发明使用含有高压（如25〜50Mpa）酶的流体将酶（如CALB）固定在多孔载体（如二氧化硅）上。所得多孔载体含有比通常在大气压下进行的方法获得的更多的固定化酶。

95. 发明申请

US20080188642A1 Process for Isolating Biomaterial From Tissue and an Isolated Biomaterial Extract Prepared Therefrom 失效
标题翻译：从组织中分离生物材料的方法和从中制备的分离的生物材料提取物
公开(公告)号：US20080188642A1
公开(公告)日：2008-08-07
申请号：US11662443
申请日：2004-09-09
申请人： Jackie Y. Ying , Shona Pek
发明人： Jackie Y. Ying , Shona Pek
IPC分类号： C07K1/36 , C07K14/00
CPC分类号： A61L27/24 , C07K1/145 , C07K14/78 , C08B37/0003 , C08B37/0021 , C08B37/003 , C08B37/0045 , C08B37/0057 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08H1/00 , C08H1/06 , C09H3/00
摘要： A process for isolating a biomaterial extract from tissue is disclosed. The process comprises the step of contacting the tissue with an extracting solution so as to extract a biomaterial into solution. A solution containing the biomaterial extract is separated before being freeze-dried at a rate sufficient to enable the biomaterial to be isolated. The examples relate to the extraction of collagen from skin or hide using an acetic acid solution as the solvent.
摘要翻译：公开了从组织中分离生物材料提取物的方法。该方法包括使组织与提取溶液接触以将生物材料提取到溶液中的步骤。将含有生物材料提取物的溶液在冷冻干燥之前被分离，其速率足以使生物材料被分离。这些实例涉及使用乙酸溶液作为溶剂从皮肤或皮肤中提取胶原蛋白。

96. 发明授权

US07211275B2 Composite materials for controlled release of water soluble products 失效
标题翻译：复合材料用于控制水溶性产品的释放
公开(公告)号：US07211275B2
公开(公告)日：2007-05-01
申请号：US11034217
申请日：2005-01-13
申请人： Jackie Y. Ying , Tseh-Hwan Yong
发明人： Jackie Y. Ying , Tseh-Hwan Yong
IPC分类号： A61K9/58
CPC分类号： C12N5/0655 , A61K9/143 , A61K9/146 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/258 , A61L2300/404 , A61L2300/412 , A61L2300/416 , A61L2300/426 , A61L2300/602 , C12N2501/155 , C12N2533/30 , C12N2533/40
摘要： Composite materials comprising a water-soluble compound adsorbed onto a basic inorganic material and a bio-degradable polymer which yields acidic degradation products, methods of producing same, and methods of use thereof are described, wherein the composite materials are designed so as to provide controlled release of the water soluble molecule.
摘要翻译：描述了包含吸附在碱性无机材料上的水溶性化合物和产生酸性降解产物的生物可降解聚合物的复合材料及其制备方法及其使用方法，其中复合材料被设计成提供受控的释放水溶性分子。

97. 发明授权

US09707563B2 Reagent fluid dispensing device, and method of dispensing a reagent fluid 有权
公开(公告)号：US09707563B2
公开(公告)日：2017-07-18
申请号：US13696063
申请日：2011-05-04
申请人： Mo-Huang Li , Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee , Emril Mohamed Ali , Tseng-Ming Hsieh
发明人： Mo-Huang Li , Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee , Emril Mohamed Ali , Tseng-Ming Hsieh
IPC分类号： B01L3/00 , B01L3/02 , F04F1/18
CPC分类号： B01L3/52 , F04F1/18
摘要： According to various embodiments, a reagent fluid dispensing device may be provided. The reagent fluid dispensing device may include a chamber for receiving a reagent fluid, the chamber having a first opening and a second opening; a first fluid conduit connected to the first opening of the chamber; a reservoir connected to the first fluid conduit, the reservoir having a first opening, wherein the first opening of the reservoir is connected to the first fluid conduit to form a passive valve, wherein the reservoir is dimensionalized for storing a predetermined volume of the reagent fluid; and a pneumatic conduit connected to the second opening of the chamber, wherein selective application of pneumatic pressure to the chamber through the pneumatic conduit transfers the reagent fluid from the reservoir to the chamber through the first fluid conduit. According to various embodiments, a microfluidic device including the reagent fluid dispensing device, and a method of dispensing a reagent fluid may be provided.

98. 发明授权

US09447407B2 Double coating procedure for the membranes of bioartificial kidneys 有权
标题翻译：生物人造肾膜双重涂层程序
公开(公告)号：US09447407B2
公开(公告)日：2016-09-20
申请号：US13019352
申请日：2011-02-02
申请人： Daniele Zink , Ming Ni , Jackie Y. Ying
发明人： Daniele Zink , Ming Ni , Jackie Y. Ying
IPC分类号： C12N11/06 , B01D67/00
CPC分类号： C12N11/06 , B01D67/0088
摘要： The present invention generally relates to modified substrates such as membranes for use in bioartificial organs, such as bioartificial kidneys, and other applications. Certain aspects are generally directed to a membrane or other substrate modified to facilitate the attachment of cells. In one set of embodiments, the substrate or membrane may be at least partially coated with an adhesive such as 3,4-dihydroxy-L-phenylalanine (DOPA), poly(dopamine), or other adhesive comprising a molecule having a catechol moiety, for example on one side of the membrane or substrate. On at least a portion of the adhesive coated portion of the substrate, a protein may be coated, such as an extracellular matrix protein (for example, a collagen), to which cells such as primary human renal proximal tubule cells may be adhered. Surprisingly, such a dual coating may be used to promote the attachment of such cells to a membrane or other substrate that otherwise may not promote cell adhesion. In certain embodiments, the coating may also facilitate or promote not only cell adhesion, but also cell proliferation and/or differentiation. Such membranes or other substrates may be useful, for example, in bioartificial organs such as bioartificial kidneys, hemodialysis cartridges, bioimplants, biosensors, bioreactors, etc. In certain embodiments, cells may be attached to a membrane or other substrate on only one side, while the other side may be kept free of attached cells.
摘要翻译：本发明一般涉及用于生物人造器官例如生物人造肾等的改性底物，例如膜。某些方面通常涉及修饰以便于细胞附着的膜或其他底物。在一组实施方案中，基底或膜可以至少部分地涂覆有粘合剂，例如3,4-二羟基-L-苯丙氨酸（DOPA），聚（多巴胺）或包含具有儿茶酚部分的分子的其它粘合剂，例如在膜或基底的一侧。在底物的粘合剂涂覆部分的至少一部分上，可以涂覆蛋白质，例如细胞外基质蛋白（例如胶原），细胞如原发性人肾近端小管细胞可以粘附到细胞上。令人惊奇的是，这种双重涂层可以用于促进这种细胞与膜或其它底物的连接，否则可能不促进细胞粘附。在某些实施方案中，该涂层还可促进或促进细胞粘附，但也促进细胞增殖和/或分化。这样的膜或其它底物可用于例如生物人造器官如生物人造肾，血液透析盒，生物移植物，生物传感器，生物反应器等中。在某些实施方案中，细胞可以仅在一侧附着于膜或其它底物，而另一侧可以保持没有附着的细胞。

99. 发明授权

US09352283B2 Tubular fiber membrane with nanoporous skin 有权
标题翻译：管状纤维膜与纳米多孔皮肤
公开(公告)号：US09352283B2
公开(公告)日：2016-05-31
申请号：US13881705
申请日：2010-10-25
申请人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
发明人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
IPC分类号： B01D63/02 , B01D63/06 , B01D71/68 , A61M1/16 , B01D67/00 , B01D69/08 , D01D5/06 , D01D5/247 , A61M1/36
CPC分类号： B01D63/02 , A61M1/1621 , A61M1/1625 , A61M1/3689 , B01D63/06 , B01D67/0088 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2313/44 , D01D5/06 , D01D5/247
摘要： A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.
摘要翻译：提供了一种用于形成管状纤维膜的湿式纺丝方法。管状纤维膜具有纳米孔表皮层和微孔腔层。表皮层限定纤维膜的外表面，内腔层限定纤维膜的内表面。表皮层中的孔可具有小于约7nm的平均孔径，并且管腔层中的孔可具有约0.5至约3μm的平均孔径。纤维膜可以用于人造肾近端小管，人造肾，生物反应器或纤维筒。

100. 发明授权

US09155707B2 Core-shell microspheres 有权
标题翻译：核壳微球
公开(公告)号：US09155707B2
公开(公告)日：2015-10-13
申请号：US14123935
申请日：2012-06-08
申请人： Jackie Y. Ying , Shona Pek , Pemakorn Pitukmanorom , Siti Thaharah Mohamed
发明人： Jackie Y. Ying , Shona Pek , Pemakorn Pitukmanorom , Siti Thaharah Mohamed
IPC分类号： A61K9/48 , A61K31/435 , A61K47/34 , C08J3/02 , C08L87/00 , C08J3/12
CPC分类号： A61K9/48 , A61K9/0024 , A61K9/0048 , A61K9/06 , A61K9/127 , A61K9/19 , A61K31/435 , A61K35/15 , A61K47/34 , A61K47/42 , C08J3/02 , C08J3/126 , C08J2387/00 , C08L87/00
摘要： The specification describes a substance comprising a plurality of microparticles. The microparticles comprise a core comprising a first polymer and a shell surrounding said core and comprising the first polymer and a second polymer, wherein the second polymer is less rapidly degradable than the first polymer. A process for making the microparticles and uses of the microparticles are also described.
摘要翻译：该说明书描述了包含多个微粒的物质。所述微粒包括包含第一聚合物和包围所述芯并且包含所述第一聚合物和第二聚合物的壳的芯，其中所述第二聚合物比所述第一聚合物不能快速降解。还描述了制备微粒的方法和微粒的用途。

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