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91. 发明授权

US06574514B2 System and assembly having conductive fixation features 失效
公开(公告)号：US06574514B2
公开(公告)日：2003-06-03
申请号：US09746614
申请日：2000-12-21
申请人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
发明人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
IPC分类号： A61N105
CPC分类号： A61N1/057 , A61N1/0573 , A61N2001/0585
摘要： A lead having a distal end electrode assembly adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines or flexible members, in combination with non-conductive fixation features. The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.

92. 发明授权

US06556862B2 Method and apparatus for treating supraventricular tachyarrhythmias 失效
标题翻译：治疗室上性快速性心律失常的方法和装置
公开(公告)号：US06556862B2
公开(公告)日：2003-04-29
申请号：US09044284
申请日：1998-03-19
申请人： William Hsu , Bruce H. KenKnight
发明人： William Hsu , Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/395
摘要： A system and method for treating atrial fibrillation using atrial pacing pulses to convert an atrial fibrillation to non-fibrillation atrial arrhythmia prior to delivering a low energy cardioversion/defibrillation shock. The system and method treats atrial fibrillations by first applying a plurality of pacing pulses to the atria which converts the atrial fibrillation to non-fibrillation atrial arrhythmia. Ventricular intervals are concurrently sensed and analyzed while the plurality of electrical pacing pulses are being applied. Upon detecting a period of stable ventricular intervals, the system then proceeds to deliver a low-energy cardioverting/defibrillating pulse of electrical energy across the atria of the heart.
摘要翻译：一种用于在递送低能量心律转复/除颤休克之前使用心房起搏脉冲来治疗心房颤动以将心房颤动转换为非纤维性心房心律失常的系统和方法。该系统和方法通过首先将多次起搏脉冲施加到将心房颤动转变为非纤维性心房心律不齐的心房来治疗房颤。在施加多个起搏脉冲的同时，同时感测和分析心室间隔。在检测到稳定的心室间隔的时间段时，系统然后继续在心脏的心房上提供电能的低能量心律转复/除颤脉冲。

93. 发明授权

US06430449B1 Catheter for treating supraventricular tachyarrhythmias 有权
标题翻译：导管用于治疗室上性快速性心律失常
公开(公告)号：US06430449B1
公开(公告)日：2002-08-06
申请号：US09464244
申请日：1999-12-16
申请人： William Hsu , Bruce H. KenKnight
发明人： William Hsu , Bruce H. KenKnight
IPC分类号： A61N105
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/395
摘要： A system and method for treating atrial fibrillation using atrial pacing pulses to convert an atrial fibrillation to non-fibrillation atrial arrhythmia prior to delivering a low energy cardioversion/defibrillation shock. The system and method treats atrial fibrillations by first applying a plurality of pacing pulses to the atria which converts the atrial fibrillation to non-fibrillation atrial arrhythmia. Ventricular intervals are concurrently sensed and analyzed while the plurality of electrical pacing pulses are being applied. Upon detecting a period of stable ventricular intervals, the system then proceeds to deliver a low-energy cardioverting/defibrillating pulse of electrical energy across the atria of the heart.
摘要翻译：一种用于在递送低能量心律转复/除颤休克之前使用心房起搏脉冲来治疗心房颤动以将心房颤动转换为非纤维性心房心律失常的系统和方法。该系统和方法通过首先将多次起搏脉冲施加到将心房颤动转变为非纤维性心房心律不齐的心房来治疗房颤。在施加多个起搏脉冲的同时，同时感测和分析心室间隔。在检测到稳定的心室间隔的时间段时，系统然后继续在心脏的心房上提供电能的低能量心律转复/除颤脉冲。

94. 发明授权

US06280462B1 Implantable intravenous cardiac stimulation system with pulse generator housing serving as optional additional electrode 失效
标题翻译：具有脉冲发生器外壳的植入式静脉内心脏刺激系统作为可选附加电极
公开(公告)号：US06280462B1
公开(公告)日：2001-08-28
申请号：US09689018
申请日：2000-10-12
申请人： Robert G. Hauser , Roger W. Dahl , Bruce H. KenKnight
发明人： Robert G. Hauser , Roger W. Dahl , Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/056 , A61N1/05 , A61N1/368 , A61N1/375 , A61N1/3756
摘要： A pulse generator housing for enclosing and containing pulse generator defibrillation circuitry. The housing is formed entirely of electrically conductive metal defining an electrically conductive outer surface which is connected to the pulse generator circuitry for delivering defibrillating energy to the heart. The pulse generator housing is implanted in the pectoral region proximate the heart with the conductive surface facing the heart. Regions of the conductive outer surface may be electrically isolated and dedicated for separately sensing and shocking. The outer surface may be coated with platinum. Additional coiled segment electrodes may extend from the housing and be electrically connected to the conductive outer surface so as to increase the effective conductive surface area. A sensor is provided to determine whether the housing is inside or outside a body of a patient to disconnect the pulse generator housing conductive surface from the pulse generator circuitry when the unit is outside the body of a patient.
摘要翻译：脉冲发生器外壳，用于封闭和包含脉冲发生器除颤电路。壳体完全由形成导电外表面的导电金属形成，该导电外表面连接到脉冲发生器电路，用于将去纤颤能量传送到心脏。脉冲发生器壳体被植入靠近心脏的胸膜区域，导电表面面向心脏。导电外表面的区域可以是电隔离的，专用于单独的感测和震动。外表面可以涂覆铂。附加的线圈段电极可以从壳体延伸并且电连接到导电外表面，以便增加有效的导电表面积。提供传感器以确定当该单元在患者身体外部时，外壳是否在患者身体内部或外部，以将脉冲发生器外壳导电表面与脉冲发生器电路断开。

95. 发明授权

US06246908B1 Method and apparatus for rapidly predicting outcome of arrhythmia therapy 失效
标题翻译：快速预测心律失常治疗结局的方法和装置
公开(公告)号：US06246908B1
公开(公告)日：2001-06-12
申请号：US09498898
申请日：2000-02-04
申请人： Nipon Chattipakorn , Raymond E. Ideker , Bruce H. KenKnight
发明人： Nipon Chattipakorn , Raymond E. Ideker , Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/3956
摘要： A method for predicting the outcome of arrhythmia therapy in a subject in need thereof comprises the steps of: (a) detecting an arrhythmia in the heart of a subject; (b) delivering a first arrhythmia therapy pulse to the heart of the subject; and then (c) determining the presence or absence of overlapping cycles in the heart of the subject, the presence of overlapping cycles indicating that the first arrhythmia therapy pulse did not successfully treat the arrhythmia. Overlapping cycles are preferably determined through the calculation of an overlapping cycles index (OCI). Apparatus for carrying out the method is also disclosed.
摘要翻译：用于预测有需要的受试者的心律失常治疗结果的方法包括以下步骤：（a）检测受试者心脏中的心律失常; （b）向受试者的心脏递送第一心律失常治疗脉搏; 然后（c）确定在受试者的心脏中存在或不存在重叠循环，指示第一心律失常治疗脉冲未能成功治疗心律失常的重叠周期的存在。重叠循环优选通过计算重叠循环指数（OCI）来确定。还公开了用于执行该方法的装置。

96. 发明授权

US06230055B1 Method and apparatus for adaptive tachycardia and fibrillation discrimination 有权
标题翻译：适应性心动过速和原纤维化鉴别的方法和装置
公开(公告)号：US06230055B1
公开(公告)日：2001-05-08
申请号：US09378591
申请日：1999-08-20
申请人： Weimin Sun , Martin Tze , Bruce H. KenKnight , Yatheendhar Manicka
发明人： Weimin Sun , Martin Tze , Bruce H. KenKnight , Yatheendhar Manicka
IPC分类号： A61N137
CPC分类号： A61N1/3622 , A61N1/3962
摘要： An implantable cardioverter/defibrillator with antitachycardia pacing capability and method for operating same in which the detection zone boundary used to discriminate between tachycardia and fibrillation is adaptively adjusted based upon operating experience. Rate zones are provided for further classifying detected episodes of tachycardia and fibrillation according to the certainty of their being correctly identified based upon past operating experience. Adjustments of the rate zones and the fibrillation detection zone boundary are made based upon the results of antitachycardia pacing in attempting to terminate arrhythmic episodes.
摘要翻译：一种具有抗心动过速起搏能力的植入式心律转复除颤器及其操作方法，其中基于操作经验自适应调整用于区分心动过速和颤动的检测区边界。提供速率区，用于根据过去的操作经验正确识别检测到的心动过速和颤动发作进一步分类。基于抗心律失常起搏试图终止心律失常发作的结果，进行速率区和原纤维化检测区边界的调整。

97. 发明授权

US06169921A Autocapture determination for an implantable cardioverter defibrillator 有权
标题翻译：植入式心律转复除颤器自动识别
公开(公告)号：US06169921A
公开(公告)日：2001-01-02
申请号：US09206896
申请日：1998-12-08
申请人： Bruce H. KenKnight , Geng Zhang , Qingsheng Zhu
发明人： Bruce H. KenKnight , Geng Zhang , Qingsheng Zhu
IPC分类号： A61N1362
CPC分类号： A61N1/3712 , A61N1/3716
摘要： A cardiac pacing/defibrillation system that enhances the ability of a cardiac pacer to automatically detect whether a pacing stimulus results in heart capture or contraction. The cardiac pacing/defibrillation system includes a pacing circuit that attenuates polarization voltages or “afterpotential” which develop at the heart tissue/electrode interface following the delivery of a stimulus to the heart tissue, which thereby allows the pacing electrodes to be utilized to sense an evoked response to the pacing stimulus. The cardiac pacing/defibrillation system may utilize the ventricular coil electrode and superior vena cava coil electrode to sense an evoked response, thereby eliminating the necessity for an additional ventricular lead for sensing an evoked response. The present invention allows accurate detection of an evoked response of the heart, to thereby determine whether each pacing stimulus results in capture.
摘要翻译：心脏起搏/除颤系统，其增强心脏起搏器自动检测起搏刺激是否导致心脏捕获或收缩的能力。心脏起搏/除颤系统包括一个起搏电路，该起搏电路在脉冲递送到心脏组织之后，衰减在心脏组织/电极界面处产生的极化电压或“后电位”，从而允许使用起搏电极感测诱发对起搏刺激的反应。心脏起搏/除颤系统可以利用心室线圈电极和上腔静脉线圈电极来感测诱发反应，从而消除额外的心室导联感测诱发反应的必要性。本发明允许准确检测心脏的诱发反应，从而确定每个起搏刺激是否导致捕获。

98. 发明授权

US5496362A Implantable conformal coil patch electrode with multiple conductive elements for cardioversion and defibrillation 失效
公开(公告)号：US5496362A
公开(公告)日：1996-03-05
申请号：US980843
申请日：1992-11-24
申请人： Bruce H. KenKnight , Roger W. Dahl , David K. Swanson
发明人： Bruce H. KenKnight , Roger W. Dahl , David K. Swanson
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/0587
摘要： Body-implantable leads with open, unbacked (uninsulated) electrode structures having electrical discharge surfaces formed by conductive elements, such as mesh and braid, and preferably coils. The electrode structures can be classified by pattern: (1) loops, (2) linear arrays and (3) radial arrays. The electrodes are located on or near the epicardial surface of the right and left heart.

99. 发明授权

US5385574A Implantable intravenous cardiac stimulation system with pulse generator housing serving as optional additional electrode 失效
公开(公告)号：US5385574A
公开(公告)日：1995-01-31
申请号：US917899
申请日：1992-07-24
申请人： Robert G. Hauser , Roger W. Dahl , Bruce H. KenKnight
发明人： Robert G. Hauser , Roger W. Dahl , Bruce H. KenKnight
IPC分类号： A61N1/362 , A61N1/05 , A61N1/368 , A61N1/372 , A61N1/375 , A61N1/39
CPC分类号： A61N1/375 , A61N1/056 , A61N1/368 , A61N1/3756
摘要： A pulse generator housing for enclosing and containing pulse generator defibrillation circuitry. The housing is formed entirely of electrically conductive metal defining an electrically conductive outer surface which is connected to the pulse generator circuitry for delivering defibrillating energy to the heart. The pulse generator housing is implanted in the pectoral region proximate the heart with the conductive surface facing the heart. Regions of the conductive outer surface may be electrically isolated and dedicated for separately sensing and shocking. The outer surface may be coated with platinum. Additional coiled segment electrodes may extend from the housing and be electrically connected to the conductive outer surface so as to increase the effective conductive surface area. A sensor is provided to determine whether the housing is inside or outside a body of a patient to disconnect the pulse generator housing conductive surface from the pulse generator circuitry when the unit is outside the body of a patient.

100. 发明授权

US5314464A Method and applicator tool for implanting cardiac defibrillation electrodes 失效
标题翻译：用于植入心脏除颤电极的方法和敷贴工具
公开(公告)号：US5314464A
公开(公告)日：1994-05-24
申请号：US954514
申请日：1992-09-30
申请人： Bruce H. KenKnight , Jeffrey A. Hall , William J. Eastman
发明人： Bruce H. KenKnight , Jeffrey A. Hall , William J. Eastman
IPC分类号： A61N1/372 , A61B1/00 , A61B17/00 , A61N1/04 , A61N1/05
CPC分类号： A61N1/0563 , A61M37/0069
摘要： A tool and method for inserting cardiac defibrillation electrodes into a patient. The tool includes an elongated electrode support tube having a rounded distal end and a proximal end; a finger grip circumferentially connected about the electrode support tube toward the proximal end thereof; and an actuating rod slidably disposed coextensively within the electrode support tube and extending beyond the rounded distal end and the proximal end of the electrode support tube. A blunt conically shaped distal tip is connected to the distal end of the actuating rod, the distal tip having a base with a diameter larger than the diameter of the electrode support tube, and an inner surface for engaging the rounded distal end of the electrode support tube. A palm member is connected to the proximal end of the actuating rod to facilitate hand manipulation of the tool. In addition, a resilient device (preferably, a spring) is included for exerting a force on the actuating rod tending to withdraw the actuating rod out through the proximal end of the electrode support tube, such withdrawal being prevented by the engagement of the inner surface of the distal tip with the rounded distal end of the electrode support tube. In use, a cardiac defibrillation electrode is wrapped around the electrode support tube with the distal end of the electrode immobilized between the distal tip of the tool and the rounded distal end of the electrode support tube.
摘要翻译：用于将心脏除颤电极插入患者体内的工具和方法。该工具包括具有圆形远端和近端的细长电极支撑管; 围绕电极支撑管朝向其近端周向连接的手指把手; 以及致动杆，其可共同延伸地设置在电极支撑管内并且延伸超过电极支撑管的圆形远端和近端。扁平的圆锥形远端尖端连接到致动杆的远端，远侧末端具有直径大于电极支撑管的直径的基部，以及用于接合电极支撑件的圆形远端的内表面管。手掌构件连接到致动杆的近端以便于手操作工具。另外，包括弹性装置（优选地是弹簧），用于在致动杆上施加力，倾向于通过电极支撑管的近端将致动杆拉出，这种退避通过内表面的接合来防止的远端具有电极支撑管的圆形远端。在使用中，将心脏除颤电极缠绕在电极支撑管周围，电极的远端固定在工具的远端和电极支撑管的圆形远端之间。

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