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91. 发明授权

US08470153B2 Cartridge and system for manipulating samples in liquid droplets 有权
标题翻译：用于操作液滴样品的墨盒和系统
公开(公告)号：US08470153B2
公开(公告)日：2013-06-25
申请号：US13188584
申请日：2011-07-22
申请人： Marc N. Feiglin , Joseph Mamone , Anne R. Kopf-Sill , Ian Fitzpatrick , Mark Rob , Phillip Duncan
发明人： Marc N. Feiglin , Joseph Mamone , Anne R. Kopf-Sill , Ian Fitzpatrick , Mark Rob , Phillip Duncan
IPC分类号： C02F1/04 , C02F11/00 , C25B9/00 , C25B11/00 , C25B13/00 , G01N27/00
CPC分类号： B01L3/502738 , B01L3/502715 , B01L3/502784 , B01L3/5029 , B01L3/523 , B01L3/527 , B01L7/52 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0647 , B01L2200/141 , B01L2300/044 , B01L2300/0672 , B01L2300/0681 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/161 , B01L2400/0427 , B01L2400/043 , B01L2400/0478 , B01L2400/0638 , B01L2400/0683
摘要： A cartridge (1) comprises a working film (10) for manipulating samples in liquid droplets with an electrode array (20) when the working film (10) of the cartridge (1) is placed on said electrode array (20). The cartridge (1) comprises a body (2,2′,2″) with a number of wells (5) configured to hold therein reagents (6) or samples (6′); a flexibly deformable top structure (7) impermeable to liquids and configured to seal a top side of the wells (5); a piercable bottom structure (8) impermeable to liquids and configured to seal a bottom side of the wells (5); a working film (10) located below a lower surface (4) of the body (2,2′,2″), the working film (10) being impermeable to liquids and comprising a hydrophobic upper surface (11); a peripheral spacer (9,9′,9″) located below the lower surface (4) of the body (2,2′,2″) and connecting the working film (10) to the body (2,2′,2″); a gap (12) between the lower surface (4) of the body (2,2′,2″) and the hydrophobic upper surface (11) of the working film (10), the gap (12) being defined by the peripheral spacer (9,9′,9″); and a number of piercing elements (13) located below piercable bottom structures (8) and configured to pierce the piercable bottom structures (8) for releasing reagents or samples (6,6′) from the wells (5) into the gap (12). Also disclosed is a system (40) with an electrode array (20) onto which the cartridge (1) can be placed.
摘要翻译：当药筒（1）的工作薄膜（10）被放置在所述电极阵列（20）上时，墨盒（1）包括用于用电极阵列（20）操纵液滴样品的工作薄膜（10）。墨盒（1）包括具有多个孔（5）的主体（2,2'，2“），所述孔被配置为容纳其中的试剂（6）或样品（6'）; 柔性可变形顶部结构（7），其不透液体并且构造成密封所述孔（5）的顶侧; 不透液体并且被构造成密封井（5）的底侧的可穿透底部结构（8）; 位于主体（2,2'，2“）的下表面（4）下方的工作薄膜（10），工作薄膜（10）不透液体并包括疏水性上表面（11）; 位于主体（2,2'，2“）的下表面（4）下方的外围间隔件（9,9'，9”），并将工作膜（10）连接到主体（2,2' ，2“）; 主体（2,2'，2“）的下表面（4）与工作膜（10）的疏水性上表面（11）之间的间隙（12），间隙（12）由外围间隔物（9,9'，9“）; 以及位于穿孔底部结构（8）下面的多个穿孔元件（13），并被构造成刺穿可穿透底部结构（8），用于将试剂或样品（6,6'）从孔（5）释放到间隙（12））。还公开了一种具有电极阵列（20）的系统（40），其上可以放置盒（1）。

92. 发明授权

US06849411B2 Microfluidic sequencing methods 有权
标题翻译：微流控测序方法
公开(公告)号：US06849411B2
公开(公告)日：2005-02-01
申请号：US10302566
申请日：2002-11-22
申请人： Michael Knapp , John Wallace Parce , Luc J. Bousse , Anne R. Kopf-Sill
发明人： Michael Knapp , John Wallace Parce , Luc J. Bousse , Anne R. Kopf-Sill
IPC分类号： B01L3/00 , B01L3/02 , B01L7/00 , C12Q1/68 , G01N35/10 , C12P19/34
CPC分类号： C12Q1/6869 , B01F13/0059 , B01L3/0262 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/0421 , G01N2035/1053 , G01N2035/1058 , C12Q2565/629
摘要： Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.
摘要翻译：提供了用于进行生化分析的综合系统，装置，软件和方法，包括DNA测序，基因组筛选，核酸和其他生物组分的纯化以及药物筛选。提供了用于使用这些装置和系统进行各种流体操作的微流体装置，系统和方法。这些装置和系统用于执行需要大量迭代，连续或平行流体操作的流体操作，其以微型或密封且容易自动的格式。

93. 发明授权

US06558944B1 High throughput screening assay systems in microscale fluidic devices 有权
公开(公告)号：US06558944B1
公开(公告)日：2003-05-06
申请号：US09346660
申请日：1999-07-01
申请人： John Wallace Parce , Anne R. Kopf-Sill , Luc J. Bousse
发明人： John Wallace Parce , Anne R. Kopf-Sill , Luc J. Bousse
IPC分类号： G01N33558
CPC分类号： G01N33/5091 , B01J19/0093 , B01L3/5025 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L9/527 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/5064 , G01N33/5094 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.

94. 发明授权

US06379974B1 Microfluidic systems 有权
标题翻译：微流控系统
公开(公告)号：US06379974B1
公开(公告)日：2002-04-30
申请号：US09377682
申请日：1999-08-19
申请人： John Wallace Parce , Anne R. Kopf-Sill , Luc J. Bousse
发明人： John Wallace Parce , Anne R. Kopf-Sill , Luc J. Bousse
IPC分类号： G01N118
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502753 , B01L2200/10 , B01L2300/0645 , B01L2300/0809 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0421 , B01L2400/0688 , G01N27/44791 , Y10T436/2575
摘要： The present invention generally provides microfluidic devices and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated, interconnected microscale channels disposed within integrated body structures. Channels are sized and positioned to provide equal resistance in different paths.
摘要翻译：本发明通常提供微流体装置和系统，其利用电动材料传输系统来选择性地控制和引导材料的输送通过设置在一体化身体结构内的集成的互连微通道的复杂布置。通道的尺寸和位置可以在不同的路径上提供相等的电阻。

95. 发明授权

US06235531B1 Modified siphons for improved metering precision 失效
标题翻译：改进的虹吸管，以提高计量精度
公开(公告)号：US06235531B1
公开(公告)日：2001-05-22
申请号：US08562327
申请日：1995-11-22
申请人： Anne R. Kopf-Sill , Carol T. Schembri
发明人： Anne R. Kopf-Sill , Carol T. Schembri
IPC分类号： G01N3500
CPC分类号： B01L3/502738 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , G01N21/07 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors include siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.
摘要翻译：本发明提供了用于将预先测量的体积的液体输送到转子中的室的离心转子。特别地，转子包括用于在转子中的第一和第二室之间输送预先测量的液体体积的虹吸管。本发明的虹吸设计成使得第一室上的虹吸入口在第二室上的虹吸出口的径向外侧。第一个室被排空到与虹吸出口的径向位置相当的水平。

96. 发明授权

US06221226B1 Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems 有权
标题翻译：用于监测和控制微流体系统中流体流速的方法和系统
公开(公告)号：US06221226B1
公开(公告)日：2001-04-24
申请号：US09413961
申请日：1999-10-07
申请人： Anne R. Kopf-Sill
发明人： Anne R. Kopf-Sill
IPC分类号： G01N2726
CPC分类号： G01N27/44752 , B01L3/502746 , B01L2200/143 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0487 , B01L2400/082
摘要： The present invention generally provides methods and systems for monitoring and controlling electroosmotic flow rates in microfluidic systems. Generally, such methods and systems monitor flow rates in electroosmotically driven microfluidic systems by flowing signaling elements within these channels and measuring the flow rate of these signals. The methods of monitoring flow rates are also applied to methods and systems for continuously monitoring and controlling these flow rates in electroosmotically driven microfluidic systems.
摘要翻译：本发明通常提供用于监测和控制微流体系统中电渗流速的方法和系统。通常，这些方法和系统通过在这些通道内流动信号元件并测量这些信号的流速来监测电动驱动微流体系统中的流速。监测流速的方法也适用于在电动驱动的微流体系统中连续监测和控制这些流速的方法和系统。

97. 发明授权

US6001231A Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems 失效
标题翻译：用于监测和控制微流体系统中流体流速的方法和系统
公开(公告)号：US6001231A
公开(公告)日：1999-12-14
申请号：US895058
申请日：1997-07-15
申请人： Anne R. Kopf-Sill
发明人： Anne R. Kopf-Sill
IPC分类号： B01L3/00 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44752 , B01L3/502746 , B01L2200/143 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0487 , B01L2400/082
摘要： The present invention generally provides methods and systems for monitoring and controlling electroosmotic flow rates in microfluidic systems. Generally, such methods and systems monitor flow rates in electroosmotically driven microfluidic systems by flowing signaling elements within these channels and measuring the flow rate of these signals. The methods of monitoring flow rates are also applied to methods and systems for continuously monitoring and controlling these flow rates in electroosmotically driven microfluidic systems.
摘要翻译：本发明通常提供用于监测和控制微流体系统中电渗流速的方法和系统。通常，这些方法和系统通过在这些通道内流动信号元件并测量这些信号的流速来监测电动驱动微流体系统中的流速。监测流速的方法也适用于在电动驱动的微流体系统中连续监测和控制这些流速的方法和系统。

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