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91. 发明申请

US20130035368A1 OLIGONUCLEOTIDE COMPOUNDS COMPRISING NON-NUCLEOTIDE OVERHANGS 有权
公开(公告)号：US20130035368A1
公开(公告)日：2013-02-07
申请号：US13521033
申请日：2011-01-06
申请人： Sharon Avkin-Nachum , Elena Feinstein
发明人： Sharon Avkin-Nachum , Elena Feinstein
IPC分类号： A61K31/713 , C07H1/00 , A61P27/16 , A61P13/12 , A61P9/00 , A61P11/00 , A61P27/02 , A61P9/10 , A61P25/00 , A61P1/16 , C07H21/02 , A61P27/06
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/344 , C12N2310/351 , C12N2310/3527
摘要： The invention relates to siRNA compounds comprising one non-nucleotide moiety covalently attached to at least one of the sense or antisense strands to down-regulate the expression of human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier and to methods of treating and/or preventing the incidence or severity of various diseases or conditions associated with the target genes and/or symptoms associated with such diseases or conditions.

92. 发明申请

US20120252875A1 METHODS AND COMPOSITIONS FOR TREATING DISEASES, DISORDERS OR INJURY OF THE CNS 有权
标题翻译：用于治疗疾病，疾病或CNS损伤的方法和组合物
公开(公告)号：US20120252875A1
公开(公告)日：2012-10-04
申请号：US13514880
申请日：2010-12-09
申请人： Elena Feinstein , Igor Spivak , Evgenia Alpert , Ron Lahav
发明人： Elena Feinstein , Igor Spivak , Evgenia Alpert , Ron Lahav
IPC分类号： A61K31/7088 , A61P9/10 , A61P27/06 , C07H21/04 , A61P27/02
CPC分类号： C12N15/113 , A61K9/0046 , A61K9/0048 , A61K31/00 , A61K31/713 , A61K47/10 , A61K49/00 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to non-invasive methods for treating diseases, disorders and injury to the central nervous system (CNS), and in particular to otic compositions and to methods of use thereof.
摘要翻译：本发明涉及用于治疗中枢神经系统（CNS）的疾病，病症和损伤的非侵入性方法，特别是涉及耳组合物及其使用方法。

93. 发明授权

US08148342B2 Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases 有权
标题翻译：寡核糖核苷酸及其用于治疗脱发，急性肾衰竭和其它疾病的方法
公开(公告)号：US08148342B2
公开(公告)日：2012-04-03
申请号：US12008578
申请日：2008-01-11
申请人： Elena Feinstein , Shai Ehrlich
发明人： Elena Feinstein , Shai Ehrlich
IPC分类号： A61K31/70
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
摘要翻译：本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

94. 发明申请

US20110230543A1 OLIGORIBONUCLEOTIDE INHIBITORS OF NRF2 AND METHODS OF USE THEREOF FOR TREATMENT OF CANCER 有权
标题翻译： NRF2的寡聚核苷酸抑制剂及其用于治疗癌症的方法
公开(公告)号：US20110230543A1
公开(公告)日：2011-09-22
申请号：US12901207
申请日：2010-10-08
申请人： Elena Feinstein
发明人： Elena Feinstein
IPC分类号： A61K31/713 , C07H21/02 , A61P35/00 , A61P11/00
CPC分类号： A01K67/0271 , A01K2207/05 , A01K2217/058 , A01K2227/105 , A01K2267/0331 , A01K2267/0393 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/321 , C12N2310/3517 , C12N2320/31 , C12N2310/3521
摘要： The invention provides novel double stranded oligoribonucleotides that inhibit the Nrf2 gene. The invention also provides a pharmaceutical composition comprising one or more such oligoribonucleotides, and a vector capable of expressing the oligoribonucleotide. The present invention also relates to methods and compositions for treating or preventing the incidence or severity of a cancerous disease, particularly various lung cancers.
摘要翻译：本发明提供抑制Nrf2基因的新型双链寡核糖核苷酸。本发明还提供了包含一种或多种这样的寡核糖核苷酸的药物组合物和能够表达寡核糖核苷酸的载体。本发明还涉及用于治疗或预防癌性疾病，特别是各种肺癌的发病率或严重程度的方法和组合物。

95. 发明申请

US20110201670A1 OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF FIBROTIC CONDITIONS AND OTHER DISEASES 有权
标题翻译：用于治疗纤维性疾病和其他疾病的低分子化合物及其使用方法
公开(公告)号：US20110201670A1
公开(公告)日：2011-08-18
申请号：US13092501
申请日：2011-04-22
申请人： Orna Mor , Elena Feinstein
发明人： Orna Mor , Elena Feinstein
IPC分类号： A61K31/713 , C07H21/02 , A61P27/02 , A61P27/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： C07H21/04 , C07K16/40 , C07K2317/21 , C07K2317/76 , C12N9/1044 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12Y203/02013 , C12N2310/3527 , C12N2310/3521
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide (siRNA), which down-regulates the expression of a human TGaseII gene at the post-transcriptional level. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from a fibrotic disease such as pulmonary, kidney and liver fibrosis or ocular, scarring comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The invention also relates to treatment of fibrotic and other diseases by use of antibodies to TGaseII polypeptide.
摘要翻译：本发明涉及在转录后水平下调人TGaseII基因表达的双链化合物，优选寡核糖核苷酸（siRNA）。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有纤维化疾病如肺，肾和肝纤维化或眼睛，瘢痕形成的患者的方法，其包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。本发明还涉及通过使用TGaseII多肽的抗体来治疗纤维化和其它疾病。

96. 发明授权

US07939652B2 Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases 有权
标题翻译：寡核糖核苷酸及其用于治疗纤维化病症和其它疾病的方法
公开(公告)号：US07939652B2
公开(公告)日：2011-05-10
申请号：US12072941
申请日：2008-02-28
申请人： Orna Mor , Elena Feinstein
发明人： Orna Mor , Elena Feinstein
IPC分类号： C07H21/02 , C07H21/04 , A61K31/70 , C12Q1/68
CPC分类号： C07H21/04 , C07K16/40 , C07K2317/21 , C07K2317/76 , C12N9/1044 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12Y203/02013 , C12N2310/3527 , C12N2310/3521
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide (siRNA), which down-regulates the expression of a human TGaseII gene at the post-transcriptional level. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from a fibrotic disease such as pulmonary, kidney and liver fibrosis or ocular, scarring comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The invention also relates to treatment of fibrotic and other diseases by use of antibodies to TGaseII polypeptide.
摘要翻译：本发明涉及在转录后水平下调人TGaseII基因表达的双链化合物，优选寡核糖核苷酸（siRNA）。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有纤维化疾病如肺，肾和肝纤维化或眼睛，瘢痕形成的患者的方法，其包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。本发明还涉及通过使用TGaseII多肽的抗体来治疗纤维化和其它疾病。

97. 发明授权

US07825099B2 Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes 有权
标题翻译：通过抑制促凋亡基因治疗或预防耳病
公开(公告)号：US07825099B2
公开(公告)日：2010-11-02
申请号：US11655610
申请日：2007-01-18
申请人： Elena Feinstein
发明人： Elena Feinstein
IPC分类号： A61K48/00 , C12N15/63 , C07H21/02 , C07H21/04
CPC分类号： A61K31/7088 , A61K31/70
摘要： The invention relates to one or more inhibitors, in particular siRNAs, which down-regulate the expression of human pro-apoptotic genes. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating or preventing the incidence or severity of hearing impairment (or balance impairment), particularly hearing impairment associated with cell death of the inner ear hair cells or outer ear hair cells, comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient.
摘要翻译：本发明涉及一种或多种抑制剂，特别是siRNA，其下调人促凋亡基因的表达。本发明还涉及包含化合物或能够表达化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗或预防听力损伤（或平衡障碍）的发生或严重性的方法，特别是与内耳毛细胞或外耳毛细胞的细胞死亡相关的听力损伤，包括向患者施用药物组合物以治疗有效剂量，从而治疗患者。

98. 发明授权

US07812002B2 Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer 失效
标题翻译： NRF2的寡核苷酸抑制剂及其用于治疗癌症的方法
公开(公告)号：US07812002B2
公开(公告)日：2010-10-12
申请号：US12077414
申请日：2008-03-19
申请人： Elena Feinstein
发明人： Elena Feinstein
IPC分类号： A01N43/04 , A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： A01K67/0271 , A01K2207/05 , A01K2217/058 , A01K2227/105 , A01K2267/0331 , A01K2267/0393 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/321 , C12N2310/3517 , C12N2320/31 , C12N2310/3521
摘要： The invention provides novel double stranded oligoribonucleotides that inhibit the Nrf2 gene. The invention also provides a pharmaceutical composition comprising one or more such oligoribonucleotides, and a vector capable of expressing the oligoribonucleotide. The present invention also relates to methods and compositions for treating or preventing the incidence or severity of a cancerous disease, particularly various lung cancers.
摘要翻译：本发明提供抑制Nrf2基因的新型双链寡核糖核苷酸。本发明还提供了包含一种或多种这样的寡核糖核苷酸的药物组合物和能够表达寡核糖核苷酸的载体。本发明还涉及用于治疗或预防癌性疾病，特别是各种肺癌的发病率或严重程度的方法和组合物。

99. 发明授权

US07666651B2 Polypeptide having heparanase activity 失效
标题翻译：具有乙酰肝素酶活性的多肽
公开(公告)号：US07666651B2
公开(公告)日：2010-02-23
申请号：US09776874
申请日：2001-02-06
申请人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
发明人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
IPC分类号： C12N9/00 , C12N9/14 , C12N9/24
CPC分类号： C12Y302/01166 , A61K38/00 , C12N9/2402
摘要： A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
摘要翻译：编码具有乙酰肝素酶活性的多肽的多核苷酸（hpa），包含其的载体，表达乙酰肝素酶的遗传修饰的细胞，具有乙酰肝素酶活性的重组蛋白和反义寡核苷酸以及用于调节肝素酶表达的构建体。

100. 发明申请

US20100029746A1 Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes 有权
公开(公告)号：US20100029746A1
公开(公告)日：2010-02-04
申请号：US12459617
申请日：2009-07-01
申请人： Elena Feinstein
发明人： Elena Feinstein
IPC分类号： A61K48/00 , A61P27/16
CPC分类号： A61K31/7088 , A61K31/70
摘要： The invention relates to one or more inhibitors, in particular siRNAs, which down-regulate the expression of human pro-apoptotic genes. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating or preventing the incidence or severity of hearing impairment (or balance impairment), particularly hearing impairment associated with cell death of the inner ear hair cells or outer ear hair cells, comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient.

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