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91. 发明授权

US08779199B2 Agomelatine intermediates and preparation method thereof 有权
标题翻译：阿莫拉坦中间体及其制备方法
公开(公告)号：US08779199B2
公开(公告)日：2014-07-15
申请号：US13702388
申请日：2011-06-08
申请人： Peng Zhang , Yu Huang , Zhedong Yuan , Hanbin Shan , Xiong Yu
发明人： Peng Zhang , Yu Huang , Zhedong Yuan , Hanbin Shan , Xiong Yu
IPC分类号： C07C233/22 , C07C231/06 , C07C233/18 , C07C231/12
CPC分类号： C07C231/06 , C07C231/12 , C07C233/18 , C07C233/22 , C07C2602/10
摘要： The present invention relates to the intermediate compounds for preparation of agomelatine, as well as the preparation methods thereof The intermediate of the present invention for preparation of agomelatine is compound A as shown in the following formula. Also provided are two novel intermediate compounds. When we use these new intermediate compounds to prepare agomelatine, it is simple to manipulate, well-controlled and with high purity, without complicated operations such as rectification and column chromatography separation, and suitable for industrial production. Meanwhile, the preparation methods of the two new intermediates themselves is simple and high yield, only using the most commonly-used 7-methoxy-tetralone as original starting material and undergoing one step of reaction to obtain the intermediates, followed by one more step of converting the intermediate compounds to desired product agomelatine. Said reaction processes are greatly simplified, with the reaction yield being improved and the difficulty in purification of previous method being overcome, as compare with the previous technique for preparation of agomelatine. Typically, the yield of the present invention is over 70%.
摘要翻译：本发明涉及用于制备阿格美兰碱的中间体化合物及其制备方法本发明的用于制备agomelatine的中间体是如下式所示的化合物A. 还提供两种新型中间体化合物。当我们使用这些新的中间体化合物来制备agomelatine时，其操作简单，控制良好，纯度高，无需精馏和柱层析分离等复杂操作，适用于工业生产。同时，两种新中间体本身的制备方法简单高产，仅使用最常用的7-甲氧基 - 四氢萘酮作为起始原料，经过一步反应得到中间体，再加入一步将中间体化合物转化成所需的产物agomelatine。所述反应过程被大大简化，与先前用于制备agMelatine的技术相比，反应产率提高并克服了先前方法的纯化困难。通常，本发明的产率超过70％。

92. 发明授权

US08738448B2 Web page ad slot identification 有权
标题翻译：网页广告位标识
公开(公告)号：US08738448B2
公开(公告)日：2014-05-27
申请号：US13369281
申请日：2012-02-08
申请人： Peng Zhang
发明人： Peng Zhang
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0277 , G06Q30/0241
摘要： Systems and methods of identifying ad elements of web pages via a computer network are provided. A script configured to identify an ad slot on a web page can be obtained by at least one data processing system having an ad slot evaluation module. The script can be executed to obtain advertisement parameters of the ad slot and web page parameters of the ad slot and generate a unique identifier of the ad slot. The generated unique identifier is associated with a URL identifier of the web page. The data processing system evaluates at least one database to determine one of a presence and an absence of the historical ad slot data. The data processing system provides content for display in the ad slot of the web page based at least in part on a result of the evaluation of the database.
摘要翻译：提供了通过计算机网络识别网页的广告元素的系统和方法。配置为识别网页上的广告位的脚本可以由具有广告位评估模块的至少一个数据处理系统获得。可以执行脚本以获得广告位的广告位和广告网页参数的广告参数，并生成广告位的唯一标识符。生成的唯一标识符与网页的URL标识符相关联。数据处理系统评估至少一个数据库以确定历史广告位数据的存在和不存在。数据处理系统至少部分地基于数据库的评估结果来提供用于在网页的广告位中显示的内容。

93. 发明授权

US08729132B2 Agomelatine hydrobromide hydrate and preparation thereof 有权
标题翻译：氢溴酸阿莫拉坦及其制备方法
公开(公告)号：US08729132B2
公开(公告)日：2014-05-20
申请号：US13635087
申请日：2011-03-17
申请人： Hanbin Shan , Zhedong Yuan , Xueyan Zhu , Peng Zhang , Hongjuan Pan , Xiong Yu
发明人： Hanbin Shan , Zhedong Yuan , Xueyan Zhu , Peng Zhang , Hongjuan Pan , Xiong Yu
IPC分类号： A01N37/18 , A61K31/16 , C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00
CPC分类号： C07C233/18 , A61K31/165
摘要： The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.
摘要翻译：本发明涉及其中X是Br的式I的氢溴酸阿尔美拉酸水合物，其制备和用途以及含有它的药物组合物。通过本发明方法获得的氢溴酸氢溴酸水合物与阿魏酸相比具有显着增加的溶解度，因此更适用于制备药物制剂。此外，该产品具有更高的稳定性和纯度。使用本方法，可以通过简单的工艺获得高纯度的产品，没有任何复杂的步骤。

94. 发明申请

US20140019262A1 PREDICTING VISIBILITY OF CONTENT ITEMS 有权
标题翻译：预测内容项目的可见性
公开(公告)号：US20140019262A1
公开(公告)日：2014-01-16
申请号：US13546978
申请日：2012-07-11
申请人： Paul Schelte Albert Reitsma , Thomas J. Murray, IV , Peng Zhang
发明人： Paul Schelte Albert Reitsma , Thomas J. Murray, IV , Peng Zhang
IPC分类号： G06F15/16 , G06Q30/02
CPC分类号： G06Q30/0254 , G06N5/02 , G06Q30/02 , G06Q30/0241
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer-readable storage medium, and including a method for predicting visibility of web pages. The method comprises identifying web pages that include slots for presenting content. The method further comprises, for each slot, creating a fingerprint based on a URL associated with the page and structural information associated with the slot's location on the page, determining a likelihood of the slot being visible when the web page is initially presented, the likelihood in the form of a predictive model, and saving the fingerprint and predictive model in a data structure. The method further comprises receiving a request for content from a web page, creating fingerprints associated with the web page, and comparing the fingerprints to fingerprints in the data structure. When a matching fingerprint is located, prediction data is used that is associated with a matching fingerprint for the web page.
摘要翻译：方法，系统和装置，包括在计算机可读存储介质上编码的计算机程序，并且包括用于预测网页的可见性的方法。该方法包括识别包括用于呈现内容的时隙的网页。该方法还包括：针对每个时隙，基于与页面相关联的URL和与该页面上的时隙位置相关联的结构信息创建指纹，确定在最初呈现网页时该时隙可见的可能性，可能性以预测模型的形式，并将指纹和预测模型保存在数据结构中。该方法还包括从网页接收对内容的请求，创建与网页相关联的指纹，以及将指纹与数据结构中的指纹进行比较。当找到匹配的指纹时，使用与网页的匹配指纹相关联的预测数据。

95. 发明申请

US20130261147A1 COMPOSITION FOR PREVENTING OR TREATING DEMENTIA 审中-公开
标题翻译：用于预防或治疗DEMENTIA的组合物
公开(公告)号：US20130261147A1
公开(公告)日：2013-10-03
申请号：US13819583
申请日：2010-08-27
申请人： Hyun Ok Yang , Hak Cheol Kwon , Jin-Soo Park , Sung-Kwon Chung , ZhiZou Wu , Hanli Ruan , Huifang Pi , Peng Zhang
发明人： Hyun Ok Yang , Hak Cheol Kwon , Jin-Soo Park , Sung-Kwon Chung , ZhiZou Wu , Hanli Ruan , Huifang Pi , Peng Zhang
IPC分类号： A61K31/4741 , A61K36/88
CPC分类号： A61K31/4741 , A61K9/08 , A61K31/4375 , A61K36/88 , A61K36/896
摘要： There is provided use of Lycoris aurea extracts, and/or fractions thereof, and/or lycoricidine and lycoricidinol separated from the extracts or fractions for prevention and/or treatment of dementia.
摘要翻译：提供了从提取物或级分分离的用于预防和/或治疗痴呆的Lycoris aurea提取物和/或其部分和/或lycoricidine和lycoricidinol的使用。

96. 发明申请

US20120251113A1 SEAMLESS CONFIGURATION UPDATE FOR OPTICAL NETWORK UNIT IN ETHERNET PASSIVE OPTICAL NETWORK 有权
标题翻译：以太网中光网络的无缝配置更新被动光网络
公开(公告)号：US20120251113A1
公开(公告)日：2012-10-04
申请号：US13433235
申请日：2012-03-28
申请人： Marek Hajduczenia , Meiyan Zang , Peng Zhang
发明人： Marek Hajduczenia , Meiyan Zang , Peng Zhang
IPC分类号： H04B10/00 , H04B10/08
CPC分类号： H04L41/082 , H04L41/0869 , H04Q11/0067 , H04Q2011/0079
摘要： Techniques for updating configuration of an Optical Network Unit (ONU) in an Ethernet Passive Optical Network (EPON) include receiving a notification that an updated configuration file is available for the ONU, obtaining the updated configuration file, performing a first validation of the updated configuration file for structural errors, determining changes between a current configuration of the ONU and the updated configuration file to identify ONU resources to implement to the changes, performing a second validation about whether the ONU resources to implement the changes are available or not at the ONU and applying the changes to the ONU when it is determined that the ONU resources to implement the changes are available at the ONU.
摘要翻译：用于更新以太网无源光网络（EPON）中的光网络单元（ONU）的配置的技术包括接收更新的配置文件可用于ONU的通知，获得更新的配置文件，执行更新配置的第一验证确定ONU的当前配置与更新的配置文件之间的变化，以识别实现该更改的ONU资源，对ONU执行关于实现该改变的ONU资源是否可用的第二验证;以及当确定实现改变的ONU资源在ONU处可用时，将该改变应用于ONU。

97. 发明授权

US08210487B2 Automatic mounting apparatus 失效
标题翻译：自动安装装置
公开(公告)号：US08210487B2
公开(公告)日：2012-07-03
申请号：US12542708
申请日：2009-08-18
申请人： Yong-Miao Fan , Hong-Jun Feng , Peng Zhang , Yu-Bin Guo
发明人： Yong-Miao Fan , Hong-Jun Feng , Peng Zhang , Yu-Bin Guo
IPC分类号： B23Q7/10
CPC分类号： B23P19/084 , Y10T29/49947 , Y10T29/53 , Y10T29/53487 , Y10T29/53961
摘要： An apparatus includes a bracket, a pushing member having a pushing surface, a magazine member to fitting about a plurality of clamping rings, a sending member, a fixing member fixed to the bracket and a resisting member fixed to the fixing member. The fixing member defines a positioning hole for fixing the magazine member, with the clamping rings freely sliding through the positioning hole. The sending member includes two guiding rods fixed to the fixing member, two elastic elements fitting about the corresponding guiding rods, and a moving board slidably mounted to the guiding rods. The elasticity of the elastic elements urges the moving board to drive one of the plurality of clamping rings to resist against the resisting member. When the pushing member is moved towards the fixing member, the pushing surface pushes the one clamping ring to clamp a shaft of a connecting piece.
摘要翻译：一种装置，包括支架，具有推动表面的推动构件，用于装配在多个夹紧环周围的料仓构件，发送构件，固定到支架的固定构件和固定到固定构件的抵抗构件。固定构件限定用于固定料仓构件的定位孔，夹紧环通过定位孔自由滑动。发送构件包括固定到固定构件的两个引导杆，围绕相应引导杆安装的两个弹性元件和可滑动地安装到引导杆的移动板。弹性元件的弹性促使移动板驱动多个夹紧环中的一个以抵抗抵抗构件。当推动构件朝向固定构件移动时，推动表面推动一个夹紧环来夹紧连接件的轴。

98. 发明申请

US20120137762A1 FLOATING MECHANISM LOADING VEHICLE PROVIDED WITH DOUBLE SHAFTS AND EIGHT WHEELS FOR PAVEMENT ACCELERATED LOADING TEST 有权
标题翻译：浮动机械加载车辆提供双重运输和车轮加速加载测试
公开(公告)号：US20120137762A1
公开(公告)日：2012-06-07
申请号：US13389694
申请日：2010-05-31
申请人： Jinxiang Feng , Xingyu Guo , Ying Han , Qingzhen Wu , Xuguang Wang , Peng Zhang , Xiangzhen Kong , Zhiguang Guan , Xianggui Li , Qian Jia , Jiwei Zhang , Huijun Wang
发明人： Jinxiang Feng , Xingyu Guo , Ying Han , Qingzhen Wu , Xuguang Wang , Peng Zhang , Xiangzhen Kong , Zhiguang Guan , Xianggui Li , Qian Jia , Jiwei Zhang , Huijun Wang
IPC分类号： G01N3/02
CPC分类号： G01M7/00 , G01M5/0066 , G01M5/0075 , G01N33/42
摘要： Disclosed is a floating mechanism loading vehicle provided with double shafts and eight wheels for pavement accelerated loading test. The floating mechanism loading vehicle comprises front and rear rotating shafts (5), on each of which two loading steel wheels (3) and two backhaul steel wheels (2) are mounted, the loading steel wheels (3) being fixed on the rotating shafts (5) and the backhaul steel wheels (2) being rotatable round the rotating shafts (5). During the loading rolling course, the loading steel wheels (3) runs on the loading rail (4), while during the unloading backhaul course, the backhaul steel wheels (2) runs on the backhaul rail (1).
摘要翻译：公开了一种浮动机构装载车辆，其具有双轴和八个车轮用于路面加速加载试验。浮动机构装载车辆包括前后旋转轴（5），其中每个安装有两个装载钢轮（3）和两个回程钢轮（2），装载钢轮（3）固定在旋转轴（5）和回转钢轮（2）可旋转地绕旋转轴（5）旋转。在加载滚动过程中，装载钢轮（3）在装载轨道（4）上运行，而在卸载回程过程中，回程钢轮（2）在回程轨道（1）上运行。

99. 发明授权

US08159973B2 Ultra-scalable supercomputer based on MPU architecture 有权
标题翻译：基于MPU架构的超可扩展超级计算机
公开(公告)号：US08159973B2
公开(公告)日：2012-04-17
申请号：US12179657
申请日：2008-07-25
申请人： Yuefan Deng , Alexander Korobka , Peng Zhang
发明人： Yuefan Deng , Alexander Korobka , Peng Zhang
IPC分类号： H04L12/28
CPC分类号： G06F15/803
摘要： The invention provides an ultra-scalable supercomputer based on MPU architecture in achieving the well-balanced performance of hundreds of TFLOPS or PFLOPS range in applications. The supercomputer system design includes the interconnect topology and its corresponding routing strategies, the communication subsystem design and implementation, the software and hardware schematic implementations. The supercomputer comprises a plurality of processing nodes powering the parallel processing and Axon nodes connecting computing nodes while implementing the external interconnections. The interconnect topology can be based on MPU architecture and the communication routing logic as required by switching logics is implemented in the FPGA chips while some modular designs for accelerating particular traffic patterns from applications and meliorating the communication overhead are able to be deployed as well.
摘要翻译：本发明提供了一种基于MPU架构的超可扩展超级计算机，以实现应用中数百个TFLOPS或PFLOPS系列的平衡性能。超级计算机系统设计包括互连拓扑及其对应的路由策略，通信子系统的设计与实现，软件和硬件原理图的实现。该超级计算机包括为并行处理提供动力的多个处理节点和连接计算节点的Axon节点，同时实现外部互连。互连拓扑可以基于MPU架构，并且切换逻辑所要求的通信路由逻辑在FPGA芯片中实现，同时也可以部署用于加速来自应用的特定流量模式并改善通信开销的一些模块化设计。

100. 发明申请

US20110313198A1 AGOMELATINE HYDROHALIDE COMPLEX AND PREPARATION METHOD THEREOF 有权
标题翻译： AGOMELATINE HYDROHALIDE COMPLEX及其制备方法
公开(公告)号：US20110313198A1
公开(公告)日：2011-12-22
申请号：US13138511
申请日：2010-02-26
申请人： Peng Zhang , Hanbin Shan , Zhedong Yuan , Xudong Jiang , Yu Huang , Hubo Wang , Xufeng Cao , Xingdong Cheng , Hongjuan Pan , Xiong Yu
发明人： Peng Zhang , Hanbin Shan , Zhedong Yuan , Xudong Jiang , Yu Huang , Hubo Wang , Xufeng Cao , Xingdong Cheng , Hongjuan Pan , Xiong Yu
IPC分类号： C07C233/22
CPC分类号： C07C233/18
摘要： The present invention relates to a complex of agomelatine and to preparation thereof. The hydrogen halide complex of agomelatine obtained through the present method is more soluble, more stable, and of higher purity than agomelatine itself, making it more suitable to be used in pharmaceutical preparation. Using this method, product of high purity can be obtained through a simple process, without having to incur further complicated steps.
摘要翻译：本发明涉及一种阿维菌素及其制备方法。通过本发明方法获得的agomelatine的卤化氢配合物比agomelatine本身更可溶，更稳定和更高纯度，使其更适合用于制药。使用这种方法，可以通过简单的工艺获得高纯度的产品，而不必进一步复杂的步骤。

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