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91. 发明授权

US4410328A Dispensing device with internal drive 失效
标题翻译：带内部驱动器的点胶装置
公开(公告)号：US4410328A
公开(公告)日：1983-10-18
申请号：US281952
申请日：1981-07-10
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61K9/00 , A61M5/145 , B65D83/00 , A61M7/00
CPC分类号： A61K9/0004 , B65D83/00 , A61M2005/14513
摘要： A device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space (2) a piston in the housing separating the space into an agent compartment and a power compartment, or a flexible container in the space, (3) an opening in the housing connecting the agent compartment or the container with the exterior of the housng, and (4) an osmotic device in the power compartment or beneath the container.
摘要翻译：公开了用于递送有益剂的装置。该装置包括（1）壳体，其限定内部空间（2）壳体中的活塞，该空间将空间分隔成空间中的空间，动力隔室或柔性容器;（3）壳体中的开口，代理舱或带有外部外壳的容器，以及（4）电源舱或集装箱下方的渗透装置。

92. 发明授权

US4331728A Laminate made of a cellulose acetate layer and an elastomeric material layer 失效
标题翻译：由乙酸纤维素层和弹性体材料层制成的层压板
公开(公告)号：US4331728A
公开(公告)日：1982-05-25
申请号：US101870
申请日：1979-12-10
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A01N25/10 , A01N25/34 , A61K9/00 , A61K9/22 , B32B23/08 , B01D39/18 , B32B5/22 , B32B23/14 , B32B23/20
CPC分类号： A61K9/0004 , A01N25/10 , A01N25/34 , B32B23/08 , Y10T428/24967 , Y10T428/24975 , Y10T428/31841 , Y10T428/31884 , Y10T428/31888 , Y10T428/31891
摘要： An osmotic system for delivering a beneficial agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway through the wall for delivering agent from the compartment. The wall is formed of a material permeable to the passage of an external fluid and impermeable to the passage of agent. The compartment contains (1) an agent that is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or (2) the compartment contains an agent having limited solubility in the fluid and exhibits a limited osmotic pressure gradient across the wall against the fluid. The compartment also contains along with (1) or (2) a volume amplifier for increasing the amount of agent delivered from the system. The amplifier comprises a membrane surrounding a gas generating couple with the membrane formed of an expandable material permeable to fluid and impermeable to the couple. In operation, agent is delivered from the system through the passageway at a controlled rate by fluid being imbibed through the wall into the compartment to produce a solution of (1), or a suspension of (2), and for imbibition by the amplifier causing the couple to generate gas and continuously fill the amplifier thereby urging it to increase in volume and fill the compartment whereby agent (1) or (2) is released at a rate controlled by the permeability of the wall, the osmotic pressure gradient across the wall, and the rate of imbibition and increase in volume of the amplifier over a prolonged period of time.
摘要翻译：公开了用于递送有益剂的渗透系统。该系统包括围绕隔室的壁，并且具有通过该壁的通道，用于从隔间输送药剂。该壁由对外部流体的通道可渗透并且不能透过试剂通过的材料形成。隔室包含（1）可溶于流体并且穿过壁表现出渗透压梯度相对于流体的试剂，或（2）隔室含有在流体中溶解度有限的试剂，并显示出有限的渗透压梯度墙壁对着流体。隔间还包含（1）或（2）个放大器，用于增加从系统传递的代理量。放大器包括围绕气体发生耦合的膜，膜由可渗透流体并且不可渗透的可膨胀材料形成。在操作中，通过流体通过壁被吸入到隔室中，通过通道以受控的速率从系统输送试剂，以产生（1）或（2）的悬浮液并由放大器吸收的溶液该对以产生气体并连续地填充放大器，从而促使其增加体积并填充隔室，由此药剂（1）或（2）以由壁的渗透性控制的速率释放，穿过壁的渗透压梯度，以及放大器的吸入速率和放大器的体积增加。

93. 发明授权

US4320759A Dispenser with diffuser 失效
标题翻译：分配器与扩散器
公开(公告)号：US4320759A
公开(公告)日：1982-03-23
申请号：US268046
申请日：1981-05-28
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M31/00 , A61M7/00
CPC分类号： A61M31/002
摘要： A system is disclosed for delivering a beneficial agent at a substantially constant rate over time. The system comprises (1) a wall formed of a microporous polymer, or (2) a wall formed in part of a microporous polymer with the remaining part of the wall formed of a semipermeable polymer. The wall in (1) surrounds a compartment comprising a flexible partition that separates the compartment into a first space containing the beneficial agent and a second space containing a swellable polymer. The wall in (2) surrounds a compartment comprising a flexible partition that separates the compartment into a first space in contact with the microporous wall and containing the beneficial agent, and a second space in contact with the semipermeable polymer containing an osmotically effective solute, or a swellable polymer. In operation, agent is delivered from the system by (a) fluid diffusing through the microporous wall into the second space causing the polymer to swell, or by (b) fluid being imbibed through the semipermeable wall into the second space causing the solute to dissolve and form a solution, or causing the polymer to swell, wherein in (a) or (b), the second space expands against the partition urging it to move into the first space and maintain the agent in a saturated state at the microporous wall, with the agent diffusing from the first space through fluid filled micropaths in the wall from the system at a substantially zero order rate over a prolonged period of time.
摘要翻译：公开了一种随时间以基本上恒定的速率递送有益试剂的系统。该系统包括（1）由微孔聚合物形成的壁，或（2）部分由微孔聚合物形成的壁，其余部分壁由半透性聚合物形成。（1）中的壁围绕包括柔性隔板的隔间，该隔板将隔室分隔成含有有益剂的第一空间和含有可溶胀聚合物的第二空间。（2）中的壁围绕包括柔性隔板的隔室，该柔性隔板将隔室分隔成与微孔壁接触并包含有益剂的第一空间，以及与含有渗透性有效溶质的半透性聚合物接触的第二空间，或可溶胀聚合物。在操作中，通过（a）流体通过微孔壁流体扩散到第二空间中使得聚合物膨胀，或者（b）流体通过半透壁吸入第二空间中，使溶质溶解并且形成溶液，或使聚合物膨胀，其中在（a）或（b）中，第二空间相对于分隔壁膨胀，促使其移动到第一空间中并将试剂维持在微孔壁处于饱和状态，其中所述试剂在长时间段内以基本上零级的速率从所述系统从所述第一空间扩散通过所述壁中的流体填充的微通道。

94. 发明授权

US4235236A Device for dispensing drug by combined diffusional and osmotic operations 失效
标题翻译：通过组合扩散和渗透操作分配药物的装置
公开(公告)号：US4235236A
公开(公告)日：1980-11-25
申请号：US011121
申请日：1979-02-12
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/22 , A61M7/00
CPC分类号： A61K9/0004
摘要： A device is disclosed for delivering an agent to an environment of use at a substantially constant rate over time. The device comprises a wall formed of a microporous material surrounding a compartment housing the agent and a thermodynamic member. The member comprises a film formed of an expandable, semipermeable material surrounding a means for expanding the member. The member can occupy any space-position in the compartment, and it also can be in contact with the wall. In operation, when the device is in the environment, agent is delivered from the device by diffusion through fluid-filled paths in the microporous wall, with external fluid simultaneously entering the compartment through the paths, also, fluid is imbibed by the member from fluid present in the compartment or directly across the wall causing it to expand, fill the compartment and continuously maintain agent in a substantially saturated state at the wall, thereby delivering agent at a substantially zero order rate of release from the device over a prolonged period of time.
摘要翻译：公开了一种用于随着时间以基本上恒定的速率将试剂递送到使用环境的装置。该装置包括由围绕容纳所述试剂的隔室和热力学构件的微孔材料形成的壁。该构件包括由围绕用于使构件膨胀的装置的可膨胀的半渗透材料形成的膜。该构件可以占据隔间中的任何空间位置，并且它也可以与墙壁接触。在操作中，当设备处于环境中时，通过扩散通过在微孔壁中的流体填充路径从设备传送代理，外部流体同时通过路径进入隔室，流体也被流体从流体中吸收存在于隔室中或直接穿过壁，导致其膨胀，填充隔室并且在壁处连续地将基本饱和状态的药剂维持在该壁上，由此以较短的时间段从该装置释放基本上零级的释放速率。

95. 发明授权

US4203439A Osmotic system with volume amplifier for increasing amount of agent delivered therefrom 失效
标题翻译：具有体积放大器的渗透系统，用于增加从其传送的剂量
公开(公告)号：US4203439A
公开(公告)日：1980-05-20
申请号：US950515
申请日：1978-10-11
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61K9/00 , A61M31/00
CPC分类号： A61K9/0004
摘要： An osmotic system for delivering a beneficial agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway through the wall for delivering agent from the compartment. The wall is formed of a material permeable to the passage of an external fluid and impermeable to the passage of agent. The compartment contains (1) an agent that is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or (2) the compartment contains an agent having limited solubility in the fluid and exhibits a limited osmotic pressure gradient across the wall against the fluid. The compartment also contains along with (1) or (2) a volume amplifier for increasing the amount of agent delivered from the system. The amplifier comprises a membrane surrounding a gas generating couple with the membrane formed of an expandable material permeable to fluid and impermeable to the couple. In operation, agent is delivered from the system through the passageway at a controlled rate by fluid being imbibed through the wall into the compartment to produce a solution of (1), or a suspension of (2), and for imbibition by the amplifier causing the couple to generate gas and continuously fill the amplifier thereby urging it to increase in volume and fill the compartment whereby agent (1) or (2) is released at a rate controlled by the permeability of the wall, the osmotic pressure gradient across the wall, and the rate of imbibition and increase in volume of the amplifier over a prolonged period of time.
摘要翻译：公开了用于递送有益剂的渗透系统。该系统包括围绕隔室的壁，并且具有通过该壁的通道，用于从隔间输送药剂。该壁由对外部流体的通道可渗透并且不能透过试剂通过的材料形成。隔室包含（1）可溶于流体并且穿过壁表现出渗透压梯度相对于流体的试剂，或（2）隔室含有在流体中溶解度有限的试剂，并显示出有限的渗透压梯度墙壁对着流体。隔间还包含（1）或（2）个放大器，用于增加从系统传递的代理量。放大器包括围绕气体发生耦合的膜，膜由可渗透流体并且不可渗透的可膨胀材料形成。在操作中，通过流体通过壁被吸入到隔室中，通过通道以受控的速率从系统输送试剂，以产生（1）或（2）的悬浮液并由放大器吸收的溶液该对以产生气体并连续地填充放大器，从而促使其增加体积并填充隔室，由此药剂（1）或（2）以由壁的渗透性控制的速率释放，穿过壁的渗透压梯度，以及放大器的吸入速率和放大器的体积增加。

96. 发明授权

US4200098A Osmotic system with distribution zone for dispensing beneficial agent 失效
标题翻译：渗透系统具有分配区域用于分配有益剂
公开(公告)号：US4200098A
公开(公告)日：1980-04-29
申请号：US953906
申请日：1978-10-23
申请人： Atul D. Ayer , Felix Theeuwes
发明人： Atul D. Ayer , Felix Theeuwes
IPC分类号： A61J3/07 , A61K9/00 , A61K9/22 , B01J4/04 , A61M7/00
CPC分类号： A61K9/0004 , Y10T428/31536
摘要： An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned distant from the first wall, said second wall a microporous or hydrogel material that extends around the first wall, and (3) a distribution zone interposed between the first and second wall and initially housing a compound soluble in an external fluid that enters the system.In operation, agent is dispensed from the system by fluid passing through the second wall into the zone from which fluid is further being imbibed through the first wall into the compartment forming a solution that is released through the passageway into the zone, and then through the second wall to the exterior of the system.
摘要翻译：公开了用于分配有益试剂的渗透系统。该系统包括（1）半透性材料的第一壁，该第一壁围绕包含药物制剂的隔室，并且具有通过所述壁的通道，用于从所述隔间释放剂，（2）位于远离所述第一壁的第二壁，所述第二壁第二壁是围绕第一壁延伸的微孔或水凝胶材料，以及（3）介于第一和第二壁之间的分配区，并且初始地容纳可溶于进入系统的外部流体的化合物。在操作中，通过流体通过第二壁将流体从系统中分配到进入区域中的流体进一步从第一壁吸入到隔室中，该隔室形成通过通道被释放到该区域中的溶液，然后通过第二个墙壁到系统的外部。

97. 发明授权

US4160020A Therapeutic device for osmotically dosing at controlled rate 失效
标题翻译：用于以受控速率渗透给药的治疗装置
公开(公告)号：US4160020A
公开(公告)日：1979-07-03
申请号：US864954
申请日：1977-12-27
申请人： Atul D. Ayer , Felix Theeuwes
发明人： Atul D. Ayer , Felix Theeuwes
IPC分类号： A61M37/00 , A61K9/00 , A61M29/04 , A61M31/00 , A61K9/24 , A61K9/44
CPC分类号： A61K9/0036 , A61K9/0004
摘要： An osmotic device is disclosed for delivering an active agent. The device comprises a wall surrounding a compartment with a passageway through the wall for releasing the agent. The wall comprises a material permeable to an external fluid and substantially impermeable to agent and at least one additional material independently selected from materials that impart stability to the wall, enhance the permeability of the wall to fluids, or aid in forming the wall. The compartment contains an agent that exhibits an osmotic pressure gradient across the wall against an external fluid, or the agent is mixed with an osmotically effective compound that exhibits an osmotic pressure gradient against the fluid. Agent is released from the device by fluid being imbided through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall, thereby producing a solution containing agent that is released through the passageway at a controlled rate over time.
摘要翻译：公开了用于递送活性剂的渗透装置。该装置包括围绕隔室的壁，通过该壁的通道用于释放该试剂。该壁包括可渗透外部流体的材料，并且基本上不可渗透到试剂和至少一种附加材料，其独立地选自赋予壁稳定性的材料，增强壁对流体的渗透性或有助于形成壁。隔间含有一种在外壁上显示渗透压梯度以抵抗外部流体的试剂，或者该试剂与渗透压梯度相对于流体的渗透性有效化合物混合。通过流体通过壁被渗透到隔室中的剂量通过壁的渗透性和穿过壁的渗透压梯度控制的速率从装置释放，从而产生溶液包含试剂，其通过通道在受控的随着时间的推移。

98. 发明授权

US3977404A Osmotic device having microporous reservoir 失效
标题翻译：具有微波储存器的操作装置
公开(公告)号：US3977404A
公开(公告)日：1976-08-31
申请号：US611504
申请日：1975-09-08
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61F6/14 , A61F9/00 , A61K9/00 , A61K9/26 , A61K9/52 , A61M31/00
CPC分类号： A61K9/0004 , A61F6/144 , A61F9/0017
摘要： An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding in at least a part, a reservoir containing agent. The wall is formed of a material permeable to an external fluid and impermeable to agent. The reservoir is formed of a microporous material permeable to agent and fluid, and having at least one micropore that is a passageway for release of agent. The agent is soluble in the fluid and exhibits an osmotic pressure gradient against the fluid, or the agent has limited solubility in the fluid and is admixed with an osmotically effective compound soluble in fluid that exhibits an osmotic pressure gradient against fluid. In operation, agent is released by fluid permeating through the wall into the reservoir producing a solution of agent or a solution of compound containing agent, which solution in either instance is released through the micropore to the exterior of the device.

99. 发明申请

US20120225033A1 Biodegradable Drug Delivery Composition 审中-公开
标题翻译：可生物降解的药物输送组合物
公开(公告)号：US20120225033A1
公开(公告)日：2012-09-06
申请号：US13304174
申请日：2011-11-23
申请人： William W. van Osdol , Su il Yum , Felix Theeuwes , Michael Sekar , John Gibson , Keith Branham , Huey-Ching Su
发明人： William W. van Osdol , Su il Yum , Felix Theeuwes , Michael Sekar , John Gibson , Keith Branham , Huey-Ching Su
IPC分类号： A61K38/27 , A61K38/16 , A61K38/26 , A61K38/21 , A61K31/7105
CPC分类号： A61K38/212 , A61K9/0019 , A61K31/7052 , A61K38/26 , A61K38/27 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/52 , A61K47/541 , A61K47/64
摘要： The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.
摘要翻译：本公开提供了包含载体和包含分散在载体中的有益剂的不溶性组分的生物可降解药物递送组合物。通常，组合物不是乳液，而是具有低粘度，并进一步提供有益剂随时间的最小化的初始爆发和持续释放。还提供了包括可生物降解的药物递送组合物或其组分的试剂盒，以及制备和使用可生物降解的药物递送组合物的方法。

100. 发明申请

US20080287464A1 Depot Formulations 审中-公开
标题翻译：仓库配方
公开(公告)号：US20080287464A1
公开(公告)日：2008-11-20
申请号：US12152764
申请日：2008-05-16
申请人： Jeremy C. Wright , Felix Theeuwes , John W. Gibson , Keith E. Branham , Stefania Sjobeck
发明人： Jeremy C. Wright , Felix Theeuwes , John W. Gibson , Keith E. Branham , Stefania Sjobeck
IPC分类号： A61K31/519 , A61K47/30 , A61P25/18
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K47/22 , A61K47/26 , A61K47/34
摘要： Disclosed are formulations and related methods that comprise a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity.
摘要翻译：公开的制剂和相关方法包括在37℃下具有至少5,000cP的粘度的非聚合非水溶性高粘度液体载体材料，其在环境或生理条件下不结晶; 包含丙交酯重复单元的指定线性聚合物; 和一种或多种具有溶剂能力的溶剂。

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