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91. 发明专利

FI945311A 未知
公开(公告)号：FI945311A
公开(公告)日：1994-11-11
申请号：FI945311
申请日：1994-11-11
申请人： ALZA CORP
发明人： LEE EUN SOO , NEDBERGE DIANE E , YUM SU IL
IPC分类号： A61K9/00 , A61K9/70 , A61K31/135 , A61K31/215 , A61K31/216 , A61K47/10 , A61K47/14 , A61K47/34 , A61P13/02 , A61P15/00 , A61P25/00 , A61K
摘要： The present invention is directed to the transdermal administration of oxybutynin together with a suitable permeation enhancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in oxybutynin- and permeation enhancer-transmitting relation with the skin site. The matrix contains sufficient amounts of a permeation enhancer and of oxybutynin, in combination, to continuously administer to the skin for a predetermined period of time the oxybutynin to provide an effective therapeutic result. The invention is also directed to a method for the transdermal administration of a therapeutically effective amount of oxybutynin together with a skin permeation-enhancing amount of a suitable permeation enhancer.

94. 发明专利

PT100015A 未知
公开(公告)号：PT100015A
公开(公告)日：1994-04-29
申请号：PT10001592
申请日：1992-01-15
申请人： ALZA CORP
发明人： YUM SU IL , WATANABE TYLER , LEE EUN SOO , CHIN IVAN W
IPC分类号： A61F5/441 , A61M1/00 , A61M1/14 , A61L29/00 , B65D
摘要： The invention disclosed and claimed an apparatus that relates to a delivery system comprising a biocide, with the delivery system designed and shaped for passages through the exit port of a urine container into the container. The invention disclosed and claim pertains also to a method of preventing infection in a patient by using the apparatus connected to a patient through a catheter.

95. 发明专利

ZA9207779B Osmotic drug delivery devices with hydrophobic wall materials. 未知
公开(公告)号：ZA9207779B
公开(公告)日：1993-07-05
申请号：ZA927779
申请日：1992-10-09
申请人： ALZA CORP
发明人： LEE EUN SOO , BURA SCOTT A , YUM SU IL , WONG PATRICK S L , THEEUWES FELIX
IPC分类号： A61M37/00 , A61K9/00 , A61K9/52 , A61K
CPC分类号： A61K9/0004

96. 发明专利

IE921615A1 SKIN PERMEATION ENHANCER COMPOSITIONS USING GLYCEROL¹MONOLINOLEATE 未知
公开(公告)号：IE921615A1
公开(公告)日：1992-12-02
申请号：IE921615
申请日：1992-07-01
申请人： ALZA CORP
发明人： LEE EUN SOO , NEDBERGE DIANE , YUM SU IL
IPC分类号： A61K9/00 , A61K47/00 , A61L15/20 , A61M37/00

97. 发明专利

ZA9200300B ANTIMICROBIAL DEVICE FOR URINE DRAINAGE CONTAINER 未知
公开(公告)号：ZA9200300B
公开(公告)日：1992-10-28
申请号：ZA9200300
申请日：1992-01-15
申请人： ALZA CORP
发明人： WATANABE TYLER , TYLER WATANABE , YUM SU IL , SU IL YUM , LEE EUN SOO , EUN SOO LEE , CHIN IVAN W , IVAN W CHIN
IPC分类号： A61F5/441 , A61M1/00 , A61F , A61M
CPC分类号： A61F5/441 , A61M1/0096

98. 发明专利

AT71287T 未知
公开(公告)号：AT71287T
公开(公告)日：1992-01-15
申请号：AT87304285
申请日：1987-05-14
申请人： ALZA CORP
发明人： LEE EUN SOO , WONG PATRICK S L , THEEUWES FELIX , YUM SU IL , ZAFFARONI ALEJANDRO
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70
摘要： A diffusional drug delivery device is described which an provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continous administration over extended time periods.

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