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91. 发明专利

SG175260A1 METHOD FOR SCREENING FOR SALTY TASTE CONTROL SUBSTANCE 未知
公开(公告)号：SG175260A1
公开(公告)日：2011-11-28
申请号：SG2011076031
申请日：2010-09-29
申请人： AJINOMOTO KK
发明人： ISHIWATARI YUTAKA , KAI YUKO , MAEKAWA TAKAMI , ETO YUZURU
IPC分类号： A23L27/00 , A23L27/40
摘要： By contacting a test substance with a cell that expresses a Kv3.2 protein, and comparing observed cation influx into the cell with cation influx into the cell observed when the test substance is not contacted with the cell, a salty taste modulating substance such as salt alternative compound, or salt perception enhancing or inhibiting compound is screened.

92. 发明专利

DE602006017421D1 SCREENING-VERFAHREN FÜR KOKUMI-VERMITTELNDE AGENTIEN 未知
公开(公告)号：DE602006017421D1
公开(公告)日：2010-11-18
申请号：DE602006017421
申请日：2006-11-08
申请人： AJINOMOTO KK
发明人： OHSU TAKEAKI , TAKESHITA SEN , ETO YUZURU , AMINO YUSUKE , MIYAMURA NAOHIRO , YAMANAKA TOMOHIKO , NAGASAKI HIROAKI
IPC分类号： G01N33/566 , A23L23/00 , A23L27/00 , A23L27/10 , A23L27/21 , A23L35/00 , C07K5/00

93. 发明专利

CA2756888A1 USE OF PEPTIDES FOR IMPARTING KOKUMI 未知
公开(公告)号：CA2756888A1
公开(公告)日：2010-10-07
申请号：CA2756888
申请日：2010-03-31
申请人： AJINOMOTO KK
发明人： FUTAKI FUMIE , YASUDA REIKO , SATO SEIICHI , MIYAKI TAKASHI , MIYAMURA NAOHIRO , ETO YUZURU
IPC分类号： A23L27/20 , A23L27/21 , A23L27/22
摘要： Disclosed are: an agent for imparting body taste comprising a substance, which is obtained by searching for a number of variation compounds having CaSR agonistic activity and finding a substance that has an improved effect of imparting body taste, in particular, an effect of imparting body taste of the first taste-type, and high stability and can be conveniently produced at a low cost; and a composite agent for imparting body taste which comprises said substance together with another substance having CaSR agonistic activity. Specifically disclosed are: an agent for imparting body taste which comprises ?-Glu-Abu (L-?-glutamyl-L-2-aminobutyric acid); and a composite agent for imparting body taste which comprises a combination of said substance with another substance having CaSR agonistic activity.

94. 发明专利

CA2686805A1 SWEETENER 未知
公开(公告)号：CA2686805A1
公开(公告)日：2008-11-20
申请号：CA2686805
申请日：2008-05-01
申请人： AJINOMOTO KK
发明人： ETO YUZURU , SEGURO KATSUYA , MIYAMURA NAOHIRO , NAGASAKI HIROAKI
IPC分类号： A23L27/00 , A23L27/30
摘要： The body taste of a sweetener (for example, aspartame, sucralose, asesulf ame, etc.) is improved by blending the sweetener with an amino acid or a pep tide having an effect of activating a calcium receptor such as .gamma.-Glu-X -Gly (wherein X represents an amino acid or an amino acid derivative), .gamm a.-Glu-Val-Y (wherein Y represents an amino acid or an amino acid derivative ), .gamma.-Glu-Ala, .gamma.-Glu-Gly, .gamma.-Glu-Cys, .gamma.-Glu-Met, .gamm a.-Glu-Thr, .gamma.-Glu-Val, .gamma.-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu -Cys, Gly-Cys, Leu-Asp, D-Cys, .gamma.-Glu-Met(O), .gamma.-Glu-.gamma.-Glu-V al, .gamma.-Glu-Val-NH2, .gamma.-Glu-Val-ol, .gamma.-Glu-Ser, .gamma.-Glu-Ta u, .gamma.-Glu-Cys(S-Me)(O), .gamma.-Glu-Leu, .gamma.-Glu-Ile, .gamma.-Glu-t -Leu, .gamma.-Glu-Cys(S-Me), etc.

95. 发明专利

DE69905462T2 未知
公开(公告)号：DE69905462T2
公开(公告)日：2004-01-15
申请号：DE69905462
申请日：1999-05-20
申请人： AJINOMOTO KK
发明人： ONO KUNIO , TSUCHIYA SHIGEKATSU , EJIMA DAISUKE , ETO YUZURU
IPC分类号： A61K38/00 , C07K1/18 , C07K14/47 , C07K14/575
摘要： A process for producing human activin with a high purity, which comprises subjecting a crude human activin to a purification procedure involving, in particular, a cation exchange chromatography by the chaotropic ion concentration gradient elution method is provided. By using this process, highly pure human activin A appropriate for pharmaceutical use can be easily isolated and purified from crude human activin, in particular, crude human activin A, and human activin A can be produced on an industrial scale. Also, highly purified human activin which is obtained or can be obtained in the above process and human activin in the form of drug product are also provided.

96. 发明专利

AU4337196A Bacillus-derived transglutaminase 未知
公开(公告)号：AU4337196A
公开(公告)日：1996-08-15
申请号：AU4337196
申请日：1996-02-07
申请人： AJINOMOTO KK
发明人： KOBAYASHI KATSUNORI , YAMANAKA SHIGERU , MIWA KIYOSHI , SUZUKI SHUNICHI , ETO YUZURU , TANITA YUKO , YOKOZEKI KENZO , HASHIGUCHI KENICHI
IPC分类号： C12N15/09 , A23J3/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/54 , C12P21/04 , C12R1/125 , C12R1/19 , C07K1/107
摘要： The invention relates to a Ca -independent transglutaminase derivable from cells of the genus Bacillus having the following properties: a) The suitable pH-value for it is from about 7 to about 9, b) the suitable temperature for it is from about 40 DEG C to about 65 DEG C, c) it has an activity of 50% or more in the presence of 5 mM Ca , and d) it has a molecular weight of from about 28,000 to about 30,000 (as measured by SDS/PAGE). The transglutaminase is obtainable form spores of Bacilli. The present invention further relates to vectors and microorganisms containing a DNA fragment encoding said transglutaminase and to methods for producing the recombinant transglutaminase.

97. 发明专利

JPS62240700A POLYPEPTIDE 失效
公开(公告)号：JPS62240700A
公开(公告)日：1987-10-21
申请号：JP15003386
申请日：1986-06-26
申请人： AJINOMOTO KK
发明人： ETO YUZURU , TAKANO YOSHITOSHI , TAKESAWA MISAKO , TSUJI TOMOKO , YOKOGAWA YASUNORI , SHIBAI HIROSHIRO
IPC分类号： C07K14/52 , A61K38/00 , A61P7/06 , A61P35/02 , C07K14/00 , C07K14/575 , C12P21/02 , C12R1/91
摘要： NEW MATERIAL:A polypeptide that has activity of differentiating mouse leukemia cells to maturate them to normal cells, 16+ or -1kd of mol.wt (SDS- electrophoresis in the presence of 1% mercaptoethanol), 25+ or -1kd of mol.wt. (SDS-electroporesis in the absence of mercaptoethanol), formula I (X is an amino acid which could not be identified) of the amino-terminal amino acid sequence and formula II of amino acid sequence of the peptide fragment after bromcyan fission. USE:Remedy for human leukemia and anemia. PREPARATION:For example, human leukemia cells are suspended in a Dulbecco- modified Eagle's basel medium containing 5% bovine fetal serum and cultured in the presence of a differentiation-inducing substance such as phorbol ester (TPA) at 37 deg.C. Then, the products are separated from the culture mixture to collect the objective polypeptide having amino-terminal amino acid sequence of formula I.

98. 发明专利

JP2517962B2 失效
公开(公告)号：JP2517962B2
公开(公告)日：1996-07-24
申请号：JP11382887
申请日：1987-05-11
申请人： AJINOMOTO KK
发明人： MATSUMOTO TOSHIO , ETO YUZURU , SHIBAI HIROSHIRO , OGATA ETSURO
IPC分类号： A61K38/00 , A61P3/00 , A61P3/14 , A61P43/00

99. 发明专利

JPH07149659A THERAPEUTIC AGENT FOR BONE INJURY 失效
公开(公告)号：JPH07149659A
公开(公告)日：1995-06-13
申请号：JP23279594
申请日：1994-09-28
申请人： AJINOMOTO KK
发明人： SAKAI YOSHINARI , ETO YUZURU
IPC分类号： A61K38/00 , A61P3/00 , A61P43/00
摘要： PURPOSE:To obtain a therapeutic agent for various bone injuries including bone coloboma and fracture, comprising a BUF as an active ingredient. CONSTITUTION:This therapeutic agent for various bone injuries contains at least one component selected from BUF-3 (action A), BUF-4 (actibin AB) and BUF-5 (actibin B) as an active ingredient. BUFs promote formation of callus in a process of fracture cure and are useful for treating bone coloboma. A dose is 1ng to 5mg per adult and administered once to several times. The therapeutic agent for various bone injuries is capable of shortening treatment period of fracture diseases and improving strength of repaired bone. The therapeutic agent can be pharmaceutically manufactured into injection, tablet, capsule, etc., and mixed with polybutyric acid, polyglycol, etc., and pharmaceutically manufactured into a sustained release administrative agents. BUFs are obtained by culturing a cell of an eucaryote transformed with a plasmid containing a gene encoding BUFs in a culture solution.

100. 发明专利

JPS63139200A HUMAN DIFFERENTIATION INDUCING FACTOR BUF-3 ANTIBODY AND DETERMINATION METHOD USING SAID ANTIBODY 失效
公开(公告)号：JPS63139200A
公开(公告)日：1988-06-10
申请号：JP28753286
申请日：1986-12-02
申请人： AJINOMOTO KK
发明人： NAGATSUKA NORIKO , TSUJI TOMOKO , TAKANO YOSHITOSHI , ETO YUZURU , SHIBAI HIROSHIRO
IPC分类号： C12N15/02 , C07K14/005 , C07K14/195 , C07K14/575 , C07K16/00 , C07K19/00 , C12N15/00 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53
摘要： NEW MATERIAL:An antibody against human differentiation inducing factor BUF-3 having activity to differentiate and mature mouse leukemia cell to normal cell. USE:A determination reagent for follicle-stimulating hormone (FSH), a contraceptive and a diagnostic for sterility. PREPARATION:For example, human differentiation inducing factor BUF-3 is mixed and emulsified in an adjuvant and the emulsion is administered to a rabbit by subcutaneous injection to immunize the rabbit. The rabbit is successively administered with an antigen 2 weeks, 3 weeks and 4 weeks after the immunization and whole blood is collected 11 days after the final infusion of an antigen solution into vein. The collected blood is left at rest and centrifuged to obtain an antiserum. The antiserum is precipitated with 40% saturation ammonium sulfate, centrifuged, dissolved in a buffer solution, dialyzed and purified with a DEAE sepharose column to obtain the objective antibody. FSH can be quantitatively determined by a solid-phase sandwich ELISA method using the antibody.

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