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91. 发明授权

EP1401801B1 SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 有权
标题翻译：作者雄GENREZEPTORS方法及其用途选择性调节剂。
公开(公告)号：EP1401801B1
公开(公告)日：2006-11-02
申请号：EP01964368.3
申请日：2001-08-23
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： DALTON, James , MILLER, Duane, D. , YIN, Donghua , HE, Yali
IPC分类号： C07C233/15 , C07C233/33 , C07C233/48 , C07C235/26 , C07C237/14 , A01N37/18 , A01N31/16 , C07C235/24 , A61K31/167
CPC分类号： C07D215/227 , A61K31/167 , A61K31/404 , A61K31/4706 , A61K31/661 , C07C235/24 , C07D209/08 , C07D271/12 , G01N33/5438 , G01N33/74
摘要： This invention provides a novel class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds which are tissue-selective androgen receptor modulators (SARM), which are useful for oral testosterone replacement therapy, male contraception, maintaining sexual desire in women, treating prostate cancer and imaging prostate cancer. These agents have an unexpected in-vivo activity for an androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. These agents may be active alone or in combination with progestins or estrogens. The invention further provides a novel class of non-steroidal agonist compounds. The invention further provides compositions containing the selective androgen modulator compounds or the non-steroidal agonist compounds and methods of binding an androgen receptor, modulating spermatogenesis, treating and imaging prostate cancer, and providing hormonal therapy for androgen-dependent conditions.

92. 发明公开

EP1475087A2 A method for chemoprevention of prostate cancer 审中-公开
标题翻译： Methode zur Vorbeugung von Prostatakrebs
公开(公告)号：EP1475087A2
公开(公告)日：2004-11-10
申请号：EP04018861.7
申请日：1999-05-07
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： Steiner, Mitchell S , Raghow, Sharon
IPC分类号： A61K31/138
CPC分类号： A61K31/138
摘要： This invention relates to the chemoprevention of prostate cancer and, more particularly, provides the use of a chemopreventive agent, e.g. toremifene and analogs or metabolites thereof, in the manufacture of a pharmaceutical preparation to prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having an elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.
摘要翻译：本发明涉及前列腺癌的化学预防，更具体地，涉及化学预防剂的用途，例如，托瑞米芬及其类似物或代谢物，用于制备防止复发，抑制或抑制前列腺癌发生的药物制剂。本发明提供了一种用于抑制或抑制潜伏性前列腺癌的安全有效的方法，并且特别可用于治疗具有升高的前列腺癌风险的受试者，例如具有良性前列腺增生，前列腺上皮内瘤变（PIN）或具有异常高水平的前列腺特异性抗体（PSA），或具有前列腺癌家族史。

93. 发明公开

EP1401801A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 有权
标题翻译：作者雄GENREZEPTORS方法及其用途选择性调节剂。
公开(公告)号：EP1401801A1
公开(公告)日：2004-03-31
申请号：EP01964368.3
申请日：2001-08-23
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： DALTON, James , MILLER, Duane, D. , YIN, Donghua , HE, Yali
IPC分类号： C07C233/15 , C07C233/33 , C07C233/48 , C07C235/26 , C07C237/14 , A01N37/18 , A01N31/16
CPC分类号： C07D215/227 , A61K31/167 , A61K31/404 , A61K31/4706 , A61K31/661 , C07C235/24 , C07D209/08 , C07D271/12 , G01N33/5438 , G01N33/74
摘要： This invention provides a novel class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds which are tissue-selective androgen receptor modulators (SARM), which are useful for oral testosterone replacement therapy, male contraception, maintaining sexual desire in women, treating prostate cancer and imaging prostate cancer. These agents have an unexpected in-vivo activity for an androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. These agents may be active alone or in combination with progestins or estrogens. The invention further provides a novel class of non-steroidal agonist compounds. The invention further provides compositions containing the selective androgen modulator compounds or the non-steroidal agonist compounds and methods of binding an androgen receptor, modulating spermatogenesis, treating and imaging prostate cancer, and providing hormonal therapy for androgen-dependent conditions.

94. 发明公开

EP1343390A2 MATERIALS AND METHODS FOR THE TREATMENT OR PREVENTION OF OBESITY 审中-公开
标题翻译：材料与用于治疗或预防过胖方法
公开(公告)号：EP1343390A2
公开(公告)日：2003-09-17
申请号：EP01968462.0
申请日：2001-09-04
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： ZEMEL, Michael, B. , SHI, Hang , CARNEY, Paula
IPC分类号： A23L1/29 , A23L1/304
CPC分类号： A61K31/00 , A23L33/16 , A23L33/30 , Y10S514/905
摘要： The subject invention provides methods of inducing the loss of adipose tissue by providing a diet high in calcium. In one aspect of the invention, the calcium is provided in the form of dairy products. In yet another aspect of the invention, calcium is provided in the form of a dietary supplement, such as calcium carbonate, of vitamin supplements. Methods of suppressing [Ca2+]i levels in individuals are also provided. The subject invention also provides methods of stimulating lipolysis, inhibiting lipogenesis, and increasing the expression of white adipose tissue uncoupling protein 2 (UCP2). The subject invention also provides methods of increasing the core temperature of an individual.

95. 发明公开

EP1307719A1 A SYSTEM FOR MEASURING LOAD SUPPLIED TO A PLATFORM 审中-公开
标题翻译：制度，衡量一个平台的负担
公开(公告)号：EP1307719A1
公开(公告)日：2003-05-07
申请号：EP01950799.5
申请日：2001-07-02
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： HODGSON, Jeffrey, W.
IPC分类号： G01L5/10
CPC分类号： G01L1/26 , G01G3/1414 , G01L5/288
摘要： The present invention relates to a system for measuring loads applied to a platform (9), wherein the accuracy of the measurements is nor adversely affected by any moments or torques resulting from the application of the load applied to the platform (9). The present invention is particularly suitable to platforms used to measure large loads and braking capability of trucks at weigh stations located along interstate highways.

96. 发明公开

EP1229903A1 A METHOD FOR CHEMOPREVENTION OF PROSTATE CANCER 审中-公开
标题翻译：方法前列腺癌的化学防治
公开(公告)号：EP1229903A1
公开(公告)日：2002-08-14
申请号：EP00978418.2
申请日：2000-11-08
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： STEINER, Mitchell, S. , RAGHOW, Sharan
IPC分类号： A61K9/14
CPC分类号： A61K45/06 , A61K31/00 , A61K31/015 , A61K31/138 , A61K31/4535 , A61K31/565 , Y10S514/938 , Y10S514/944 , Y10S514/965
摘要： This invention relates to the chemoprevention of prostate cancer and, more particularly, to a method of suppressing or inhibiting latent prostate cancer comprising administering to a mammalian subject a chemopreventive agent and analogs and metabolites thereof. The chemopreventive agent prevents, prevents recurrence of, suppresses or inhibits prostate carcinogenesis; and treats prostate cancer.

97. 发明授权

EP0719172B1 POST-TREATMENT OF LAMINATED NONWOVEN WEBS 失效
标题翻译：治疗层压腹板
公开(公告)号：EP0719172B1
公开(公告)日：2002-04-10
申请号：EP94922702.9
申请日：1994-07-22
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： HASSENBOEHLER, Charles, B., Jr. , WADSWORTH, Larry, C.
IPC分类号： B01D39/16 , D04H13/00 , B01D39/02 , B29C55/06 , B32B5/26 , D06C3/00
CPC分类号： B01D39/163 , B01D2239/0414 , B01D2239/0435 , B01D2239/0471 , B01D2239/0622 , B01D2239/0627 , B01D2239/065 , B01D2239/1216 , B01D2239/1233 , B03C3/28 , B29C55/06 , B32B5/02 , B32B5/26 , B32B27/12 , D04H1/54 , D04H1/559 , D04H1/56 , D04H13/00 , D06C3/00 , Y10S55/05 , Y10S55/39
摘要： A method for post-treating a laminated precursor nonwoven web which includes layers of thermoplastic man-made fibers and at least one layer of cellulose-based staple natural fibers, including consolidating the web longitudinally and thereby reducing the maximum pore size measure of the web. The precursor web and the resultant consolidated nonwoven web are also disclosed, as is utilization of the product web in medical uses.

98. 发明授权

EP0625043B1 RECOMBINANT MULTIVALENT M PROTEIN VACCINE 失效
标题翻译：重组多价M-蛋白疫苗
公开(公告)号：EP0625043B1
公开(公告)日：2002-03-20
申请号：EP93922201.4
申请日：1993-09-15
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： DALE, James, B. , LEDERER, James, W., Jr.
IPC分类号： A61K31/18 , A61K39/085 , C12N1/21 , C07K14/315
CPC分类号： C07K14/315 , A61K39/00 , C07K2319/40
摘要： The invention relates to DNA sequences encoding epitopes which are used in recombinant multivalent hybrid protein vaccines to control group A streptococcal infections of multiple serotypes which may result in rheumatic fever.

99. 发明公开

EP1165771A2 RT-PCR OF CLONAL NEUROSPHERES 审中-公开
标题翻译：克隆神经鞘瘤的RT-PCR
公开(公告)号：EP1165771A2
公开(公告)日：2002-01-02
申请号：EP00915004.6
申请日：2000-03-17
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
发明人： SUSLOV, Oleg, N.,The Univ. of Tennessee, Memphis , STEINDLER, Dennis, A.,The Univ. Of Tennessee , KUKEKOV, Valery, G.
IPC分类号： C12N15/10 , C12N5/06
CPC分类号： C12N15/1096
摘要： A method is described for the preparation, characterization and utilization of temporally ordered panels of cDNA libraries from human microclones. Each microclone undergoing morphogenetic differentiation in vitro differs in discrete gene expression. The developmental stage of the microclone is determined and the gene expression patterns of the microclones temporally ordered and arranged into expression profiles and temporal spectra. Direct comparison of the cDNAs produced from different neural microclones allows identification of novel RNA transcripts.
摘要翻译：描述了一种用于从人类微克隆中制备，表征和利用时间排序的cDNA文库的方法。经历体外形态发生分化的每个微克隆在离散基因表达方面不同。确定微克隆的发育阶段，并将微克隆的基因表达模式暂时排序并排列成表达谱和时间谱。直接比较不同神经微克隆产生的cDNA可鉴定新的RNA转录物。

100. 发明公开

EP1053448A1 METHOD AND APPARATUS FOR MAKING ABSOLUTE RANGE MEASUREMENTS 审中-公开
标题翻译：绝对距离测量的设备和方法（菲涅耳衍射）
公开(公告)号：EP1053448A1
公开(公告)日：2000-11-22
申请号：EP99905436.4
申请日：1999-01-14
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION , Lockheed Martin Energy Research Corporation
发明人： SANDERS, Alvin, J. , EARL, Dennis, D. , ALLISON, Stephen, W. , CATES, Michael, R. , KEY, William, S.
IPC分类号： G01B11/14 , G01B9/02
CPC分类号： G01S17/32 , G01B11/026
摘要： The invention relates to a method and apparatus for making absolute distance or ranging measurements using Fresnel diffraction. The invention employs a source of electromagnetic radiation having a known wavelength or wavelength distribution, which sends a beam of electromagnetic radiation through an object which causes it to be split (hereinafter referred to as a 'beamsplitter') (22), and then to a target (18). The beam is reflected from the target onto a screen containing an aperture spaced a known distance from the beamsplitter (22). The aperture is sized so as to produce a Fresnel diffraction pattern. A portion of the beam travels through the aperture to a detector, spaced a known distance from the screen. The detector defects the central intensity of the beam. The distance from the object which causes the beam to be split to the target can then be calculated based upon the known wavelength, aperture radius, beam intensity, and distance from the detector to the screen (26). Several apparatus embodiments are disclosed for practicing the method embodiments of the present invention.

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