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91. 发明公开

EP0487745A4 PYRIDINE DERIVATIVE WITH ANGIOTENSIN II ANTAGONISM 失效
标题翻译：吡啶衍生物与血管紧张素II拮抗剂
公开(公告)号：EP0487745A4
公开(公告)日：1993-01-20
申请号：EP91910846
申请日：1991-06-19
申请人： MEIJI SEIKA KABUSHIKI KAISHA
发明人： KATANO, KIYOAKI, MEIJI SEIKA K.K. YAKUHIN SOGO , OGINO, HIROKO, MEIJI SEIKA K.K. YAKUHIN SOGO , SHITARA, EIKI, MEIJI SEIKA K.K. YAKUHIHIN SOGO , WATANABE, HIROMI, MEIJI SEIKA K.K. YAKUHIN SOGO , NAGURA, JUN, MEIJI SEIKA KABUSHIKI KAISHA YAKUHIN , OSADA, NAOMI, MEIJI SEIKA KABUSHIKI KAISHA YAKUHIN , ICHIMARU, YASUYUKI, MEIJI SEIKA KABUSHIKI KAISHA , KONNO, FUKIO, MEIJI SEIKA KABUSHIKI KAISHA , MACHINAMI, TOMOYA, MEIJI SEIKA KABUSHIKI KAISHA , TSURUOKA, TAKASHI, MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/80 , C07D221/04 , C07D401/10 , C07D401/12
CPC分类号： C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/80 , C07D221/04 , C07D401/10 , C07D401/12
摘要： A compound of general formula (I) and a pharmacologically acceptable salt thereof wherein A represents (a), (b) or (c), B represents a carboxylic acid residue or a tetrazole residue, and X represents O, NH or S(O)t. The compound (I) has an angiotensin (II) antagonism and is used as hypotensive, cardiac failure remedy, anxiolytic drug and agent for mnemonics.

92. 发明授权

EP0173327B1 Bialaphos producing gene 失效
标题翻译：生物碱生物基因
公开(公告)号：EP0173327B1
公开(公告)日：1991-11-06
申请号：EP85110856.3
申请日：1985-08-28
申请人： MEIJI SEIKA KABUSHIKI KAISHA
发明人： Murakami, Takeshi , Imai, Satoshi , Anzai, Hiroyuki , Satoh, Atsuyuki , Nagaoka, Kozo
IPC分类号： C12N15/31 , C12N1/21 , C12P21/00
CPC分类号： C12P21/02 , C12N15/52 , C12P13/02

93. 发明公开

EP0452076A1 Thiazole and imidazole derivatives and antiulcer composition containing same 失效
标题翻译：。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。
公开(公告)号：EP0452076A1
公开(公告)日：1991-10-16
申请号：EP91303091.2
申请日：1991-04-09
申请人： MEIJI SEIKA KABUSHIKI KAISHA
发明人： Machinami, Tomoya, c/o Meiji Seika K.K. , Yasufuku, Kazue, c/o Meiji Seika K.K. , Shibahara, Seiji, c/o Meiji Seika K.K. , Yuda, Yasukatsu, c/o Meiji Seika K.K. , Hirano, Fumiya, c/o Meiji Seika K.K.
IPC分类号： C07D277/74 , A61K31/425 , C07D235/28 , C07D277/36 , C07D417/04 , C07D417/12 , A61K31/415
CPC分类号： C07D417/04 , C07D235/28 , C07D277/36 , C07D277/56 , C07D277/74 , C07D277/76 , C07D417/12
摘要： A thiazole or imidazole derivative having the general formula (I):

wherein:

R¹ and R², which may be the same or different, each independently represent a hydrogen atom, or a phenyl or heteroaryl group, or R¹ and R² may together form a benzene ring which may be optionally substituted by a halogen atom or a lower alkyl optionally substituted by a halogen atom, lower alkoxy or nitro group;
A represents a sulfur atom or -NH-;
B represents a lower alkoxy group optionally substituted by a halogen atom; a five- or six-membered saturated heterocyclic ring containing one nitrogen or oxygen atom which ring may be optionally substituted; a six-membered saturated heterocyclic ring containing one oxygen atom plus one nitrogen atom; a group -XR³ where X represents a group -NR⁴ wherein R³ and R⁴, which may be the same or different, each independently represent a lower alkyl group; or a group -NHC(=Y)R⁵ where Y represents an oxygen or sulfur atom or a group =NCN or =CHNO₂, and R⁵ represents a group -NHR⁶ or -SR⁶ wherein R⁶ represents a lower alkyl group optionally substituted by a halogen atom;
m is an integer from 1 to 4; and
n is an integer from 0 to 2;
and their pharmacologically acceptable salts. The compounds has an antiulcerative activity.
摘要翻译：具有通式（I）的噻唑或咪唑衍生物：其中：R 1和R 2可以相同或不同，各自独立地表示氢原子或苯基或杂芳基，或R 1和R 2可以一起形成苯环，其可任选被卤素原子或任选被卤素原子，低级烷氧基或硝基取代的低级烷基取代; A表示硫原子或-NH-; B表示任选被卤素原子取代的低级烷氧基; 含有一个氮原子或氧原子的五元或六元饱和杂环，该环可以任选被取代; 含有一个氧原子加上一个氮原子的六元饱和杂环; 基团-XR 3，其中X表示基团-NR 4，其中R 3和R 4可以相同或不同，各自独立地表示低级烷基; 或基团-NHC（= Y）R 5，其中Y表示氧或硫原子或基团= NCN或= CHNO 2，R 5表示-NHR 6或-SR 6基团，其中 R 6表示任选被卤素原子取代的低级烷基; m是1至4的整数; n为0〜2的整数。及其药理学上可接受的盐。该化合物具有抗溃疡活性。

94. 发明公开

EP0407192A2 4-Acyloxyquinoline derivatives and insecticidal or acaricidal compositions containing same 失效
标题翻译： 4-Acyloxychinolin-Derivate und diese enthaltende insektizide und akarizide Mittel。
公开(公告)号：EP0407192A2
公开(公告)日：1991-01-09
申请号：EP90307357.5
申请日：1990-07-05
申请人： MEIJI SEIKA KABUSHIKI KAISHA
发明人： Minowa, Nobuto, c/o Meiji Seika K.K. Yakuhin , Machinami, Tomoya, c/o Meiji Seika K.K. Yakuhin , Shibahara, Seiji, c/o Meiji Seika K.K. Yakuhin , Imamura, Keiichi, c/o Meiji Seika K.K. Yakuhin , Iwata, Michiaki, c/o Meiji Seika K.K. Yakuhin , Shimura, Masaru, c/o Meiji Seika K.K. Yakuhin , Inouye, Shigeharu, c/o Meiji Seika K.K. Yakuhin
IPC分类号： C07D215/233 , C07D215/56 , C07D219/06 , C07D409/12 , C07D405/12 , A01N43/42
CPC分类号： C07D215/233 , A01N43/42 , A01N47/06 , A01N53/00 , C07D215/56 , C07D219/06 , C07D405/12 , C07D409/12
摘要： A 4-acyloxyquinoline derivative represented by the general formula (I):
wherein R 1 represents a hydrogen atom, a C 1 -C 18 alkyl, C 2 -C 18 alkenyl, C 3 -C 10 cycloalkyl which may be optionally substituted, phenylloweralkyl, phenoxyloweralkyl, aryl group, a group OR 4 , where R 4 represents a lower alkyl or aryl group, or a grou p
where X represents an oxygen or a sulphur atom; R 2 represents a hydrogen atom, a lower alkyl group or a group -COOR S where R 5 represents a hydrogen atom or a lower alkyl group; R 3 represents a hydrogen atom, a C 1 -C 10 alkyl or C 2 -C 10 alkenyl group, provided that R 1 does not represent OR 4 when R 2 is a hydrogen atom and R 3 is methyl; R 2 and R 3 together represent a group (CH 2 ) m , wherein m is 3 or 4, and W represents a hydrogen atom, 1 to 4 halogen atoms, a lower alkyl or lower alkoxy group which may be the same or different and with which the left-hand nucleus is substituted, provided that the compound wherein R 1 represents methyl, R 2 , R 3 and W each represent a hydrogen atom is excluded.
摘要翻译：由通式（I）表示的4-酰氧基喹啉衍生物：其中R 1表示氢原子，C 1 -C 18烷基，C 2 -C 18烯基，可以任意取代的C 3 -C 10环烷基，苯基低级烷基，苯氧基低级烷基，芳基，OR 4基团，其中R 4表示低级烷基或芳基，或杂环，其中X表示氧或硫原子; R 2表示氢原子，低级烷基或-COOR 5基团，其中R 5表示氢原子或低级烷基; R 3表示氢原子，C 1 -C 10烷基或C 2 -C 10烯基，条件是当R 2为氢原子且R 3为甲基时，R 1不表示OR 4 ; R 2和R 3一起表示基团（CH 2）m，其中m为3或4，W表示氢原子，1至4个卤素原子，可以相同的低级烷基或低级烷氧基或不同的，并且左侧核被取代，条件是其中R 1表示甲基，R 2，R 3和W各自表示氢原子的化合物被排除。

95. 发明公开

EP0405976A1 Azole derivatives and antiulcerative composition containing same 失效
标题翻译： Azolderivate und diese enthaltende Antiulcus-Zusammensetzungen。
公开(公告)号：EP0405976A1
公开(公告)日：1991-01-02
申请号：EP90307086.0
申请日：1990-06-28
申请人： MEIJI SEIKA KABUSHIKI KAISHA
发明人： Katano, Kiyoaki, Meiji Seika K. K. Yakuhin Sogo , Tomomoto, Tamako, Meiji Seika K. K. Yakuhin Sogo , Ogino, Hiroko, Meiji Seika K. K. Yakuhin Sogo , Yamazaki, Naoki, Meiji Seika K. K. Yakuhin Sogo , Hirano, Fumiya, Meiji Seika K. K. Yakuhin Sogo , Yuda, Yasukatsu, Meiji Seika K. K. Yakuhin Sogo , Konno, Fukio, Meiji Seika K. K. Yakuhin Sogo , Nishio, Motohiro, Meiji Seika K. K. Yakuhin Sogo , Machinami, Tomoya, Meiji Seika K. K. Yakuhin Sogo , Shibahara, Seiji, Meiji Seika K. K. Yakuhin Sogo , Tsuruoka, Takashi, Meiji Seika K. K. Yakuhin Sogo , Inouye, Shigeharu, Meiji Seika K. K. Yakuhin Sogo
IPC分类号： C07D471/04 , C07D498/04 , C07D513/04 , A61K31/435
CPC分类号： C07D471/04 , C07D513/04
摘要： Compounds of the general formula (I):
and pharmaceutically acceptable salts thereof,
in which A, B, C and D each represent -CH= or -N=, with the proviso that at least one of them is -N=;
X represents -NH-, -O- or -S-;
Y represents -(CH₂) p - wherein p is an integer from 0 to 4, -C(CH₃)₂-, -CH₂CH=CH-, -CH₂CO-, -CF₂- or -CH₂COCH₂-;
R¹ represents a hydrogen atom, a C₁₋₄ alkyl group, a halogen atom or a C₁₋₄ alkoxy group;
R² represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a carboxyl group, a saturated or unsaturated C₁₋₁₂ alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-membered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, -CONR³R⁴, -NR³R⁴, -OCOR³ or -NHCONHR³ wherein R³ and R⁴, which may be the same or different, represent a C₁₋₆ alkyl group which may be optionally substituted or a cycloalkyl group, and
m and n each represent an integer from 0 to 2.
摘要翻译：其中A，B，C和D各自表示-CH =或-N =的通式（I）的化合物：及其药学上可接受的盐，条件是它们中的至少一个为-N = ; X表示-NH-，-O-或-S-; Y表示 - （CH 2）p - ，其中p是0至4的整数，-C（CH 3）2 - ， - CH 2 CH = CH - ， - CH 2 CO - ， - CF 2 - 或-CH 2 COCH 2 - R 1表示氢原子，C 1-4烷基，卤素原子或C 1-4烷氧基; R 2表示氢原子，羟基，饱和或不饱和的C 1-6烷基，C 1-6烷氧基，羧基，可以被任意取代的饱和或不饱和的C 1-12烷氧基羰基，环烷氧基羰基，任选含有一个或多个氮原子和/或氧原子的至少一个氮原子的饱和或不饱和五元或六元杂环基，其可以任选地被缩合和/或取代，-CONR 3 R R 4，-NR 3 R 4，-OCOR 3或-NHCONHR 3，其中R 3和R 4可以相同或不同，表示C1-6烷基其可以是任选取代的或环烷基，m和n各自表示0-2的整数。

96. 发明授权

EP0196375B1 Gene coding for signal peptides and utilization thereof 失效
标题翻译：信号肽的基因编码及其利用
公开(公告)号：EP0196375B1
公开(公告)日：1990-07-25
申请号：EP85302177.2
申请日：1985-03-28
申请人： MEIJI SEIKA KABUSHIKI KAISHA
发明人： Hoshiko, Shigeru , Makabe, Osamu , Fukatsu, Shunzo , Nagaoka, Kozo
IPC分类号： C12N15/00
CPC分类号： C12N9/2417 , C07K2319/00 , C07K2319/02 , C12N15/76 , Y10S930/30

97. 发明授权

EP0169563B1 Easy-to-open carton for confectionery or other food products 失效
标题翻译：容易开放的食品或其他食品的纸盒
公开(公告)号：EP0169563B1
公开(公告)日：1989-12-20
申请号：EP85109331.0
申请日：1985-07-25
申请人： MEIJI SEIKA KABUSHIKI KAISHA , DAI NIPPON INSATSU KABUSHIKI KAISHA
发明人： Mizoguchi, Yoshihiko , Sekine, Keiichi , Komiya, Yasutoyo , Nishida, Yoshio
IPC分类号： B65D3/26
CPC分类号： B32B1/02 , B32B3/02 , B32B27/10 , B32B2307/31 , B65D3/06 , B65D3/262 , B65D75/26 , B65D75/5844 , Y10S229/926

98. 发明公开

EP0328111A2 Cancer cell metastasis inhibitors 失效
标题翻译： Krebszellenmetastaseninhibitoren。
公开(公告)号：EP0328111A2
公开(公告)日：1989-08-16
申请号：EP89102252.7
申请日：1989-02-09
申请人： MEIJI SEIKA KABUSHIKI KAISHA
发明人： Tsuruoka, Tsutomu c/o Central Research Lab. , Nakabayashi, Satoru c/o Central Research Lab. , Fukuyasu, Harumi c/o Central Research Lab. , Ishii, Yuuko c/o Central Research Lab. , Tsuruoka, Takashi c/o Central Research Lab. , Yamamoto, Haruo c/o Central Research Lab. , Inouye, Shigeharu c/o Central Research Lab. , Kondo, Shinichi c/o Central Research Lab.
IPC分类号： A61K31/445 , C07D211/76
CPC分类号： A61K31/445 , C07D211/76
摘要： Sugar lactams of formula (I) such as N-(3-phenylpropyl)-1-deoxynojirimycin, 1-deoxynojirimycin, D-glucaro-δ-lactam, 6-O-triphenylmethyl-D-gluco-δ-lactam, etc. markedly inhibit metastasis of cancer cells. Sugar lactam derivatives of formula (I') are novel compounds.
摘要翻译：式（I）的糖内酰胺如N-（3-苯基丙基）-1-脱氧野尻霉素，1-脱氧野尻霉素，D-葡聚糖-δ-内酰胺，6-O-三苯基甲基-D-葡萄糖-δ-内酰胺等抑制癌细胞转移。式（Ⅰmin）的内酰胺衍生物是新化合物。

99. 发明公开

EP0196375A1 Gene coding for signal peptides and utilization thereof 失效
标题翻译： Fond Signalpeptide kodierendes Gen und Verwendung desselben。
公开(公告)号：EP0196375A1
公开(公告)日：1986-10-08
申请号：EP85302177.2
申请日：1985-03-28
申请人： MEIJI SEIKA KABUSHIKI KAISHA
发明人： Hoshiko, Shigeru , Makabe, Osamu , Fukatsu, Shunzo , Nagaoka, Kozo
IPC分类号： C12N15/00
CPC分类号： C12N9/2417 , C07K2319/00 , C07K2319/02 , C12N15/76 , Y10S930/30
摘要： A DNA strand of a gene coding for a signal peptide to be used in the host-vector system employing a bacterium belonging to the genus Streptomyces as a host by incorporation in the vector DNA, which comprises a DNA having a base sequence coding for the peptide having the amino acid sequence from X to Y in the annexed Fig. 1, is disclosed.
A vector plasmid to be used for transformation of bacteria belonging to the genus Streptomyces, comprising a DNA strand with a base sequence coding for an extra-cellular a-amylase derived from Streptomyces hygroscopicus SF-1084 strain or a mutant thereof, the DNA strand being incorporated in a vector plasmid to be used in the host-vector system employing a bacterium belonging to the genus Streptomyces as a host and also having a DNA necessary for expression of the gene information of the DNA strand, the DNA being introduced in the vector plasmid is also disclosed.
The present invention may be applied to the production of a desired protein which will be secreted outside the host microorganism.
摘要翻译：编码用于宿主 - 载体系统中的信号肽的基因的DNA链，其使用通过掺入载体DNA中的属于链霉菌属的细菌作为宿主，其包含具有编码肽的碱基序列的DNA 在附图中具有X至Y的氨基酸序列。 1，被公开。 ...用于转化属于链霉菌属的细菌的载体质粒，其包含编码源自吸水链霉菌SF-1084菌株的细胞外α-淀粉酶的碱基序列的DNA链或其突变体，将DNA链整合到载体质粒中，用于使用属于链霉菌属的细菌的宿主 - 载体系统作为宿主，并且还具有表达DNA链的基因信息所必需的DNA，DNA为引入载体质粒也被公开。 ...本发明可以应用于生产将被分泌到宿主微生物外部的所需蛋白质。

100. 发明公开

EP0173327A2 Bialaphos producing gene 失效
标题翻译： Bialaphos产品
公开(公告)号：EP0173327A2
公开(公告)日：1986-03-05
申请号：EP85110856.3
申请日：1985-08-28
申请人： MEIJI SEIKA KABUSHIKI KAISHA
发明人： Murakami, Takeshi , Imai, Satoshi , Anzai, Hiroyuki , Satoh, Atsuyuki , Nagaoka, Kozo
IPC分类号： C12N15/31 , C12N1/21 , C12P21/00
CPC分类号： C12P21/02 , C12N15/52 , C12P13/02
摘要： Disclosed are DNA strands comprising genes coding for the steps of biosynthesis of Bialaphos which is an antibiotic produced by Streptomyces hygroscopicus SF 1293, FERM BP-130/ATCC 21705, and is a fungicide/herbicide. A typical example of the DNA strands is in a hybrid plasmid pMSB 13-3 having a molecular weight of 41 kb and a restriction endonuclease cleavage site shown in Fig. 3.
摘要翻译：公开了包含编码双糖双磷酸生物合成步骤的基因的DNA链，其是由吸水链霉菌SF1293，FERM BP-130 / ATCC 21705产生的抗生素，并且是杀真菌剂/除草剂。 DNA链的典型实例是在分子量为41kb和限制性内切核酸酶切割位点的杂交质粒pMSB 13-3中，如图1所示。 3。

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