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91. 发明申请

US20040164840A1 Extraordinary hall effect sensors and arrays 审中-公开
标题翻译：非凡的霍尔效应传感器和阵列
公开(公告)号：US20040164840A1
公开(公告)日：2004-08-26
申请号：US10371321
申请日：2003-02-21
申请人： Brown University Research Foundation
发明人： Gang Xiao , Guo-Xing Miao
IPC分类号： B32B009/00
CPC分类号： G11C11/14 , G01R33/0094 , G01R33/07 , G11B5/372 , G11B5/49 , H01L43/06 , Y10T428/115 , Y10T428/1171
摘要： An EHE magnetic sensor has an alloy of the form RynullMxN100nullxnull100nully, M being Fe, Co, Ni, or magnetic alloys that contain Fe, Co or Ni. N is from the fifth or sixth period of the periodic table. If present, R is a rare earth element. In one embodiment, the alloy exhibits a Temperature Coefficient null0.003 Knull1 in the room temperature region. Various geometric shapes of sensors are presented including one and two-dimensional arrays of sensors for measuring spatial magnetic fields. Vias (98, 100, 102, 104) defined by a substrate (92) onto which an alloy layer (106) is disposed are filled with a conductive material in certain embodiments of arrays. Methods are disclosed for making a sensor, for designing a sensor at a thickness, for determining maximum acceptable current through a sensor, for reducing Joule heating of a sensor, and for making an array of sensors.
摘要翻译： EHE磁传感器具有Ry [MxN100-x] 100-y，M为Fe，Co，Ni或含有Fe，Co或Ni的磁性合金的合金。 N是周期表的第五或第六周期。如果存在，R是稀土元素。在一个实施方案中，合金在室温区域中显示温度系数<= 0.003K -1。提出了传感器的各种几何形状，包括用于测量空间磁场的一维和二维传感器阵列。在阵列的某些实施例中，由布置有合金层（106）的基板（92）限定的通孔（98,100,102,104）填充有导电材料。公开了用于制造传感器的方法，用于设计厚度的传感器，用于确定通过传感器的最大可接受电流，以减少传感器的焦耳加热，以及用于制造传感器阵列。

92. 发明申请

US20040067978A1 Methods of treating disorders with Group I mGluR antagonists 失效
标题翻译：用I组mGluR拮抗剂治疗疾病的方法
公开(公告)号：US20040067978A1
公开(公告)日：2004-04-08
申请号：US10408771
申请日：2003-04-04
申请人： Brown University Research Foundation (BURF) , Emory University
发明人： Mark F. Bear , Kimberly M. Huber , Stephen T. Warren
IPC分类号： A61K031/47 , A61K031/44
CPC分类号： A61K31/195 , A61K31/00 , A61K31/198 , A61K31/44 , A61K31/472 , A61K31/4725
摘要： mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be used to treat epilepsy and anxiety in a human having Fragile X syndrome, autism, mental retardation, schizophrenia and Down's Syndrome.
摘要翻译： mGluR5拮抗剂用于治疗和预防疾病，包括脆性X，孤独症，精神发育迟滞，精神分裂症和唐氏综合征。本发明的方法可用于治疗具有脆性X综合征，自闭症，精神发育迟滞，精神分裂症和唐氏综合征的人中的癫痫和焦虑。

93. 发明申请

US20040038818A1 Non-metal aerogel materials and detectors, liquid and gas absorbing objects, and optical devices comprising same 失效
标题翻译：非金属气凝胶材料和检测器，液体和气体吸收物体，以及包括其的光学装置
公开(公告)号：US20040038818A1
公开(公告)日：2004-02-26
申请号：US10424033
申请日：2003-04-25
申请人： Brown University Research Foundation
发明人： William M. Risen JR. , Shuang Ji , Xiangjun Hu , Ruiyun Zhang
IPC分类号： B01J020/10
CPC分类号： C08J3/11 , B01D53/02 , B01D2253/106 , B01D2253/202 , B01J20/103 , B01J20/24 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28042 , B01J20/28047 , B01J20/3204 , B01J20/3268 , B01J21/08 , B01J23/10 , B01J23/40 , B01J23/44 , B01J23/462 , B01J23/464 , B01J23/75 , B01J35/1023 , B01J37/036 , B01J2220/46 , B01J2220/4825 , B41M5/52 , B41M5/5218 , B41M5/5236 , B41M5/5245 , B41M5/529 , C08J2305/00 , D21H19/40 , D21H19/44 , Y02P20/544 , Y10T428/249954
摘要： New aerogels are disclosed which comprise silica and at least one organic polymer having polar functional groups. Also disclosed are methods for making such aerogels and for making them as substantially transparent objects. In addition, gas detectors, liquid and gas absorbing objects, and optical devices made using these aerogels are disclosed. The present invention concerns optical elements which are substantially transparent and exhibit low refractive indices. The invention further relates to detectors of reactive and absorbate gases based on the physical changes exhibited by the aerogels upon reacting with or absorbing such gases. The present invention further concerns printable objects comprising these aerogels, specifically when the print media are imaged by the absorption of liquid and the spatial localization of pigments or dyes. The invention further concerns reactive gas absorbers comprising these aerogels and the catalytic function the aerogels serve to catalyze subsequent chemical reaction. Furthermore, the present invention concerns the absorption of chemical compounds from condensed states including liquid, critical and supercritical fluids.
摘要翻译：公开了包含二氧化硅和至少一种具有极性官能团的有机聚合物的新型气凝胶。还公开了制造这种气凝胶并使其形成为基本上透明的物体的方法。此外，公开了使用这些气凝胶制造的气体检测器，液体和气体吸收物体以及光学装置。本发明涉及基本透明且具有低折射率的光学元件。本发明还涉及基于气凝胶在与这些气体反应或吸收时所表现的物理变化的反应性和吸收气体的检测器。本发明进一步涉及包括这些气凝胶的可印刷物体，特别是当通过吸收液体和颜料或染料的空间定位对印刷介质进行成像时。本发明还涉及包含这些气凝胶的反应性气体吸收剂和气凝胶用于催化随后的化学反应的催化功能。此外，本发明涉及从包括液体，临界和超临界流体在内的冷凝状态吸收化学化合物。

94. 发明申请

US20030104068A1 Micronized freeze-dried particles 审中-公开
公开(公告)号：US20030104068A1
公开(公告)日：2003-06-05
申请号：US10135466
申请日：2002-04-30
申请人： Brown University Research Foundation
发明人： Edith Mathiowitz , Yong S. Jong , Jules S. Jacob
IPC分类号： A61K009/16 , A61K009/50
CPC分类号： A61K9/5153 , A61K9/1641 , A61K9/1647 , A61K9/1694 , A61K9/5192
摘要： A process is provided for making dry, micronized particles of an agent, such as a drug. The method includes (a) dissolving a macromolecular material, preferably a polymer, in an effective amount of a solvent, to form a solution; (b) dissolving or dispersing the agent in the solution to form a mixture; (c) freezing the mixture; and (d) drying by vacuum the mixture to form solid particles of the agent dispersed in solid macromolecular material. The micronization in this process occurs directly in a macromolecular matrix and hardening of the particles of agent by solvent removal takes place by lyophilization of the bulk matrix, which stabilizes the drug particles during hardening and prevents coalesence, thereby resulting in smaller final drug particles. The method is particularly preferred for protein agents. The process can be used in conjunction with a standard microencapsulation technique, typically following separation of the agent from the macromolecular matrix. The process yields microparticles having a homogenous size distribution, preferably less than 2 nullm, and more preferably less than 1 nullm, in size. The microparticles have well defined, predictable properties, which is particularly critical in drug delivery applications.

95. 发明申请

US20040214238A1 Nociceptive neuron specific calcium channel isoform and uses thereof 审中-公开
标题翻译：伤害性神经元特异性钙通道同种型及其用途
公开(公告)号：US20040214238A1
公开(公告)日：2004-10-28
申请号：US10736883
申请日：2003-12-15
申请人： Brown University Research Foundation
发明人： Diane Lipscombe , Andrew J. Castiglioni , Thomas J. Bell , Christopher J. Thaler
IPC分类号： G01N033/53 , G01N033/567 , C12N005/08 , C07K014/705
CPC分类号： G01N33/6872 , C07K14/705 , C12N5/0619 , C12N2503/02 , C12N2510/00 , G01N2500/10
摘要： The invention pertains to N-type calcium channel isoforms containing exon 37a (Cav2.2enull37anull), which are specifically expressed in nociceptive neurons, and nucleic acids relating thereto. Also included are methods for identifying antagonists of Cav2.2enull37anull subunit activity that act by inhibiting the expression or function of the subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitor molecules in the treatment and/or diagnosis of disease, such as in methods for treating pain, particularly neuropathic pain.
摘要翻译：本发明涉及含有在伤害性神经元中特异性表达的外显子37a（Cav2.2e [37a]）的N型钙通道同种型和与之有关的核酸。还包括用于鉴定通过抑制亚单位的表达或功能起作用的Cav2.2e [37a]亚基活性的拮抗剂的方法。本发明还涉及在治疗和/或诊断疾病中使用此类核酸，多肽和抑制剂分子的方法，例如用于治疗疼痛的方法，特别是神经性疼痛。

96. 发明申请

US20030234781A1 Method, apparatus and computer program product for the interactive rendering of multivalued volume data with layered complementary values 有权
标题翻译：用于交互式渲染具有分层互补值的多值体数据的方法，装置和计算机程序产品
公开(公告)号：US20030234781A1
公开(公告)日：2003-12-25
申请号：US10431130
申请日：2003-05-06
申请人： Brown university Research Foundation
发明人： David H. Laidlaw , Andreas Wenger
IPC分类号： G06T015/00
CPC分类号： G06T15/08
摘要： Described is a system, method and computer program product for rendering volumetric multivalued primary data. The system includes a rendering engine having an input coupled to a source of multivalued primary data and an output coupled to a display. The rendering engine includes a data processor for calculating additional data values from the primary data, deriving at least one visual representation from the primary data and the additional data values, and mapping the derived visual representation through transfer functions to hardware primitives for volumetrically rendering the derived visual representation to provide a visualization. The system further includes a user interface for interacting with the visualization. The source of primary data can be a magnetic resonance imaging system, and the primary data may be a multivalued combination obtained from T1 weighted data, T2 weighted data, diffusion data, velocity data, magnetization transfer data, perfusion data, data derived from other imaging modalities (e.g., PET), and simulation data. The primary data can be diffusion tensor data generated by the MRI system from tissue, and the data processor operates to identify directed diffusion paths and to render the directed diffusion paths as thread-like structures. Indications of at least flowing blood velocity and vorticity can also be rendered from MRI data or from simulations.
摘要翻译：描述了一种用于渲染体积多值主数据的系统，方法和计算机程序产品。该系统包括渲染引擎，其具有耦合到多值主数据源的输入和耦合到显示器的输出。呈现引擎包括用于从主数据计算附加数据值的数据处理器，从主数据和附加数据值导出至少一个视觉表示，并且通过传递函数将导出的视觉表示映射到硬件基元，用于体积地渲染所导出的视觉表示来提供可视化。系统还包括用于与可视化进行交互的用户界面。主要数据源可以是磁共振成像系统，主要数据可以是从T1加权数据，T2加权数据，扩散数据，速度数据，磁化传递数据，灌注数据，从其他成像得到的数据获得的多值组合模式（例如PET）和模拟数据。主要数据可以是由MRI系统从组织产生的扩散张量数据，并且数据处理器操作以识别定向扩散路径并将定向扩散路径呈现为线状结构。至少流动的血液速度和涡度的指示也可以从MRI数据或模拟中得到。

97. 发明申请

US20020054295A1 Optical method for the determination of grain orientation in films 有权
标题翻译：用于测定薄膜晶粒取向的光学方法
公开(公告)号：US20020054295A1
公开(公告)日：2002-05-09
申请号：US10012985
申请日：2001-11-05
申请人： Brown University Research Foundation
发明人： Humphrey J. Maris
IPC分类号： G01B011/02
CPC分类号： G01N21/8422 , H01L22/12
摘要： A method for the determination of grain orientation in a film sample is provided comprising the steps of measuring a first transient optical response of the film and determining the contribution to the transient optical response arising from a change in the energy distribution of the electrons in the sample, determining the contribution to the transient optical response arising from a propagating strain pulse within the sample, and determining the contribution to the transient optical response arising from a change in sample temperature of the sample. The grain orientation of the sample may be determined using the contributions to the transient optical response arising from the change in the energy distribution of the electrons, the propagating strain pulse, and the change in sample temperature. Additionally, a method for determination of the thickness of a film sample is provided. The grain orientation of the sample is first determined. The grain orientation, together with the velocity of sound and a propagation time of a strain pulse through the sample are then used to determine the thickness of the film sample.
摘要翻译：提供了一种用于确定膜样品中的晶粒取向的方法，包括以下步骤：测量薄膜的第一瞬态光学响应并确定由于样品中的电子的能量分布的变化引起的瞬态光学响应的贡献确定对由样品内的传播应变脉冲引起的瞬态光学响应的贡献，以及确定由于样品的样品温度变化引起的瞬态光学响应的贡献。可以使用由电子的能量分布的变化，传播的应变脉冲和样品温度的变化引起的瞬态光学响应的贡献来确定样品的晶粒取向。另外，提供了用于确定膜样品的厚度的方法。首先确定样品的晶粒取向。然后使用晶粒取向以及通过样品的应变脉冲的声速和传播时间来确定膜样品的厚度。

98. 发明申请

US20150108423A1 APPARATUS, METHOD AND COMPUTER PROGRAM PRODUCT PROVIDING RADIAL ADDRESSING OF NANOWIRES 有权
标题翻译：装置，方法和计算机程序产品提供纳米级的径向寻址
公开(公告)号：US20150108423A1
公开(公告)日：2015-04-23
申请号：US14520524
申请日：2014-10-22
申请人： Brown University Research Foundation
发明人： Andre Dehon , Charles M. Lieber , John E. Savage , Eric Rachlin
IPC分类号： H01L29/06 , H01L27/28 , H01L51/10 , H01L27/10
CPC分类号： H01L29/0669 , B82Y10/00 , H01L27/10 , H01L27/28 , H01L29/0673 , H01L51/10
摘要： Disclosed is a method to construct a device that includes a plurality of nanowires (NWs) each having a core and at least one shell. The method includes providing a plurality of radially encoded NWs where each shell contains one of a plurality of different shell materials; and differentiating individual ones of the NWs from one another by selectively removing or not removing shell material within areas to be electrically coupled to individual ones of a plurality of mesowires (MWs). Also disclosed is a nanowire array that contains radially encoded NWs, and a computer program product useful in forming a nanowire array.
摘要翻译：公开了一种构建包括多个纳米线（NW）的装置的方法，每个纳米线具有芯部和至少一个壳体。该方法包括提供多个径向编码的NW，其中每个壳包含多个不同的壳材料之一; 并且通过选择性地去除或不去除要电耦合到多个介质（MW）中的各个的区域的区域内的壳体材料来区分NW中的各个。还公开了包含径向编码的NW的纳米线阵列和用于形成纳米线阵列的计算机程序产品。

99. 发明申请

US20040166168A1 Methods for micronization of hydrophobic drugs 失效
公开(公告)号：US20040166168A1
公开(公告)日：2004-08-26
申请号：US10758990
申请日：2004-01-16
申请人： Brown University Research Foundation
发明人： Edith Mathiowitz , Christopher Thanos , Zhi Liu
IPC分类号： A61K009/16 , A61K009/50
CPC分类号： A61K9/5138 , A61K9/14 , A61K9/146 , A61K9/1688 , A61K9/1694 , A61K9/5146 , A61K9/5192 , B01D9/00 , B01J13/06 , Y10T428/2982 , Y10T428/2985 , Y10T428/2989 , Y10T428/31685 , Y10T428/31696
摘要： The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.

100. 发明申请

US20040073414A1 Method and system for inferring hand motion from multi-cell recordings in the motor cortex using a kalman filter or a bayesian model 审中-公开
标题翻译：使用卡尔曼滤波器或贝叶斯模型从运动皮质中的多细胞记录推断手运动的方法和系统
公开(公告)号：US20040073414A1
公开(公告)日：2004-04-15
申请号：US10455509
申请日：2003-06-04
申请人： Brown University Research Foundation
发明人： Lucien J.E. Bienenstock , Michael J. Black , Wei Wu , Yun Gao
IPC分类号： G06F017/10
CPC分类号： G06F3/015
摘要： A method and system to decode neural activity in the motor cortex to infer at least the position and velocity of a subject's hand from neural spiking activity of some number of nerve cells. In one embodiment the method includes simultaneously recording electrical activity of the nerve cells in the primary motor cortex to obtain neural data; and modeling the encoding and decoding of the neural data using a Kalman filter, where a measurement model assumes a cell firing rate to be a stochastic linear function of at least the position and velocity of the hand, and where the measurement model is learned from training data in conjunction with a system model that encodes a manner in which the hand moves. In another embodiment the method includes using the neural data to generate training data of neural firing activity conditioned on hand kinematics; learning a non-parametric representation of the firing activity using a Bayesian model; inferring an a posterior probability distribution over hand motion, conditioned on the neural training data using Bayesian inference; defining a non-Gaussian likelihood term that is combined with a prior probability for the kinematics based on learned firing models of multiple nerve cells; and using a particle filtering method is to represent, update, and propagate the posterior distribution over time.
摘要翻译：一种解决运动皮层神经活动的方法和系统，至少推断受试者的手从一些神经细胞的神经刺激活动的位置和速度。在一个实施方案中，该方法包括同时记录神经细胞在主运动皮层中的电活动以获得神经数据; 并且使用卡尔曼滤波器对神经数据的编码和解码进行建模，其中测量模型假定小区发射速率至少是手的位置和速度的随机线性函数，并且其中从训练中学习测量模型数据结合编码手移动方式的系统模型。在另一个实施例中，该方法包括使用神经数据来产生以手运动学为条件的神经发射活动的训练数据; 使用贝叶斯模型学习射击活动的非参数表示; 推导使用贝叶斯推理的神经训练数据的手部运动后验概率分布; 基于多个神经细胞的学习的发射模型定义与运动学的先验概率相结合的非高斯似然项; 并且使用粒子滤波方法是表示，更新和传播随时间的后验分布。

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