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1. 发明授权

US06811786B1 Methods for reducing cholesterol using Bacillus coagulans spores, systems and compositions 有权
标题翻译：使用凝结芽孢杆菌孢子，系统和组合物降低胆固醇的方法
公开(公告)号：US06811786B1
公开(公告)日：2004-11-02
申请号：US09647695
申请日：2001-04-06
申请人： Sean Farmer , Andrew R. Lefkowitz
发明人： Sean Farmer , Andrew R. Lefkowitz
IPC分类号： A61K3907
CPC分类号： A61K35/742 , A23L29/244 , A23L29/35 , A23L33/10 , A23L33/135 , A23V2002/00 , A61K31/366 , A61K31/395 , A61K31/445 , A61K31/555 , A61K31/60 , A61K33/00 , A61K33/06 , A61K33/18 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K35/74 , A61K36/68 , A61K45/06 , C12N1/20 , A61K2300/00 , A23V2200/3202 , A23V2200/3204 , A23V2200/3262 , A23V2250/28
摘要： The invention describes therapeutic compositions including a lactic acid-producing bacteria, such as isolated Bacillus coagulans, in combination with a bifidogenic oligosaccharides or other cholesterol-reducing agents for use in reducing LDL cholesterol and serum triglycerides. Also described are therapeutic methods using the compositions and systems containing the therapeutic compositions.
摘要翻译：本发明描述了治疗组合物，其包括产生乳酸的细菌，例如分离的凝结芽孢杆菌，与用于降低LDL胆固醇和血清甘油三酸酯的双歧寡糖或其它降胆固醇的组合。还描述了使用含有治疗组合物的组合物和系统的治疗方法。

2. 发明授权

US06506389B2 ADHERENCE FACTORS OF NON PATHOGENIC MICROORGANISMS AND APPLICATIONS THEREOF FOR SCREENING MICROORGANISMS FOR SPECIFIC PROBIOTIC PROPERTIES; NOVEL PHARMACEUTICAL COMPOSITIONS AND FOOD ADDITIVES COMPRISING SUCH MICROORGANISMS AND ADHERENCE FACTORS 失效
标题翻译：非致病微生物的辅助因子及其筛选特异性生物特性微生物的应用; 新型药物组合物和包含这些微生物和干扰因子的食品添加剂
公开(公告)号：US06506389B2
公开(公告)日：2003-01-14
申请号：US09051755
申请日：1998-09-30
申请人： Robert Jan Leer , Pieter Hendrik Pouwels , Patricia Lynne Conway
发明人： Robert Jan Leer , Pieter Hendrik Pouwels , Patricia Lynne Conway
IPC分类号： A61K3907
CPC分类号： C07K14/335 , A61K38/00 , Y02A50/47
摘要： A protein obtainable from a non pathgenic microorgansim, said protein having mucosa binding promoting activity and a molecular weight of 20-40 kD is disclosed. Application of such a protein or a peptide derived therefrom in a method of screening non pathogenic microorganisms for a microorganism capable of specifically binding mucosa, said method comprising detection in a manner known per se of the presence of a particular protein on or in a microorganism or in a culture of microorganisms, said particular protein being the already defined protein. Kits suitable for such a screening method are also disclosed. Use of a component selected from the group of components comprising a protein or peptide as defined; an expression vector comprising nucleic acid encoding such protein or peptide; a recombinant microorganism or a part of said microorganism expressing such protein or peptide, said part expressing mucosa binding promoting activity; a non pathogenic microorganism capable of expressing such protein or peptide or a part of said microorganism, said part expressing mucosa binding promoting activity as pharmaceutically active component in a pharmaceutical composition for prophylaxis and/or treatment of disease or illness associated with a mucosa colonizing pathogenic microorganism. Use of such components as food additive and compositions comprising such components are described.
摘要翻译：可从非致病微生物获得的蛋白质，所述蛋白质具有粘膜结合促进活性和20-40kD的分子量。将这种蛋白质或其衍生的肽应用于筛选非特异性结合粘膜的微生物的非病原微生物的方法中，所述方法包括以本身已知的方式检测特定蛋白质在微生物上或微生物中的存在，或在微生物培养物中，所述特定蛋白质是已经定义的蛋白质。还公开了适用于这种筛选方法的试剂盒。使用选自包含定义的蛋白质或肽的组分组的组分; 包含编码这种蛋白质或肽的核酸的表达载体; 表达所述蛋白质或肽的重组微生物或所述微生物的一部分，所述部分表达粘膜结合促进活性; 能够表达这种蛋白质或肽或一部分所述微生物的非致病微生物，所述部分表达作为药物活性成分的粘膜结合促进活性，用于预防和/或治疗与粘膜定植病原微生物相关的疾病或疾病的药物组合物。描述了使用这些组分作为食品添加剂和包含这些组分的组合物。

3. 发明授权

US06752992B2 Toxins active against pests 有权
标题翻译：毒性有毒物
公开(公告)号：US06752992B2
公开(公告)日：2004-06-22
申请号：US10099285
申请日：2002-03-15
申请人： H. Ernest Schnepf , Carol Wicker , Kenneth E. Narva , Michele Walz , Brian A. Stockhoff , Judy Muller-Cohn
发明人： H. Ernest Schnepf , Carol Wicker , Kenneth E. Narva , Michele Walz , Brian A. Stockhoff , Judy Muller-Cohn
IPC分类号： A61K3907
CPC分类号： C12N15/8286 , C07K14/325 , C07K2319/00 , C12N2799/026 , Y02A40/162
摘要： The subject invention concerns materials and methods useful in the control of non-mammalian pests and, particularly, plant pests. In a specific embodiment, the subject invention provides new Bacillus thuringiensis toxins useful for the control of lepidopterans. The subject invention further provides nucleotide sequences which encode the toxins of the subject invention. The nucleotide sequences of the subject invention can be used to transform hosts, such as plants, to express the pesticidal toxins of the subject invention. The subject invention further concerns novel nucleotide primers for the identification of genes encoding toxins active against pests. The primers are useful in PCR techniques to produce gene fragments which are characteristic of genes encoding these toxins. The primers are also useful as nucleotide probes to detect the toxin-encoding genes.
摘要翻译：本发明涉及可用于控制非哺乳动物害虫，特别是植物害虫的材料和方法。在具体实施方案中，本发明提供了可用于控制鳞翅目昆虫的新的苏云金芽孢杆菌毒素。本发明进一步提供编码本发明毒素的核苷酸序列。本发明的核苷酸序列可用于转化宿主如植物，以表达本发明的杀虫毒素。本发明还涉及用于鉴定编码针对害虫的毒素的基因的新型核苷酸引物。引物可用于PCR技术以产生编码这些毒素的基因特征的基因片段。引物也可用作检测毒素编码基因的核苷酸探针。

4. 发明授权

US06592872B1 Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein 失效
标题翻译：将抗原用炭疽毒素融合蛋白靶向MHC I类加工途径
公开(公告)号：US06592872B1
公开(公告)日：2003-07-15
申请号：US08937276
申请日：1997-09-15
申请人： Kurt Klimpel , Theresa J. Goletz , Naveen Arora , Stephen H. Leppla , Jay A. Berzofsky
发明人： Kurt Klimpel , Theresa J. Goletz , Naveen Arora , Stephen H. Leppla , Jay A. Berzofsky
IPC分类号： A61K3907
CPC分类号： C07K14/005 , A61K39/00 , C07K14/32 , C07K2319/00 , C12N2740/16122 , Y02A50/412 , Y02A50/423 , Y10S514/885 , Y10S530/806 , Y10S530/825
摘要： The present invention provides a vaccine for inducing an immune response in mammal to a specific antigen, where the vaccine comprises a unit dose of a binary, cytotoxic T lymphocyte vaccine comprising an anthrax protective antigen and a full length protein antigen bound to a nontoxic anthrax protective antigen binding protein comprising at least about the first 250 amino acid residues of the lethal factor of Bacillus anthracis and less than all of the amino acid residues of the lethal factor. The present invention also provides a method of immunizing a mammal against an antigen using the vaccine, and a method of inducing antigen-presenting mammalian cells to present specific antigens via the MHC class I processing pathway.
摘要翻译：本发明提供了用于在哺乳动物中诱导特异性抗原的免疫应答的疫苗，其中疫苗包含单位剂量的二元细胞毒性T淋巴细胞疫苗，其包含炭疽保护性抗原和与无毒性炭疽保护性结合的全长蛋白质抗原抗原结合蛋白，其包含至少约大约碳芽孢杆菌致死因子的250个氨基酸残基并且小于致死因子的全部氨基酸残基。本发明还提供了使用该疫苗免疫哺乳动物抗原的方法，以及通过MHC I类加工途径诱导抗原呈递哺乳动物细胞呈递特异性抗原的方法。

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