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1. 发明申请

US20050117708A1 Method and system for calibrating a source and detector instrument 有权
标题翻译：用于校准源和检测仪器的方法和系统
公开(公告)号：US20050117708A1
公开(公告)日：2005-06-02
申请号：US10915015
申请日：2004-08-09
申请人： Young-bin Cho , Douglas Moseley , Jeffrey Siewerdsen , David Jaffray
发明人： Young-bin Cho , Douglas Moseley , Jeffrey Siewerdsen , David Jaffray
IPC分类号： A61B6/00 , A61N5/10 , G21K1/00 , H05G1/28
CPC分类号： A61B6/583 , A61B6/027 , A61B6/4071 , A61B6/547 , A61B6/584 , A61B6/585 , A61B6/587 , A61N5/1049 , A61N2005/1061
摘要： A system for obtaining coordinate data of a source and detector instrument are described. The system includes a marker assembly having a plurality of markers with a particular geometry, and an energy source for targeting the plurality of markers with energy packets. The system further includes a detector for detecting energy packets after the plurality of markers have interacted therewith, and an image device for forming image data of the plurality of markers from the energy packets detected by the detector. A calibration module for utilizes the particular geometry of the plurality of markers and the image data to non-iteratively determine coordinate data.
摘要翻译：描述用于获取源和检测器仪器的坐标数据的系统。该系统包括具有特定几何形状的多个标记的标记组件，以及用能量包对准多个标记的能量源。该系统还包括一个检测器，用于在多个标记与之相互作用之后检测能量包;以及图像装置，用于根据由检测器检测到的能量包形成多个标记的图像数据。用于利用多个标记的特定几何和图像数据的校准模块来非迭代地确定坐标数据。

2. 发明申请

US20070025496A1 Computed Tomography Scanning 有权
标题翻译：计算机断层扫描
公开(公告)号：US20070025496A1
公开(公告)日：2007-02-01
申请号：US11531471
申请日：2006-09-13
申请人： Kevin Brown , David Jaffray , Jeffrey Siewerdsen , Marcel van Herk , Jan-Jakob Sonke
发明人： Kevin Brown , David Jaffray , Jeffrey Siewerdsen , Marcel van Herk , Jan-Jakob Sonke
IPC分类号： A61B6/00 , G01N23/00 , G21K1/12 , H05G1/60
CPC分类号： G06T5/009 , A61N5/1064 , G06T5/003 , G06T7/0016 , G06T7/20 , G06T11/005 , G06T2207/10081 , G06T2207/20068 , G06T2207/20192 , G06T2207/30061 , G06T2207/30096 , G06T2211/412
摘要： Artifacts in the reconstructed volume data of cone beam CT systems can be removed by the application of respiration correlation techniques to the acquired projection images. To achieve this, the phase of the patients breathing is monitored while acquiring projection images continuously. On completion of the acquisition, projection images that have comparable breathing phases can be selected from the complete set, and these are used to reconstruct the volume data using similar techniques to those of conventional CT. Any phase can be selected and therefore the effect of breathing can be studied. It is also possible to use a feature in the projection images such as the patient's diaphragm to determine the breathing phase. This feature in the projection images can be used to control delivery of therapeutic radiation dependent on the patient's breathing cycle, to ensure that the tumor is in the correct position when the radiation is delivered.
摘要翻译：通过对所获取的投影图像应用呼吸相关技术，可以去除锥束CT系统的重建体数据中的伪像。为了实现这一点，在持续拍摄投影图像的同时监测患者呼吸的阶段。完成采集后，可以从完整组中选择具有相似呼吸相位的投影图像，并使用与常规CT类似的技术来重建体积数据。可以选择任何相位，因此可以研究呼吸的效果。也可以使用诸如患者隔膜的投影图像中的特征来确定呼吸阶段。投影图像中的该特征可以用于控制取决于患者呼吸周期的治疗辐射的传递，以确保当辐射被递送时肿瘤处于正确的位置。

3. 发明授权

US08039790B2 Phantoms and methods for verification in radiotherapy systems 有权
标题翻译：放射治疗系统中的尸体和验证方法
公开(公告)号：US08039790B2
公开(公告)日：2011-10-18
申请号：US12780460
申请日：2010-05-14
申请人： Young-Bin Cho , Mohammad Islam , Monique van Prooijen , David Jaffray , Mark Taylor
发明人： Young-Bin Cho , Mohammad Islam , Monique van Prooijen , David Jaffray , Mark Taylor
IPC分类号： G01D18/00
CPC分类号： G01D1/00 , A61N5/1071 , A61N2005/1076 , G01D15/00
摘要： Methods and phantoms for verification in radiotherapy systems. A phantom for verification in a radiotherapy system may include a body to support a detector surface for obtaining a panoramic image of individual radiation beams in the radiotherapy system. The detector surface may be positioned in an intermediate region between the one or more sources and a target isocenter of the radiotherapy system. The detector surface may at least partially surround the target isocenter.
摘要翻译：放射治疗系统验证的方法和模型。在放射治疗系统中用于验证的体模可以包括支撑检测器表面的主体，用于获得放射治疗系统中的各个辐射束的全景图像。检测器表面可以位于一个或多个源之间的中间区域和放射治疗系统的目标等中心点之间。检测器表面可以至少部分地围绕目标等角点。

4. 发明授权

US09138597B2 Quantitative endoscopy 有权
标题翻译：定量内窥镜检查
公开(公告)号：US09138597B2
公开(公告)日：2015-09-22
申请号：US13320375
申请日：2010-05-13
申请人： Robert Weersink , Andrew Hope , Jeff Siewerdsen , David Jaffray , Aidin Kashigar , Michael Daly , Jonathon Eubank , John Cho
发明人： Robert Weersink , Andrew Hope , Jeff Siewerdsen , David Jaffray , Aidin Kashigar , Michael Daly , Jonathon Eubank , John Cho
IPC分类号： G06K9/00 , A61N5/10 , G06T7/00 , G06F19/00
CPC分类号： A61N5/103 , A61N5/1039 , G06F19/00 , G06F19/321 , G06T7/344 , G06T2207/10068 , G06T2207/30004
摘要： A method, computer program product and processor for quantitatively registering a 2D endoscopic ROI in a 3D volumetric imaging dataset. An endoscopic dataset and a volumetric imaging are registered to a common coordinate system. A 2D endoscopic ROI is generated within the endoscopic imaging dataset. A 3D surface ROI is generated within the volumetric imaging dataset corresponding to the 2D endoscopic ROI, based on a projection of the 2D endoscopic ROI to the registered common coordinate system.
摘要翻译：一种用于在3D体积成像数据集中定量注册2D内窥镜ROI的方法，计算机程序产品和处理器。将内窥镜数据集和体积成像记录到公共坐标系。在内窥镜成像数据集内产生2D内窥镜ROI。基于2D内窥镜ROI对所登记的共同坐标系的投影，在对应于2D内窥镜ROI的体积成像数据集内生成3D表面ROI。

5. 发明授权

US07399977B2 Apparatus and method for determining radiation dose 有权
标题翻译：用于确定辐射剂量的装置和方法
公开(公告)号：US07399977B2
公开(公告)日：2008-07-15
申请号：US11187810
申请日：2005-07-25
申请人： Alexandra Rink , David Jaffray , I. Alex Vitkin
发明人： Alexandra Rink , David Jaffray , I. Alex Vitkin
IPC分类号： G01T1/02
CPC分类号： G01T1/04 , G01T1/161
摘要： A radiation dosimeter system and method for estimating a deposited radiation dose to an object involves locating at least one radiation dosimeter at the object. The radiation dosimeter includes a radiation sensitive medium having an optical property that changes due to the deposited radiation dose. An optical interrogation signal is provided to the radiation dosimeter via an enclosed optical path for interacting with the radiation sensitive medium. During irradiation, the optical interrogation signal is transformed into an optical information signal that encodes an ionizing radiation induced change in the optical property of the radiation sensitive medium. The radiation dosimeter system then processes the optical information signal for estimating the deposited radiation dose.
摘要翻译：用于估计对物体的放射辐射剂量的辐射剂量计系统和方法包括将至少一个辐射剂量计定位在物体处。辐射剂量计包括具有由于沉积的辐射剂量而改变的光学性质的辐射敏感介质。通过用于与辐射敏感介质相互作用的封闭光路，向辐射剂量计提供光学询问信号。在照射期间，光询问信号被转换成光信息信号，其编码电离辐射引起的辐射敏感介质的光学特性变化。然后，辐射剂量计系统处理用于估计沉积辐射剂量的光学信息信号。

6. 发明授权

US08554573B2 Interactive atlas to image registration 有权
标题翻译：互动地图集图像注册
公开(公告)号：US08554573B2
公开(公告)日：2013-10-08
申请号：US12670541
申请日：2008-07-11
申请人： Vladimir Pekar , Torbjoern Vik , Heinrich Schulz , David Jaffray
发明人： Vladimir Pekar , Torbjoern Vik , Heinrich Schulz , David Jaffray
IPC分类号： G06Q10/00
CPC分类号： G06Q50/22 , G06F19/00 , G06T7/12 , G06T7/149 , G06T7/33 , G06T19/00 , G06T2200/24 , G06T2207/20101 , G06T2207/30004 , G06T2210/41
摘要： When modeling anatomical structures in a patient for diagnosis or therapeutic planning, an atlas (26) of predesigned anatomical structure models can be accessed, and model of one or more such structures can be selected and overlaid on an a 3D image of corresponding structure(s) in a clinic image of a patient. A user can click and drag a cursor on the model to deform the model to align with the clinical image. Additionally, a processor (16) can generate a volumetric deformation function using splines, parametric techniques, or the like, and can deform the model to fit the image in real time, in response to user manipulation of the model.
摘要翻译：当对病人的解剖结构进行建模以进行诊断或治疗计划时，可以访问预先设计的解剖结构模型的图集（26），并且可以选择一个或多个这样的结构的模型并覆盖在对应结构的3D图像上）在患者的诊所图像中。用户可以单击并拖动模型上的光标，使模型变形以与临床图像对齐。另外，处理器（16）可以使用样条曲线，参数技术等来产生体积变形函数，并且可以响应于模型的用户操纵而实时变形模型以适合图像。

7. 发明申请

US20130105692A1 FIBER OPTIC RADIOCHROMIC DOSIMETER PROBE AND METHOD TO MAKE THE SAME 有权
标题翻译：光纤光学放射性计量器探头及其制作方法
公开(公告)号：US20130105692A1
公开(公告)日：2013-05-02
申请号：US13806342
申请日：2011-07-06
申请人： Alexandra Rink , David Jaffray , Ozzy Mermut , Serge Caron , André Croteau , François Roy-Moisan
发明人： Alexandra Rink , David Jaffray , Ozzy Mermut , Serge Caron , André Croteau , François Roy-Moisan
IPC分类号： G01T1/06
CPC分类号： G01T1/06 , G01T1/04 , G01T1/201 , Y10T29/49826
摘要： A fiber optic dosimeter probe for sensing radiation dose including an optical fiber having a free end and a sensitive end, a window having a sensitive side and a rear side; a radiation sensitive layer between the sensitive end of the optical fiber and a sensitive side of the window, the radiation sensitive layer being made of a material having an optical property that changes with absorbed radiation dose, an amount of the material corresponding to a predetermined sensitivity to radiation; wherein the window and the optical fiber have a near water equivalent interaction with radiation and are MR compatible.
摘要翻译：一种用于感测辐射剂量的光纤剂量计探针，包括具有自由端和敏感端的光纤，具有敏感侧和后侧的窗口; 在光纤的敏感端和窗口的敏感侧之间的辐射敏感层，辐射敏感层由具有随吸收辐射剂量变化的光学性质的材料制成，材料的量对应于预定灵敏度辐射; 其中窗口和光纤与辐射具有近水当量的相互作用并且是MR兼容的。

8. 发明授权

US09000401B2 Fiber optic radiochromic dosimeter probe and method to make the same 有权
标题翻译：光纤放射性染料剂量计探头和方法制作相同
公开(公告)号：US09000401B2
公开(公告)日：2015-04-07
申请号：US13806342
申请日：2011-07-06
申请人： Alexandra Rink , David Jaffray , Ozzy Mermut , Serge Caron , André Croteau , François Roy-Moisan
发明人： Alexandra Rink , David Jaffray , Ozzy Mermut , Serge Caron , André Croteau , François Roy-Moisan
IPC分类号： G01T1/06 , G01T1/20
CPC分类号： G01T1/06 , G01T1/04 , G01T1/201 , Y10T29/49826
摘要： A fiber optic dosimeter probe for sensing radiation dose including an optical fiber having a free end and a sensitive end, a window having a sensitive side and a rear side; a radiation sensitive layer between the sensitive end of the optical fiber and a sensitive side of the window, the radiation sensitive layer being made of a material having an optical property that changes with absorbed radiation dose, an amount of the material corresponding to a predetermined sensitivity to radiation; wherein the window and the optical fiber have a near water equivalent interaction with radiation and are MR compatible.
摘要翻译：一种用于感测辐射剂量的光纤剂量计探针，包括具有自由端和敏感端的光纤，具有敏感侧和后侧的窗口; 在光纤的敏感端和窗口的敏感侧之间的辐射敏感层，辐射敏感层由具有随吸收辐射剂量变化的光学性质的材料制成，材料的量对应于预定灵敏度辐射; 其中窗口和光纤与辐射具有近水当量的相互作用并且是MR兼容的。

9. 发明申请

US20120155731A1 QUANTITATIVE ENDOSCOPY 有权
标题翻译：定量内镜
公开(公告)号：US20120155731A1
公开(公告)日：2012-06-21
申请号：US13320375
申请日：2010-05-13
申请人： Robert Weersink , Andrew Hope , Jeff Siewerdsen , David Jaffray , Aidin Kashigar , Michael Daly , Jonathon Eubank , John Cho
发明人： Robert Weersink , Andrew Hope , Jeff Siewerdsen , David Jaffray , Aidin Kashigar , Michael Daly , Jonathon Eubank , John Cho
IPC分类号： G06K9/32
CPC分类号： A61N5/103 , A61N5/1039 , G06F19/00 , G06F19/321 , G06T7/344 , G06T2207/10068 , G06T2207/30004
摘要： A method, computer program product and processor for quantitatively registering a 2D endoscopic ROI in a 3D volumetric imaging dataset. An endoscopic dataset and a volumetric imaging are registered to a common coordinate system. A 2D endoscopic ROI is generated within the endoscopic imaging dataset. A 3D surface ROI is generated within the volumetric imaging dataset corresponding to the 2D endoscopic ROI, based on a projection of the 2D endoscopic ROI to the registered common coordinate system.
摘要翻译：一种用于在3D体积成像数据集中定量注册2D内窥镜ROI的方法，计算机程序产品和处理器。将内窥镜数据集和体积成像记录到公共坐标系。在内窥镜成像数据集内产生2D内窥镜ROI。基于2D内窥镜ROI对所登记的共同坐标系的投影，在对应于2D内窥镜ROI的体积成像数据集内生成3D表面ROI。

10. 发明申请

US20080206131A1 Compositions and Method for Multimodal Imaging 有权
标题翻译：多模式成像的组成和方法
公开(公告)号：US20080206131A1
公开(公告)日：2008-08-28
申请号：US11816054
申请日：2006-02-10
申请人： David Jaffray , Christine Allen , Jinzi Zheng , Raymond Matthew Reilly , Gregory Jason Perkins
发明人： David Jaffray , Christine Allen , Jinzi Zheng , Raymond Matthew Reilly , Gregory Jason Perkins
IPC分类号： A61K49/00 , A61K51/00
CPC分类号： A61K49/04 , A61B5/055 , A61B5/415 , A61B5/418 , A61B6/00 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61K9/127 , A61K9/1271 , A61K49/0002 , A61K49/0466 , A61K49/1812 , A61K51/1234
摘要： Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.
摘要翻译：提供了用于医学成像的信号调节组合物，其包含载体和两种或更多种对两种或多种成像模态特异的信号调节剂。组合物的特征在于相对于信号调节剂的保留效率，其使得能够延长对比度成像，而信号调节剂不会从载体中显着消耗。本发明的载体是基于脂质或基于聚合物的，其物理化学性质可以被修饰以捕获或螯合不同的信号调节剂及其混合物，并靶向哺乳动物内的特定器官或肿瘤或组织。

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