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1. 发明授权

US5158760A .sup.99m TC labeled liposomes 失效
标题翻译： 99m TC标记的脂质体
公开(公告)号：US5158760A
公开(公告)日：1992-10-27
申请号：US530847
申请日：1990-05-30
申请人： William T. Phillips , Robert W. Klipper , James H. Timmons , Alan S. Rudolph
发明人： William T. Phillips , Robert W. Klipper , James H. Timmons , Alan S. Rudolph
IPC分类号： A61K51/12
CPC分类号： A61K51/1234 , A61K2123/00 , Y10S436/829
摘要： The invention relates to a .sup.99m Tc-labeled liposome encapsulated protein and to a highly efficient method of radiolabeling liposome encapsulated protein. In particular, a .sup.99m Tc carrier is used to label preformed liposome-encapsulated hemoglobin. The liposome-encapsulated .sup.99m Tc labeled hemoglobin is highly stable in vitro and in vivo and is suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of using technetium-.sup.99m labeled liposome encapsulated hemoglobin to label neutrophils. A kit method which could be used for the convenient preparation of .sup.99m Tc-labeled liposome encapsulated hemoglobin for clinical use is also disclosed.
摘要翻译：本发明涉及99mTc标记的脂质体包封的蛋白质和一种高效的放射性标记脂质体包封的蛋白质的方法。特别地，99mTc载体用于标记预先形成的脂质体包封的血红蛋白。脂质体包封的99mTc标记的血红蛋白在体外和体内高度稳定，适用于各种临床应用，包括生物分布成像研究。本发明还涉及使用锝-99m标记的脂质体包封的血红蛋白标记嗜中性粒细胞的方法。还公开了可用于方便制备99mTc标记的脂质体包封的血红蛋白用于临床应用的试剂盒方法。

2. 发明授权

US5143713A .sup.99m Tc labeled liposomes 失效
标题翻译： 99MTC标签脂肪
公开(公告)号：US5143713A
公开(公告)日：1992-09-01
申请号：US610204
申请日：1990-11-05
申请人： William T. Phillips , Robert W. Klipper , James H. Timmons , Alan S. Rudolph
发明人： William T. Phillips , Robert W. Klipper , James H. Timmons , Alan S. Rudolph
IPC分类号： A61K51/12
CPC分类号： A61K51/1234 , A61K2123/00 , Y10T428/2984
摘要： The invention relates to the efficient preparation of radionuclide labeled liposomes and radionuclide-labeled liposome-encapsulated protein. In particular, a .sup.99m Tc carrier is used to label preformed liposomes or liposome-encapsulated hemoglobin. .sup.99m Tc-labeled liposomes and liposome-encapsulated .sup.99m Tc labeled hemoglobin are highly stable in vitro and in vivo and are suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of labeling neutrophils using .sup.99m technetium-labeled liposomes or liposome-encapsulated hemoglobin. A kit method useful for the convenient preparation of .sup.99m Tc-labeled liposomes or liposome-encapsulated hemoglobin for clinical use is also disclosed.
摘要翻译：本发明涉及放射性核素标记的脂质体和放射性核素标记的脂质体包封的蛋白质的有效制备。特别地，99mTc载体用于标记预先形成的脂质体或脂质体包封的血红蛋白。 99mTc标记的脂质体和脂质体包封的99mTc标记的血红蛋白在体外和体内都是高度稳定的，并且适用于各种临床用途，包括生物分布成像研究。本发明还涉及使用99mtechnet标记的脂质体或脂质体包封的血红蛋白标记嗜中性粒细胞的方法。还公开了用于方便地制备用于临床用途的99mTc标记的脂质体或脂质体包封的血红蛋白的试剂盒方法。

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