专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060177919A1 Process for the preparation of (S) - or (R) -3,3,3- trifluoro-2-hydroxy-2-methylpropionic acid 失效
标题翻译：制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的方法
公开(公告)号：US20060177919A1
公开(公告)日：2006-08-10
申请号：US11200182
申请日：2005-08-10
申请人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
发明人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
IPC分类号： C12N9/80 , C12N1/21
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： The present invention relates to a novel process for the preparation of (S)— or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.
摘要翻译：本发明涉及一种制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的新方法，以及能够利用下式的丙酰胺的新型微生物外消旋体或其旋光异构体的形式作为唯一的氮源。

2. 发明授权

US07074606B2 Process for the preparation of (S) - or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 失效
公开(公告)号：US07074606B2
公开(公告)日：2006-07-11
申请号：US10086082
申请日：2002-02-28
申请人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
发明人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
IPC分类号： C12P21/06 , C12N9/00 , C12N9/80 , C07H21/04
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： The present invention relates to a novel process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.

3. 发明授权

US07553652B2 Process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 失效
标题翻译：制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的方法
公开(公告)号：US07553652B2
公开(公告)日：2009-06-30
申请号：US11200182
申请日：2005-08-10
申请人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
发明人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
IPC分类号： C12N9/80
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： The present invention relates to a novel process for the preparation of (S)— or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.
摘要翻译：本发明涉及一种制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的新方法，以及能够利用下式的丙酰胺的新型微生物外消旋体或其旋光异构体的形式作为唯一的氮源。

4. 发明授权

US06773910B1 Method of preparing (S)- or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 失效
标题翻译：制备（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的方法
公开(公告)号：US06773910B1
公开(公告)日：2004-08-10
申请号：US09214679
申请日：1999-12-30
申请人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
发明人： Walter Brieden , Andrew Naughton , Karen Robins , Nicholas Shaw , Andreas Tinschert , Thomas Zimmermann
IPC分类号： C12N100
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： Described are new micro-organisms and a new enzyme capable of using as sole source of nitrogen the propionic acid amide of formula (VI), in racemate form or as optically active isomers. Described also is a method of preparing (S)- or (R)-3,3,2-trifluoro-2-hydroxy-2-methylpropionic acid of formulas (I) and (II) starting from trifluoroaceto-acetic ester. The first three process steps are chemical, the fourth process step microbiological.
摘要翻译：描述了新的微生物和能够以外消旋形式或作为光学活性异构体使用式（VI）的丙酸酰胺作为氮源的唯一来源的新酶。还描述了由三氟乙酸 - 乙酸酯制备式（I）和（II）的（S） - 或（R）-3,3,2-三氟-2-羟基-2-甲基丙酸的方法。前三个过程步骤是化学，第四个步骤微生物。

5. 发明授权

US5789596A Process for the preparation of 1-acyl-4-arylpiperidines 失效
标题翻译： 1-酰基-4-芳基哌啶的制备方法
公开(公告)号：US5789596A
公开(公告)日：1998-08-04
申请号：US933527
申请日：1997-09-18
申请人： Walter Brieden , Didier Loetscher , Andrew Naughton
发明人： Walter Brieden , Didier Loetscher , Andrew Naughton
IPC分类号： C07D211/02 , B01J27/08 , B01J31/24 , C07B61/00 , C07D211/20 , C07D211/82
CPC分类号： C07D211/20
摘要： 1-Acyl-4-arylpiperidines of the general formula: ##STR1## wherein R.sup.1 is an aryl group optionally substituted by one or more C.sub.1-6 -alkyl groups, C.sub.1-6 -alkoxy groups, benzyloxy groups or C.sub.1-6 -alkylthio groups and/or one or more fluorine atoms, and R.sup.2 is a C.sub.1-6 -alkyl group, a C.sub.1-6 -alkoxy group, an optionally substituted aryl group, alkylaryl group or a benzyloxy group optionally substituted on the phenyl radical. The 1-acyl-4-arylpiperidines of formula I are prepared by reacting an arylmagnesium halide with a 1-acylpyridinium halide, obtainable from pyridine and an acyl halide, in the presence of a copper compound to give the corresponding 1-acyl-4-aryl-1,4-dihydropyridine, and hydrogenating the latter. The 1-acyl-4-arylpiperidines are intermediates in the synthesis of pharmaceutical active ingredients, for example, neurokinin receptor antagonists.
摘要翻译：具有以下通式的1-酰基-4-芳基哌啶：其中R 1是任选被一个或多个C 1-6 - 烷基，C 1-6 - 烷氧基，苄氧基或C 1-6 - 烷硫基任选取代的芳基基团和/或一个或多个氟原子，并且R 2是任选在苯基上被取代的C 1-6 - 烷基，C 1-6 - 烷氧基，任选取代的芳基，烷基芳基或苄氧基。式I的1-酰基-4-芳基哌啶通过在铜化合物的存在下使卤化芳基镁卤化物与可从吡啶和酰基卤获得的1-酰基吡啶鎓卤化物反应来制备，得到相应的1-酰基-4- 芳基-1,4-二氢吡啶，并将其加氢。 1-酰基-4-芳基哌啶是合成药物活性成分例如神经激肽受体拮抗剂的中间体。

6. 发明授权

US5908935A Process for the preparation of 1-Acyl-4-arylpiperidines 失效
标题翻译： 1-酰基-4-芳基哌啶的制备方法
公开(公告)号：US5908935A
公开(公告)日：1999-06-01
申请号：US80929
申请日：1998-05-19
申请人： Walter Brieden , Didier Loetscher , Andrew Naughton
发明人： Walter Brieden , Didier Loetscher , Andrew Naughton
IPC分类号： C07D211/02 , B01J27/08 , B01J31/24 , C07B61/00 , C07D211/20 , C07D211/82
CPC分类号： C07D211/20
摘要： 1-Acyl-4-arylpiperidines of the general formula: ##STR1## wherein R.sup.1 is an aryl group optionally substituted by one or more C.sub.1-6 -alkyl groups, C.sub.1-6 -alkoxy groups, benzyloxy groups or C.sub.1-6 -alkylthio groups and/or one or more fluorine atoms, and R.sup.2 is a C.sub.1-6 -alkyl group, a C.sub.1-6 -alkoxy group, an optionally substituted aryl group, alkylaryl group or a benzyloxy group optionally substituted on the phenyl radical. The 1-acyl-4-arylpiperidines of formula I are prepared by reacting an arylmagnesium halide with a 1-acylpyridinium halide, obtainable from pyridine and an acyl halide, in the presence of a copper compound to give the corresponding 1-acyl-4-aryl-1,4-dihydropyridine, and hydrogenating the latter. The 1-acyl-4-arylpiperidines are intermediates in the synthesis of pharmaceutical active ingredients, for example, neurokinin receptor antagonists.
摘要翻译：具有以下通式的1-酰基-4-芳基哌啶：其中R 1是任选被一个或多个C 1-6 - 烷基，C 1-6 - 烷氧基，苄氧基或C 1-6 - 烷硫基取代的芳基和/或一个或多个氟原子，R 2是任选在苯基上被取代的C 1-6 - 烷基，C 1-6 - 烷氧基，任选取代的芳基，烷基芳基或苄氧基。式I的1-酰基-4-芳基哌啶通过在铜化合物的存在下使卤化芳基镁卤化物与可从吡啶和酰基卤获得的1-酰基吡啶鎓卤化物反应来制备，得到相应的1-酰基-4- 芳基-1,4-二氢吡啶，并将其加氢。 1-酰基-4-芳基哌啶是合成药物活性成分例如神经激肽受体拮抗剂的中间体。

7. 发明授权

US06599721B2 Process for preparing optically active 3,3,3-trifluoromethyl-2-alkylpropionic acid derivatives 失效
标题翻译：光学活性3,3,3-三氟甲基-2-烷基丙酸衍生物的制备方法
公开(公告)号：US06599721B2
公开(公告)日：2003-07-29
申请号：US09938333
申请日：2001-08-23
申请人： Andrew Naughton , Nicholas Shaw
发明人： Andrew Naughton , Nicholas Shaw
IPC分类号： C12P1302
CPC分类号： C07C235/06 , C07B2200/07
摘要： The invention relates to a novel method for the preparation of optically active 3,3,3-trifluoromethyl-2-alkyl propionic acid derivatives of the general formulae (I) and (II), in which R is ethyl or methyl and X is OH or NH2, provided that if R is methyl X≠—OH. The method comprises the reaction of a racemic propionic acid amide of the general formula (III) either by means of microorganisms which are able to use the propionic acid amide in the form of the racemate or one of its optically active isomers as the only nitrogen source or by means of a polypeptide with amidohydrolase activity which is able to hydrolyze the propionic acid amide. The invention also relates to new optically active representatives of this category of compounds.
摘要翻译：本发明涉及一种制备通式（I）和（II）的光学活性3,3,3-三氟甲基-2-烷基丙酸衍生物的新方法，其中R是乙基或甲基，X是OH 或NH 2，条件是如果R是甲基X≠-OH。该方法包括通过能够使用外消旋体形式的丙酰胺或其旋光异构体之一的微生物作为唯一的氮源，使通式（III）的外消旋丙酸酰胺反应或通过能够水解丙酸酰胺的具有酰胺水解酶活性的多肽。本发明还涉及这类化合物的新的光学活性代表。

8. 发明申请

US20070100031A1 Ultraviolet light absorbers 失效
公开(公告)号：US20070100031A1
公开(公告)日：2007-05-03
申请号：US11640808
申请日：2006-12-18
申请人： Ramanathan Ravichandran , Stephen Pastor , Deborah Judd , Joseph Babiarz , Andrew Naughton , Mervin Wood , Anthony Debellis , Rong Xiong , Robert Detlefsen , Joseph Suhadolnik
发明人： Ramanathan Ravichandran , Stephen Pastor , Deborah Judd , Joseph Babiarz , Andrew Naughton , Mervin Wood , Anthony Debellis , Rong Xiong , Robert Detlefsen , Joseph Suhadolnik
IPC分类号： C08K5/34 , C08K5/48
CPC分类号： C07D239/91 , C07D239/74 , C07D239/86 , C07D249/20 , C07D265/22 , C07D405/04
摘要： The present invention relates to novel ultraviolet light absorbers of the benzoxazinone, oxanilide, benzylidene malonate, quinazoline and benzotriazole classes. The invention also relates to polymer and photographic compositions stabilized against the deleterious effects of light induced degradation which comprise the novel ultraviolet light absorbers.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式