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1. 发明授权

US5910246A Device for isolating nucleic acids 失效
公开(公告)号：US5910246A
公开(公告)日：1999-06-08
申请号：US617696
申请日：1996-04-01
申请人： Thomas Walter , Michael Fritz , Herbert Harttig , Hans Lange , Rolf Lerch
发明人： Thomas Walter , Michael Fritz , Herbert Harttig , Hans Lange , Rolf Lerch
IPC分类号： G01N33/50 , B01J20/00 , B01L3/14 , B04B5/02 , B04B7/18 , C07H1/06 , C07H21/00 , C12M1/00 , C12Q1/68 , G01N15/06 , G01N33/53
CPC分类号： B01L3/5021 , C07H1/06
摘要： Device for the isolation of nucleic acids from a liquid sample by introducing the liquid into the device through an inlet opening and passage of the sample through a nucleic acid binding material and discharging of the resulting liquid through an outlet opening, wherein the nucleic acid binding material is inserted through the outlet opening during the manufacture of the device and the outlet opening is narrowed in order to hold the material. The device is particularly simple and reliable to manufacture but yet ensures that nucleic acids can be isolated without contamination.

2. 发明授权

US6090936A Device for isolating nucleic acids 有权
标题翻译：用于分离核酸的装置
公开(公告)号：US6090936A
公开(公告)日：2000-07-18
申请号：US251151
申请日：1999-02-17
申请人： Thomas Walter , Michael Fritz , Herbert Harttig , Hans Lange , Rolf Lerch
发明人： Thomas Walter , Michael Fritz , Herbert Harttig , Hans Lange , Rolf Lerch
IPC分类号： G01N33/50 , B01J20/00 , B01L3/14 , B04B5/02 , B04B7/18 , C07H1/06 , C07H21/00 , C12M1/00 , C12Q1/68 , G01N15/06
CPC分类号： B01L3/5021 , C07H1/06
摘要： Device for the isolation of nucleic acids from a liquid sample by introducing the liquid into the device through an inlet opening and passage of the sample through a nucleic acid binding material and discharging of the resulting liquid through an outlet opening, wherein the nucleic acid binding material is inserted through the outlet opening during the manufacture of the device and the outlet opening is narrowed in order to hold the material. The device is particularly simple and reliable to manufacture but yet ensures that nucleic acids can be isolated without contamination.
摘要翻译：用于通过将样品通过入口打开并通过核酸结合材料并将所得液体通过出口开口排出而将液体引入装置中以从液体样品中分离核酸的装置，其中所述核酸结合材料在制造装置期间通过出口插入，并且出口开口变窄以便保持材料。该装置制造特别简单和可靠，但是确保核酸可以分离而不被污染。

3. 发明授权

US06287867B1 Asymmetric porous membranes 失效
标题翻译：不对称多孔膜
公开(公告)号：US06287867B1
公开(公告)日：2001-09-11
申请号：US08296855
申请日：1994-08-26
申请人： Herbert Harttig , Hartmut Merdes , Hans Lange , Manfred Zeiler
发明人： Herbert Harttig , Hartmut Merdes , Hans Lange , Manfred Zeiler
IPC分类号： G01N3350
CPC分类号： G01N33/525 , B01L3/5023 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/084 , G01N1/34 , G01N33/521 , G01N2001/4016
摘要： The invention concerns the use of an asymmetric porous membrane for the evenly distributed concentration of a substance which is not or not substantially adsorbed to the membrane and which is brought into contact with the membrane in the form of a membrane-wetting solution on the fine-pored side of the membrane.
摘要翻译：本发明涉及使用不对称多孔膜来均匀分布浓度的物质，该物质不是或基本上不吸附到膜上，并且以薄膜润湿溶液的形式与膜接触，沉积在膜的侧面。

4. 发明授权

US5906947A Method for the repeated transfer of liquids 失效
标题翻译：重复转移液体的方法
公开(公告)号：US5906947A
公开(公告)日：1999-05-25
申请号：US996150
申请日：1997-12-22
申请人： Gerhard Bienhaus , Hans Lange , Thomas Walter
发明人： Gerhard Bienhaus , Hans Lange , Thomas Walter
IPC分类号： G01N33/50 , B01L3/02 , C12Q1/00 , C12Q1/68 , G01N1/00 , G01N35/10 , G01N33/543
CPC分类号： B01L3/0275 , C12Q1/68 , G01N35/10 , G01N2035/103 , Y10S435/81 , Y10S436/805 , Y10S436/808 , Y10S436/81
摘要： A method for the repeated transfer of liquids from one of several storage containers into a transfer container wherein protective tips are placed onto a tip of a pipette in order to avoid contamination.
摘要翻译：一种用于将液体从多个储存容器中的一个重复转移到转移容器中的方法，其中将保护尖端放置在移液管的尖端上以避免污染。

5. 发明授权

US5821436A Method for the repeated transfer of liquids 失效
公开(公告)号：US5821436A
公开(公告)日：1998-10-13
申请号：US489580
申请日：1995-06-12
申请人： Gerhard Bienhaus , Hans Lange , Thomas Walter
发明人： Gerhard Bienhaus , Hans Lange , Thomas Walter
IPC分类号： G01N33/50 , B01L3/02 , C12Q1/00 , C12Q1/68 , G01N1/00 , G01N35/10
CPC分类号： B01L3/0275 , C12Q1/68 , G01N35/10 , G01N2035/103 , Y10S435/81 , Y10S436/805 , Y10S436/808 , Y10S436/81
摘要： A method for the repeated transfer of liquids from one of several storage containers into a transfer container wherein protective tips are placed onto a tip of a pipette in order to avoid contamination.

6. 再颁专利

USRE35803E Blood lancet device for and method withdrawing blood for diagnostic purposes 失效
标题翻译：用于诊断目的的血液刺血针装置和方法取出血液
公开(公告)号：USRE35803E
公开(公告)日：1998-05-19
申请号：US609627
申请日：1996-03-01
申请人： Hans Lange , Dirk Bocker , Hermann Edelmann , Wolfgang Rudinger , Herbert Argauer
发明人： Hans Lange , Dirk Bocker , Hermann Edelmann , Wolfgang Rudinger , Herbert Argauer
IPC分类号： A61B5/151 , A61B5/15 , A61B17/32
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150183 , A61B5/150412 , A61B5/15113 , A61B5/15117 , A61B5/1513
摘要： Blood lancet device for withdrawing blood for diagnostic purposes, in which with the aid of a lancet drive (3) in a housing (1) a lancet holder (6) with a lancet (34) positioned in it and moveable along a predetermined, straight puncture path is moved until the tip (35) of the lancet emerges from the outlet (84), in order to produce a wound in a body part adjoining the outlet (84). The lancet holder (6) also serves to retract the lancet (34) into a position in which the tip (35) is again positioned within the housing (1). In order to make possible a puncture involving especially little pain, the lancet drive (3) has a rotary/sliding transmission system (4) whose input side (16) is formed by a transmission member which is rotatable about an axis of rotation parallel to the predetermined puncture path. This input-side transmission member (5) of the rotary/sliding transmission system is coupled with the elastic drive element (9) of the lancet drive (3) and converts a torque transmitted to the transmission member (5) into a longitudinal displacement in the direction of the predetermined puncture path, which is transmitted to the lancet holder (6). .Iadd.A method for withdrawing blood for diagnostic purposes using the blood lancet device is also presented..Iaddend.
摘要翻译：一种用于诊断用于抽出血液的血液针刺装置，其中借助于壳体（1）中的刺血针驱动器（3），具有定位在其中的刺血针（34）的刺血针保持器（6），并且可沿着预定的直线穿刺路径移动直到柳叶刀的尖端（35）从出口（84）出来，以便在与出口（84）相邻的主体部分中产生卷绕。柳叶刀套（6）还用于将柳叶刀（34）缩回到其中尖端（35）再次位于壳体（1）内的位置。为了使可能的穿刺特别小的疼痛，刺血针驱动器（3）具有旋转/滑动传动系统（4），其输入侧（16）由传动构件形成，该传动构件可绕平行于预定穿刺路径。旋转/滑动传动系统的输入侧传动部件（5）与柳叶刀驱动装置（3）的弹性驱动元件（9）相连接，并将传递到传动部件（5）的转矩变换为纵向位移传送到柳叶刀套（6）的预定穿刺路径的方向。还提出了使用血液穿刺装置进行诊断的血液提取方法。

7. 发明授权

US5846489A System for opening closures of vessels and for the contamination-free operation of reaction sequences 失效
标题翻译：用于打开船只关闭和反应序列无污染操作的系统
公开(公告)号：US5846489A
公开(公告)日：1998-12-08
申请号：US834043
申请日：1997-04-11
申请人： Gerhard Bienhaus , Hans Lange
发明人： Gerhard Bienhaus , Hans Lange
IPC分类号： G01N35/02 , B01L3/14 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N35/00 , G01N35/04 , G01N1/00 , G01N35/10
CPC分类号： B01L3/50825 , G01N35/0099 , G01N2035/00287 , G01N2035/0405 , Y10T436/11 , Y10T436/25
摘要： System for the automatic operation of reactions using several vessels which can be closed by individual closures using a device for automatically opening the closures.
摘要翻译：使用几个容器进行反应的自动操作的系统，该容器可以通过使用用于自动打开盖子的装置的单独闭合来关闭。

8. 发明授权

US4613569A Stabilized composition of tetrazolium salts 失效
标题翻译：四唑盐的稳定组成
公开(公告)号：US4613569A
公开(公告)日：1986-09-23
申请号：US593192
申请日：1984-03-27
申请人： Edda Geisler , Helmut Feuerstein , Hans Lange
发明人： Edda Geisler , Helmut Feuerstein , Hans Lange
IPC分类号： G01N33/82 , C12Q1/26 , C12Q1/32 , G01N33/48 , G01N33/52 , C12Q1/28 , C12Q1/54
CPC分类号： C12Q1/32 , G01N33/52 , Y10S435/805 , Y10S435/81 , Y10S436/903 , Y10T436/142222 , Y10T436/144444 , Y10T436/146666 , Y10T436/201666 , Y10T436/2525
摘要： The present invention provides stabilized compositions of tetrazolium salts for analytical purposes, wherein they contain 1 to 10 moles of a complex-forming acid which is soluble in polar solvents per mole of tetrazolium salt.The present invention also provides a process for the detection of reducing materials, wherein one of the above stabilized compositions is added to a test batch.
摘要翻译：本发明提供用于分析目的的稳定的四唑盐组合物，其中它们含有1至10摩尔的络合物形成酸，其每摩尔四唑鎓盐可溶于极性溶剂。本发明还提供了一种用于检测还原材料的方法，其中将一种上述稳定的组合物加入到试验批料中。

9. 发明授权

US4605629A Method of eluting reagent from reagent strips for chemical analyses and reagent strip therefor 失效
标题翻译：从试剂条中洗脱试剂的方法进行化学分析和试剂条
公开(公告)号：US4605629A
公开(公告)日：1986-08-12
申请号：US634667
申请日：1984-07-27
申请人： Hans Lange , Edda Geisler , Wolfgang Werner
发明人： Hans Lange , Edda Geisler , Wolfgang Werner
IPC分类号： C12Q1/52 , G01N31/22 , G01N33/52 , G01N21/78
CPC分类号： G01N31/22 , G01N33/525 , Y10S435/805
摘要： The present invention provides a method of improving reagent elution from a reagent strip comprising a handle on one end which is affixed an absorbent carrier impregnated with a reagent. The absorbent carrier is pressed against the handle by a thin mesh which is stuck or sealed on to the handle on opposite sides of the carrier.Another mesh is between the carrier and the handle. When the carrier is immersed in a liquid, the meshes improve the elution of the reagent into the liquid.
摘要翻译：本发明提供了一种改进试剂从试剂洗脱的方法，该试剂条在一端具有手柄，该手柄固定着浸渍有试剂的吸收载体。吸收性载体通过在载体的相对侧上被卡住或密封在手柄上的细网被压靠在手柄上。另一个网格在载体和手柄之间。当载体浸没在液体中时，网眼会提高试剂在液体中的溶出度。

10. 发明授权

US4439527A Composition and method for the detection of hydrogen peroxide 失效
标题翻译：用于检测过氧化氢的组合物和方法
公开(公告)号：US4439527A
公开(公告)日：1984-03-27
申请号：US385760
申请日：1982-06-07
申请人： Bernd Pakebusch , Carsten A. Carstensen , Bernward Sojka , Hans Lange
发明人： Bernd Pakebusch , Carsten A. Carstensen , Bernward Sojka , Hans Lange
IPC分类号： G01N33/50 , C12Q1/28 , G01N31/00 , G01N21/78
CPC分类号： C12Q1/28 , C12Q2326/96 , Y10S436/904 , Y10T436/206664
摘要： Means and method for the detection of hydrogen peroxide or of hydrogen peroxide-forming substrates, consisting of 4-aminoantipyrine and an aromatic amine or phenol and a neutral to weakly acid buffer as well as other additives and reagents which form H.sub.2 O.sub.2 with the substrate and which are known for use in Trinder's reaction, the 4-aminoantipyrine, in the immiscible state before use, being separate from the acid buffer and from the other reagents if any, and being mixed with a small amount of an alkaline buffer having a pH of 8.5 to 14.0, the two compositions being combined, in a quantity ratio to one another that is suitable for the detection test, in a single package or in a single-use unit.
摘要翻译：用于检测过氧化氢或形成过氧化氢的底物的方法和方法，由4-氨基安替比林和芳族胺或苯酚和中性至弱酸性缓冲剂以及与底物形成H 2 O 2的其它添加剂和试剂组成，其中已知Trinder反应中使用4-氨基安替比林，在使用前不混溶状态，与酸缓冲液和其他试剂分离，如果有的话，并与少量pH为8.5的碱性缓冲液混合至14.0，两种组合物在单个包装或一次性单元中以彼此的量相互组合，适合于检测试验。

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