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1. 发明授权

US5804599A Interleukin-1 production inhibiting compound 失效
标题翻译：白介素-1产生抑制化合物
公开(公告)号：US5804599A
公开(公告)日：1998-09-08
申请号：US534852
申请日：1995-09-27
申请人： Takeo Tanaka , Eiji Tsukuda , Keiko Ochiai , Katsuhiko Ando , Hidemasa Kondo , Youichi Uosaki , Yutaka Saitoh , Yuzuru Matsuda , Fumito Koizumi , Tsutomu Agatsuma
发明人： Takeo Tanaka , Eiji Tsukuda , Keiko Ochiai , Katsuhiko Ando , Hidemasa Kondo , Youichi Uosaki , Yutaka Saitoh , Yuzuru Matsuda , Fumito Koizumi , Tsutomu Agatsuma
IPC分类号： A61K31/335 , A61K31/336 , A61P1/00 , A61P1/16 , A61P9/00 , A61P9/10 , A61P13/02 , A61P15/00 , A61P19/06 , A61P19/10 , A61P29/00 , A61P31/04 , A61P43/00 , C07D303/46 , C12P17/02 , C12R1/465 , A01N43/20 , A01N37/18 , A01N43/24 , A61K31/16
CPC分类号： C12R1/465 , C07D303/46 , C12P17/02
摘要： Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.
摘要翻译：本发明提供由式（I）表示的白细胞介素-1产生抑制化合物，其中R表示4-甲基-1-戊烯基，5-甲基-1,3-庚二烯基或1-甲基戊基。

2. 发明授权

US5874592A Physiologically active substance EI-2128-1 失效
标题翻译：生理活性物质EI-2128-1
公开(公告)号：US5874592A
公开(公告)日：1999-02-23
申请号：US945981
申请日：1997-11-12
申请人： Takeo Tanaka , Fumito Koizumi , Tsutomu Agatsuma , Hidemasa Kondo , Yutaka Saitoh , Katsuhiko Ando , Yuzuru Matsuda
发明人： Takeo Tanaka , Fumito Koizumi , Tsutomu Agatsuma , Hidemasa Kondo , Yutaka Saitoh , Katsuhiko Ando , Yuzuru Matsuda
IPC分类号： C07D493/20 , C12P17/18 , C07D307/94
CPC分类号： C07D493/20 , C12P17/181
摘要： The present invention relates to a novel compound EI-2128-1 having IL-1 production inhibitory activity which is represented by formula (I): ##STR1##
摘要翻译： PCT No.PCT / JP97 / 01135 Sec。 371日期：1997年11月12日 102（e）日期1997年11月12日PCT 1997年4月2日PCT公布。公开号WO97 / 37034 日期：1997年10月9日本发明涉及具有由式（I）表示的具有IL-1产生抑制活性的新型化合物EI-2128-1：

3. 发明授权

US5686485A Physiologically active EI-1941 compounds 失效
标题翻译：生理活性的EI-1941化合物
公开(公告)号：US5686485A
公开(公告)日：1997-11-11
申请号：US728552
申请日：1996-10-09
申请人： Takeo Tanaka , Hidemasa Kondo , Fumito Koizumi , Hiroki Ishiguro , Mayumi Yoshida , Katsuhiko Ando , Yuzuru Matsuda
发明人： Takeo Tanaka , Hidemasa Kondo , Fumito Koizumi , Hiroki Ishiguro , Mayumi Yoshida , Katsuhiko Ando , Yuzuru Matsuda
IPC分类号： A61K31/35 , A61K31/352 , A61K31/365 , A61P1/00 , A61P1/16 , A61P9/00 , A61P9/10 , A61P13/02 , A61P15/00 , A61P19/10 , A61P29/00 , A61P31/04 , A61P43/00 , C07D311/76 , C07D493/04 , C12P17/06 , C12R1/645
CPC分类号： C12P17/06 , C07D311/76
摘要： The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R.sup.1 and R.sup.2 is hydrogen and the other is hydroxy, or R.sup.1 and R.sup.2 together represent oxygen; and R.sup.3 is hydroxy and R.sup.4 is hydrogen, or R.sup.3 and R.sup.4 together represent --0--.
摘要翻译：本发明涉及具有白细胞介素-1产生抑制活性的EI-1941化合物，其由下式表示：其它为羟基，或R1和R2一起代表氧; 并且R 3是羟基，R 4是氢，或者R 3和R 4一起表示-O-。

4. 发明授权

US06194195B1 Strains of streptomyces producing endothelin antagonistic peptides 失效
标题翻译：产生内皮素拮抗肽的链霉菌菌株
公开(公告)号：US06194195B1
公开(公告)日：2001-02-27
申请号：US09181083
申请日：1998-10-27
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C12N120
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1021 , C07K5/1024 , C07K7/08 , C07K14/36 , C07K14/57536 , C12R1/465
摘要： The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.
摘要翻译：本发明涉及链霉菌属的生物纯培养物。 RE-701（FERM BP-3624）和Streptomyces sp。产生内皮素拮抗肽的RE-629（FERM BP-4126）。

5. 发明授权

US5639860A Endothelin-antagonizing peptide 失效
标题翻译：内皮素拮抗肽
公开(公告)号：US5639860A
公开(公告)日：1997-06-17
申请号：US321625
申请日：1994-10-12
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C07K5/113 , C07K5/117 , C07K7/06 , C07K7/08 , C07K14/575 , A61K38/10
CPC分类号： C07K7/06 , C07K14/57536 , C07K5/1021 , C07K5/1024 , C07K7/08
摘要： Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 represents hydroxy;and Z represents, in case of (1),Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z.sup.1Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1,Trp-Phe-Phe-Asn-Tyr-R-T-Z.sup.1wherein Z.sup.1 is an organic moiety,wherein R is Tyr or a covalent bond,T is Trp, Ala, Phe, Tyr, Trp-Trp, Asn-Tyr-Tyr-Trp, Trp-Asn-Tyr-Tyr-Trp, Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp,or in case of (2), Z representsTrp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1.These peptides have endothelin-antagonizing activity, and are useful for treating hypertension, asthma, cerebral apoplexy, angina pectoris, acute renal failure, cardiac infarction and cerebral vasospasm.
摘要翻译：由下式（I）表示的肽：其中A表示Asn或Asp; B代表His或Lys; E表示Ala或Ser; （1）将X1和Y1组合在一起形成单键作为X1-Y1，或（2）X1表示氢，Y1表示羟基; 而在（1）的情况下，Z表示Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z1 Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1， Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1，Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z1，Trp- Phe-Phe-Asn-Tyr-RT-Z1，其中Z1是有机部分，其中R是Tyr或共价键，T是Trp，Ala，Phe，Tyr，Trp-Trp，Asn-Tyr-Tyr-Trp，Trp -Tn-Tyr-Tyr-Trp，Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp，或在（2）的情况下，Z表示Trp-Val-Tyr-Phe-Ala -His-Leu-Asp-Ile-Ile-Trp-Z1 Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1 Trp-Leu-Tyr-Phe-Ala-His-Gln -Asp-Val-Ile-Trp-Z1。这些肽具有内皮素拮抗作用，可用于治疗高血压，哮喘，脑中风，心绞痛，急性肾功能衰竭，心肌梗死和脑血管痉挛。

6. 发明授权

US06642355B2 Endothelin-antagonizing peptide 失效
标题翻译：内皮素拮抗肽
公开(公告)号：US06642355B2
公开(公告)日：2003-11-04
申请号：US09750754
申请日：2001-01-02
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C07K700
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1021 , C07K5/1024 , C07K7/08 , C07K14/36 , C07K14/57536 , C12R1/465
摘要： The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式（I）的内皮素拮抗肽：其中代表Asn或Asp; B代表His或Lys; E表示Ala或Ser; G表示Ala或Pro; X表示X 1 -Gly或Y表示羟基，低级烷氧基，氨基，其中X 1，X 3，Y 1，Y 2和Z进一步定义，或其药学上可接受的盐。

7. 发明授权

US5631222A Endothelin-antagonizing peptide 失效
标题翻译：内皮素拮抗肽
公开(公告)号：US5631222A
公开(公告)日：1997-05-20
申请号：US382013
申请日：1995-02-10
申请人： Kenji Shibata , Toshiyuki Suzawa , Motoo Yamasaki , Takeo Tanaka , Eiji Tsukuda , Koji Yamada , Tetsuji Ohno
发明人： Kenji Shibata , Toshiyuki Suzawa , Motoo Yamasaki , Takeo Tanaka , Eiji Tsukuda , Koji Yamada , Tetsuji Ohno
IPC分类号： A61K38/00 , C07K7/06 , C07K14/575 , C07K5/12 , C07K7/08
CPC分类号： C07K7/06 , C07K14/57536 , A61K38/00
摘要： Disclosed is a peptide compound represented by the following formula (I):R.sup.1 -R.sup.2 -R.sup.3 -R.sup.4 -R.sup.5 -R.sup.6 -R.sup.7 -R.sup.8 -R.sup.9 -R.sup.10 -R.sup.11 -R.sup.12 -Phe-R.sup.14 -R.sup.15 -R.sup.16 -R.sup.17 -R.sup.18 -Ile-R.sup.20 -Z SEQ. ID NO. 64, (I)wherein R.sup.1-12, R.sup.14-18, and R.sup.20 are as defined in the specification.
摘要翻译： PCT No.PCT / JP94 / 01011 Sec。 371日期1995年2月10日 102（e）1995年2月10日PCT PCT 1994年6月23日PCT公布。第WO95 / 00546号公报日期：1995年5月1日公开了由下式（I）表示的肽化合物：R1-R2-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-Phe-R14-R15-R16- R17-R18-Ile-R20-Z SEQ。证件号码。 64，（I）其中R1-12，R14-18和R20如说明书中所定义。

8. 发明授权

US4762605A Oxygen sensor 失效
标题翻译：氧传感器
公开(公告)号：US4762605A
公开(公告)日：1988-08-09
申请号：US008655
申请日：1987-01-30
申请人： Takeo Tanaka , Keisuke Sugimoto , Yuji Sugiyama , Hideo Shiraishi , Teizo Takahama , Masahiko Masuda
发明人： Takeo Tanaka , Keisuke Sugimoto , Yuji Sugiyama , Hideo Shiraishi , Teizo Takahama , Masahiko Masuda
IPC分类号： C04B35/48 , C04B35/64 , G01N27/407 , G01N27/409 , G01N27/413 , G01N27/416 , H05B3/18 , G01N27/58
CPC分类号： G01N27/4071 , G01N27/4072
摘要： A limited current type oxygen sensor comprises a solid electrolyte element formed from material having high oxygen-ion conductivity such as yittria-stabilized zirconia. Electrodes are provided on the top surface and the bottom surface of the element and are formed by calcining a mixture of small ceramic particles that are relatively sinter-retardant as compared with oxygen-ion conducting ceramics, of 200 .ANG. in average particle size fine precious metal particles, and a binder. A cover is provided over the second electrode and the cover includes at least one diffusion orifice that permits ambient gas to diffuse toward the second electrode. The dry-gas-based and humid-gas-based oxygen content of the gas is determined by applying a first voltage less than the theoretical water decomposition voltage and a second voltage greater than the theoretical water decomposition voltage to the electrodes to generate corresponding currents associated with the oxygen-ions which flow through the electrolyte element between the first electrode and the second electrode. A heater may be buried in the electrolyte element to increase the flow rate of oxygen ions between the electrodes.
摘要翻译：有限电流型氧传感器包括由具有高氧离子传导性的材料形成的固体电解质元件，例如氧化钇稳定的氧化锆。电极设置在元件的顶表面和底表面上，通过煅烧与氧离子传导陶瓷相比具有相对阻燃性的小陶瓷颗粒的混合物形成，平均粒度细的贵金属为200埃颗粒和粘合剂。覆盖物设置在第二电极上方，并且盖包括允许环境气体朝向第二电极扩散的至少一个扩散孔。通过向电极施加小于理论水分解电压的第一电压和大于理论水分解电压的第二电压来确定气体的干气基和湿气基氧含量，以产生相应的电流其中氧离子在第一电极和第二电极之间流过电解质元件。加热器可以被埋在电解质元件中以增加电极之间的氧离子的流速。

9. 发明授权

US4469167A Heat exchanger fin 失效
标题翻译：热交换器翅片
公开(公告)号：US4469167A
公开(公告)日：1984-09-04
申请号：US326814
申请日：1981-12-02
申请人： Masaaki Itoh , Takeo Tanaka , Masakatsu Hayashi , Mituo Kudo , Akira Tomita
发明人： Masaaki Itoh , Takeo Tanaka , Masakatsu Hayashi , Mituo Kudo , Akira Tomita
IPC分类号： F28F1/30 , F24F13/30 , F28D1/047 , F28F1/12 , F28F1/32 , F28D1/04
CPC分类号： F28F1/128 , F24F13/30 , F28D1/0478 , F28F1/325
摘要： A heat exchanger fin according to the invention has a multiplicity of fins arranged substantially in parallel with the direction of air flow and at least one heat transfer tube to which said fins are connected in a heat conducting relation. A multiplicity of louvers inclined by a small angle to the direction of air flow are formed in said fins.According to this construction, it is possible that the air as a whole can flow substantially straight across the heat exchanger and can strongly collide with all louvers, thereby to ensure a reduced flow resistance encountered by the air flow, as well as improved heat transfer performance of the heat exchanger.
摘要翻译：根据本发明的换热器翅片具有大致平行于空气流动方向布置的多个翅片，以及至少一个传热管，所述翅片以热传导关系连接到该传热管。在所述翅片中形成有多个向空气流动方向倾斜小角度的百叶窗。根据该结构，空气整体可能基本上直线地流过热交换器，并且可能与所有百叶窗强烈碰撞，从而确保空气流动遇到的流动阻力降低，并且提高传热性能的热交换器。

10. 发明授权

US4285385A Method for the production of heat exchangers 失效
标题翻译：热交换器生产方法
公开(公告)号：US4285385A
公开(公告)日：1981-08-25
申请号：US51141
申请日：1979-06-22
申请人： Masakatsu Hayashi , Takeo Tanaka , Tatsuo Natori , Tatsushi Aizawa , Shigeru Kojima , Takao Senshu
发明人： Masakatsu Hayashi , Takeo Tanaka , Tatsuo Natori , Tatsushi Aizawa , Shigeru Kojima , Takao Senshu
IPC分类号： B22D25/02 , B22C7/02 , B22C9/04 , B22D18/04 , B22D19/00 , F28D1/047 , F28F1/10 , F28F1/12 , F28F13/00
CPC分类号： F28F13/003 , B22C9/26 , B22D18/04 , B22D19/0063 , B22D19/0072 , B22D25/005 , F28D1/0477 , B22C9/04 , Y10S165/907 , Y10T29/4935
摘要： A method of producing a heat exchanger in which a fin block of porous metal and fin plates connected to the fin block are unitarily secured to a serpentine heat-transmitting pipe. A plurality of fin molds produced with the use of plastic patterns formed therein with continuous, three-dimensional cavities are assembled with the heat-transmitting pipe shaped beforehand into a serpentine form in such a manner that the fin molds enclose the heat-transmitting pipe with suitable spacing intervals defined between the fin molds themselves and between the fin molds and the heat-transmitting pipe. Molten metal of high thermal conductivity is cast into continuous cavities in the fin molds and into the spacing intervals, and the material of the fin molds is removed after the molten metal has solidified.
摘要翻译：一种制造热交换器的方法，其中连接到翅片块的多孔金属和翅片板的翅片块整体地固定到蛇形传热管。使用其中形成有连续的三维空腔的塑料图案制造的多个翅片模具与预先成形为蛇形的传热管组装，使得翅片模具将传热管与限定在翅片模具本身之间以及翅片模具和传热管之间的合适的间隔间隔。具有高导热性的熔融金属被铸造成翅片模具中的连续空腔并进入间隔间隔，并且在熔融金属固化后去除翅片模具的材料。

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