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1. 发明授权

US07419955B2 Method for treating arteriosclerosis 有权
标题翻译：治疗动脉硬化的方法
公开(公告)号：US07419955B2
公开(公告)日：2008-09-02
申请号：US10514715
申请日：2003-05-26
申请人： Takashi Kadowaki , Toshimasa Yamauchi , Naoto Kubota , Yasuo Terauchi , Tetsuya Kubota , Tetsuo Noda , Ryozo Nagai , Yasushi Imai
发明人： Takashi Kadowaki , Toshimasa Yamauchi , Naoto Kubota , Yasuo Terauchi , Tetsuya Kubota , Tetsuo Noda , Ryozo Nagai , Yasushi Imai
IPC分类号： A61K38/00
CPC分类号： A61K38/2264 , A61K48/00
摘要： A scavenger receptor A expression down-regulator and a drug for preventing or treating arteriosclerosis which contain, as the active ingredient, a C-terminal globular domain of adiponectin, adiponectin, or a gene encoding the domain or adiponectin. According to the present invention, there is provided a preventive or therapeutic agent capable of directly preventing intimal thickening, which constitutes an essential feature of arteriosclerosis. This effect can be attained through arresting the onset and development of arteriosclerosis by reducing the expression level of scavenger receptor A in arterial walls and preventing lipid buildup in macrophages.
摘要翻译：清道夫受体A表达下调和用于预防或治疗动脉硬化的药物，其含有脂联素，脂联素或编码结构域或脂联素的基因的C-末端球状结构域作为活性成分。根据本发明，提供能够直接防止内膜增厚的预防或治疗剂，其构成动脉硬化的基本特征。通过降低动脉壁中清道夫受体A的表达水平并防止巨噬细胞中的脂质积聚，可以通过阻止动脉硬化的发生和发展来实现该效果。

2. 发明申请

US20060166873A1 Preventive/remedy for arteriosclerosis 有权
标题翻译：动脉硬化的预防/治疗
公开(公告)号：US20060166873A1
公开(公告)日：2006-07-27
申请号：US10514715
申请日：2003-05-26
申请人： Takashi Kadowaki , Toshimasa Yamauchi , Naoto Kubota , Yasuo Terauchi , Tetsuya Kubota , Tetsuo Noda , Ryozo Nagai , Yasushi Imai
发明人： Takashi Kadowaki , Toshimasa Yamauchi , Naoto Kubota , Yasuo Terauchi , Tetsuya Kubota , Tetsuo Noda , Ryozo Nagai , Yasushi Imai
IPC分类号： A61K48/00 , A61K38/17
CPC分类号： A61K38/2264 , A61K48/00
摘要： A scavenger receptor A expression down-regulator and a drug for preventing or treating arteriosclerosis which contain, as the active ingredient, a C-terminal globular domain of adiponectin, adiponectin, or a gene encoding the domain or adiponectin. According to the present invention, there is provided a preventive or therapeutic agent capable of directly preventing intimal thickening, which constitutes an essential feature of arteriosclerosis. This effect can be attained through arresting the onset and development of arteriosclerosis by reducing the expression level of scavenger receptor A in arterial walls and preventing lipid buildup in macrophages.
摘要翻译：清道夫受体A表达下调和用于预防或治疗动脉硬化的药物，其含有脂联素，脂联素或编码结构域或脂联素的基因的C-末端球状结构域作为活性成分。根据本发明，提供能够直接防止内膜增厚的预防或治疗剂，其构成动脉硬化的基本特征。通过降低动脉壁中清道夫受体A的表达水平并防止巨噬细胞中的脂质积聚，可以通过阻止动脉硬化的发生和发展来实现该效果。

3. 发明申请

US20060059578A1 Adiponectin-knoucout nonhuman animal 审中-公开
标题翻译：脂联素 - 非球形非人动物
公开(公告)号：US20060059578A1
公开(公告)日：2006-03-16
申请号：US10514716
申请日：2003-05-26
申请人： Takashi Kadowaki , Naoto Kubota , Yasuo Terauchi , Toshimasa Yamauchi , Tetsuo Noda
发明人： Takashi Kadowaki , Naoto Kubota , Yasuo Terauchi , Toshimasa Yamauchi , Tetsuo Noda
IPC分类号： A01K67/027
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0362 , A01K2267/0375 , C07K14/575
摘要： The animals of the present invention enable elucidation of the onset mechanisms of obesity, diabetes, and arteriosclerosis. Moreover, they are useful for screening preventive and therapeutic drugs for treating any of these diseases.
摘要翻译：本发明的动物能够阐明肥胖，糖尿病和动脉硬化的发病机制。此外，它们可用于筛选用于治疗任何这些疾病的预防和治疗药物。

4. 发明申请

US20070238098A1 Method and Kit for Predicting Adverse Side Effects of Paclitaxel Therapy 审中-公开
标题翻译：紫杉醇治疗预防不良反应的方法和试剂盒
公开(公告)号：US20070238098A1
公开(公告)日：2007-10-11
申请号：US10578077
申请日：2004-11-05
申请人： Yoshio Miki , Masaaki Matsuura , Minoru Isomura , Satoshi Miyata , Masataka Yoshimoto , Tetsuo Noda
发明人： Yoshio Miki , Masaaki Matsuura , Minoru Isomura , Satoshi Miyata , Masataka Yoshimoto , Tetsuo Noda
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： A method is disclosed for predicting the risk of the occurrence of granulocytopenia caused by paclitaxel therapy in a subject. The method of the present invention comprises identifying a genetic polymorphism in a gene isolated from the subject for five SNPs in CYP2C8 gene (IMS-JST111898 (SEQ ID NO: 1), IMS-JST105874 (SEQ ID NO: 2), IMS-JST082397 (SEQ ID NO: 3), IMS-JST071852 (SEQ ID NO: 4) and IMS-JST071853 (SEQ ID NO: 5)) and for five SNPs in BUB1b gene (IMS-JST074538 (SEQ ID NO: 6), IMS-JST079837 (SEQ ID NO: 7), IMS-JST044164 (SEQ ID NO: 8), IMS-JST 063023 (SEQ ID NO: 9) and IMS-JST042569 (SEQ ID NO: 10)). A kit comprising a reagent used in the method of the present invention is also disclosed.
摘要翻译：公开了一种用于预测受试者由紫杉醇治疗引起的粒细胞减少的风险的方法。本发明的方法包括鉴定CYP2C8基因（IMS-JST111898（SEQ ID NO：1），IMS-JST105874（SEQ ID NO：2）），IMS-JST082397中的5个SNP的受试者分离的基因中的遗传多态性（SEQ ID NO：3），IMS-JST071852（SEQ ID NO：4）和IMS-JST071853（SEQ ID NO：5））和BUB1b基因（IMS-JST074538（SEQ ID NO：6））中的五个SNP，IMS -JST079837（SEQ ID NO：7），IMS-JST044164（SEQ ID NO：8），IMS-JST 063023（SEQ ID NO：9）和IMS-JST042569（SEQ ID NO：10））。还公开了包含本发明方法中使用的试剂的试剂盒。

5. 发明授权

US4796244A Disc player 失效
标题翻译：光盘播放器
公开(公告)号：US4796244A
公开(公告)日：1989-01-03
申请号：US163913
申请日：1988-03-03
申请人： Yukiyasu Tsuruta , Saburo Yorizane , Koichiro Kimura , Tetsuo Noda , Taizo Isshiki , Masanori Okada , Masato Ishihara
发明人： Yukiyasu Tsuruta , Saburo Yorizane , Koichiro Kimura , Tetsuo Noda , Taizo Isshiki , Masanori Okada , Masato Ishihara
IPC分类号： G11B17/04 , G11B17/28 , G11B5/48
CPC分类号： G11B17/056
摘要： A disc player comprising a lift chassis 5 liftably supported on a main chassis 1 and having a signal reproduction unit 31 mounted thereon, and a drive slide 9 supported by the main chassis 1 and movable in a direction intersecting the direction of movement of the lift chassis 5. The drive slide 9 has a straight cam portion in engagement with a cam follower on the lift chassis 5 for reciprocatingly driving the lift chassis 5. An intermittent feed mechanism is provided between the drive slide 9 and a motor 23 for reciprocatingly moving the drive slide. The feed mechanism comprises a drive portion for receiving a torque directly from the motor, and a driven portion to be intermittently driven by the drive portion while the drive portion is in continuous rotation. The power given to the driven portion is delivered to the drive slide to thereby move the slide stepwise. The drive portion has an engaging portion which, while the drive slide is at rest, engages with the driven portion to lock the drive slide, whereby the reproduction unit can be held properly in position.
摘要翻译：一种光盘播放器，包括可提升地支撑在主机架1上并具有安装在其上的信号再现单元31的升降机架5和由主机架1支撑并可沿与提升机架的运动方向相交的方向移动的驱动滑动件9 驱动滑块9具有与升降机架5上的凸轮从动件接合的直的凸轮部分，用于往复驱动提升机架5.间歇进给机构设置在驱动滑动件9和马达23之间，用于使驱动器往复移动滑动。进给机构包括用于从马达直接接收扭矩的驱动部分和驱动部分连续旋转时由驱动部分间歇驱动的被驱动部分。给驱动部分的动力传递到驱动滑块，从而逐步移动滑块。驱动部分具有接合部分，当驱动滑块处于静止状态时，该啮合部分与被驱动部分接合以锁定驱动滑块，由此可以将再现单元保持在适当位置。

6. 发明授权

US4792489A Synthetic fibers having uneven surfaces and a method of producing same 失效
标题翻译：具有不均匀表面的合成纤维及其制造方法
公开(公告)号：US4792489A
公开(公告)日：1988-12-20
申请号：US941351
申请日：1986-12-15
申请人： Hiroshi Kakiuchi , Setsuo Fukuhara , Michinobu Fujiwara , Hiroshi Maeda , Yutaka Shirakashi , Osamu Asakura , Yoshihiro Yoneda , Tetsuo Noda , Naoyuki Fujita
发明人： Hiroshi Kakiuchi , Setsuo Fukuhara , Michinobu Fujiwara , Hiroshi Maeda , Yutaka Shirakashi , Osamu Asakura , Yoshihiro Yoneda , Tetsuo Noda , Naoyuki Fujita
IPC分类号： A41G3/00 , D01D5/088 , D01D5/253 , D01F1/10 , D01F6/60 , D02G3/00
CPC分类号： A41G3/0083 , D01D5/0885 , D01D5/253 , D01F1/10 , D01F6/60 , Y10T428/2927 , Y10T428/2973 , Y10T428/2978
摘要： A synthetic fiber having an uneven surface structure consisting of wrinkles having ridges and recesses of the surface of the fiber and not presenting specular luster, which may be used, for example, as artificial hair for wigs, can be produced easily and stably by melt-spinning a starting synthetic resin such as nylon and passing the spun mono-filament through a cooling bath at a temperature not lower than 30.degree. C. for a period of time sufficient for developing wrinkles in its surface. Inclusion of a pigment such as carbon black in an appropriate amount in the starting material is effective in providing dense distribution of wrinkles.
摘要翻译：具有不均匀的表面结构的合成纤维可以容易且稳定地通过熔融粘合剂制造，该表面结构由具有脊部和纤维表面凹陷的褶皱组成，并且不呈现镜面光泽，例如可用作假发的人造毛发，旋转起始合成树脂如尼龙，并将纺丝单丝通过冷却浴，温度不低于30℃，持续一段足以在其表面产生皱纹的时间。在起始材料中包含适量的碳黑等颜料在提供致密的皱纹分布方面是有效的。

7. 发明授权

US5615184A Disc playing device 失效
标题翻译：光盘播放设备
公开(公告)号：US5615184A
公开(公告)日：1997-03-25
申请号：US175282
申请日：1993-12-28
申请人： Yukiyasu Tsuruta , Tetsuo Noda , Akihiro Yoshioka
发明人： Yukiyasu Tsuruta , Tetsuo Noda , Akihiro Yoshioka
IPC分类号： G11B17/04 , G11B17/24 , G11B33/02 , G11B17/22
CPC分类号： G11B17/24 , G11B17/0404 , G11B17/0405 , G11B33/027
摘要： A disc playing device including a magazine rotatably mounted on a base chassis, and a guide member attached to the base chassis so as to cover the magazine and permitting the rotation of the magazine. A pair of rollers are provided between a front panel and magazine. The disc is accommodated in the magazine by the rollers through a slit in the from panel. The magazine rotates to transport the disc to a playing portion, and the disc is pushed out by a kick-out member and then held between a clamp and a head mount assembly. The clamp and the assembly are pivotally movable by a slide plate.
摘要翻译：一种盘式播放装置，包括可旋转地安装在底架上的盒子，以及安装在底座上以便覆盖盒子并允许盒子旋转的导向件。一对辊子设置在前面板和盒子之间。该盘通过辊通过从面板上的狭缝容纳在盒中。盒子旋转以将盘传送到游戏部分，并且盘被推出构件推出，然后保持在夹具和头部安装组件之间。夹具和组件通过滑板可枢转地移动。

8. 发明授权

US5237555A Disc player 失效
标题翻译：光盘播放器
公开(公告)号：US5237555A
公开(公告)日：1993-08-17
申请号：US695130
申请日：1991-05-03
申请人： Yukiyasu Tsuruta , Tetsuo Noda
发明人： Yukiyasu Tsuruta , Tetsuo Noda
IPC分类号： G11B17/035 , G11B17/04
CPC分类号： G11B17/056 , G11B17/035
摘要： A disc player comprising a disc loading mechanism (2) for moving a tray (5) for placing a disc thereon from a disc discharge position to an intermediate position above a turntable (10) and then to a loading completed position below the intermediate position, a clamp mechanism (7) for pressing the disc into contact with the turntable (10), and signal recording-reproduction means for reproducing signals from the disc on the turntable (10) or recording signals on the disc. The clamp mechanism (7) comprises a clamp lever (71) movable toward and away from the turntable (10) with the movement of the tray (5) to thereby clamp the disc and release the disc from the clamp.
摘要翻译：一种光盘播放器，包括用于移动用于将盘放置在其上的盘从盘排出位置到盘台（10）上方的中间位置然后到中间位置下方的装载完成位置的盘（5）的盘装载机构（2）用于按压盘与转盘（10）接触的夹紧机构（7），以及信号记录再现装置，用于从转盘（10）上的盘再现信号或在盘上记录信号。夹紧机构（7）包括夹板（71），随着托架（5）的运动，可以朝向和远离转盘（10）移动的夹紧杆（71），从而夹紧盘并将盘从夹具中释放出来。

9. 发明授权

US4970042A Synthetic fibers having uneven surfaces method for melt-spinning 失效
标题翻译：用于熔融纺丝的合成纤维具有不均匀表面的方法
公开(公告)号：US4970042A
公开(公告)日：1990-11-13
申请号：US393051
申请日：1989-08-08
申请人： Hiroshi Kakiuchi , Setsuo Fukuhara , Michinobu Fujiwara , Hiroshi Maeda , Yutaka Shirakashi , Osamu Asakura , Yoshihiro Yoneda , Tetsuo Noda , Naoyuki Fujita
发明人： Hiroshi Kakiuchi , Setsuo Fukuhara , Michinobu Fujiwara , Hiroshi Maeda , Yutaka Shirakashi , Osamu Asakura , Yoshihiro Yoneda , Tetsuo Noda , Naoyuki Fujita
IPC分类号： A41G3/00 , D01D5/088 , D01D5/253 , D01F1/10 , D01F6/60
CPC分类号： A41G3/0083 , D01D5/0885 , D01D5/253 , D01F1/10 , D01F6/60 , Y10T428/2927 , Y10T428/2973 , Y10T428/2978
摘要： A synthetic fiber having an uneven surface structure consisting of wrinkles having ridges and recesses of the surface of the fiber and not presenting specular luster, which may be used, for example, as artificial hair for wigs, can be produced easily and stably by melt-spinning a starting synthetic resin such as nylon and passing the spun monofilament through a cooling bath at a temperature not lower than 30.degree. C. for a period of time sufficient for developing wrinkles in its surface. Inclusion of a pigment such as carbon black in an appropriate amount in the starting material is effective in providing dense distribution of wrinkles.

10. 发明授权

US07883890B2 Transposon transfer factor functioned in mammal 有权
标题翻译：转座子转运因子在哺乳动物中起作用
公开(公告)号：US07883890B2
公开(公告)日：2011-02-08
申请号：US10504535
申请日：2003-02-14
申请人： Koichi Kawakami , Tetsuo Noda
发明人： Koichi Kawakami , Tetsuo Noda
IPC分类号： C12N5/0735
CPC分类号： C12N9/22 , A01K2217/05 , A01K2227/10 , C12N15/90
摘要： Genetically modified mammalian cells comprising a Tol2 transposon transferred into a chromosome can be obtained by co-transfecting mammalian cells with a Tol2 transposase encoded by a Tol2 transposon found in medaka fish, and a Tol2 transposon lacking this transposase.
摘要翻译：包含转移到染色体中的Tol2转座子的转基因哺乳动物细胞可以通过用在medaka鱼中发现的Tol2转座子编码的Tol2转座酶和缺少该转座酶的Tol2转座子共转染哺乳动物细胞来获得。

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