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1. 发明申请

WO2006023675A3 MICROSCOPY SYSTEM HAVING AUTOMATIC AND INTERACTIVE MODES FOR FORMING A MAGNIFIED MOSAIC IMAGE AND ASSOCIATED METHOD 审中-公开
标题翻译：具有用于形成扩大的马赛克图像的自动和交互模式的显微系统及相关方法
公开(公告)号：WO2006023675A3
公开(公告)日：2006-04-20
申请号：PCT/US2005029448
申请日：2005-08-17
申请人： TRIPATH IMAGING INC , SCHMID JOACHIM HELMUT , GAHM THOMAS , KOOY KEVIN RUSSELL , DORRER RAINER , KRIEF BRUNO , CHEESEMANN JOHN ROYAL
发明人： SCHMID JOACHIM HELMUT , GAHM THOMAS , KOOY KEVIN RUSSELL , DORRER RAINER , KRIEF BRUNO , CHEESEMANN JOHN ROYAL
IPC分类号： G02B21/36 , G02B21/00
CPC分类号： G02B21/0016 , G01N15/042 , G01N15/05 , G01N2035/00039 , G02B21/26 , G02B21/367 , G06K9/00127 , G06T2200/32
摘要： A scanning device for biological slides is provided, which can be operated in an interactive routine mode as well as in an unsupervised high speed automatic mode. In the first case, typical components, which the pathologist is used to operating manually, such as the microscope, the stage and the focus, and which have to be motorized for the automatic unsupervised system mode, are configured to simulate manual use, operation, and response. A non-interlaced area scan camera supports the interactive selection and acquisition of individual images in the manual mode, as well as the continuous high-speed scan motion for the rare event detection and virtual slide scan applications of the system. Due to the particular requirements to accommodate both operational modes, methods are described for constructing the virtual slide out of image tiles with varying overlap areas in the x- and y- directions.
摘要翻译：提供了用于生物载玻片的扫描装置，其可以以交互式常规模式以及无监督高速自动模式操作。在第一种情况下，病理学家用于手动操作的典型部件（例如显微镜，台架和焦点）以及必须用于自动无监督系统模式的机动化部件被配置为模拟手动使用，操作，和回应。非隔行扫描区域扫描摄像机支持手动模式下交互式选择和采集单个图像，以及系统罕见事件检测和虚拟幻灯片扫描应用的连续高速扫描运动。由于适应两种操作模式的特定要求，描述了用于在x方向和y方向上具有变化的重叠区域的图像瓦片之外构建虚拟载片的方法。

2. 发明申请

WO03025554A3 METHOD QUANTITATIVE VIDEO-MICROSCOPY AND ASSOCIATED SYSTEM AND COMPUTER SOFTWARE PROGRAM PRODUCT 审中-公开
标题翻译：方法定量视频显微镜和相关系统和计算机软件程序产品
公开(公告)号：WO03025554A3
公开(公告)日：2003-08-21
申请号：PCT/US0229567
申请日：2002-09-18
申请人： TRIPATH IMAGING INC , MARCELPOIL RAPHAEL , GAHM THOMAS
发明人： MARCELPOIL RAPHAEL , GAHM THOMAS
IPC分类号： G01J3/51 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/483 , G02B21/36 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/60 , G01N21/78 , G02B21/24
CPC分类号： G06K9/00127 , G01N21/27 , G06T7/60 , G06T2207/10056
摘要： A method of determining an amount of at least one molecular specie comprising a sample is provided, each molecular specie being indicated by a dye. The amount of the molecular specie is determined from an image of the sample captured as image data by a color image acquisition device in a video-microscopy system. An optical density of the sample is first determined in each of a red, green, and blue channel at a particular pixel in the image. A corresponding optical density matrix is thereafter formed for that pixel. The optical density matrix is then multiplied by the inverse of a relative absorption coefficient matrix so as to form a resultant matrix for the pixel. The relative absorption coefficient matrix comprises a relative absorption coefficient for each dye, independently of the sample, in each of the red, green, and blue channels. The resultant matrix thus comprises the amount of each molecular specie, as indicated by the respective dye, for that pixel. Associated systems and computer software program products are also provided.
摘要翻译：提供了确定包含样品的至少一种分子物质的量的方法，每种分子物质由染料指示。通过视频显微镜系统中的彩色图像获取装置，从作为图像数据捕获的样本的图像确定分子种类的量。首先在图像中的特定像素处的红色，绿色和蓝色通道中的每一个中确定样本的光密度。此后为该像素形成对应的光密度矩阵。然后将光密度矩阵乘以相对吸收系数矩阵的倒数，以形成像素的合成矩阵。相对吸收系数矩阵包括在红色，绿色和蓝色通道中的每一个中独立于样品的每种染料的相对吸收系数。所得到的基质因此包含针对该像素的每种分子物质的量，如各染料所示。还提供相关系统和计算机软件程序产品。

3. 发明专利

JP2010078611A Method for quantitative video-microscopy and associated system therewith and computer software program product 有权
标题翻译：量化视频显微镜及其相关系统及计算机软件程序产品的方法
公开(公告)号：JP2010078611A
公开(公告)日：2010-04-08
申请号：JP2009273163
申请日：2009-12-01
申请人： Tripath Imaging Inc , トライパスイメージングインコーポレイテッド
发明人： MARCELPOIL RAPHAEL , GAHM THOMAS
IPC分类号： G01J3/51 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/483 , G02B21/36 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/60
CPC分类号： G06K9/00127 , G01N21/27 , G06T7/60 , G06T2207/10056
摘要： PROBLEM TO BE SOLVED: To provide an excellent colorimetric analysis technique with respect to a method for quantitative video-microscopy and associated system, etc. SOLUTION: The method for quantitative video-microscopy determining an amount of at least one molecular specie comprising a sample, each molecular specie being indicated by a dye, is provided. The amount of the molecular specie is determined from the image of a sample captured as image data by a color image acquisition device in a video-microscopy system. An optical density of the sample is first determined in each of a red, green, and blue channels at a particular pixel in the image. A corresponding optical density matrix is thereafter formed for the pixel. The optical density matrix is then multiplied by the inverse of a relative absorption coefficient matrix to form a resultant matrix for the pixel. The relative absorption coefficient matrix includes a relative absorption coefficient for each dye, independent of the sample, in each of the red, green, and blue channels. The resultant matrix thus includes the amount of each molecular specie, as indicated by the respective dye, for the pixel. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为定量视频显微镜和相关系统等提供优异的比色分析技术。解决方案：定量视频显微镜的方法确定至少一个量提供了包含样品的分子物质，每种分子物质由染料表示。通过视频显微镜系统中的彩色图像获取装置，从作为图像数据捕获的样本的图像确定分子种类的量。首先在图像中的特定像素处的红色，绿色和蓝色通道中的每一个中确定样本的光密度。此后为像素形成对应的光密度矩阵。然后将光密度矩阵乘以相对吸收系数矩阵的倒数，以形成用于像素的合成矩阵。相对吸收系数矩阵包括在每个红色，绿色和蓝色通道中的每种染料的独立于样品的相对吸收系数。所得到的基质因此包括像素所示的每种分子物质的量，如各染料所示。版权所有（C）2010，JPO＆INPIT

4. 发明专利

CA2485414A1 VIDEO MICROSCOPY SYSTEM AND MULTI-VIEW VIRTUAL SLIDE VIEWER CAPABLE OF SIMULTANEOUSLY ACQUIRING AND DISPLAYING VARIOUS DIGITAL VIEWS OF AN AREA OF INTEREST LOCATED ON A MICROSCOPIC SLIDE 未知
公开(公告)号：CA2485414A1
公开(公告)日：2003-11-20
申请号：CA2485414
申请日：2003-05-09
申请人： TRIPATH IMAGING INC
发明人： DORRER RAINER , SCHMID JOACHIM , GAHM THOMAS
IPC分类号： G01B11/00 , G02B21/00 , G02B21/36 , G06F3/048 , G06F17/30 , H04N1/04 , H04N1/21
摘要： The present invention provides a slide viewer capable of simultaneous displa y of more than one scan of an area of interest of a slide. The slide viewer includes a database containing at least two data files representing differen t scans for a same area of interest on one or multiple correlated slides or at least two different digital presentations of the same scan. The scans are views of different illumination and/or of different contrast. Associated wit h the database are a processor and a display. The processor retrieves data fil es representing different scans of the same of area of interest and displays th em on the display. The present invention allows a user to simultaneously view scans of the same area of interest, where the scans are of views different from each other by either illumination and/or contrast or by the digital information content presented, and/or by the information acquired from multiple correlated slides.

5. 发明专利

AU2003237810A1 VIDEO MICROSCOPY SYSTEM AND MULTI-VIEW VIRTUAL SLIDE VIEWER CAPABLE OF SIMULTANEOUSLY ACQUIRING AND DISPLAYING VARIOUS DIGITAL VIEWS OF AN AREA OF INTEREST LOCATED ON A MICROSCOPIC SLIDE 未知
公开(公告)号：AU2003237810A1
公开(公告)日：2003-11-11
申请号：AU2003237810
申请日：2003-05-09
申请人： TRIPATH IMAGING INC
发明人： GAHM THOMAS , DORRER RAINER , SCHMID JOACHIM
IPC分类号： G01B11/00 , G02B21/00 , G02B21/36 , G06F3/048 , G06F17/30 , H04N1/04 , H04N1/21
摘要： A slide viewer capable of simultaneous display of more than one representation of an area of interest of a slide is provided. The slide viewer includes a database containing at least two data files representing different representations for a same area of interest on one or multiple correlated slides or at least two different digital presentations of the same representation. The representations are views of different illumination and/or of different contrast. Associated with the database are a processor and a display. The processor retrieves data files representing different representations of the same of area of interest and displays them on the display. A user is allowed to simultaneously view representations of the same area of interest, where the representations are of views different from each other by either illumination and/or contrast or by the digital information content presented, and/or by the information acquired from multiple correlated slides.

6. 发明专利

CA2460801C METHOD FOR QUANTITATIVE VIDEO-MICROSCOPY AND ASSOCIATED SYSTEM AND COMPUTER SOFTWARE PROGRAM PRODUCT 未知
公开(公告)号：CA2460801C
公开(公告)日：2011-08-23
申请号：CA2460801
申请日：2002-09-18
申请人： TRIPATH IMAGING INC
发明人： MARCELPOIL RAPHAEL , GAHM THOMAS
IPC分类号： G01J3/51 , G01N21/78 , G01N21/27 , G01N21/64 , G01N21/93 , G01N33/48 , G01N33/483 , G02B21/24 , G02B21/36 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/60
摘要： A method of determining an amount of at least one molecular specie comprising a sample is provided, each molecular specie being indicated by a dye. The amount of the molecular specie is determined from an image of the sample captured as image data by a color image acquisition device in a video-microscopy system. An optical density of the sample is first determined in each of a red, green, and blue channel at a particular pixel in the image. A corresponding optical density matrix is thereafter formed for that pixel. The optical density matrix is then multiplied by the inverse of a relative absorption coefficient matrix so as to form a resultant matrix for the pixel. The relative absorption coefficient matrix comprises a relative absorption coefficient for each dye, independently of the sample, in each of the red, green, and blue channels. The resultant matrix thus comprises the amount of each molecular specie, as indicated by the respective dye, for that pixel. Associated systems and computer software program products are also provided.

7. 发明专利

CA2460801A1 METHOD FOR QUANTITATIVE VIDEO-MICROSCOPY AND ASSOCMETHOD FOR QUANTITATIVE VIDEO-MICROSCOPY AND ASSOCIATED SYSTEM AND COMPUTER SOFTWARE PROGRAM PRODUCTIATED SYSTEM AND COMPUTER SOFTWARE PROGRAM PRODUCT 未知
公开(公告)号：CA2460801A1
公开(公告)日：2003-03-27
申请号：CA2460801
申请日：2002-09-18
申请人： TRIPATH IMAGING INC
发明人： GAHM THOMAS , MARCELPOIL RAPHAEEL
IPC分类号： G01J3/51 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/483 , G02B21/36 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/60 , G01N21/78 , G02B21/24 , G01N21/93
摘要： A method of determining an amount of at least one molecular specie comprisin g a sample is provided, each molecular specie being indicated by a dye. The amount of the molecular specie is determined from an image of the sample captured as image data by a color image acquisition device in a video- microscopy system. An optical density of the sample is first determined in each of a red, green, and blue channel at a particular pixel in the image. A corresponding optical density matrix is thereafter formed for that pixel. Th e optical density matrix is then multiplied by the inverse of a relative absorption coefficient matrix so as to form a resultant matrix for the pixel . The relative absorption coefficient matrix comprises a relative absorption coefficient for each dye, independently of the sample, in each of the red, green, and blue channels. The resultant matrix thus comprises the amount of each molecular specie, as indicated by the respective dye, for that pixel. Associated systems and computer software program products are also provided.

8. 发明专利

DE60226043T2 未知
公开(公告)号：DE60226043T2
公开(公告)日：2009-05-14
申请号：DE60226043
申请日：2002-09-18
申请人： TRIPATH IMAGING INC
发明人： MARCELPOIL RAPHAIL , GAHM THOMAS
IPC分类号： G01J3/51 , G01N21/78 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/483 , G02B21/36 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/60
摘要： A method of determining an amount of at least one molecular specie comprising a sample is provided, each molecular specie being indicated by a dye. The amount of the molecular specie is determined from an image of the sample captured as image data by a color image acquisition device in a video-microscopy system. An optical density of the sample is first determined in each of a red, green, and blue channel at a particular pixel in the image. A corresponding optical density matrix is thereafter formed for that pixel. The optical density matrix is then multiplied by the inverse of a relative absorption coefficient matrix so as to form a resultant matrix for the pixel. The relative absorption coefficient matrix comprises a relative absorption coefficient for each dye, independently of the sample, in each of the red, green, and blue channels. The resultant matrix thus comprises the amount of each molecular specie, as indicated by the respective dye, for that pixel. Associated systems and computer software program products are also provided.

9. 发明专利

AU2007249081B2 Method quantitative video-microscopy and associated system and computer software program product 未知
公开(公告)号：AU2007249081B2
公开(公告)日：2008-10-02
申请号：AU2007249081
申请日：2007-12-18
申请人： TRIPATH IMAGING INC
发明人： GAHM THOMAS , MARCELPOIL APHAEL
IPC分类号： G01J3/51 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/483 , G02B21/36 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/60

10. 发明专利

ES2301706T3 METODO DE VIDEOMICROSCOPIA CUANTITATIVA Y SISTEMA ASOCIADO ASI COMO EL PRODUCTO DE PROGRAMA INFORMATICO DE SOFWARE. 未知
公开(公告)号：ES2301706T3
公开(公告)日：2008-07-01
申请号：ES02798993
申请日：2002-09-18
申请人： TRIPATH IMAGING INC
发明人： MARCELPOIL RAPHAEL , GAHM THOMAS
IPC分类号： G01J3/51 , G01N21/78 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/483 , G02B21/36 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/60
摘要： Un método de determinación de una magnitud de al menos una especie molecular que comprende una muestra (500), en donde cada especie molecular está indicada por un colorante, en un sistema de videomicroscopía (100), comprendiendo el mencionado método: capturar una imagen (450) de la muestra como datos de la imagen con un dispositivo de adquisición de imágenes de banda ancha; determinar una densidad óptica de la muestra a partir de los datos de la imagen, en cada uno de los canales del rojo, verde y azul (550, 600, 650) en un píxel en la imagen, de forma tal que se FOME una matriz de densidades ópticas correspondientes para el píxel; y multiplicar la matriz de densidades ópticas por el inverso de la matriz de coeficientes de absorción relativa, con el fin de formar una matriz resultante para el píxel, en donde la matriz de coeficientes de absorción relativa comprende un coeficiente de absorción relativa para cada colorante, independientemente de la muestra, en cada uno de los canales del rojo, verde y azul, comprendiendo la matriz resultante la magnitud de cada especie molecular, según lo indicado por el colorante respectivo para el píxel.

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