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1. 发明专利

JP2010091577A Method and composition for detection of cervical disease 审中-公开
标题翻译：检测宫颈疾病的方法和组成
公开(公告)号：JP2010091577A
公开(公告)日：2010-04-22
申请号：JP2009273812
申请日：2009-12-01
申请人： Tripath Imaging Inc , トライパスイメイジングインク
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , TAYLOR ADRIANN J , PARKER MARGARET R
IPC分类号： G01N33/574 , C07K16/18 , C07K16/30 , C12P19/34 , C12Q1/68 , C12Q1/70 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： G01N33/57411 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/6875 , G01N2333/025
摘要： PROBLEM TO BE SOLVED: To provide a method and composition for identifying high-grade cervical disease in a patient sample.
SOLUTION: The method includes detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In specific claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In concrete claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. A kit for practicing the method is further provided.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供用于鉴定患者样品中的高级子宫颈疾病的方法和组合物。解决方案：该方法包括检测身体样品中至少一种生物标志物的过表达，其中生物标志物在高级子宫颈疾病中选择性地过表达。在具体的权利要求中，身体样品是子宫颈涂片或单层宫颈细胞。生物标志物包括参与细胞周期调节，信号转导和DNA复制和转录的基因和蛋白质。具体地说，生物标志物是S期基因。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测目标生物标志物的过表达。还提供了用于实施该方法的套件。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2012188442A Monoclonal antibody and method for its use in the detection of cervical disease 有权
标题翻译：单克隆抗体及其用于检测宫颈疾病的方法
公开(公告)号：JP2012188442A
公开(公告)日：2012-10-04
申请号：JP2012127116
申请日：2012-06-04
申请人： Tripath Imaging Inc , トリパスイメージング, インコーポレイテッド
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , TAYLOR ADRIANN J
IPC分类号： C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08
CPC分类号： G01N33/57411 , C07K14/4738 , C07K16/3069 , C07K2317/34
摘要： PROBLEM TO BE SOLVED: To provide antibodies that are capable of detecting expression of a biomarker that is selectively overexpressed in high-grade cervical disease.SOLUTION: There are provided: novel monoclonal antibodies, variants and fragments thereof that specifically bind to MCM2; and hybridoma cell lines that produce the monoclonal antibodies. There are also provided: compositions for diagnosing high-grade cervical disease, including the monoclonal antibodies and the variants and fragments thereof; and methods for diagnosing high-grade cervical disease.
摘要翻译：要解决的问题：提供能够检测在高级子宫颈疾病中选择性过表达的生物标志物的表达的抗体。提供：提供：特异性结合MCM2的新型单克隆抗体，其变体和片段; 和产生单克隆抗体的杂交瘤细胞系。还提供：用于诊断高级宫颈疾病的组合物，包括单克隆抗体及其变体和片段; 以及诊断高级子宫颈疾病的方法。版权所有（C）2013，JPO＆INPIT

3. 发明申请

WO2005095964A3 METHODS AND COMPOSITIONS FOR THE DETECTION OF CERVICAL DISEASE 审中-公开
标题翻译：检测宫颈疾病的方法和组成
公开(公告)号：WO2005095964A3
公开(公告)日：2006-03-02
申请号：PCT/US2005009740
申请日：2005-03-23
申请人： TRIPATH IMAGING INC , FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , TAYLOR ADRIANN J , PARKER MARGARET R
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , TAYLOR ADRIANN J , PARKER MARGARET R
IPC分类号： G01N33/574 , C07K16/18 , C07K16/30 , C12P19/34 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/68
CPC分类号： G01N33/57411 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/6875 , G01N2333/025
摘要： Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了用于鉴定患者样品中高级别宫颈疾病的方法和组合物。本发明的方法包括检测身体样品中至少一种生物标志物的过表达，其中生物标志物在高级子宫颈疾病中选择性地过度表达。在具体的权利要求中，身体样品是宫颈涂片或宫颈细胞单层。本发明的生物标志物包括参与细胞周期调节，信号转导和DNA复制和转录的基因和蛋白质。在具体的权利要求中，生物标志物是S期基因。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测目标生物标志物的过表达。还提供了用于实施本发明的方法的试剂盒。

4. 发明申请

WO2007090076A3 METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：用于鉴别具有OVARIAN癌症和其组合物的增加的患者的患者的方法
公开(公告)号：WO2007090076A3
公开(公告)日：2007-11-08
申请号：PCT/US2007061205
申请日：2007-01-29
申请人： TRIPATH IMAGING INC , FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , HE QIN , WHITEHEAD CLARK M , CHEEK ROBERT L , GROELKE JOHN W
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , HE QIN , WHITEHEAD CLARK M , CHEEK ROBERT L , GROELKE JOHN W
IPC分类号： G01N33/574
CPC分类号： G01N33/57449
摘要： Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了鉴定患卵巢癌可能性增加的筛查方法。筛选方法涉及检测体内样品中多种生物标志物的表达，其中生物标志物的过表达表明卵巢癌的可能性增加。筛选方法还可以包括两步分析。感兴趣的生物标志物包括例如参与DNA复制/细胞周期控制，细胞生长和增殖，逃避凋亡，血管生成或淋巴发生的缺陷或癌细胞运动和侵袭的机制的基因和蛋白质。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测生物标志物的表达。本文进一步公开了患者卵巢癌检测方法。还提供了用于实施本发明的方法的试剂盒。

5. 发明申请

WO2006036788A3 METHODS AND COMPOSITIONS FOR EVALUATING BREAST CANCER PROGNOSIS 审中-公开
标题翻译：评估乳腺癌预后的方法和组合物
公开(公告)号：WO2006036788A3
公开(公告)日：2006-08-17
申请号：PCT/US2005034152
申请日：2005-09-22
申请人： TRIPATH IMAGING INC , FISCHER TIMOTHY J , WHITEHEAD CLARK M , MALINOWSKI DOUGLAS P , MARCELPOIL RAPHAEL , MOREL DIDIER
发明人： FISCHER TIMOTHY J , WHITEHEAD CLARK M , MALINOWSKI DOUGLAS P , MARCELPOIL RAPHAEL , MOREL DIDIER
IPC分类号： G01N33/574 , G06F19/18
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G06F19/18
摘要： Methods and compositions for evaluating the prognosis of a breast cancer patient, particularly an early-stage breast cancer patient, are provided. The methods of the invention comprise detecting expression of at least one, more particularly at least two, biomarker(s) in a body sample, wherein overexpression of the biomarker or a combination of biomarkers is indicative of breast cancer prognosis. In some embodiments, the body sample is a breast tissue sample, particularly a primary breast tumor sample. The biomarkers of the invention are proteins and/or genes whose overexpression is indicative of either a good or bad cancer prognosis. Biomarkers of interest include proteins and genes involved in cell cycle regulation, DNA replication, transcription, signal transduction, cell proliferation, invasion, proteolysis, or metastasis. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques.
摘要翻译：提供了用于评估乳腺癌患者，特别是早期乳腺癌患者的预后的方法和组合物。本发明的方法包括检测身体样品中至少一种，更特别是至少两种生物标志物的表达，其中生物标志物或生物标志物组合的过表达指示乳腺癌预后。在一些实施例中，身体样本是乳房组织样本，特别是原发性乳房肿瘤样本。本发明的生物标志物是蛋白质和/或基因，其过度表达指示癌症预后的好或不好。感兴趣的生物标志物包括涉及细胞周期调控，DNA复制，转录，信号转导，细胞增殖，侵入，蛋白水解或转移的蛋白质和基因。在本发明的一些方面中，使用生物标志物特异性抗体在蛋白质水平检测感兴趣生物标志物的过表达或使用核酸杂交技术在核酸水平检测感兴趣生物标志物的过表达。

6. 发明申请

WO2007090076A8 METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：用于鉴别具有OVARIAN癌症和其组合物的增加的患者的患者的方法
公开(公告)号：WO2007090076A8
公开(公告)日：2011-03-03
申请号：PCT/US2007061205
申请日：2007-01-29
申请人： TRIPATH IMAGING INC , FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , HE QIN , WHITEHEAD CLARK M , CHEEK ROBERT L , GROELKE JOHN W
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , HE QIN , WHITEHEAD CLARK M , CHEEK ROBERT L , GROELKE JOHN W
IPC分类号： G01N33/574
CPC分类号： G01N33/57449
摘要： Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了鉴定患卵巢癌可能性增加的筛查方法。筛选方法涉及检测体内样品中多种生物标志物的表达，其中生物标志物的过表达表明卵巢癌的可能性增加。筛选方法还可以包括两步分析。感兴趣的生物标志物包括例如参与DNA复制/细胞周期控制，细胞生长和增殖，逃避凋亡，血管生成或淋巴发生的缺陷或癌细胞运动和侵袭的机制的基因和蛋白质。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测生物标志物的表达。本文进一步公开了患者卵巢癌检测方法。还提供了用于实施本发明的方法的试剂盒。

7. 发明申请

WO2009032974A2 NUCLEIC ACID-BASED METHODS AND COMPOSITIONS FOR THE DETECTION OF OVARIAN CANCER 审中-公开
标题翻译：基于核酸的方法和组合物检测卵巢癌
公开(公告)号：WO2009032974A2
公开(公告)日：2009-03-12
申请号：PCT/US2008075322
申请日：2008-09-05
申请人： TRIPATH IMAGING INC , MALINOWSKI DOUGLAS P , FISCHER TIMOTHY J , GROELKE JOHN W
发明人： MALINOWSKI DOUGLAS P , FISCHER TIMOTHY J , GROELKE JOHN W
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Methods and compositions for identifying ovarian cancer in a patient sample are provided. The methods of the invention comprise detecting overexpression or underexpression of at least one nucleic acid biomarker in a body sample, wherein the biomarker is selectively overexpressed or underexpressed in ovarian cancer. The body sample may be, for example, an ovarian tissue sample. The biomarkers of the invention include any nucleic acid molecule that is selectively overexpressed in ovarian cancer, including, for example, MMP-7, PAEP, CA125, HE4, PLAUR, MUC-I, SLPI, SSPl, MSLN, SPONl, interleukin-7, folate receptor 1, claudin 3, inhibin A, inhibin BB, inhibin BA, and PAI-I. Overexpression or underexpression of a biomarker of interest is detected at the nucleic acid level using such methods as realtime PCR and various nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了用于鉴定患者样品中卵巢癌的方法和组合物。本发明的方法包括检测身体样品中至少一种核酸生物标志物的过表达或低表达，其中所述生物标志物在卵巢癌中选择性地过表达或低表达。身体样品可以是例如卵巢组织样品。本发明的生物标志物包括在卵巢癌中选择性过表达的任何核酸分子，包括例如MMP-7，PAEP，CA125，HE4，PLAUR，MUC-1，SLPI，SSP1，MSLN，SPON1，白细胞介素-7 ，叶酸受体1，紧密连蛋白3，抑制素A，抑制素BB，抑制素BA和PAI-1。在核酸水平上使用实时PCR和各种核酸杂交技术等方法检测感兴趣的生物标志物的过度表达或低表达。还提供了用于实施本发明的方法的试剂盒。

8. 发明申请

WO2006116442A3 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE 审中-公开
标题翻译：用于检测宫颈疾病的单克隆抗体及其使用方法
公开(公告)号：WO2006116442A3
公开(公告)日：2007-07-05
申请号：PCT/US2006015706
申请日：2006-04-26
申请人： TRIPATH IMAGING INC , FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , TAYLOR ADRIANN J
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , TAYLOR ADRIANN J
IPC分类号： C07K16/18 , C07K14/47 , C07K16/40 , C12N5/20 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： G01N33/57411 , C07K14/4738 , C07K16/3069 , C07K2317/34
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM 2 monoclonal antibody of the application are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the application are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present application.
摘要翻译：提供了用于诊断患者样本中高级别宫颈疾病的组成和方法。组合物包括特异性结合MCM2的单克隆抗体及其变体和片段。进一步提供具有本发明MCM2抗体结合特征的单克隆抗体。产生本申请的MCM2单克隆抗体的杂交瘤细胞系也在本文中公开。该组合物可用于诊断高级宫颈疾病的实践方法，包括检测来自患者的子宫颈样品中MCM2的过表达。进一步提供用于实施应用方法的套件。包含MCM2表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本申请中。

9. 发明专利

CA2606250C MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE 未知
公开(公告)号：CA2606250C
公开(公告)日：2014-02-04
申请号：CA2606250
申请日：2006-04-26
申请人： TRIPATH IMAGING INC
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , TAYLOR ADRIANN J
IPC分类号： C07K16/18 , C07K14/47 , C12N5/16 , C12N5/20 , G01N33/574 , G01N33/577 , G01N33/68
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM 2 monoclonal antibody of the application are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the application are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present application.

10. 发明专利

BRPI0620627A2 未知
公开(公告)号：BRPI0620627A2
公开(公告)日：2011-11-16
申请号：BRPI0620627
申请日：2006-08-10
申请人： TRIPATH IMAGING INC
发明人： MALINOWSKI DOUGLAS P , FISCHER TIMOTHY J , TAYLOR ADRIANN J
IPC分类号： C07K14/47 , C07K16/30 , G01N33/574
摘要： Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6. Monoclonal antibodies having the binding characteristics of an MCM6 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

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