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1. 发明申请

WO2009006404A2 HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS 审中-公开
标题翻译：杂环化合物可用作RAF激酶抑制剂
公开(公告)号：WO2009006404A2
公开(公告)日：2009-01-08
申请号：PCT/US2008068789
申请日：2008-06-30
申请人： SUNESIS PHARMACEUTICALS INC , COSSROW JENNIFER , GUAN BING , ISHCHENKO ALEXEY , JONES JOHN HOWARD , KUMARAVEL GNANASAMBANDAM , LUGOVSKOY ALEXEY , PENG HAIRUO , POWELL NOEL , RAIMUNDO BRIAN , TANAKA HIROKO , VESSELS JEFFREY , WYNN THOMAS , XIN ZHILI
发明人： COSSROW JENNIFER , GUAN BING , ISHCHENKO ALEXEY , JONES JOHN HOWARD , KUMARAVEL GNANASAMBANDAM , LUGOVSKOY ALEXEY , PENG HAIRUO , POWELL NOEL , RAIMUNDO BRIAN , TANAKA HIROKO , VESSELS JEFFREY , WYNN THOMAS , XIN ZHILI
IPC分类号： C07D413/12 , A61K31/505 , A61P35/00 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译：本发明提供了可用作Raf蛋白激酶抑制剂的化合物。本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。

2. 发明专利

AU2008273017B2 Heterocyclic compounds useful as Raf kinase inhibitors 未知
公开(公告)号：AU2008273017B2
公开(公告)日：2013-10-10
申请号：AU2008273017
申请日：2008-06-30
申请人： MILLENNIUM PHARM INC , SUNESIS PHARMACEUTICALS INC
发明人： PENG HAIRUO , ISHCHENKO ALEXEY , VESSELS JEFFREY , POWELL NOEL , GUAN BING , WYNN THOMAS , KUMARAVEL GNANASAMBANDAM , RAIMUNDO BRIAN , XIN ZHILI , COSSROW JENNIFER , JONES JOHN HOWARD , LUGOVSKOY ALEXEY , TANAKA HIROKO
IPC分类号： C07D413/12 , A61K31/505 , A61P35/00 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy

3. 发明专利

NZ582349A HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS 未知
公开(公告)号：NZ582349A
公开(公告)日：2012-06-29
申请号：NZ58234908
申请日：2008-06-30
申请人： SUNESIS PHARMACEUTICALS INC , MILLENNIUM PHARM INC
发明人： COSSROW JENNIFER , GUAN BING , ISHCHENKO ALEXEY , JONES JOHN HOWARD , KUMARAVEL GNANASAMBANDAM , LUGOVSKOY ALEXEY , PENG HAIRUO , POWELL NOEL , RAIMUNDO BRIAN , TANAKA HIROKO , VESSELS JEFFREY , WYNN THOMAS , XIN ZHILI
IPC分类号： C07D413/12 , A61K31/505 , A61P35/00 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Disclosed is a pyrimidine amide of formula I or a pharmaceutically acceptable salt thereof, wherein the substituents are defined in the specification for the treatment of a proliferative disorder, a cardiac disorder, a neurodegenerative disorder, an autoimmune disorder, a condition associated with organ transplant, an inflammatory disorder, an immunologically-mediated disorder, a viral disease, or bone disorder.

4. 发明专利

CA2748274A1 HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS 未知
公开(公告)号：CA2748274A1
公开(公告)日：2010-07-08
申请号：CA2748274
申请日：2009-12-30
申请人： MILLENNIUM PHARM INC , SUNESIS PHARMACEUTICALS INC
发明人： CHUAQUI CLAUDIO , COSSROW JENNIFER , DOWLING JAMES , GUAN BING , HOEMANN MICHAEL , ISHCHENKO ALEXEY , JONES JOHN HOWARD , KABIGTING LORI , KUMARAVEL GNANASAMBANDAM , PENG HAIRUO , POWELL NOEL , RAIMUNDO BRIAN , TANAKA HIROKO , VAN VLOTEN KURT , VESSELS JEFFREY , XIN ZHILI
IPC分类号： C07D261/08 , A61K31/416 , A61K31/422 , A61K31/428 , A61K31/429 , A61K31/437 , A61P35/00 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.

5. 发明专利

AU2008273017C1 Heterocyclic compounds useful as Raf kinase inhibitors 未知
公开(公告)号：AU2008273017C1
公开(公告)日：2014-02-13
申请号：AU2008273017
申请日：2008-06-30
申请人： MILLENNIUM PHARM INC , SUNESIS PHARMACEUTICALS INC
发明人： PENG HAIRUO , ISHCHENKO ALEXEY , VESSELS JEFFREY , POWELL NOEL , GUAN BING , WYNN THOMAS , KUMARAVEL GNANASAMBANDAM , RAIMUNDO BRIAN , XIN ZHILI , COSSROW JENNIFER , JONES JOHN HOWARD , LUGOVSKOY ALEXEY , TANAKA HIROKO
IPC分类号： C07D413/12 , A61K31/505 , A61P35/00 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy

6. 发明公开

EP2485589A4 HETEROARYL BTK INHIBITORS 审中-公开
标题翻译：杂芳基BTK-缝边
公开(公告)号：EP2485589A4
公开(公告)日：2013-02-06
申请号：EP10814583
申请日：2010-09-03
申请人： BIOGEN IDEC INC , SUNESIS PHARMACEUTICALS INC
发明人： BUI MINNA , CONLON PATRICK , ERLANSON DANIEL A , FAN JUNFA , GUAN BING , HOPKINS BRIAN T , ISHCHENKO ALEXEY , JENKINS TRACY J , KUMARAVEL GNANASAMBANDAM , MARCOTTE DOUG , POWELL NOEL , SCOTT DANIEL , TAVERAS ART , WANG DEPING , ZHONG MIN
IPC分类号： C07D401/04 , A61K31/506 , A61K31/52 , A61P29/00 , A61P35/02 , A61P37/00 , C07D473/34 , C07D487/04
CPC分类号： C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04

7. 发明专利

CA2694284A1 HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS 未知
公开(公告)号：CA2694284A1
公开(公告)日：2009-01-08
申请号：CA2694284
申请日：2008-06-30
申请人： SUNESIS PHARMACEUTICALS INC , BIOGEN IDEC INC
发明人： COSSROW JENNIFER , GUAN BING , ISHCHENKO ALEXEY , JONES JOHN HOWARD , KUMARAVEL GNANASAMBANDAM , LUGOVSKOY ALEXEY , PENG HAIRUO , POWELL NOEL , RAIMUNDO BRIAN , TANAKA HIROKO , VESSELS JEFFREY , WYNN THOMAS , XIN ZHILI
IPC分类号： C07D413/12 , A61K31/505 , A61P35/00 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently se-lected ted from nitrogen, oxygen, or sulfur; L1 is a direct bond of an optionally substituted, straight or branched C1-6 alkylene chain; L is a direct bond, or is an optionally substituted, straight or branched C1-6 alkylene chain wherein 1 or 2 methylene units of L2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydro-gen or an optionally substituted C1-6 aliphatic group; The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently se-lected from nitrogen, oxygen, or sulfur; L1 is a direct bond of an optionally substituted, straight or branched C1-6 alkylene chain; L2 is a direct bond, or is an optionally substituted, straight or branched C1-6 alkylene chain wherein 1 or 2 methylene units of L2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydro-gen or an optionally substituted C1-6 aliphatic group;

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