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1. 发明申请

WO2009120313A3 IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER LIGANDS IN SOY AND RELATED ASSAYS FOR IDENTIFYING BITTER TASTE MODULATORS 审中-公开
标题翻译：识别大豆中双歧杆菌配偶体的人类T2R受体的鉴定和相关测定用于鉴别叮咬调味品
公开(公告)号：WO2009120313A3
公开(公告)日：2009-12-30
申请号：PCT/US2009001829
申请日：2009-03-24
申请人： SENOMYX INC , LI XIAODONG , XU HONG , ZHANG LAN , LIU HANGHUI , WU KEPING
发明人： LI XIAODONG , XU HONG , ZHANG LAN , LIU HANGHUI , WU KEPING
IPC分类号： C12Q1/68 , A23L11/00 , A61K36/48 , C07K14/705 , C12Q1/00 , G01N33/566 , G01N33/567
CPC分类号： C12Q1/6895 , G01N33/5008 , G01N33/566 , G01N2500/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1, hT2R8, hT2R14, hT2R44, hT2R55, hT2R61, hT2R63, hT2R64, hT2R67 and hT2R71 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于水解大豆蛋白衍生物质中的特定苦味化合物的反应的发现。本发明还涉及这些T2R受体在用于鉴定通过存在于水解大豆蛋白材料及其衍生物和相关化合物中的特定苦味配体调节这些味觉受体的活化的配体的测定中的用途。这些化合物可以用作添加剂和/或从大豆基食品，饮料，化妆品和药物中去除，以便改变（阻断）水解大豆蛋白材料中存在的苦配子引起的与T2R相关的苦味。此外，这些T2R配体潜在地可以用作治疗和调节hT2R1，hT2R8，hT2R14，hT2R44，hT2R55，hT2R61，hT2R63，hT2R64，hT2R67和hT2R71相关的胃肠道和代谢功能如血清胆固醇水平以及治疗胃肠道和代谢疾病如饮食失调，食物感染，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等。

2. 发明申请

WO2012021837A2 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER 审中-公开
标题翻译：增强甜味剂稳定性的方法和含稳定甜味剂增强剂的组合物
公开(公告)号：WO2012021837A2
公开(公告)日：2012-02-16
申请号：PCT/US2011047636
申请日：2011-08-12
申请人： SENOMYX INC , TACHDJIAN CATHERINE , KARANEWSKY DONALD S , TANG XIAO-QING , LIU HANGHUI
发明人： TACHDJIAN CATHERINE , KARANEWSKY DONALD S , TANG XIAO-QING , LIU HANGHUI
IPC分类号： A23L2/60 , A23L27/20 , A23L2/62 , A23L27/00 , A23L27/30
CPC分类号： A23L1/22678 , A23L2/56 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K47/22 , A61K47/26
摘要： The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.
摘要翻译：本发明包括当将一种或多种甜味增强剂暴露于光源时稳定的方法以及含有一种或多种甜味增强剂和一种或多种光稳定剂的液体组合物。

3. 发明专利

BR112013003332A2 método para melhorar a estabilidade de intensificador de doce e composição contendo intensificador de doce estabilizado 未知
公开(公告)号：BR112013003332A2
公开(公告)日：2016-07-12
申请号：BR112013003332
申请日：2011-08-12
申请人： SENOMYX INC
发明人： TACHDJIAN CATHERINE , KARANEWSKY DONALD S , LIU HANGHUI , TANG XIAO-QING
IPC分类号： A23L27/20 , A23L2/60 , A23L2/62 , A23L27/00 , A23L27/30
摘要： método para melhorar a estabilidade de itensificador de doce e composição contendo intensificador de doce estabilizado. a presente invenção inclui métodos para a estabilização de um ou mais intensificadores de doce quando eles são expostos a uma fonte de luz, bem como composições líquidas contendo um ou mais intensificadores de doce e um ou mais fotoestabilizadores.

4. 发明专利

HK1185520A1 提高甜味增强劑的穩定性的方法和包含穩定的甜味增强劑的組合物未知
公开(公告)号：HK1185520A1
公开(公告)日：2014-02-21
申请号：HK13113034
申请日：2013-11-21
申请人： SENOMYX INC
发明人： TACHDJIAN CATHERINE , KARANEWSKY DONALD S S , TANG XIAO-QING , LIU HANGHUI
IPC分类号： A23L20060101 , A23L27/20 , A23L27/00 , A23L27/30 , A61K20060101

5. 发明公开

EP2603098A4 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER 审中-公开
公开(公告)号：EP2603098A4
公开(公告)日：2018-01-17
申请号：EP11817131
申请日：2011-08-12
申请人： SENOMYX INC
发明人： TACHDJIAN CATHERINE , KARANEWSKY DONALD S , TANG XIAO-QING , LIU HANGHUI
IPC分类号： A23L2/60 , A23L27/20 , A23L2/56 , A23L2/62 , A23L27/00 , A23L27/30 , A61K47/22 , A61K47/26
CPC分类号： A23L1/22678 , A23L2/56 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K47/22 , A61K47/26
摘要： The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

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