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1. 发明申请

US20090198185A1 HYDRAULICALLY ACTUATED PUMP FOR LONG DURATION MEDICAMENT ADMINISTRATION 有权
标题翻译：液压驱动泵长期服用药物管理
公开(公告)号：US20090198185A1
公开(公告)日：2009-08-06
申请号：US12336363
申请日：2008-12-16
申请人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
发明人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
IPC分类号： A61M5/145
CPC分类号： A61M5/16877 , A61M1/1032 , A61M5/1452 , A61M5/14526 , A61M5/14593 , A61M5/155 , A61M37/0015 , A61M2005/14264 , A61M2005/14506 , A61M2005/14513 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2250/00 , F04B9/103 , F04B9/1095 , F04B15/02 , F04B53/14 , F04B53/16
摘要： Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may thence flow through any suitable infusion set into a patient removeably attached thereto.
摘要翻译：目前公开的是液压泵装置及其用途，特别是在流体输送系统中。在一个实施例中，流体输送系统是用于慢剂量药物应用的廉价的一次性装置。流体输送系统可以使用弹簧压缩的波纹管曲柄或根据公知的蠕动原理操作的简单机构的其他组合，以迫使一定体积的超纯生物惰性液压流体穿过孔，从而扩大两个室的一个室液压缸。容纳药物的第二液体储存室响应于泵室的膨胀而通过常规孔排空。然后，药物可以通过任何合适的输注装置流入可移除地附接到其上的患者。

2. 发明授权

US09125983B2 Hydraulically actuated pump for fluid administration 有权
标题翻译：用于流体管理的液压致动泵
公开(公告)号：US09125983B2
公开(公告)日：2015-09-08
申请号：US12762307
申请日：2010-04-17
申请人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
发明人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
IPC分类号： A61M37/00 , A61M5/145 , A61M1/10 , A61M5/155 , F04B9/109 , F04B15/02 , A61M5/142
CPC分类号： A61M5/16877 , A61M1/1032 , A61M5/1452 , A61M5/14526 , A61M5/14593 , A61M5/155 , A61M37/0015 , A61M2005/14264 , A61M2005/14506 , A61M2005/14513 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2250/00 , F04B9/103 , F04B9/1095 , F04B15/02 , F04B53/14 , F04B53/16
摘要： A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir. A second actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir.
摘要翻译：液体输送装置包括具有液压流体的液压泵室。流体储存器联接到液压泵室，并且构造成容纳可递送给患者的流体。第一致动器联接到液压泵室并且构造成对液压泵室加压并且构造成将能量通过液压泵室传递到流体储存器。第二致动器联接到液压泵室并且构造成对液压泵室加压并且构造成将能量通过液压泵室传递到流体储存器。

3. 发明申请

US20090157005A1 HYDRAULICALLY ACTUATED PUMP FOR LONG DURATION MEDICAMENT ADMINISTRATION 有权
公开(公告)号：US20090157005A1
公开(公告)日：2009-06-18
申请号：US12336395
申请日：2008-12-16
申请人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
发明人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
IPC分类号： A61M5/142
CPC分类号： A61M5/16877 , A61M1/1032 , A61M5/1452 , A61M5/14526 , A61M5/14593 , A61M5/155 , A61M37/0015 , A61M2005/14264 , A61M2005/14506 , A61M2005/14513 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2250/00 , F04B9/103 , F04B9/1095 , F04B15/02 , F04B53/14 , F04B53/16
摘要： Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may thence flow through any suitable infusion set into a patient removeably attached thereto.

4. 发明授权

US09072828B2 Hydraulically actuated pump for long duration medicament administration 有权
标题翻译：液压驱动泵，用于长时间的药物管理
公开(公告)号：US09072828B2
公开(公告)日：2015-07-07
申请号：US12336395
申请日：2008-12-16
申请人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
发明人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
IPC分类号： A61M37/00 , A61M5/145 , A61M1/10 , A61M5/155 , A61M5/142
CPC分类号： A61M5/16877 , A61M1/1032 , A61M5/1452 , A61M5/14526 , A61M5/14593 , A61M5/155 , A61M37/0015 , A61M2005/14264 , A61M2005/14506 , A61M2005/14513 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2250/00 , F04B9/103 , F04B9/1095 , F04B15/02 , F04B53/14 , F04B53/16
摘要： Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may then flow through any suitable infusion set into a patient removeably attached thereto.
摘要翻译：目前公开的是液压泵装置及其用途，特别是在流体输送系统中。在一个实施例中，流体输送系统是用于慢剂量药物应用的廉价的一次性装置。流体输送系统可以使用弹簧压缩的波纹管曲柄或根据公知的蠕动原理操作的简单机构的其他组合，以迫使一定体积的超纯生物惰性液压流体穿过孔，从而扩大两个室的一个室液压缸。容纳药物的第二液体储存室响应于泵室的膨胀而通过常规孔排空。然后药物可以通过任何合适的输注装置流入可移除地附接到其上的患者。

5. 发明授权

US08162901B2 Microneedle array patch 失效
标题翻译： Microneedle阵列补丁
公开(公告)号：US08162901B2
公开(公告)日：2012-04-24
申请号：US11975717
申请日：2007-10-19
申请人： Robert R. Gonnelli , Devin V. McAllister
发明人： Robert R. Gonnelli , Devin V. McAllister
IPC分类号： A61M5/315
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , B33Y80/00
摘要： Microneedle devices for transport of molecules, including drugs and biological molecules, across tissue, are provided. The microneedle devices permit drug delivery or removal of body fluids at clinically relevant rates across skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. Microneedles can be formed of biodegradable or non-biodegradable polymeric materials or metals. In a preferred embodiment, a microneedle device includes a plugging element comprising a platform including a plurality of microneedle plugs for preventing skin or other tissue barriers from entering the hollow microneedles. In another preferred embodiment, a microneedle device includes a plurality of bioerodible elements for temporarily plugging the hollow microneedles, thereby preventing skin or other tissue barriers from entering the hollow microneedles.
摘要翻译：提供用于跨组织输送分子（包括药物和生物分子）的微针装置。微针装置允许以临床相关的速率在皮肤或其他组织屏障上进行药物输送或去除体液，对组织进行最少或没有损伤，疼痛或刺激。微针可由可生物降解或不可生物降解的聚合物材料或金属形成。在优选实施例中，微针装置包括插入元件，其包括平台，该平台包括用于防止皮肤或其他组织屏障进入中空微针的多个微针塞。在另一优选实施例中，微针装置包括用于暂时堵塞中空微针的多个生物腐蚀元件，从而防止皮肤或其他组织屏障进入中空微针。

6. 发明授权

US08070726B2 Hydraulically actuated pump for long duration medicament administration 有权
标题翻译：液压驱动泵，用于长时间的药物管理
公开(公告)号：US08070726B2
公开(公告)日：2011-12-06
申请号：US12336363
申请日：2008-12-16
申请人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
发明人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
IPC分类号： A61M37/00
CPC分类号： A61M5/16877 , A61M1/1032 , A61M5/1452 , A61M5/14526 , A61M5/14593 , A61M5/155 , A61M37/0015 , A61M2005/14264 , A61M2005/14506 , A61M2005/14513 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2250/00 , F04B9/103 , F04B9/1095 , F04B15/02 , F04B53/14 , F04B53/16
摘要： Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may thence flow through any suitable infusion set into a patient removeably attached thereto.
摘要翻译：目前公开的是液压泵装置及其用途，特别是在流体输送系统中。在一个实施例中，流体输送系统是用于慢剂量药物应用的廉价的一次性装置。流体输送系统可以使用弹簧压缩的波纹管曲柄或根据公知的蠕动原理操作的简单机构的其他组合，以迫使一定体积的超纯生物惰性液压流体穿过孔，从而扩大两个室的一个室液压缸。容纳药物的第二液体储存室响应于泵室的膨胀而通过常规孔排空。然后，药物可以通过任何合适的输注装置流入可移除地附接到其上的患者。

7. 发明申请

US20090118672A1 Microneedle array patch 失效
标题翻译： Microneedle阵列补丁
公开(公告)号：US20090118672A1
公开(公告)日：2009-05-07
申请号：US11975717
申请日：2007-10-19
申请人： Robert R. Gonnelli , Devin V. McAllister
发明人： Robert R. Gonnelli , Devin V. McAllister
IPC分类号： A61M5/32 , A61M5/20
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , B33Y80/00
摘要： Microneedle devices for transport of molecules, including drugs and biological molecules, across tissue, are provided. The microneedle devices permit drug delivery or removal of body fluids at clinically relevant rates across skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. Microneedles can be formed of biodegradable or non-biodegradable polymeric materials or metals. In a preferred embodiment, a microneedle device includes a plugging element comprising a platform including a plurality of microneedle plugs for preventing skin or other tissue barriers from entering the hollow microneedles. In another preferred embodiment, a microneedle device includes a plurality of bioerodible elements for temporarily plugging the hollow microneedles, thereby preventing skin or other tissue barriers from entering the hollow microneedles.
摘要翻译：提供用于跨组织输送分子（包括药物和生物分子）的微针装置。微针装置允许以临床相关的速率在皮肤或其他组织屏障上进行药物输送或去除体液，对组织进行最少或没有损伤，疼痛或刺激。微针可由可生物降解或不可生物降解的聚合物材料或金属形成。在优选实施例中，微针装置包括插入元件，其包括平台，该平台包括用于防止皮肤或其他组织屏障进入中空微针的多个微针塞。在另一优选实施例中，微针装置包括用于暂时堵塞中空微针的多个生物腐蚀元件，从而防止皮肤或其他组织屏障进入中空微针。

8. 发明申请

US20090131905A1 Microneedle devices and methods of manufacture and use thereof 审中-公开
公开(公告)号：US20090131905A1
公开(公告)日：2009-05-21
申请号：US12150945
申请日：2008-05-01
申请人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
发明人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
IPC分类号： A61M5/32 , A61N1/32 , B29C45/00 , G03F7/20 , B22D23/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

9. 发明授权

US07060192B2 Methods of fabricating physiological sample collection devices 有权
公开(公告)号：US07060192B2
公开(公告)日：2006-06-13
申请号：US10143127
申请日：2002-05-09
申请人： Vadim V Yuzhakov , Devin V. McAllister , Lorin Olson , Koon-wah Leong , Maria Teodorczyk , Ernest Kiser
发明人： Vadim V Yuzhakov , Devin V. McAllister , Lorin Olson , Koon-wah Leong , Maria Teodorczyk , Ernest Kiser
IPC分类号： B32B31/00 , C03C25/68
CPC分类号： A61B5/15146 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150282 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150954 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15153 , A61B5/15184 , A61B5/1519 , A61B5/15194 , A61B5/157
摘要： Methods of fabricating devices for collecting a sample of physiological and for measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. The fabrication methods provide various or forming the test strip and the skin-piercing element.

10. 发明授权

US09561042B2 Methods and devices for delivering agents across biological barriers 有权
标题翻译：在跨越生物屏障的情况下递送药剂的方法和装置
公开(公告)号：US09561042B2
公开(公告)日：2017-02-07
申请号：US12617566
申请日：2009-11-12
申请人： Devin V. McAllister , Ciro DiMeglio
发明人： Devin V. McAllister , Ciro DiMeglio
IPC分类号： A61M5/32 , A61B17/20 , A61M37/00
CPC分类号： A61B17/205 , A61M5/322 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , A61M2037/0061 , Y10T29/49826
摘要： The invention provides for microneedle devices for delivering agents across biological barriers. The microneedles include agent reservoirs integrated into the bodies of the microneedles, themselves.
摘要翻译：本发明提供了用于在跨越生物屏障传递物体的微针装置。微针包括集成在微针体中的药剂储存器。

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