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1. 发明申请

WO2006029075A8 FIBRATE COMPOUNDS HAVING PPAR AGONIST ACTIVITY 审中-公开
标题翻译：具有PPAR激动剂活性的纤维化合物
公开(公告)号：WO2006029075A8
公开(公告)日：2007-04-26
申请号：PCT/US2005031532
申请日：2005-09-06
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , DAS SAIBAL KUMAR , SINGH SUNIL KUMAR , MADHAVAN GURRAM RANGA , BHUNIYA DEBNATH , IQBAL JAVED , SHARMA SUDHIR KUMAR , CHAKRABARTI RANJAN
发明人： DAS SAIBAL KUMAR , SINGH SUNIL KUMAR , MADHAVAN GURRAM RANGA , BHUNIYA DEBNATH , IQBAL JAVED , SHARMA SUDHIR KUMAR , CHAKRABARTI RANJAN
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , C07D239/90
摘要： There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARa agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARa agonist activity and a PPARa agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.
摘要翻译：提供了具有PPAR激动剂活性的衍生物。衍生物包括化合物和/或其药学上可接受的盐; 其中A具有结构（II）或（III）的具有式（I）的化合物; X选自-CH 2 - ， - O - ， - NH-和-S-; Y选自-O - ， - NH-和-S-; 可以位于任何取代位置的Z是氢或卤素; R 1和R 2可以相同或不同，独立地选自氢和C 1 -C 8烷基，烷基或R 1和R 2一起形成具有4至6个碳原子的碳环; R 3选自氢和C 1 -C 8烷基; R 3选自氢和C 1 -C 8烷基; R 4，R 5和R 6可以相同或不同，独立地选自氢和C 1 -C 4烷基， -C 8烷基; 并且n是1至6.提供了各种实施例和变体。根据其它方面，本发明还提供了在哺乳动物中产生PPARα激动剂活性的方法，所述方法包括向哺乳动物施用有效量的本发明第一方面的某些衍生物，产生 PPARα激动剂活性和PPARα激动剂活性，所述方法包括给哺乳动物施用有效量的某些衍生物; 以及包含本发明第一方面的衍生物和一种或多种药学上可接受的赋形剂的药物组合物。提供了各种实施例和变体。

2. 发明申请

WO2006029075A2 FIBRATE COMPOUNDS HAVING PPAR AGONIST ACTIVITY 审中-公开
标题翻译：具有PPAR激动剂活性的纤维化合物
公开(公告)号：WO2006029075A2
公开(公告)日：2006-03-16
申请号：PCT/US2005031532
申请日：2005-09-06
申请人： REDDYS LAB LTD DR , REDDYS LAB LTD DR , DAS SAIBAL KUMAR , SINGH SUNIL KUMAR , MADHAVAN GURRAM RANGA , BHUNIYA DEBNATH , IQBAL JAVED , SHARMA SUDHIR KUMAR , CHAKRABARTI RANJAN
发明人： DAS SAIBAL KUMAR , SINGH SUNIL KUMAR , MADHAVAN GURRAM RANGA , BHUNIYA DEBNATH , IQBAL JAVED , SHARMA SUDHIR KUMAR , CHAKRABARTI RANJAN
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , C07D239/90
摘要： There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARa agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARa agonist activity and a PPARa agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.
摘要翻译：提供具有PPAR激动剂活性的衍生物。衍生物包括化合物和/或其药学上可接受的盐; 具有式（I）的化合物其中A具有结构（II）或（III）; X选自-CH 2 - ， - O - ， - N - 和-S-; Y选自-O - ， - NH-和-S-; 可以位于任何取代位置的Z是氢或卤素; R 1和R 2可以相同或不同，独立地选自氢和C 1 -C 8烷基，或者R 1和R 2一起形成具有4至6个碳原子的碳环; R 3选自氢和C 1 -C 8烷基; R 4，R 5，R 5和R 6可以相同或不同，独立地选自氢和C 1 C 8 -C 14烷基; 并且n为1至6.提供了各种实施方案和变体。根据其它方面，本发明还提供了在哺乳动物中产生PPARα激动剂活性的方法，所述方法包括向哺乳动物施用有效量的本发明第一方面的某些衍生物， PPARα激动剂活性和PPARα激动剂活性，所述方法包括向哺乳动物施用有效量的某些衍生物; 和包含本发明第一方面的衍生物和一种或多种药学上可接受的赋形剂的药物组合物。提供了各种实施例和变型。

3. 发明专利

CA2579230A1 FIBRATE COMPOUNDS HAVING PPAR AGONIST ACTIVITY 未知
公开(公告)号：CA2579230A1
公开(公告)日：2006-03-16
申请号：CA2579230
申请日：2005-09-06
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR
发明人： IQBAL JAVED , BHUNIYA DEBNATH , MADHAVAN GURRAM RANGA , CHAKRABARTI RANJAN , SHARMA SUDHIR KUMAR , SINGH SUNIL KUMAR , DAS SAIBAL KUMAR
IPC分类号： A61K31/519 , C07D487/02
摘要： There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARalpha agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARalpha agonist activity and a PPARalpha agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.

4. 发明申请

WO2012042539A3 3 -AZABICYCLO [3.1.0] HEXANE COMPOUNDS USEFUL FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译： 3 -AZABICYCLO [3.1.0]用于治疗CNS疾病的HEXANE化合物
公开(公告)号：WO2012042539A3
公开(公告)日：2012-05-31
申请号：PCT/IN2011000669
申请日：2011-09-27
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , SINGH NISHAN , SHARMA SUDHIR KUMAR
发明人： JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , SINGH NISHAN , SHARMA SUDHIR KUMAR
IPC分类号： C07D209/52 , A61K31/403 , A61P25/00
CPC分类号： C07D209/52 , A61K31/403 , A61K45/06
摘要： The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention further provides pharmaceutical compositions comprising compounds of Formula I and methods of treating or preventing one or more disorders of the central and/or peripheral nervous system, preferably by modulating neurological and/or psychiatric targets (GPCR and/or non-GPCR).
摘要翻译：本发明涉及式I的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂化物。本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。本发明还提供包含式I化合物的药物组合物和治疗或预防中枢和/或周围神经系统的一种或多种病症的方法，优选通过调节神经和/或精神病学靶标（GPCR和/或非GPCR）。

5. 发明申请

WO2013038429A3 NOVEL SGLT INHIBITORS 审中-公开
标题翻译：新的SGLT抑制剂
公开(公告)号：WO2013038429A3
公开(公告)日：2013-11-28
申请号：PCT/IN2012000612
申请日：2012-09-12
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , NANDA GURMEET KAUR , THUNGATHURTHI SASTRY V R S , SINGH NISHAN , SHARMA SUDHIR KUMAR
发明人： JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , NANDA GURMEET KAUR , THUNGATHURTHI SASTRY V R S , SINGH NISHAN , SHARMA SUDHIR KUMAR
IPC分类号： A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07D309/10 , C07D493/08 , C07H7/04
摘要： The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula (I) and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).
摘要翻译：本发明涉及式（I）的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂化物。本发明还涉及合成式（I）的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。本发明还提供了包含式（I）的新化合物的药物组合物以及治疗或预防可通过抑制葡萄糖协同转运蛋白-2（SGLT-2）而调节或正常化的一种或多种病症或疾病的方法。

6. 发明申请

WO2010058423A3 NOVEL ANTIMICROBIALS 审中-公开
标题翻译：新的抗生素
公开(公告)号：WO2010058423A3
公开(公告)日：2010-12-09
申请号：PCT/IN2009000658
申请日：2009-11-18
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , KANWAR SANDEEP , MAGADI SITARAM KUMAR , SHARMA SUDHIR KUMAR
发明人： JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , KANWAR SANDEEP , MAGADI SITARAM KUMAR , SHARMA SUDHIR KUMAR
IPC分类号： C07D413/10 , C07D413/14
CPC分类号： C07D487/04 , C07D263/20 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.
摘要翻译：本发明涉及式I的新型苯基恶唑烷酮化合物，其药学上可接受的类似物，互变异构形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂化物。本发明还涉及合成新型式I化合物或其药学上可接受的类似物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。本发明还提供了包含新颖的式I化合物和使用它们的方法的药物组合物。本发明的化合物可用作抗微生物剂，对许多需氧和/或厌氧革兰氏阳性和/或革兰氏阴性病原体有效，如葡萄球菌，链球菌，肠球菌，细菌，梭菌，流感嗜血杆菌，莫拉氏菌，耐酸菌，如结核分枝杆菌，以及耐盐霉菌属的霉菌和肠球菌。

7. 发明申请

WO2012172566A2 NOVEL SGLT INHIBITORS 审中-公开
标题翻译：新型SGLT抑制剂
公开(公告)号：WO2012172566A2
公开(公告)日：2012-12-20
申请号：PCT/IN2012000416
申请日：2012-06-13
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , NANDA GURMEET KAUR , THUNGATHURTHI SASTRY V R S , SINGH NISHAN , SHARMA SUDHIR KUMAR
发明人： JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , NANDA GURMEET KAUR , THUNGATHURTHI SASTRY V R S , SINGH NISHAN , SHARMA SUDHIR KUMAR
IPC分类号： C07H15/203
CPC分类号： A61K31/7048 , A61K31/70 , C07D309/10 , C07D401/04 , C07D493/08 , C07H7/04 , C07H9/04 , C07H13/04 , C07H13/12 , C07H15/04 , C07H19/01
摘要： The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula (I) and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).
摘要翻译：本发明涉及式（I）的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂合物。本发明还涉及合成式（I）的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。本发明还提供包含式（I）的新型化合物和治疗或预防可通过抑制葡萄糖转运蛋白-2（SGLT-2）调节或归一化的一种或多种病症或疾病的药物组合物。

8. 发明申请

WO2011070592A2 NOVEL SUGAR DERIVATIVES 审中-公开
标题翻译：新糖衍生物
公开(公告)号：WO2011070592A2
公开(公告)日：2011-06-16
申请号：PCT/IN2010000796
申请日：2010-12-09
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , TREHAN SANJAY , THUNGATHURTHI SASTRY V R S , NANDA GURMEET KAUR , DAS JAGATTARAN , MAGADI SITARAM KUMAR , SHARMA SUDHIR KUMAR
发明人： JAIN RAJESH , TREHAN SANJAY , THUNGATHURTHI SASTRY V R S , NANDA GURMEET KAUR , DAS JAGATTARAN , MAGADI SITARAM KUMAR , SHARMA SUDHIR KUMAR
CPC分类号： C07H15/04 , C07D309/10
摘要： The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2). The invention also relates to the use of compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof, for the manufacture of a medicament for the prophylaxis, amelioration and/or treatment of conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2) and the related diseases, disorders and conditions, in a subject in need thereof.
摘要翻译：本发明涉及式（I）的新化合物，其药学上可接受的衍生物，类似物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂合物。本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，类似物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。本发明还提供包含式I的新化合物和治疗或预防一种或多种可通过抑制葡萄糖转运蛋白-2（SGLT-2）调节或归一化的病症或疾病的药物组合物。本发明还涉及式I化合物，其药学上可接受的衍生物，类似物，互变异构体形式，异构体，多晶型物，前体药物，代谢物，盐或溶剂合物在制备用于预防和/或改善在有需要的受试者中通过抑制葡萄糖转运蛋白-2（SGLT-2）和相关疾病，病症和病症来调节或归一化的病症或疾病的治疗。

9. 发明申请

WO2010150281A3 NOVEL AZABICYCLOHEXANES 审中-公开
标题翻译：新的雅各布
公开(公告)号：WO2010150281A3
公开(公告)日：2011-04-21
申请号：PCT/IN2010000428
申请日：2010-06-22
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , KAUR GURMEET , KANWAR SANDEEP , SINGH NISHAN , NANDA GURMEET KAUR , MAGADI SITARAM KUMAR , SHARMA SUDHIR KUMAR
发明人： JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , KAUR GURMEET , KANWAR SANDEEP , SINGH NISHAN , NANDA GURMEET KAUR , MAGADI SITARAM KUMAR , SHARMA SUDHIR KUMAR
IPC分类号： C07D221/22 , A61K31/46 , A61K31/496 , A61K31/498 , A61K31/5355 , A61K31/551 , A61P25/00 , A61P31/00 , C07D401/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/08
CPC分类号： C07D221/22 , C07D209/52 , C07D401/10 , C07D409/04 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/08
摘要： The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof.
摘要翻译：本发明涉及式（I）的新化合物，其药学上可接受的衍生物，互变异构体，立体异构体，包括R和S异构体，多晶型物，前药，代谢物，盐或溶剂化物。本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。

10. 发明申请

WO2010058423A2 NOVEL ANTIMICROBIALS 审中-公开
标题翻译：新的抗微生物剂
公开(公告)号：WO2010058423A2
公开(公告)日：2010-05-27
申请号：PCT/IN2009000658
申请日：2009-11-18
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , KANWAR SANDEEP , MAGADI SITARAM KUMAR , SHARMA SUDHIR KUMAR
发明人： JAIN RAJESH , TREHAN SANJAY , DAS JAGATTARAN , KANWAR SANDEEP , MAGADI SITARAM KUMAR , SHARMA SUDHIR KUMAR
IPC分类号： C07D413/10 , C07D413/14
CPC分类号： C07D487/04 , C07D263/20 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.
摘要翻译：本发明涉及式I的新型苯基恶唑烷酮化合物，其药学上可接受的类似物，互变异构形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂化物。本发明还涉及合成式I的新化合物或其药学上可接受的类似物，互变异构形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。本发明还提供了包含新型式I化合物和使用它们的方法的药物组合物。本发明化合物可用作抗微生物剂，有效对抗许多需氧和/或厌氧革兰氏阳性和/或革兰氏阴性病原体，例如葡萄球菌，链球菌，肠球菌，细菌，梭菌，流感嗜血菌，莫拉菌属（Moraxella），耐酸生物体如结核分枝杆菌（Mycobacterium tuberculosis）以及耐利奈唑胺菌（Staphylococcus and Enterococcus）。

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