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1. 发明授权

US07144867B2 Anticancer glycoside compounds 有权
标题翻译：抗癌糖苷化合物
公开(公告)号：US07144867B2
公开(公告)日：2006-12-05
申请号：US11044496
申请日：2005-01-27
申请人： Thomas E. Adrian , Peter D. Collin
发明人： Thomas E. Adrian , Peter D. Collin
IPC分类号： A01N43/04 , A61K31/70 , A01N57/00 , A61K31/665
CPC分类号： A61K31/704
摘要： The present invention relates to new classes of anti-cancer compounds. In particular, the present invention provides glycoside compounds as anti-cancer agent, alone, or in combination with other anti-cancer agents or therapies.
摘要翻译：本发明涉及新类型的抗癌化合物。特别地，本发明提供作为抗癌剂的糖苷化合物，单独使用或与其它抗癌剂或疗法组合。

2. 发明授权

US07387797B2 Compositions derived from Modiolus modiolus and methods for making and using same 失效
标题翻译：衍生自Modiolus modiolus的组合物及其制备和使用方法
公开(公告)号：US07387797B2
公开(公告)日：2008-06-17
申请号：US10239345
申请日：2001-03-22
申请人： Peter D. Collin , Thomas E. Adrian
发明人： Peter D. Collin , Thomas E. Adrian
IPC分类号： A61K35/56 , A61K9/14
CPC分类号： A61K35/618
摘要： Disclosed are compositions which include an isolated soft tissue from Modiolus modiolus (“MM”) and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.
摘要翻译：公开了包括来自Modiolus modiolus（“MM”）的分离的软组织的组合物和包含从MM或其一部分分离的油的组合物。还公开了在受试者中治疗腺癌的方法; 降低腺癌细胞增殖或诱导腺癌细胞凋亡或诱导腺癌细胞分化为非癌细胞的方法; 抑制5-脂氧合酶或12-脂氧合酶或两者在细胞中的活性的方法; 以及治疗患有与过量的5-脂氧合酶活性或12-脂肪氧合酶活性或两者有关的疾病或病症的受试者的方法。还描述了在有效从MM或其部分提取一种或多种材料的条件下使MM或其一部分与溶剂接触来制备MM提取物的方法。

3. 发明授权

US07335382B1 Compositions and methods for the treatment and prevention of cancer 有权
标题翻译：用于治疗和预防癌症的组合物和方法
公开(公告)号：US07335382B1
公开(公告)日：2008-02-26
申请号：US11066802
申请日：2005-02-25
申请人： Xian-Zhong Ding , Thomas E. Adrian , Peter D. Collin
发明人： Xian-Zhong Ding , Thomas E. Adrian , Peter D. Collin
IPC分类号： A61K35/36 , A61K35/12
CPC分类号： A61K35/616
摘要： The present invention relates to new classes of anti-cancer agents. In particular, the present invention provides materials derived from natural sources as anti-cancer agents, alone, or in combination with other anti-cancer agents or therapies.
摘要翻译：本发明涉及新类型的抗癌剂。特别地，本发明提供源自天然来源的作为抗癌剂的材料，单独或与其它抗癌剂或疗法组合。

4. 发明授权

US07709443B2 Cyclic peptide antitumor agents 有权
标题翻译：环肽类抗肿瘤剂
公开(公告)号：US07709443B2
公开(公告)日：2010-05-04
申请号：US10962168
申请日：2004-10-08
申请人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
发明人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
IPC分类号： A61K38/00
CPC分类号： A61K38/12 , C07K7/64
摘要： Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
摘要翻译：通过治疗人黑素瘤，胰腺，乳腺癌，前列腺癌细胞所示的具有抗肿瘤活性的环肽化合物及其衍生物。

5. 发明授权

US08492345B2 Cyclic peptide antitumor agents 有权
标题翻译：环肽类抗肿瘤剂
公开(公告)号：US08492345B2
公开(公告)日：2013-07-23
申请号：US13295653
申请日：2011-11-14
申请人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
发明人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
IPC分类号： A61K38/00 , A61P35/00
CPC分类号： A61K38/12 , C07K7/64
摘要： Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
摘要翻译：通过治疗人黑素瘤，胰腺，乳腺癌，前列腺癌细胞所示的具有抗肿瘤活性的环肽化合物及其衍生物。

6. 发明申请

US20120122799A1 CYCLIC PEPTIDE ANTITUMOR AGENTS 有权
标题翻译：循环肽类抗菌剂
公开(公告)号：US20120122799A1
公开(公告)日：2012-05-17
申请号：US13295653
申请日：2011-11-14
申请人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
发明人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
IPC分类号： A61K38/12 , A61P35/00
CPC分类号： A61K38/12 , C07K7/64
摘要： Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
摘要翻译：通过治疗人黑素瘤，胰腺，乳腺癌，前列腺癌细胞所示的具有抗肿瘤活性的环肽化合物及其衍生物。

7. 发明授权

US08058244B2 Cyclic peptide antitumor agents 有权
标题翻译：环肽类抗肿瘤剂
公开(公告)号：US08058244B2
公开(公告)日：2011-11-15
申请号：US12722026
申请日：2010-03-11
申请人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
发明人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
IPC分类号： A61K38/00
CPC分类号： A61K38/12 , C07K7/64
摘要： Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
摘要翻译：通过治疗人黑素瘤，胰腺，乳腺癌，前列腺癌细胞所示的具有抗肿瘤活性的环肽化合物及其衍生物。

8. 发明申请

US20100204088A1 Cyclic Peptide Antitumor Agents 有权
标题翻译：循环肽抗肿瘤剂
公开(公告)号：US20100204088A1
公开(公告)日：2010-08-12
申请号：US12722026
申请日：2010-03-11
申请人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
发明人： Richard B. Silverman , Shouxin Liu , Wenxin Gu , Thomas E. Adrian , Gerald A. Soff
IPC分类号： A61K38/12
CPC分类号： A61K38/12 , C07K7/64
摘要： Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
摘要翻译：通过治疗人黑素瘤，胰腺，乳腺癌，前列腺癌细胞所示的具有抗肿瘤活性的环肽化合物及其衍生物。

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