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1. 发明申请

US20050277176A1 Human and mouse beta-defensins, antimicrobial peptides 审中-公开
标题翻译：人和小鼠β-防御素，抗菌肽
公开(公告)号：US20050277176A1
公开(公告)日：2005-12-15
申请号：US11121301
申请日：2005-05-03
申请人： Paul McCray , Brian Schutte , Hong Jia , Thomas Casavant , Michael Welsh
发明人： Paul McCray , Brian Schutte , Hong Jia , Thomas Casavant , Michael Welsh
IPC分类号： A61K38/17 , C07H21/04 , C07K14/47 , C12N5/06 , C12N5/08 , C12N15/86 , C12N15/867 , C12P21/02
CPC分类号： C07K14/4723
摘要： The present invention employs an iterative application of BLAST and Hidden Markov Model (HMM) based searches which identified 34 β-defensin genes in the human genome and 48 in the mouse genome. The present invention relates to novel antimicrobial peptides and derivatives thereof as well as the β-defensin genes encoding the peptides. The invention further relates to methods of use of the peptides including a method of inhibiting microbial growth by administering an effective amount of the peptide alone or in combination with other antimicrobial agents or antibiotics.
摘要翻译：本发明使用基于BLAST和隐马尔可夫模型（HMM）的搜索的迭代应用，其在人类基因组中鉴定出34个β-防御素基因，在小鼠基因组中鉴定出48个。本发明涉及新型抗微生物肽及其衍生物以及编码肽的β-防御素基因。本发明还涉及肽的使用方法，包括通过单独施用有效量的肽或与其它抗微生物剂或抗生素组合来抑制微生物生长的方法。

2. 发明申请

US20050192221A1 Methods and compositions related to plunc polypeptides 审中-公开
标题翻译：与plunc多肽相关的方法和组合物
公开(公告)号：US20050192221A1
公开(公告)日：2005-09-01
申请号：US11003126
申请日：2004-12-03
申请人： Paul McCray , Jerry Weiss , Hong Jia , Brian Schutte , Jennifer Bartlett
发明人： Paul McCray , Jerry Weiss , Hong Jia , Brian Schutte , Jennifer Bartlett
IPC分类号： A61K31/4745 , A61K31/496 , A61K31/65 , A61K31/704 , A61K31/7048 , A61K38/17
CPC分类号： A61K38/1709
摘要： The present invention concerns compositions and methods related to the use of peptides and polypeptides corresponding to all or part of the SPLUNC1 and LPLUNC1 proteins. Particular aspects of the invnetion include the use of SPLUNC1 and LPLUNC1 peptides and polypeptides as antimicrobials, anti-inflammatory, and immune modulatory agents.
摘要翻译：本发明涉及与使用与全部或部分SPLUNC1和LPLUNC1蛋白相对应的肽和多肽相关的组合物和方法。侵入的特定方面包括使用SPLUNC1和LPLUNC1肽和多肽作为抗微生物剂，抗炎剂和免疫调节剂。

3. 发明申请

US20050089885A1 IRF6 polymorphisms associated with cleft lip and/or palate 审中-公开
标题翻译：与唇裂和/或腭裂相关的IRF6多态性
公开(公告)号：US20050089885A1
公开(公告)日：2005-04-28
申请号：US10840139
申请日：2004-05-06
申请人： Brian Schutte , Jeffrey Murray , Shinji Kondo , Michael Dixon
发明人： Brian Schutte , Jeffrey Murray , Shinji Kondo , Michael Dixon
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： This invention relates to polymorphisms in the IRF6 gene which are associated with various diseases, such as Van der Woude syndrome, Poplitieal syndrome, isolated cleft lip and/or palate, and other orofusial clefting disorders. The invention also relates to the nucleotide sequences of this gene, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. In addition the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, or antibodies for use in diagnostics and therapeutics for IRF6 associated disorders, e.g., Van der Woude syndrome, Poplitieal syndrome, isolated cleft lip and/or palate, and other orofusial clefting disorders.
摘要翻译：本发明涉及与各种疾病相关的IRF6基因的多态性，例如范德伍德综合征，普遍综合征，孤立性唇裂和/或腭裂以及其他肛裂开裂病症。本发明还涉及该基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。此外，本发明涉及使用所公开的核酸，多肽或肽或用于诊断和治疗IRF6相关疾病的抗体的方法和组合物，例如范德伍德综合征，普遍综合征，分离的唇裂和/或腭裂，和其他无性解剖障碍。

4. 发明申请

US20070009992A1 Variant TLR4 nucleic acid and uses thereof 失效
标题翻译：变体TLR4核酸及其用途
公开(公告)号：US20070009992A1
公开(公告)日：2007-01-11
申请号：US11517172
申请日：2006-09-07
申请人： David Schwartz , Brian Schutte
发明人： David Schwartz , Brian Schutte
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705 , A01K2217/05
摘要： The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
摘要翻译：本发明提供了鉴定人TLR4基因座上的多态性的方法，以及识别具有增加其发病率和死亡率的适应症风险的个体的方法。

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