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1. 发明申请

US20070065389A1 Genes from chromosomes 3, 5 and 11 involved in premature canities 审中-公开
标题翻译：来自染色体3,5和11的基因涉及早衰
公开(公告)号：US20070065389A1
公开(公告)日：2007-03-22
申请号：US11583512
申请日：2006-10-18
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
IPC分类号： A61K8/73 , C12Q1/68 , A61K48/00
CPC分类号： A61Q5/10 , A61K8/35 , A61K48/00 , A61Q19/04 , C12Q1/6883 , C12Q2600/148 , C12Q2600/156 , C12Q2600/172
摘要： The disclosure provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 3 selected from KIAA1042, CCK, CACNA1D, ARHGEF3 and AL133097 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 5 selected from the KLHL3, HNRPA0, CDC25C, EGR1, C5orf7, LOC51308, ETF1, HSPA9B, PDCHA1 to PDCHA13, CSF1R, RPL7, PDGFRB, TCOF1, AL133039, CD74, RPS14, NDST1, G3BP, GLRA1, C5orf3, MFAP3, GALNT10 and FLJ117151 genes, or the sequence of which corresponds to all or part of a gene or human chromosome 11 selected from the GUCY1A2, CUL5, ACAT1, NPAT, ATM, AF035326, AF035327m A0035328m BC029536, FLJ20535, DRD2, ENS303941, IGSF4, LOC1092, BC010946, TAGLN, PCSK7 and ENS300650 genes, and diagnostic methods employing same.
摘要翻译：本公开提供了一种用于对抗癌症和/或刺激天然色素沉着和/或治疗色素沉着病症的化妆品或治疗方法，其包括施用至少一种包含18个连续核苷酸的多核苷酸片段，其中所述多核苷酸片段的序列对应于人的全部或部分基因染色体3选自KIAA1042，CCK，CACNA1D，ARHGEF3和AL133097基因，或其序列对应于选自KLHL3，HNRPA0，CDC25C，EGR1，C5orf7，LOC51308，ETF1，HSPA9B的人染色体5上的全部或部分基因，PDCHA1至PDCHA13，CSF1R，RPL7，PDGFRB，TCOF1，AL133039，CD74，RPS14，NDST1，G3BP，GLRA1，C5orf3，MFAP3，GALNT10和FLJ117151基因，或其序列对应于全部或部分基因或人染色体 11选自GUCY1A2，CUL5，ACAT1，NPAT，ATM，AF035326，AF035327m A0035328m BC029536，FLJ20535，DRD2，ENS303941，IGSF4，LOC1092，BC010946，TAGLN，PCSK7和ENS300650基因，以及采用相同

2. 发明申请

US20090239312A1 Chromosome 6 and 9 Genes Involved in Premature Canities 审中-公开
标题翻译：染色体6和9基因涉及早产性
公开(公告)号：US20090239312A1
公开(公告)日：2009-09-24
申请号：US12474244
申请日：2009-05-28
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
IPC分类号： G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 9 selected from the group consisting of the FREQ, NT_030046.18, NT_030046.17, GTF3C5, CEL, CELL, FS, ABO, BARBLI, DDX31, GTF3C4 and Q96MA6 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 6 selected from the HLAG, NT_007592.445, NT_007592.446, NT_007592.506, NT_007592.507, NT_007592.508, HSPA1 B, G8, NEU1, NG22, BAT8, HLA-DMB, HLA-DMA, BRD2, HLA-DQA1, HLA-DQA2, NT_007592.588, GRM4, RNF23, FLJ22638, NT_007592.459 and NT_007592.457 genes, and diagnostic methods employing same.
摘要翻译：本发明提供了一种用于对抗癌症和/或刺激天然色素沉着和/或治疗色素沉着病症的化妆品或治疗方法，其包括施用至少一种包含18个连续核苷酸的多核苷酸片段，其序列对应于人的全部或部分基因染色体9选自FREQ，NT_030046.18，NT_030046.17，GTF3C5，CEL，CELL，FS，ABO，BARBLI，DDX31，GTF3C4和Q96MA6基因，或其序列对应于全部或部分选自HLAG，NT_007592.445，NT_007592.446，NT_007592.506，NT_007592.507，NT_007592.508，HSPA1B，G8，NEU1，NG22，BAT8，HLA-DMB，HLA-DMA，BRD2的人6号染色体上的基因，HLA-DQA1，HLA-DQA2，NT_007592.588，GRM4，RNF23，FLJ22638，NT_007592.459和NT_007592.457基因以及使用其的诊断方法。

3. 发明申请

US20070092894A1 Methods and kits for detecting single nucleotide polymorphisms of chromosome implicated in premature canities 审中-公开
标题翻译：用于检测涉及早产儿的染色体单核苷酸多态性的方法和试剂盒
公开(公告)号：US20070092894A1
公开(公告)日：2007-04-26
申请号：US11486062
申请日：2006-07-14
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis , Emmanouil Dermitzakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis , Emmanouil Dermitzakis
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/172
摘要： Methods and kits for diagnosing a predisposition to premature canities in an individual are disclosed. A method for diagnosing a predisposition to premature canities in an individual comprises detecting at least one SNP marker of the human chromosome 9, selected from the group consisting of rs306534, rs3739902, rs575916, and rs365297. A kit for diagnosing a predisposition to premature canities comprises a means for detecting in a sample of human genetic material, the allele of a SNP marker of the human chromosome 9 selected from the markers rs306534, rs3739902, rs575916 and rs365297; and a positive or negative control.
摘要翻译：公开了用于诊断个体早产儿倾向的方法和试剂盒。用于诊断个体早产性易感性的方法包括检测选自rs306534，rs3739902，rs575916和rs365297的人染色体9的至少一个SNP标记。用于诊断早产性易感性的试剂盒包括在人类遗传物质的样品中检测选自标记rs306534，rs3739902，rs575916和rs365297的人染色体9的SNP标记的等位基因的方法; 和正或负控制。

4. 发明申请

US20050214821A1 Chromosome 6 and 9 genes involved in premature canities 审中-公开
标题翻译：染色体6和9基因涉及早产儿
公开(公告)号：US20050214821A1
公开(公告)日：2005-09-29
申请号：US11031012
申请日：2005-01-10
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
IPC分类号： C12Q1/68 , A61K7/06 , A61K7/11
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 9 selected from the group consisting of the FREQ, NT_030046.18, NT_030046.17, GTF3C5, CEL, CELL, FS, ABO, BARHL1, DDX31, GTF3C4 and Q96MA6 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 6 selected from the HLAG, NT_007592.445, NT_007592.446, NT_007592.506, NT_007592.507, NT_007592.508, HSPA1B, G8, NEU1, NG22, BAT8, HLA-DMB, HLA-DMA, BRD2, HLA-DQA1, HLA-DQA2, NT_007592.588, GRM4, RNF23, FLJ22638, NT_007592.459 and NT_007592.457 genes, and diagnostic methods employing same.
摘要翻译：本发明提供了一种用于对抗癌症和/或刺激天然色素沉着和/或治疗色素沉着病症的化妆品或治疗方法，其包括施用至少一种包含18个连续核苷酸的多核苷酸片段，其序列对应于人的全部或部分基因染色体9选自FREQ，NT_030046.18，NT_030046.17，GTF3C5，CEL，CELL，FS，ABO，BARHL1，DDX31，GTF3C4和Q96MA6基因，或其序列对应于全部或部分选自HLAG，NT_007592.445，NT_007592.446，NT_007592.506，NT_007592.507，NT_007592.508，HSPA1B，G8，NEU1，NG22，BAT8，HLA-DMB，HLA-DMA，BRD2， HLA-DQA1，HLA-DQA2，NT_007592.588，GRM4，RNF23，FLJ22638，NT_007592.459和NT_007592.457基因，以及采用其的诊断方法。

5. 发明申请

US20050208010A1 Genes from Chromosome 3, 5 and 11 involved in premature canities 审中-公开
标题翻译：来自染色体3,5和11的基因涉及早衰
公开(公告)号：US20050208010A1
公开(公告)日：2005-09-22
申请号：US11031033
申请日：2005-01-10
申请人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
发明人： Olivier De Lacharriere , Jean-Louis Blouin , Claire Deloche , Stylianos Antonarakis
IPC分类号： A61K8/35 , A61K48/00 , A61Q5/10 , A61Q19/04 , C12Q1/68 , A61K7/06 , A61K7/11
CPC分类号： A61Q5/10 , A61K8/35 , A61K48/00 , A61Q19/04 , C12Q1/6883 , C12Q2600/148 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 3 selected from KIAA 042, CCK, CACNA1D, ARHGEF3 and AL133097 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 5 selected from the KLHL3, HNRPA0, CDC25C, EGR1, C5orf6, C5orf7, LOC51308, ETF1, HSPA9B, PCDHA1 to PCDHA13, CSF1R, RPL7, PDGFRB, TCOF1, AL133039, CD74, RPS14, NDST1, G3BP, GLRA1, C5orf3, MFAP3, GALNT10 and FLJ 117151 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 11 selected from the GUCY1A2, CUL5, ACAT1, NPAT, ATM, AF035326, AF035327, AF035328, BC029536, FLJ20535, DRD2, ENS303941, IGSF4, LOC51092, BC010946, TAGLN, PCSK7 and ENS300650 genes, and diagnostic methods employing same.
摘要翻译：本发明提供了一种用于对抗癌症和/或刺激天然色素沉着和/或治疗色素沉着病症的化妆品或治疗方法，其包括施用至少一种包含18个连续核苷酸的多核苷酸片段，其序列对应于人的全部或部分基因染色体3选自KIAA 042，CCK，CACNA1D，ARHGEF3和AL133097基因，或其序列对应于选自KLHL3，HNRPA0，CDC25C，EGR1，C5orf6，C5orf7，LOC51308等的人类染色体5上的全部或部分基因。 ETF1，HSPA9B，PCDHA1至PCDHA13，CSF1R，RPL7，PDGFRB，TCOF1，AL133039，CD74，RPS14，NDST1,3GBP，GLRA1，C5orf3，MFAP3，GALNT10和FLJ 117151基因，或其序列对应于全部或部分基因，选自GUCY1A2，CUL5，ACAT1，NPAT，ATM，AF035326，AF035327，AF035328，BC029536，FLJ20535，DRD2，ENS303941，IGSF4，LOC51092，BC010946，TAGLN，PCSK7和ENS300650基因的人染色体11基因和诊断方法用同样的

6. 发明授权

US4952149A Process and apparatus for taking a medical cast 失效
标题翻译：用于医疗演习的过程和设备
公开(公告)号：US4952149A
公开(公告)日：1990-08-28
申请号：US155325
申请日：1988-02-12
申请人： Francois Duret , Jean-Louis Blouin
发明人： Francois Duret , Jean-Louis Blouin
IPC分类号： A61B5/107 , A61C9/00 , A61C19/04 , G01B11/25 , G01Q80/00
CPC分类号： B82Y15/00 , A61C19/04 , A61C9/00 , A61C9/006 , G01B11/2527
摘要： A method and apparatus for taking impressions of a portion of the body which utilizes the projection of a grid of sinusoidal profile onto the body portion of which the impression is to be taken. The projections are phase-shifted and resulting images are memorized and from the memorized images, the variations in intensity resulting from the phase-shift at each given point can be ascertained to enable the configuration of the region to be calculated.
摘要翻译：一种用于拍摄身体的一部分的印模的方法和装置，其利用正弦曲线网格的投影到其要拍摄的身体部分上。投影是相移的并且所得到的图像被存储，并且从存储的图像中，可以确定由每个给定点处的相移导致的强度变化，以使得能够计算该区域的配置。

7. 发明授权

US5237998A Method of correlating the three-dimensional images of human organs and device for implementation of the method 失效
标题翻译：用于实现人体器官的三维图像的方法和方法
公开(公告)号：US5237998A
公开(公告)日：1993-08-24
申请号：US548947
申请日：1990-07-27
申请人： Francois Duret , Jean-Louis Blouin , Gilles Dechellete
发明人： Francois Duret , Jean-Louis Blouin , Gilles Dechellete
IPC分类号： A61B5/107 , A61C9/00 , A61C13/00 , A61C19/04
CPC分类号： A61C13/0004 , A61C19/04 , A61C9/00 , A61C9/0053
摘要： The three-dimensional correlation of images of a human organ, especially dental arcades, uses an impression in the occlusive position, providing a reference in the form of three mutually spaced reference points. Three-dimensional views are taken of the impression and the points and views are also taken with the impression removed. Using the images of the reference points as a basis, the sets of views are then correlated to bring them into a single referential system.
摘要翻译： PCT No.PCT / FR89 / 00594 Sec。 371日期1990年7月27日第 102（e）日期1990年7月27日PCT 1989年11月17日PCT PCT。公开号WO90 / 05483 日期1990年5月31日。人体器官特别是牙科拱廊的图像的三维相关性在闭塞位置使用印象，以三个相互间隔的参考点的形式提供参考。拍摄三维视图，并将删除的印象视为观点。使用参考点的图像作为基础，然后将视图集合相关联，使其成为单个参考系统。

8. 发明授权

US5143086A Device for measuring and analyzing movements of the human body or of parts thereof 失效
标题翻译：用于测量和分析人体或其部件的运动的装置
公开(公告)号：US5143086A
公开(公告)日：1992-09-01
申请号：US548948
申请日：1990-07-27
申请人： Francois Duret , Jean-Louis Blouin
发明人： Francois Duret , Jean-Louis Blouin
IPC分类号： A61B5/11 , A61B19/00 , A61C13/00 , A61C19/045
CPC分类号： A61B5/1127 , A61C13/0004 , A61C19/045 , A61B2090/363 , A61B5/1114 , A61B5/4528 , A61B5/4547
摘要： A device for determining mandibular motion wherein three light emitting diodes at the vertices of a triangle are temporarily fixed to teeth of the subject, the light emitting diodes are sequentially energized, and two sensors responsive to the light emitting diodes are mounted on a headpiece applied to the head of the subject and are trained on the light emitting diodes.
摘要翻译： PCT No.PCT / FR89 / 00593 Sec。 371日期1990年7月27日第 102（e）日期1990年7月27日PCT 1989年11月17日PCT PCT。出版物WO90 / 05484 日期：1990年5月31日。一种用于确定下颌运动的装置，其中三角形顶点处的三个发光二极管临时固定到受试者的牙齿，发光二极管依次通电，并且响应于发光二极管的两个传感器安装在施加到被摄体头部的头盔上并在发光二极管上进行训练。

9. 发明授权

US4736851A Process and apparatus for the automatic inspection by transparency contrast in particular of containers 失效
标题翻译：用于通过透明度对比特别是容器的自动检查的方法和装置
公开(公告)号：US4736851A
公开(公告)日：1988-04-12
申请号：US775952
申请日：1985-09-13
申请人： Alain Ricros , Jean-Louis Blouin , Jean-Paul Darnault , Yannick Pinson
发明人： Alain Ricros , Jean-Louis Blouin , Jean-Paul Darnault , Yannick Pinson
IPC分类号： G01N21/88 , G01B11/24 , G01N21/90 , G01N21/93 , G01N21/94 , B07C5/34
CPC分类号： G01N21/9036 , Y10S209/939
摘要： The invention concerns a process and an apparatus for automatic inspection of transparency contrast, consisting of illuminating the body of a container transversely to its axis (8), placing the container (3) against the light simultaneously with the aid of two charge transfer cameras, the sighting axes (11) of which are off-set angularly, of eliminating with the aid of an electronic window appropriate for each type of container, all signals originating in elementary points of the photosensitive matrix devices of said cameras (10) located outside the window, of analyzing successively each elementary point of the window by taking into account a predetermined number of immediately surrounding elementary points, of comparing the electric level of each elementary point weighted in this manner with a reference level pre-established for each type of container and of actuating the rejection of the container being inspected when the number of elementary points detected out of reference is higher than a predetermined number.Application in particular to the inspection of bottles.
摘要翻译：本发明涉及一种用于自动检查透明度对比度的方法和装置，其包括横向于其轴线（8）照射容器的主体，借助于两个电荷转移相机将容器（3）同时放置在光上，其瞄准轴（11）被角度偏移，借助于适合于每种类型的容器的电子窗口消除所有来自所述照相机（10）的感光矩阵装置的基本点的信号，位于窗口，通过考虑预定数量的紧邻周围基本点连续分析窗口的每个基本点，将以这种方式加权的每个基本点的电平与每种类型的容器预先建立的参考水平进行比较，以及当检测到的基准点的数量超过参考值时，致动被检查的容器的排除 r超过预定数。特别适用于检验瓶子。

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