专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120071342A1 SYSTEM AND METHOD FOR DETECTING MULTIPLE MOLECULES IN ONE ASSAY 有权
标题翻译：用于在一个测定中检测多个分子的系统和方法
公开(公告)号：US20120071342A1
公开(公告)日：2012-03-22
申请号：US13233794
申请日：2011-09-15
申请人： Michael J. Lochhead , Jeffrey Ives , Kathryn Todorof , Charles Greef , Marie J. Delaney , Kevin D. Moll , Kurt R. Vogel , Keagan B. Rowley , Evelyn S. Woodruff , John S. Dunn , Christopher J. Myatt , Daniel T. Nieuwlandt
发明人： Michael J. Lochhead , Jeffrey Ives , Kathryn Todorof , Charles Greef , Marie J. Delaney , Kevin D. Moll , Kurt R. Vogel , Keagan B. Rowley , Evelyn S. Woodruff , John S. Dunn , Christopher J. Myatt , Daniel T. Nieuwlandt
IPC分类号： C40B30/04 , G01N21/64 , C12Q1/70 , C12M1/34 , G01N21/75 , C40B60/12
CPC分类号： G01N33/54373 , B01L3/502715 , B01L9/52 , B01L2300/0636 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , G01N21/6452 , G01N21/648 , G01N21/7703
摘要： A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.
摘要翻译：描述了使用少量血液，血清或血浆提供一组血清学测定结果的快速诊断系统。该系统包括基于平面波导成像技术的一次性盒和读取器。该盒在流体通道中结合重组抗原和抗体对照的微阵列，为单个样品提供多个平行的荧光测定结果。

2. 发明授权

US08586347B2 System and method for detecting multiple molecules in one assay 有权
标题翻译：在一个测定中检测多个分子的系统和方法
公开(公告)号：US08586347B2
公开(公告)日：2013-11-19
申请号：US13233794
申请日：2011-09-15
申请人： Michael J. Lochhead , Jeffrey Ives , Kathryn Todorof , Charles Greef , Marie J. Delaney , Kevin D. Moll , Kurt R. Vogel , Keagan B. Rowley , Evelyn S. Woodruff , John S. Dunn , Christopher J. Myatt , Daniel T. Nieuwlandt
发明人： Michael J. Lochhead , Jeffrey Ives , Kathryn Todorof , Charles Greef , Marie J. Delaney , Kevin D. Moll , Kurt R. Vogel , Keagan B. Rowley , Evelyn S. Woodruff , John S. Dunn , Christopher J. Myatt , Daniel T. Nieuwlandt
IPC分类号： C40B30/04 , G01N21/75 , C12Q1/68 , C12M1/00
CPC分类号： G01N33/54373 , B01L3/502715 , B01L9/52 , B01L2300/0636 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , G01N21/6452 , G01N21/648 , G01N21/7703
摘要： A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.
摘要翻译：描述了使用少量血液，血清或血浆提供一组血清学测定结果的快速诊断系统。该系统包括基于平面波导成像技术的一次性盒和读取器。该盒在流体通道中结合重组抗原和抗体对照的微阵列，为单个样品提供多个平行的荧光测定结果。

3. 发明申请

US20120316077A1 System And Method For Detection And Analysis Of A Molecule In A Sample 审中-公开
标题翻译：用于样品中分子的检测和分析的系统和方法
公开(公告)号：US20120316077A1
公开(公告)日：2012-12-13
申请号：US13491380
申请日：2012-06-07
申请人： Charles Greef , Michael J. Lochhead
发明人： Charles Greef , Michael J. Lochhead
IPC分类号： G01N21/64 , C40B30/04 , G01N33/53
CPC分类号： G01N33/54373
摘要： Disclosed here is a system and method for analyzing and/or detecting one or more target analytes in a sample by using a competitive assay. A standard curve may be constructed using known amounts of a molecule that is identical or substantially identical to the target analyte. Signals obtained from the target analyte can be compared against the standard curve in order to determine the level of the target analyte in the sample. The disclosed methods may be used in a multiplexed analyte detection and quantitation system.
摘要翻译：这里公开了通过使用竞争性测定来分析和/或检测样品中的一种或多种目标分析物的系统和方法。可以使用已知量的与靶分析物相同或基本相同的分子构建标准曲线。可以将从目标分析物获得的信号与标准曲线进行比较，以确定样品中目标分析物的水平。所公开的方法可以用于复用的分析物检测和定量系统中。

4. 发明申请

US20110201080A1 BIOMOLECULES HAVING MULTIPLE ATTACHMENT MOIETIES FOR BINDING TO A SUBSTRATE SURFACE 有权
标题翻译：具有多个附着力的生物分子结合到基底表面
公开(公告)号：US20110201080A1
公开(公告)日：2011-08-18
申请号：US12946777
申请日：2010-11-15
申请人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
发明人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
IPC分类号： C12N9/96 , C07K14/00 , C07K16/00 , C07H21/00
CPC分类号： C07H19/04 , C07H21/00 , C12Q1/68 , G01N33/54353
摘要： Compounds relating to attachment chemistries for binding biomolecules to a substrate surface are described. These include compounds of the following structure: The biomolecule includes a single nucleic acid, oligonucleotides, polynucleotides, DNAs, RNAs, proteins, peptides, enzymes, antibodies, CNAs (cyclohexyl nucleic acids), p-MeNAs (methyl or methoxy phosphate nucleic acids), peptide nucleic acids (PNAs), and pyranosyl RNAs (p-RNAs).
摘要翻译：描述了与用于将生物分子结合到基底表面的附着化学物质有关的化合物。这些包括以下结构的化合物：生物分子包括单个核酸，寡核苷酸，多核苷酸，DNAs，RNAs，蛋白质，肽，酶，抗体，CNA（环己基核酸），p-MeNA（甲基或甲氧基磷酸核酸），肽核酸（PNA）和吡喃糖基RNA（p-RNA）。

5. 发明授权

US07186813B1 Biomolecules having multiple attachment moieties for binding to a substrate surface 有权
标题翻译：具有多个附着部分的生物分子用于结合底物表面
公开(公告)号：US07186813B1
公开(公告)日：2007-03-06
申请号：US10181207
申请日：2000-08-11
申请人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
发明人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H21/00 , A61K47/61 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07F9/65616 , C40B40/00 , G01N33/54353
摘要： Biomolecules are provided having multiple binding sites for attachment to a substrate surface. The multiple attachment sites may be produced directly on the biomolecule or through use of branched phosphoramidite moieties that can be added in multiple to form dendritic structures which can in turn provide attachment sites for substrate binding moieties. Substrate binding moieties may include noncovalent binding moieties. For covalent binding moieties oligonucleotides containing hydrazides are provided. These hydrazides can be introduced via protected building blocks such as phosphoramidites or via building blocks containing precursor forms of such hydrazides.
摘要翻译：提供了生物分子，其具有用于附着到基底表面的多个结合位点。多个附着位点可以直接在生物分子上生产，或通过使用可以多次加入以形成树突状结构的支链亚磷酰胺部分，这又可以提供底物结合部分的附着位点。底物结合部分可以包括非共价结合部分。对于共价结合部分，提供了含有酰肼的寡核苷酸。这些酰肼可以通过保护的结构单元如亚磷酰胺或通过含有这种酰肼前体形式的构建块引入。

6. 发明授权

US07833715B1 Biomolecules having multiple attachment moieties for binding to a substrate surface 有权
标题翻译：具有多个附着部分的生物分子用于结合底物表面
公开(公告)号：US07833715B1
公开(公告)日：2010-11-16
申请号：US11655009
申请日：2007-01-18
申请人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
发明人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02
CPC分类号： C07H19/04 , C07H21/00 , C12Q1/68 , G01N33/54353
摘要： Methods of binding biomolecules to a substrate are provided that include contacting the biomolecule with a branched linking moiety to form a branched linking structure. The branched linking structure is then contacted with a binding moiety on the substrate to form a coupled substrate binding structure, thereby binding the biomolecule to the substrate. The biomolecule may contain a Lewis base or a nucleophile to react with a Lewis acid or electrophile in the branched linking moiety. Alternatively, the biomolecule may contain a Lewis acid or electrophile that can react with a Lewis base or nucleophile in the branched linking moiety. Additionally, the biomolecule can be bound to the substrate through a covalent or non-covalent bond.
摘要翻译：提供了将生物分子与底物结合的方法，包括使生物分子与支链连接部分接触以形成支链结构。然后将支链连接结构与基底上的结合部分接触以形成偶联的底物结合结构，从而将生物分子结合到底物上。生物分子可以含有路易斯碱或亲核试剂以与支链连接部分中的路易斯酸或亲电子试剂反应。或者，生物分子可以含有路易斯酸或亲电子试剂，其可以与支链连接部分中的路易斯碱或亲核试剂反应。此外，生物分子可以通过共价或非共价键与底物结合。

7. 发明申请

US20100286377A1 BIOMOLECULES HAVING MULTIPLE ATTACHMENT MOIETIES FOR BINDING TO A SUBSTRATE SURFACE 有权
标题翻译：具有多个附着力的生物分子结合到基底表面
公开(公告)号：US20100286377A1
公开(公告)日：2010-11-11
申请号：US11655009
申请日：2007-01-18
申请人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
发明人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
IPC分类号： C07H21/02 , C07H21/00 , C07H21/04
CPC分类号： C07H19/04 , C07H21/00 , C12Q1/68 , G01N33/54353
摘要： Methods of binding biomolecules to a substrate are provided that include contacting the biomolecule with a branched linking moiety to form a branched linking structure. The branched linking structure is then contacted with a binding moiety on the substrate to form a coupled substrate binding structure, thereby binding the biomolecule to the substrate. The biomolecule may contain a Lewis base or a nucleophile to react with a Lewis acid or electrophile in the branched linking moiety. Alternatively, the biomolecule may contain a Lewis acid or electrophile that can react with a Lewis base or nucleophile in the branched linking moiety. Additionally, the biomolecule can be bound to the substrate through a covalent or non-covalent bond.
摘要翻译：提供了将生物分子与底物结合的方法，包括使生物分子与支链连接部分接触以形成支链结构。然后将支链连接结构与基底上的结合部分接触以形成偶联的底物结合结构，从而将生物分子结合到底物上。生物分子可以含有路易斯碱或亲核试剂以与支链连接部分中的路易斯酸或亲电子试剂反应。或者，生物分子可以含有路易斯酸或亲电子试剂，其可以与支链连接部分中的路易斯碱或亲核试剂反应。此外，生物分子可以通过共价或非共价键与底物结合。

8. 发明授权

US08067581B2 Biomolecules having multiple attachment moieties for binding to a substrate surface 有权
标题翻译：具有多个附着部分的生物分子用于结合底物表面
公开(公告)号：US08067581B2
公开(公告)日：2011-11-29
申请号：US12946777
申请日：2010-11-15
申请人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
发明人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
IPC分类号： C07H19/04 , C07H21/02 , C07K2/00 , C07K16/00 , C12Q1/68
CPC分类号： C07H19/04 , C07H21/00 , C12Q1/68 , G01N33/54353
摘要： Compounds relating to attachment chemistries for binding biomolecules to a substrate surface are described. These include compounds of the following structure: The biomolecule includes a single nucleic acid, oligonucleotides, polynucleotides, DNAs, RNAs, proteins, peptides, enzymes, antibodies, CNAs (cyclohexyl nucleic acids), p-MeNAs (methyl or methoxy phosphate nucleic acids), peptide nucleic acids (PNAs), and pyranosyl RNAs (p-RNAs).
摘要翻译：描述了与用于将生物分子结合到基底表面的附着化学物质有关的化合物。这些包括以下结构的化合物：生物分子包括单个核酸，寡核苷酸，多核苷酸，DNAs，RNAs，蛋白质，肽，酶，抗体，CNA（环己基核酸），p-MeNA（甲基或甲氧基磷酸核酸），肽核酸（PNA）和吡喃糖基RNA（p-RNA）。

9. 发明申请

US20050147758A1 Hydroxyl functional surface coating 失效
标题翻译：羟基官能表面涂层
公开(公告)号：US20050147758A1
公开(公告)日：2005-07-07
申请号：US11035849
申请日：2005-01-13
申请人： Guoqiang Mao , Steven Metzger , Michael Lochhead , David Goldberg , Charles Greef , David Grainger
发明人： Guoqiang Mao , Steven Metzger , Michael Lochhead , David Goldberg , Charles Greef , David Grainger
IPC分类号： G01N33/53 , G01N33/543 , G01N35/00 , B05D3/02
CPC分类号： G01N33/54393 , A61L27/34 , A61L29/085 , A61L31/10 , G01N33/5306 , G01N2035/00158
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式