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    • 1. 发明授权
    • Reciprocating-piston internal combustion engine
    • 往复活塞内燃机
    • US07455041B2
    • 2008-11-25
    • US11656752
    • 2007-01-23
    • Markus MeyerFrank Van Der Seylberg
    • Markus MeyerFrank Van Der Seylberg
    • F02B75/32
    • F02B75/048
    • A reciprocating-piston internal combustion engine has a crank drive and a transmission lever indirectly coupled with the piston and intersecting the cylinder axis. The lever is articulated onto the crank drive's connecting rod and onto an adjustable bearing guided in the cylinder block. For greater variation of the translation of movements between crank drive and piston, the pulling and pushing rod connected with the piston has a guide at its end facing the transmission lever. The guide is preferably a pivotally-mounted slide shoe that engages into a guide extending along the transmission lever. The transmission lever is pivotally connected with the crankshaft connecting rod and connected with a setting drive for variably setting the articulation of the pulling and pushing rod on the transmission lever. A guide lever pivotally connected with the pulling and pushing rod and pivotally articulated onto the cylinder block guides the pulling and pushing rod.
    • 往复活塞式内燃机具有曲柄驱动器和与活塞间接联接并与气缸轴线相交的传动杆。 杠杆铰接到曲柄驱动器的连杆上,并连接到在气缸体中引导的可调节轴承。 为了更好地改变曲柄驱动和活塞之间的运动的平移,与活塞连接的拉杆和推杆在其面向传动杆的端部具有导向件。 引导件优选地是枢转地安装的滑靴,其接合到沿着传动杆延伸的引导件中。 传动杆与曲轴连杆枢转连接,并与设定驱动器连接,用于可变地设定拉杆和推杆在传动杆上的铰接。 与拉杆和推杆枢转连接并且枢转地铰接到气缸体上的引导杆引导拉杆和推杆。
    • 2. 发明申请
    • Reciprocating-piston internal combustion engine
    • 往复活塞内燃机
    • US20070169739A1
    • 2007-07-26
    • US11656752
    • 2007-01-23
    • Markus MeyerFrank Van Der Seylberg
    • Markus MeyerFrank Van Der Seylberg
    • F02B75/32F02B75/04F16C7/00
    • F02B75/048
    • A reciprocating-piston internal combustion engine has a crank drive and a transmission lever indirectly coupled with the piston and intersecting the cylinder axis. The lever is articulated onto the crank drive's connecting rod and onto an adjustable bearing guided in the cylinder block. For greater variation of the translation of movements between crank drive and piston, the pulling and pushing rod connected with the piston has a guide at its end facing the transmission lever. The guide is preferably a pivotally-mounted slide shoe that engages into a guide extending along the transmission lever. The transmission lever is pivotally connected with the crankshaft connecting rod and connected with a setting drive for variably setting the articulation of the pulling and pushing rod on the transmission lever. A guide lever pivotally connected with the pulling and pushing rod and pivotally articulated onto the cylinder block guides the pulling and pushing rod.
    • 往复活塞式内燃机具有曲柄驱动器和与活塞间接联接并与气缸轴线相交的传动杆。 杠杆铰接到曲柄驱动器的连杆上,并连接到在气缸体中引导的可调节轴承。 为了更好地改变曲柄驱动和活塞之间的运动的平移,与活塞连接的拉杆和推杆在其面向传动杆的端部具有导向件。 引导件优选地是枢转地安装的滑靴,其接合到沿着传动杆延伸的引导件中。 传动杆与曲轴连杆枢转连接,并与设定驱动器连接,用于可变地设定拉杆和推杆在传动杆上的铰接。 与拉杆和推杆枢转连接并且枢转地铰接到气缸体上的引导杆引导拉杆和推杆。
    • 8. 发明申请
    • METHODS AND COMPOSITIONS FOR ORGAN PROTECTION
    • 用于组织保护的方法和组合
    • US20100266501A1
    • 2010-10-21
    • US12312093
    • 2007-11-06
    • Markus MeyerMartin M. LeWinterHarold L. DauermanStephen P. Bell
    • Markus MeyerMartin M. LeWinterHarold L. DauermanStephen P. Bell
    • A61K49/00A61P9/10A61P9/14A61P13/12A61P39/06
    • A61K49/0447A61K31/195A61K45/06A61K2300/00
    • The invention relates in some aspects to compositions that include a contrast agent and an antioxidant compound and the use of such compositions to prevent (e.g., reduce) organ damage in a subject. In some aspects, the invention relates to compositions that include N— acetylcysteine (NAC) and a contrast agent and the use of such compositions for preventing organ damage in a subject. Methods of preventing organ damage may include the simultaneous administration of a composition of the invention, such that a contrast agent and an antioxidant compound or a contrast agent and NAC are administered intravascularly to a subject. Examples of organ damage that may be treated with compositions and methods of the invention include contrast-induced and non-contrast induced organ damage associated with myocardial ischemia, myocardial infarction, reperfusion damage, nephropathy, etc. The invention, in some aspects, also includes kits that may include a contrast agent and NAC and/or an antioxidant compound.
    • 本发明在一些方面涉及包括造影剂和抗氧化剂化合物的组合物,以及这些组合物用于预防(例如减少)受试者器官损害的用途。 在一些方面,本发明涉及包含N-乙酰半胱氨酸(NAC)和造影剂的组合物,以及这些组合物用于预防受试者器官损伤的用途。 预防器官损害的方法可以包括同时施用本发明的组合物,使得造影剂和抗氧化剂化合物或造影剂和NAC被血管内施用于受试者。 可以用本发明的组合物和方法治疗的器官损伤的实例包括与心肌缺血,心肌梗塞,再灌注损伤,肾病等相关的造影诱导和非造影诱导的器官损伤。在一些方面,本发明还包括 可以包括造影剂和NAC和/或抗氧化剂化合物的试剂盒。