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1. 发明申请

WO2009051638A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 审中-公开
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：WO2009051638A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/011109
申请日：2008-09-25
申请人： MEDTRONIC, INC. , MOLNAR, Gregory, F. , GILL, Steven, S. , MIESEL, Keith, A. , LENT, Mark, S. , DENISON, Timothy, J. , PANKEN, Eric, J. , WAHLSTRAND, Carl, D. , WERDER, Jonathan, C.
发明人： MOLNAR, Gregory, F. , GILL, Steven, S. , MIESEL, Keith, A. , LENT, Mark, S. , DENISON, Timothy, J. , PANKEN, Eric, J. , WAHLSTRAND, Carl, D. , WERDER, Jonathan, C.
IPC分类号： A61N1/36 , A61B5/04 , G06F3/01
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

2. 发明申请

WO2006135766A2 REGIONAL THERAPIES FOR TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的区域治疗
公开(公告)号：WO2006135766A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022519
申请日：2006-06-09
申请人： MEDTRONIC, INC. , HERUTH, Kenneth, T. , LENT, Mark, S. , SINGHAL, Ruchika , SCHENDEL, Michael, J.
发明人： HERUTH, Kenneth, T. , LENT, Mark, S. , SINGHAL, Ruchika , SCHENDEL, Michael, J.
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Systems and methods for coordinated delivery of a therapeutic agent and low (less than about 20 Hz) and high (greater than about 50 Hz)frequency stimulation therapy are described. The systems include a control unit for coordinating therapy delivery between an infusion device and a pulse generator, such that a therapeutic agent is administered at a predetermined time relative to application of either low frequency or high frequency stimulation. For example, the control unit may instruct the infusion device to deliver therapeutic agent at a predetermined time prior to delivery of low frequency stimulation. Systems that include more than one infusion device or an infusion pump capable of delivering more than one therapeutic agent are also described.
摘要翻译：描述了用于协调递送治疗剂和低（小于约20Hz）和高（大于约50Hz）频率刺激疗法的系统和方法。该系统包括用于协调输注装置和脉冲发生器之间的治疗递送的控制单元，使得治疗剂在相对于低频或高频刺激的施加的预定时间被施用。例如，控制单元可以在输送低频刺激之前的预定时间指示输注装置递送治疗剂。还描述了包括多于一个输注装置或能够递送多于一种治疗剂的输液泵的系统。

3. 发明申请

WO2006002275A3 CATHETERS INCORPORATING VALVES AND PERMEABLE MEMBRANES 审中-公开
公开(公告)号：WO2006002275A3
公开(公告)日：2006-01-05
申请号：PCT/US2005/022136
申请日：2005-06-22
申请人： MEDTRONIC, INC. , HERUTH, Kenneth, T. , LENT, Mark, S. , BLANCO, Justin, A.
发明人： HERUTH, Kenneth, T. , LENT, Mark, S. , BLANCO, Justin, A.
IPC分类号： A61M25/00 , A61M5/142
摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes and one or more valves that control flow to the infusion sections.

4. 发明申请

WO2009137119A1 PERIPHERAL NERVE FIELD STIMULATION CONTROL 审中-公开
标题翻译：外周神经网络刺激控制
公开(公告)号：WO2009137119A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/031852
申请日：2009-01-23
申请人： MEDTRONIC, INC. , KING, Gary, W. , GOETZ, Steven, M. , HOUCHINS, Andrew, H. , KEACHER, Jeffrey, T. , GREENBERG, Jordan, J. , HERUTH, Kenneth, T. , LENT, Mark, S. , WACNIK, Paul, W.
发明人： KING, Gary, W. , GOETZ, Steven, M. , HOUCHINS, Andrew, H. , KEACHER, Jeffrey, T. , GREENBERG, Jordan, J. , HERUTH, Kenneth, T. , LENT, Mark, S. , WACNIK, Paul, W.
IPC分类号： A61N1/34
CPC分类号： A61N1/36139 , A61N1/36057 , A61N1/36071
摘要： Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.
摘要翻译：可以基于PNFS的检测到的生理效应来控制外周神经区域刺激（PNFS），这可能是对PNFS的传出响应。在一些示例中，闭环治疗系统可以包括感测患者的生理参数的感测模块，其可以指示患者对PNFS的反应。基于由感测模块产生的信号，可以激活，去激活或修改PNFS。患者的生理参数示例包括患者身体的心率，呼吸频率，皮肤活动，肌肉活动，血流速度，汗腺活动，引导运动反射或热活动。在一些示例中，可以基于由感测模块生成的信号来检测患者疼痛状态，并且可以基于疼痛状态的检测来控制治疗。

5. 发明申请

WO2005036502A2 THREE-DIMENSIONAL IN-VITRO SPINAL MODELS AND METHODS OF ANALYZING SUBSTANCE DISTRIBUTION THEREIN 审中-公开
标题翻译：三维体内脊髓模型和分析其中物质分布的方法
公开(公告)号：WO2005036502A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/032642
申请日：2004-10-01
申请人： MEDTRONIC, INC. , HERUTH, Kenneth, T. , LENT, Mark, S. , HEGLAND, Michael
发明人： HERUTH, Kenneth, T. , LENT, Mark, S. , HEGLAND, Michael
IPC分类号： G09B23/28
CPC分类号： G09B23/34 , B33Y50/00 , B33Y80/00 , G09B23/30
摘要： An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure of an adult human spinal canal. Also included is a cord structure that may be located and anchored within the passageway. The cord structure substantially mimics the size, shape, and structure of an adult human spinal cord. For example, the cord structure may include connecting elements that resemble nerve roots, dentate ligaments, and the septum posticurn of a human spine. The passageway of the model apparatus may be filled with a first fluid that simulates cerebro-spinal fluid (CSF), and a second fluid containing a drug (or simulated drug) may be introduced into the passageway, after which the drug's distribution within the passageway may be analyzed.
摘要翻译：人体脊柱的体外模型装置和用于检测和分析其中的物质分布模式的方法在一个实施例中，模型设备包括限定通道的柱体，该通道基本上模仿成人椎管的尺寸，形状和结构。还包括可以定位并锚定在通道内的绳索结构。绳结构基本上模仿成人脊髓的尺寸，形状和结构。例如，绳结构可以包括类似于神经根，齿状韧带和人体脊柱的间隔的连接元件。模型设备的通道可以填充模拟脑脊髓液（CSF）的第一流体，并且可以将含有药物（或模拟药物）的第二流体引入通道中，之后药物在通道内分布可能会被分析。

6. 发明申请

WO2003101512A1 IMPLANTABLE INFUSION DEVICE WITH MOTOR CONNECTION AND SEAL SYSTEM 审中-公开
标题翻译：具有电机连接和密封系统的可植入式输液装置
公开(公告)号：WO2003101512A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/015550
申请日：2003-05-15
申请人： MEDTRONIC, INC.
发明人： CHRISTENSON, Steven, R. , PECLAT, Christian , LENT, Mark, S.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/1413
摘要： A medical device known as an implantable infusion device is configured for implanting in humans to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spasticity, cancer, and many other conditions. The infusion device incorporates a motor coil connector and mechanical sealing system between the clean motor compartment and the potentially corrosive pump compartment that provides a reliable electrical connection between the motor coil and the motor drive electronics. The motor coil connector provides for bonding of a very small diameter coil wire to one end of the connector and a highly corrosion resistant connection at the other end of the connector. Additionally, the motor coil connector and mechanical sealing system provides a seal against harmful corrosion materials that could emanate from the pump compartment and reach the motor compartment and cause malfunction of the motor.
摘要翻译：被称为植入式输注装置的医疗装置被配置用于在人体中植入以输送治疗物质，例如药物组合物，遗传物质和生物制剂，以治疗各种医学病症如疼痛，痉挛状态，癌症等许多病症。输液装置包括电机线圈连接器和机械密封系统，位于清洁的电动机室和潜在的腐蚀性泵室之间，其在电动机线圈和电动机驱动电子装置之间提供可靠的电连接。马达线圈连接器用于将非常小直径的线圈线接合到连接器的一端，并且在连接器的另一端处具有高度耐腐蚀的连接。另外，电动机线圈连接器和机械密封系统提供了可以从泵室发出的有害腐蚀材料的密封，并到达电动机室并引起电动机故障。

7. 发明授权

EP1509263B1 IMPLANTABLE INFUSION DEVICE WITH MOTOR CONNECTION AND SEAL SYSTEM 有权
标题翻译：与电动机连接和密封装置，可植入的输液设备
公开(公告)号：EP1509263B1
公开(公告)日：2006-06-07
申请号：EP03728981.6
申请日：2003-05-15
申请人： MEDTRONIC, INC.
发明人： CHRISTENSON, Steven, R. , PECLAT, Christian , LENT, Mark, S.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/1413
摘要： A medical device known as an implantable infusion device is configured for implanting in humans to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spasticity, cancer, and many other conditions. The infusion device incorporates a motor coil connector and mechanical sealing system between the clean motor compartment and the potentially corrosive pump compartment that provides a reliable electrical connection between the motor coil and the motor drive electronics. The motor coil connector provides for bonding of a very small diameter coil wire to one end of the connector and a highly corrosion resistant connection at the other end of the connector. Additionally, the motor coil connector and mechanical sealing system provides a seal against harmful corrosion materials that could emanate from the pump compartment and reach the motor compartment and cause malfunction of the motor.

8. 发明公开

EP1578495A1 COUPLING MODULE OF A MODULAR IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：连接模块用于模块化的植入式医疗设备
公开(公告)号：EP1578495A1
公开(公告)日：2005-09-28
申请号：EP03790404.2
申请日：2003-12-09
申请人： MEDTRONIC, INC.
发明人： JANZIG, Darren, A. , WAHLSTRAND, Carl, D. , SKIME, Robert, M. , LENT, Mark, S. , MIESEL, Keith, A. , CABAK, James, E.
IPC分类号： A61N1/375 , A61N1/36
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： In an implantable medical device (101, 201, 401A-F, 501, 601, 701, 801, 901) having individual modules (103-105, 210-212, 410-412, 510-512, 610-611, 711-713, 811-812, 911-912, 1110-1111, 1201-1202), a coupling module (521, 612, 721, 722, 821, 921, 1001, 1101, 1222) couples the modules to one another. The coupling module supports electrical and/or mechanical coupling of the modules. The coupling module may assume a variety of shapes or configurations. The various embodiments of the coupling module may offer the modules varying degrees of freedom of movement relative to one another.

9. 发明授权

EP1578495B1 COUPLING MODULE OF A MODULAR IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：连接模块用于模块化的植入式医疗设备
公开(公告)号：EP1578495B1
公开(公告)日：2010-06-02
申请号：EP03790404.2
申请日：2003-12-09
申请人： Medtronic, Inc.
发明人： JANZIG, Darren, A. , WAHLSTRAND, Carl, D. , SKIME, Robert, M. , LENT, Mark, S. , MIESEL, Keith, A. , CABAK, James, E.
IPC分类号： A61N1/375 , A61N1/36
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： In an implantable medical device (101, 201, 401A-F, 501, 601, 701, 801, 901) having individual modules (103-105, 210-212, 410-412, 510-512, 610-611, 711-713, 811-812, 911-912, 1110-1111, 1201-1202), a coupling module (521, 612, 721, 722, 821, 921, 1001, 1101, 1222) couples the modules to one another. The coupling module supports electrical and/or mechanical coupling of the modules. The coupling module may assume a variety of shapes or configurations. The various embodiments of the coupling module may offer the modules varying degrees of freedom of movement relative to one another.

10. 发明公开

EP1385570A2 IMPLANTABLE MEDICAL DEVICE AND PATCH SYSTEM 有权
标题翻译：医疗设备和电极植入冷暖坐垫
公开(公告)号：EP1385570A2
公开(公告)日：2004-02-04
申请号：EP02734124.7
申请日：2002-04-30
申请人： Medtronic, INC.
发明人： LAPORTE, Steve , HALLER, Markus , HOOPER, William, J. , LENT, Mark, S. , RIFF, Kenneth, M. , HERUTH, Kenneth, T. , OLSEN, James, M.
IPC分类号： A61M35/00 , A61N1/32 , A61N1/37
CPC分类号： A61N1/37235 , A61B5/0031 , A61B2560/0271 , A61M5/14216 , A61M5/14244 , A61M5/14248 , A61M5/1723 , A61M37/0092 , A61M2005/14208 , A61M2005/14268 , A61M2205/3523 , A61N1/08 , A61N1/30 , A61N1/3702 , A61N1/37217 , A61N1/37258 , A61N1/37288 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： An external physiologic or implanted device monitor/controller ("monitor") designed to be attached to the body, as for example, to the skin of the patient. The monitor is designed to detect the therapeutic outputs actually produced by the implanted medical device. Having knowledge of the operation of the implanted medical device, the monitor may then deduce, or decode, the physiologic conditions and/or devices conditions sensed by the implanted medical device. The monitor is then able to perform an action appropriate to the sensed condition and the specific implementation.

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