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1. 发明授权

US4863066A System for dispensing precisely metered quantities of a fluid and method of utilizing the system 失效
标题翻译：用于分配精确计量的流体的系统和利用该系统的方法
公开(公告)号：US4863066A
公开(公告)日：1989-09-05
申请号：US277274
申请日：1988-11-29
申请人： Kenneth F. Uffenheimer , Kent M. Negersmith
发明人： Kenneth F. Uffenheimer , Kent M. Negersmith
IPC分类号： G01F11/08
CPC分类号： G01F11/08
摘要： A fluid delivery system for dispensing precisely metered quantities of a fluid, and more particularly, a fluid delivery system incorporating a diaphragm pump for effectuation of the precise control over the dispensing of a metered quantity of the fluid through the formation of a fluid flow-occluding air bubble at the point of discharge inhibiting the formation of droplets tending to adversely influence the accuracy of the system. Also disclosed is a method for delivering and dispensing precisely metered quantities of a fluid through the utilization of the system.
摘要翻译：用于分配精确计量的流体的流体递送系统，更具体地，包括隔膜泵的流体输送系统，用于通过形成流体阻塞的流体来实现对计量量的流体的分配的精确控制在放电点处的气泡抑制液滴的形成倾向于不利地影响系统的精度。还公开了一种通过利用该系统来精确计量的流体的输送和分配的方法。

2. 再颁专利

USRE35316E Method for filtering a fluid sample using an in-line fluid filter for an automated analyzer 失效
标题翻译：使用自动分析仪的在线流体过滤器过滤流体样品的方法
公开(公告)号：USRE35316E
公开(公告)日：1996-08-27
申请号：US970044
申请日：1992-11-02
申请人： Kent M. Negersmith , Gregory A. Farrell
发明人： Kent M. Negersmith , Gregory A. Farrell
IPC分类号： B01D29/03 , B01D35/02 , B01D39/10 , B01D29/62
CPC分类号： B01D39/10 , B01D29/03 , B01D35/02 , Y10T436/25375
摘要： A method for filtering a whole blood sample using a filter element constructed and arranged to block the passage of fibrous and particulate matter which may be present in a liquid sample, such as a whole blood sample, while allowing the blood cells to pass is disclosed. In one embodiment, the filter element is part of an in-line filter assembly which assembly may include two complementary mating components. One component may take the form of a coupling provided with a male threaded portion adapted to be received into and engage the female threaded portion of the complementary mating component. This complemnetary mating component may be another coupling or an analysis system component, such as a valve. Each complementary mating component is adapted to receive a liquid sample carrying conduit therethrough. The coupling is also adapted to receive a filter mount which holds a filter element constructed and arranged as discussed hereinabove. When the complementary mating components are assembled, their respective conduits and the filter element are brought into alignment and fluid tight seal. In an alterntive embodiment, the filter element is permanently retained in a section of conduit which is provided with appropriate connecting means to allow the conduit section to be readily removed from the apparatus when cleaning or replacement is desired.
摘要翻译：公开了一种使用过滤元件过滤整个血液样品的方法，所述过滤元件被构造和布置成阻止可能存在于诸如全血样品的液体样品中的纤维和颗粒物质的通过，同时允许血细胞通过。在一个实施例中，过滤元件是串联过滤器组件的一部分，该组件可以包括两个互补的配合部件。一个部件可以采用联接件的形式，其具有适于被接纳到互补配合部件的内螺纹部分并与其接合的外螺纹部分。该互补配合部件可以是另一耦合或分析系统部件，例如阀。每个互补配合部件适于接收穿过其中的液体样品携带导管。联接器还适于接收保持如上所述构造和布置的过滤元件的过滤器支架。当互补的配合部件被组装时，它们各自的管道和过滤器元件被对准并且是流体密封的。在替代实施例中，过滤元件永久地保持在导管的一部分中，该部分具有适当的连接装置，以便在需要清洁或更换时允许导管部分从设备中移除。

3. 发明授权

US5064542A Method for filtering a whole blood sample using an in-line fluid filter for an automated analyzer 失效
标题翻译：使用自动分析仪的在线流体过滤器过滤全血样品的方法
公开(公告)号：US5064542A
公开(公告)日：1991-11-12
申请号：US430197
申请日：1990-03-08
申请人： Kent M. Negersmith , Gregory A. Farrell
发明人： Kent M. Negersmith , Gregory A. Farrell
IPC分类号： B01D29/03 , B01D35/02 , B01D39/10
CPC分类号： B01D39/10 , B01D29/03 , B01D35/02 , Y10T436/25375
摘要： A method for filtering a whole blood sample using a filter element constructed and arranged to block the passage of fibrous and particulate matter which may be present in a liquid sample, such as a whole blood sample, while allowing the blood cells to pass is disclosed. In one embodiment, the filter element is part of an in-line filter assembly which assembly may include two complementary mating components. One component may take the form of a coupling provided with a male threaded portion adapted to be received into and engage the female threaded portion of the complementary mating component. This complementary mating component may be another coupling or an analysis system component, such as a valve. Each complementary mating component is adapted to receive a liquid sample carrying conduit therethrough. The coupling is also adapted to receive a filter mount which holds a filter element constructed and arranged as discussed hereinabove. When the complementary mating components are assembled, their respective conduits and the filter element are brought into alignment and fluid tight seal. In an alternative embodiment, the filter element is permanently retained in a section of conduit which is provided with appropriate connecting means to allow the conduit section to be readily removed from the apparatus when cleaning or replacement is desired.
摘要翻译：公开了一种使用过滤元件过滤整个血液样品的方法，所述过滤元件被构造和布置成阻止可能存在于诸如全血样品的液体样品中的纤维和颗粒物质的通过，同时允许血细胞通过。在一个实施例中，过滤元件是串联过滤器组件的一部分，该组件可以包括两个互补的配合部件。一个部件可以采用联接件的形式，其具有适于被接纳到互补配合部件的内螺纹部分并与其接合的外螺纹部分。该互补的配合部件可以是另一个耦合或分析系统部件，例如阀。每个互补配合部件适于接收穿过其中的液体样品携带导管。联接器还适于接收保持如上所述构造和布置的过滤元件的过滤器支架。当互补的配合部件被组装时，它们各自的管道和过滤器元件被对准并且是流体密封的。在替代实施例中，过滤元件永久地保持在导管的一部分中，该部分具有适当的连接装置，以便在需要清洁或更换时允许导管部分从设备中移除。

4. 发明授权

US4300906A Method for the operation of automated analysis apparatus 失效
标题翻译：自动化分析仪操作方法
公开(公告)号：US4300906A
公开(公告)日：1981-11-17
申请号：US194320
申请日：1980-10-06
申请人： Kent M. Negersmith
发明人： Kent M. Negersmith
IPC分类号： G01N35/08
CPC分类号： G01N35/08 , Y10T436/118339
摘要： Method is provided for the operation of substantially constant flow rate sample analysis apparatus in such manner that the adverse effects upon sample analysis accuracy of periodic variations in analysis apparatus flow rate and/or sample-analysis reagent proportioning are negated to insure the sample-to-sample consistency and accuracy of the sample analysis results.
摘要翻译：提供了以基本上恒定的流量样品分析装置的操作方式，使得分析装置流量和/或样品分析试剂比例的周期性变化对样品分析精度的不利影响被否定以确保样品 - 样品一致性和样品分析结果的准确性。

5. 发明授权

US4002269A Liquid proportioning system in a liquid sample analyzer 失效
标题翻译：液体样品分析仪中的液体配比系统
公开(公告)号：US4002269A
公开(公告)日：1977-01-11
申请号：US564583
申请日：1975-04-02
申请人： Kent M. Negersmith
发明人： Kent M. Negersmith
IPC分类号： G01N1/38 , G01N35/08 , B67D5/60 , G01N31/22 , G01N33/16
CPC分类号： G01N1/38 , G01N35/08 , Y10T436/118339
摘要： A liquid sample analyzer having a first fixed-volume chamber into which a first liquid is flowed filling it for subsequent displacement of the liquid volume therefrom by a second liquid into a substantially larger second fixed-volume chamber through a first port thereof, the second liquid acting as a pilot fluid. Prior to such liquid volume displacement from the first chamber, the second chamber, having an overflow outlet at a location remote with respect to the first port, is washed out and filled to an overflow level by a flow of the second liquid entering the second chamber through a second port. On such displacement of the volume of the first liquid into the second chamber, the last-mentioned volume and a relatively small volume of the second liquid entering the second chamber displace from the second chamber through the aforementioned outlet an equivalent volume of the second liquid, so that a reproducible volume of the first liquid remains in the second chamber with a reproducible volume of the second liquid. In this manner, the volumes of such liquids are precisely proportioned with substantial independence with respect to flow rates. One of the liquids may be a sample and the other may be a diluent. Sample analysis may take place in the second chamber prior to evacuation of the chamber contents therethrough the second port.
摘要翻译：一种液体样品分析器，具有第一固定容积室，第一液体流入该第一固定容积室中，以便随后将其中的液体体积由第二液体移动到通过其第一端口的基本上较大的第二固定容积室中，第二液体作为先导流体。在从第一腔室排出这种液体体积之前，具有在相对于第一端口远离的位置处具有溢流出口的第二腔室被洗出并通过进入第二腔室的第二液体的流动被填充到溢流水位通过第二个港口。在将第一液体的体积移动到第二室中时，进入第二室的最后提到的体积和相对小体积的第二液体通过前述出口从第二室排出等同体积的第二液体，使得第一液体的可再现体积保留在第二室中，具有可再现的第二液体的体积。以这种方式，这种液体的体积与流速相当的独立性精确地成比例。其中一种液体可以是样品，另一种可以是稀释剂。样品分析可以在第二室中排空之前在第二室中进行。

6. 发明授权

US4130394A Short sample detection 失效
标题翻译：样本检测短
公开(公告)号：US4130394A
公开(公告)日：1978-12-19
申请号：US839146
申请日：1977-10-03
申请人： Kent M. Negersmith
发明人： Kent M. Negersmith
IPC分类号： G01N35/10 , G01F11/00 , G01N1/00 , G01N1/14 , G01N1/28 , G01N1/38 , G01N35/08
CPC分类号： G01N1/38 , G01N35/08 , G01N2001/382 , Y10T436/25625
摘要： A dilutor/dispenser system wherein a marker, e.g., an air bubble, is introduced at the probe inlet prior to each aspiration cycle, so as to be displaced along the probe system during such cycle. The location of the marker is detected at the end of the aspiration cycle, to indicate whether an appropriate liquid volume has been aspirated. The aspirated liquid, along with the marker and a predetermined volume of diluent, is subsequently dispensed. An alarm may be activated, if an improper volume has been aspirated.
摘要翻译：一种稀释器/分配器系统，其中在每个抽吸循环之前在探针入口处引入标记例如气泡，以便在该循环期间沿着探针系统移位。在抽吸循环结束时检测标记的位置，以指示是否吸出适当的液体体积。吸入的液体以及标记物和预定体积的稀释剂随后被分配。如果吸收了不正确的体积，则可能会激活报警。

7. 发明授权

US4009999A Reagent supply control in automated fluid analysis 失效
标题翻译：自动化流体分析中的试剂供应控制
公开(公告)号：US4009999A
公开(公告)日：1977-03-01
申请号：US582059
申请日：1975-05-29
申请人： Kent M. Negersmith
发明人： Kent M. Negersmith
IPC分类号： G01N33/48 , G01N1/10 , G01N21/77 , G01N35/08 , G01N31/00 , G01N33/00
CPC分类号： G01N35/08 , Y10T436/115831 , Y10T436/118339
摘要： Apparatus and method for analyzing successive liquid samples and conserving reagent. The method includes flowing a stream of discrete samples along a conduit from a source, which conduit includes a portion for reacting the successive samples with a reagent and a portion for analyzing the reaction product. It further includes introducing the reagent into the conduit upstream of the reaction portion to form a sample-reagent mixture, identifying the successive samples at the source, and responsive to such identification discontinuing the introduction of the reagent into the conduit and substituting therefore a pilot fluid displacing the mixture at the same flow rate along the reacting and analysis portions of the conduit.
摘要翻译：用于分析连续液体样品和保存试剂的装置和方法。该方法包括使来自源的管道流动离散样品流，该导管包括用于使连续样品与试剂反应的部分和用于分析反应产物的部分。其还包括将试剂引入到反应部分上游的导管中以形成样品 - 试剂混合物，鉴定来源的连续样品，并且响应于这种鉴定停止将试剂引入导管中并由此代替先导流体沿着导管的反应和分析部分以相同的流速移动混合物。

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