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1. 发明授权

US4584272A Adenylate kinase and process for the production thereof 失效
标题翻译：腺苷酸激酶及其制备方法
公开(公告)号：US4584272A
公开(公告)日：1986-04-22
申请号：US309346
申请日：1981-10-07
申请人： Kazutomo Imahori , Hiroshi Nakajima , Kazuhiko Nagata
发明人： Kazutomo Imahori , Hiroshi Nakajima , Kazuhiko Nagata
IPC分类号： C12N9/12 , C12N11/00 , C12P1/00 , C12P19/32 , C12R1/07
CPC分类号： C12P1/00 , C12N11/00 , C12N9/12 , Y10S435/832
摘要： A heat-resistant adenylate kinase is described whose activity after an incubation in a buffer solution at about 50.degree. C. for about 15 minutes is at least about 80% of the original activity prior to the incubation. This adenylate kinase can be obtained by cultivating a bacterium belonging to the genus Bacillus and collecting adenylate kinase from the resulting culture broth. This heat-resistant enzyme is very stable against heat and, therefore, after isolation, it can be stored for a long period of time compared with the conventional adenylate kinase.
摘要翻译：描述了耐热腺苷酸激酶，其在约50℃下在缓冲溶液中孵育约15分钟后的活性是孵育前至少约80％的原始活性。该腺苷酸激酶可以通过培养属于芽孢杆菌属的细菌并从得到的培养肉汤中收集腺苷酸激酶来获得。该耐热酶对于热是非常稳定的，因此在分离后，与常规腺苷酸激酶相比可以长时间储存。

2. 发明授权

US4960696A Process for producing physiololgically active substance by multienzyme process 失效
标题翻译：通过多酶法生产生理活性物质的方法
公开(公告)号：US4960696A
公开(公告)日：1990-10-02
申请号：US202606
申请日：1988-06-06
申请人： Kazutomo Imahori , Hitoshi Kondo , Hiroshi Nakajima , Tatsuo Iwasaki
发明人： Kazutomo Imahori , Hitoshi Kondo , Hiroshi Nakajima , Tatsuo Iwasaki
IPC分类号： C12M1/40 , C12P1/00 , C12P13/20 , C12P19/32 , C12P21/02
CPC分类号： C12P21/02 , C12P1/00 , C12P13/20 , C12P19/32
摘要： A process for converting AMP into ATP which comprises (a) using an enzyme which converts AMP into ADP and has been produced from microorganisms having an optimum growth temperature of 50.degree. C. to 85.degree. C. and an enzyme which converts ADP into ATP and has been produced from microorganisms having an optimum growth temperature of 50.degree. C. to 85.degree. C. is disclosed. In addition, there is disclosed a process for producing a physiologically active substance by a multienzyme process which comprises forming ATP from AMP by the step (a), (b) synthesizing a physiologically active substance with the resulting ATP, converting AMP resulting from the reaction in step (b) into ATP by the reaction in step (a), and repeatedly utilizing the converted ATP for synthesis of the physiologically active substance in step (b). By using the process it is possible to stably and efficiently carry out conversion of AMP into ATP over a long period of time. Further, it is possible to carry out continuously and economically an enzymic reaction using ATP as an auxiliary factor with very good efficiency. Whereby it has become possible to practically operate the so-called bioreactor wherein synthetic reactions in the living body are carried out as industrial chemical reactions outside the living body.
摘要翻译：将AMP转化为ATP的方法，其包括（a）使用将AMP转化成ADP并由具有50℃至85℃的最佳生长温度的微生物产生的酶和将ADP转化为ATP的酶已经从具有50℃至85℃的最佳生长温度的微生物生产。此外，公开了一种通过多酶法生产生理活性物质的方法，其包括通过步骤（a）从AMP形成ATP，（b）用生成的ATP合成生理活性物质，将由反应产生的AMP转化在步骤（b）中通过步骤（a）中的反应进入ATP，并且在步骤（b）中反复利用转化的ATP合成生理活性物质。通过使用该方法，可以在长时间内稳定高效地进行AMP向ATP的转化。此外，可以以非常好的效率使用ATP作为辅助因子连续且经济地进行酶反应。由此，可以实际地操作所谓的生物反应器，其中生物体内的合成反应作为生物体外的工业化学反应进行。

3. 发明授权

US4882276A Process for producing physiologically active substance by multienzyme process 失效
标题翻译：多酶法生产生理活性物质的方法
公开(公告)号：US4882276A
公开(公告)日：1989-11-21
申请号：US461308
申请日：1983-01-26
申请人： Kazutomo Imahori , Hitoshi Kondo , Hiroshi Nakajima , Tatsuo Iwasaki
发明人： Kazutomo Imahori , Hitoshi Kondo , Hiroshi Nakajima , Tatsuo Iwasaki
IPC分类号： C12M1/40 , C12P1/00 , C12P13/20 , C12P19/32 , C12P21/02 , C12R1/07
CPC分类号： C12P1/00 , C12P13/20 , C12P19/32 , C12P21/02 , Y10S435/813
摘要： A process for converting AMP into ATP which comprises (a) using an enzyme which converts AMP into ADP and has been produced from microorganisms having an optimum growth temperature of 50.degree. C. to 85.degree. C. and an enzyme which converts ADP into ATP and has been produced from microorganisms having an optimum growth temperature of 50.degree. to 85.degree. C. is disclosed. In addition, there is disclosed a process for producing a physiologically active substance by a multienzyme process which comprises forming ATP from AMP by the step (a), (b) synthesizing a physiologically active substance with the resulting ATP, coverting AMP resulting from the reaction in step (b) into ATP by the reaction in step (a), and repeatedly utilizing the converted ATP for synthesis of the physiologically active substance in step (b). By using the process it is possible to stably and efficiently carry out conversion of AMP into ATP over a long period of time. Further, it is possible to carry out continuously and economically an enzymic reaction using ATP as an auxiliary factor with very good efficiency. Whereby it has become possible to practically operate the so-called bioreactor wherein synthetic reactions in the living body are carried out as industrial chemical reactions outside the living body.
摘要翻译：将AMP转化为ATP的方法，其包括（a）使用将AMP转化成ADP并由具有50℃至85℃的最佳生长温度的微生物产生的酶和将ADP转化为ATP的酶已经从具有50℃至85℃的最佳生长温度的微生物生产。此外，公开了通过多酶法生产生理活性物质的方法，其包括通过步骤（a）从AMP形成ATP，（b）合成生理活性物质与所得ATP，由反应产生的覆盖AMP 在步骤（b）中通过步骤（a）中的反应进入ATP，并且在步骤（b）中反复利用转化的ATP合成生理活性物质。通过使用该方法，可以在长时间内稳定高效地进行AMP向ATP的转化。此外，可以以非常好的效率使用ATP作为辅助因子连续且经济地进行酶反应。由此，可以实际地操作所谓的生物反应器，其中生物体内的合成反应作为生物体外的工业化学反应进行。

4. 发明授权

US4572894A Process for synthesizing peptides or peptide derivatives 失效
标题翻译：合成肽或肽衍生物的方法
公开(公告)号：US4572894A
公开(公告)日：1986-02-25
申请号：US461307
申请日：1983-01-26
申请人： Kazutomo Imahori , Hiroshi Nakajima , Tatsuo Iwasaki , Isao Tomioka , Keiichi Yamamoto
发明人： Kazutomo Imahori , Hiroshi Nakajima , Tatsuo Iwasaki , Isao Tomioka , Keiichi Yamamoto
IPC分类号： C12P21/02 , C12P21/00 , C12N9/00
CPC分类号： C12P21/02
摘要： A process for synthesizing peptides or peptide derivatives is disclosed. The process involves using aminoacyl-tRNA synthetase as a condensing agent when synthesizing peptides or peptide derivatives from amino acids. According to the process, peptides or peptide derivatives which are useful as various hormones such as bradykinin having antihypertensive activity or somatostatin having an internal or external secretion controlling function and other biologically active substances such as antibiotic peptides or seasoning peptides can be produced at a moderate price without using protective groups.
摘要翻译：公开了合成肽或肽衍生物的方法。当从氨基酸合成肽或肽衍生物时，该方法包括使用氨酰-tRNA合成酶作为缩合剂。根据该方法，可以以适度的价格生产可用作各种激素的肽或肽衍生物，例如具有抗高血压活性的缓激肽或具有内部或外部分泌控制功能的生长抑素和其他生物活性物质如抗生素肽或调味肽不使用保护组。

5. 发明授权

US5001055A Process for producing physiologically active substance 失效
标题翻译：生产生理活性物质的方法
公开(公告)号：US5001055A
公开(公告)日：1991-03-19
申请号：US862731
申请日：1986-05-13
申请人： Kazutomo Imahori , Isao Tomioka , Hiroshi Nakajima , Senji Kitabatake
发明人： Kazutomo Imahori , Isao Tomioka , Hiroshi Nakajima , Senji Kitabatake
IPC分类号： C07H19/20 , C12P1/00 , C12P13/00 , C12P13/04 , C12P13/14 , C12P19/02 , C12P19/32
CPC分类号： C12P13/001 , C07H19/20 , C12P1/00 , C12P13/00 , C12P13/04 , C12P13/06 , C12P13/14 , C12P13/20 , C12P19/02 , C12P19/32 , Y10S435/813
摘要： A process for producing a physiologically active substance by a combined enzymatic method is disclosed. In the combined enzymatic method, a reactant solution containing a precursor or precursors for the physiologically active substance, AXP, and a divalent metal ion is supplied at one end of a reactor incorporating either the combined enzymatic reaction system (a) or (b), wherein (a) is a reaction system including an enzyme for converting AMP to ADP, an enzyme for converting ADP to ATP, and an enzyme which catalyzes the synthesis of the physiologically active substance as it converts ATP to AMP; and (b) is a reaction system including an enzyme for converting ADP to ATP and an enzyme which catalyzes the synthesis of the physiologically active substance as it converts ATP to ADP, wherein the concentration of the divalent metal ion supplied into the reactor is held at a level no higher than 30 mM while the concentration of the AXP is held below that of that of the precursor or precursors for the physilogically active substance, and the physiologically active substance produced is withdrawn from the other end of the reactor.
摘要翻译：公开了通过组合的酶法生产生理活性物质的方法。在组合的酶法中，在包含组合的酶反应体系（a）或（b）的反应器的一端提供含有生理活性物质前体或前体的反应物溶液AXP和二价金属离子，其中（a）是包含用于将AMP转化成ADP的酶的反应体系，用于将ADP转化为ATP的酶，以及当ATP转化成AMP时催化生理活性物质合成的酶; 和（b）是包含用于将ADP转化为ATP的酶的反应体系，以及当ATP向ADP转化时催化生理活性物质的合成的酶，其中供给到反应器中的二价金属离子的浓度保持在水平不高于30mM，而AXP的浓度低于物理活性物质的前体或前体的浓度，生成的生理活性物质从反应器的另一端排出。

6. 发明授权

US4554253A Apparatus for synthesizing adenosine-5'-triphosphate 失效
标题翻译：合成腺苷-5'-三磷酸的装置
公开(公告)号：US4554253A
公开(公告)日：1985-11-19
申请号：US461309
申请日：1983-01-26
申请人： Kazutomo Imahori , Tatsuo Iwasaki , Hiroshi Nakajima , Hitoshi Kondo , Isao Tomioka , Masaru Kashima , Toshihiko Tsukamoto
发明人： Kazutomo Imahori , Tatsuo Iwasaki , Hiroshi Nakajima , Hitoshi Kondo , Isao Tomioka , Masaru Kashima , Toshihiko Tsukamoto
IPC分类号： C12M1/40 , C12P1/00 , C12P13/20 , C12P19/32 , C12P21/02
CPC分类号： C12P13/20 , C12M21/14 , C12M21/18 , C12M25/18 , C12M47/12 , C12P1/00 , C12P19/32 , C12P21/02
摘要： An apparatus for converting into ATP which comprises an enzyme reactor, a source of AMP supply, a source of phosphoric acid donator supply, variable fluid sending apparatus, an automatic sampling apparatus and an analyzing apparatus for the reacting solution, an arithmetic control apparatus, and a recovery apparatus. According to this apparatus, conversion from AMP or ADP into ATP can be effectively carried out and ATP conversion can be kept at substantial 100% over a long period of time. The device makes it possible for ATP to be used more and more in future as an energy source for bioreactors and as medicines because the ATP will be more readily available and less expensive.
摘要翻译：一种用于转化成ATP的装置，包括酶反应器，AMP供应源，磷酸供体源，可变流体送出装置，自动取样装置和用于反应溶液的分析装置，运算控制装置和恢复装置。根据该装置，可以有效地进行从AMP或ADP向ATP的转化，并且可以长时间将ATP转化率保持在100％左右。该装置可以使ATP越来越多地被用作生物反应器和药物的能源，因为ATP将更容易获得并且更便宜。

7. 发明授权

US5837853A Preventive or therapeutic agents for alzheimers disease a screening method of alzheimers disease and tau-protein kinase I originated from human being 失效
标题翻译：阿尔茨海默病预防或治疗剂阿尔茨海默病和tau蛋白激酶I的筛选方法源于人类
公开(公告)号：US5837853A
公开(公告)日：1998-11-17
申请号：US602264
申请日：1996-02-20
申请人： Akihiko Takashima , Toshimitsu Hoshino , Kazutomo Imahori , Ken-ichi Saito , Akiko Shiratsuchi , Showbu Sato
发明人： Akihiko Takashima , Toshimitsu Hoshino , Kazutomo Imahori , Ken-ichi Saito , Akiko Shiratsuchi , Showbu Sato
IPC分类号： A61K31/00 , C12N9/12 , C12N15/113 , C12N15/12 , C07H21/02 , C07H21/04
CPC分类号： A61K31/00 , A61K31/70 , C12N15/1137 , C12N9/12 , C12Y207/11026 , C12N2310/315
摘要： A preventive or therapeutic agent for Alzheimer's disease which comprises a substance exhibiting an inhibitory action to tau-protein kinase I as an effective component is provided. A pharmaceutical composition comprising said agent and a method of inhibiting neuronal cell death in the brain are also provided.
摘要翻译：提供了包含对tau蛋白激酶I作为有效成分具有抑制作用的物质的阿尔茨海默氏病的预防或治疗剂。还提供了包含所述药物的药物组合物和抑制脑中神经元细胞死亡的方法。

8. 发明授权

US4282352A Adenosine triphosphate derivative 失效
标题翻译：腺苷三磷酸衍生物
公开(公告)号：US4282352A
公开(公告)日：1981-08-04
申请号：US91996
申请日：1979-11-07
申请人： Kazutomo Imahori , Kosuke Tomita
发明人： Kazutomo Imahori , Kosuke Tomita
IPC分类号： B01D15/08 , C07H19/20 , C12P19/32 , C12Q1/00 , C07H17/00
CPC分类号： C07H19/20
摘要： An adenosine triphosphate derivative represented by the formula: ##STR1## and salts thereof.
摘要翻译：由下式表示的腺苷三磷酸衍生物及其盐。

9. 发明授权

US06248559B1 Gene encoding human tau-protein kinase I and use thereof 失效
标题翻译：编码人tau蛋白激酶I的基因及其用途
公开(公告)号：US06248559B1
公开(公告)日：2001-06-19
申请号：US09216958
申请日：1998-12-21
申请人： Akihiko Takashima , Toshimitsu Hoshino , Kazutomo Imahori , Ken-ichi Saito , Akiko Shiratsuchi , Showbu Sato
发明人： Akihiko Takashima , Toshimitsu Hoshino , Kazutomo Imahori , Ken-ichi Saito , Akiko Shiratsuchi , Showbu Sato
IPC分类号： C12N1512
CPC分类号： A61K31/00 , A61K31/70 , C12N9/12 , C12N15/1137 , C12N2310/315 , C12Y207/11026
摘要： A preventive or therapeutic agent for Alzheimer's disease which comprises a substance exhibiting an inhibitory action to tau-protein kinase I as an effective component is provided. A pharmaceutical composition comprising said agent and a method of inhibiting neuronal cell death in the brain are also provided.
摘要翻译：提供了包含对tau蛋白激酶I具有抑制作用的物质作为有效成分的阿尔茨海默氏病的预防或治疗剂。还提供了包含所述药物的药物组合物和抑制脑中神经元细胞死亡的方法。

10. 发明授权

US6071694A Screening method for therapeutic agents against Alzheimer's disease 失效
标题翻译：针对阿尔茨海默病的治疗剂的筛选方法
公开(公告)号：US6071694A
公开(公告)日：2000-06-06
申请号：US461018
申请日：1995-06-05
申请人： Akihiko Takashima , Toshimitsu Hoshino , Kazutomo Imahori , Ken-ichi Saito , Akiko Shiratsuchi , Showbu Sato
发明人： Akihiko Takashima , Toshimitsu Hoshino , Kazutomo Imahori , Ken-ichi Saito , Akiko Shiratsuchi , Showbu Sato
IPC分类号： A61K31/00 , C12N9/12 , C12N15/113 , C12N15/12 , C12Q1/68
CPC分类号： A61K31/00 , A61K31/70 , C12N15/1137 , C12N9/12 , C12Y207/11026 , C12N2310/315
摘要： A preventive or therapeutic agent for Alzheimer's disease which comprises a substance exhibiting an inhibitory action to tau-protein kinase I as an effective component is provided. A pharmaceutical composition comprising said agent and a method of inhibiting neuronal cell death in the brain are also provided.
摘要翻译：提供了包含对tau蛋白激酶I具有抑制作用的物质作为有效成分的阿尔茨海默氏病的预防或治疗剂。还提供了包含所述药物的药物组合物和抑制脑中神经元细胞死亡的方法。

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