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    • 3. 发明授权
    • Tape heater
    • 胶带加热器
    • KR101108577B1
    • 2012-01-30
    • KR20100072964
    • 2010-07-28
    • KOOKJE ELECTRIC KOREA CO LTD
    • PARK YONG SUNGLEE SUNG KWANGKIM DONG YEUL
    • H01L21/02H01L21/205
    • H01L21/67098F16L53/30F16L55/1686
    • PURPOSE: A tape heater is provided to be universally used regardless of the size of a pipe and to be easily installed to the pipe. CONSTITUTION: The heat generation film part(100) of a tape form is includes a heating element(130) in inside. A first film sheet and a second film sheet support the heating element. A keeping warm film part(200) is provided to be stepped from the upper side of the heat generation film part and covers the upper side of the heat generation film part. The keeping warm film part comprises a connecting part which is bonded to a part of the upper side of the heat generation film part and a cover part which covers the upper side of the heat generation film part which is exposed. A velcro fastener is installed in the upper side of the heat generation film part and the bottom surface of the cover part.
    • 目的:无论管道的尺寸如何,都能提供普遍使用的带式加热器,并且易于安装到管道上。 构成:带状的发热膜部分(100)包括内部的加热元件(130)。 第一膜片和第二膜片支撑加热元件。 保温膜部(200)从发热膜部的上侧设置为阶梯状,覆盖发热膜部的上侧。 保温膜部分包括粘合到发热膜部分的上侧的一部分的连接部分和覆盖发热膜部分的暴露的上侧的盖部分。 天花布紧固件安装在发热膜部分的上侧和盖部分的底表面上。
    • 4. 发明申请
    • METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR
    • 使用原子指纹描述符或原子描述符预测激活能的方法
    • WO2010056053A3
    • 2010-09-10
    • PCT/KR2009006660
    • 2009-11-12
    • BIOINFORMATICS & MOLECULAR DESNO KYOUNG TAIKIM DOO NAMOH WON SEOKLEE SUNG KWANGJUNG JI HOONCHO KWANG HWILEE CHANG JOONNAM KY YOUB
    • NO KYOUNG TAIKIM DOO NAMOH WON SEOKLEE SUNG KWANGJUNG JI HOONCHO KWANG HWILEE CHANG JOONNAM KY YOUB
    • C12Q1/26G06F19/00G06F19/16
    • G06F19/704G06F19/702G06F19/706G06F19/709
    • The present invention provides a process for constructing an atomic fingerprint descriptor database, and a method for predicting activation energy using an atomic fingerprint descriptor or an atomic descriptor. The method comprises the steps of: (i) calculating an atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the atomic fingerprint descriptor database constructed by the abovementioned process to select the atomic position at which the metabolic responses by the cytochrome P450 enzyme may occur; and (iii) predicting activation energy for the selected atomic position by using an atomic descriptor. Further, the present invention provides a method for predicting the activation energy of phase I metabolism performed by the CYP450 enzyme through use of an effective atomic descriptor. In detail, the present invention provides a method for predicting the activation energy of the formation of tetrahedral intermediate from a hydrogen separation or aromatic hydroxylation by the cytochrome P450 enzyme through use of an equation containing an effective atomic descriptor. The present invention can rapidly predict activation energy for metabolites of phase I at a practical level even without a docking experiment between any additional CYP450 and the substrate, or a quantum mechanical calculation, to thereby make the development of new drugs using a computer even easier. The present invention may propose a strategy for increasing the bioavailability of drugs through metabolite avoidance design by analysis of the metabolic reaction possibilities of drugs. Further, the activation energy prediction of the present invention enables the prediction of i) metabolic products, ii) the relative speed of metabolism, iii) metabolic regioselectivity iv) metabolic inhibition v) drug interaction, and vi) the toxicity of a metabolite.
    • 本发明提供了一种用于构建原子指纹描述符数据库的过程以及一种使用原子指纹描述符或原子描述符来预测活化能的方法。 该方法包括以下步骤:(i)计算衬底的原子指纹描述符; (ii)将计算的原子指纹描述符与通过上述过程构建的原子指纹描述符数据库进行比较,以选择细胞色素P450酶可能发生代谢反应的原子位置; 和(iii)通过使用原子描述符来预测所选原子位置的活化能。 此外,本发明提供了一种通过使用有效原子描述符预测由CYP450酶进行的I期代谢活化能的方法。 具体而言,本发明提供了一种通过使用包含有效原子描述符的方程来预测由细胞色素P450酶进行氢分离或芳族羟基化而形成四面体中间体的活化能的方法。 即使没有任何额外的CYP450与底物之间的对接实验或量子力学计算,本发明也可以在实际水平上快速预测阶段I的代谢物的活化能,从而使得使用计算机的新药物的开发更容易。 本发明可以提出通过分析药物的代谢反应可能性来通过代谢避免设计增加药物的生物利用度的策略。 此外,本发明的活化能预测能够预测i)代谢产物,ii)代谢的相对速度,iii)代谢区域选择性,iv)代谢抑制,v)药物相互作用,以及vi)代谢物的毒性。