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1. 发明授权

US07022287B2 Single particle electrochemical sensors and methods of utilization 有权
公开(公告)号：US07022287B2
公开(公告)日：2006-04-04
申请号：US10141806
申请日：2002-05-08
申请人： Joseph Schoeniger , Albert W. Flounders , Robert C. Hughes , Antonio J. Ricco , Karl Wally , Stanley H. Kravitz , Richard P. Janek
发明人： Joseph Schoeniger , Albert W. Flounders , Robert C. Hughes , Antonio J. Ricco , Karl Wally , Stanley H. Kravitz , Richard P. Janek
IPC分类号： G01N15/06
CPC分类号： G01N33/5438 , G01N27/22
摘要： The present invention discloses an electrochemical device for detecting single particles, and methods for using such a device to achieve high sensitivity for detecting particles such as bacteria, viruses, aggregates, immuno-complexes, molecules, or ionic species. The device provides for affinity-based electrochemical detection of particles with single-particle sensitivity. The disclosed device and methods are based on microelectrodes with surface-attached, affinity ligands (e.g., antibodies, combinatorial peptides, glycolipids) that bind selectively to some target particle species. The electrodes electrolyze chemical species present in the particle-containing solution, and particle interaction with a sensor element modulates its electrolytic activity. The devices may be used individually, employed as sensors, used in arrays for a single specific type of particle or for a range of particle types, or configured into arrays of sensors having both these attributes.

2. 发明授权

US5834627A Calorimetric gas sensor 失效
标题翻译：热量气体传感器
公开(公告)号：US5834627A
公开(公告)日：1998-11-10
申请号：US766142
申请日：1996-12-17
申请人： Antonio J. Ricco , Robert C. Hughes , James H. Smith , Daniel J. Moreno , Ronald P. Manginell , Stephen D. Senturia , Robert J. Huber
发明人： Antonio J. Ricco , Robert C. Hughes , James H. Smith , Daniel J. Moreno , Ronald P. Manginell , Stephen D. Senturia , Robert J. Huber
IPC分类号： G01N27/16 , G01N7/00
CPC分类号： G01N27/16
摘要： A combustible gas sensor that uses a resistively heated, noble metal-coated, micromachined polycrystalline Si filament to calorimetrically detect the presence and concentration of combustible gases. The filaments tested to date are 2 .mu.m thick.times.10 .mu.m wide.times.100, 250, 500, or 1000 .mu.m-long polycrystalline Si; some are overcoated with a 0.25 .mu.m-thick protective CVD Si.sub.3 N.sub.4 layer. A thin catalytic Pt film was deposited by CVD from the precursor Pt(acac).sub.2 onto microfilaments resistively heated to approximately 500.degree. C.; Pt deposits only on the hot filament. Using a constant-resistance-mode feedback circuit, Pt-coated filaments operating at ca. 300.degree. C. (35 mW input power) respond linearly, in terms of the change in supply current required to maintain constant resistance (temperature), to H.sub.2 concentrations between 100 ppm and 1% in an 80/20 N.sub.2 /O.sub.2 mixture. Other catalytic materials can also be used.
摘要翻译：一种可燃气体传感器，其使用电阻加热的贵金属涂覆的微加工多晶硅丝来量热检测可燃气体的存在和浓度。到目前为止测试的长丝是2μm厚的10μm宽×100,250,500或1000μm长的多晶Si; 有些被外涂了0.25μm厚的保护性CVD Si 3 N 4层。通过CVD将Pt催化Pt薄膜从前体Pt（acac）2沉积到电阻加热至约500℃的微丝上; Pt仅在热丝上沉积。使用恒电阻模式反馈电路，Pt涂层长丝在约在80/20 N2 / O2混合物中，在保持恒定电阻（温度）所需的电源电流变化为100 ppm和1％之间，300°C（35 mW输入功率）线性响应。也可以使用其它催化剂。

3. 发明授权

US4976266A Methods of in vivo radiation measurement 失效
标题翻译：体内辐射测量方法
公开(公告)号：US4976266A
公开(公告)日：1990-12-11
申请号：US224282
申请日：1988-07-25
申请人： Dennis D. Huffman , Robert C. Hughes , Charles A. Kelsey , Richard Lane , Antonio J. Ricco , Jay B. Snelling , Thomas E. Zipperian
发明人： Dennis D. Huffman , Robert C. Hughes , Charles A. Kelsey , Richard Lane , Antonio J. Ricco , Jay B. Snelling , Thomas E. Zipperian
IPC分类号： A61N5/10 , G01T1/161 , G01T1/24
CPC分类号： G01T1/24 , A61B6/4258 , G01T1/026 , G01T1/161 , A61N2005/1072 , A61N5/1048 , A61N5/1071
摘要： Methods of and apparatus for in vivo radiation measurements relay on a MOSFET dosimeter of high radiation sensitivity with operates in both the passive mode to provide an integrated dose detector and active mode to provide an irradiation rate detector. A compensating circuit with a matched unirradiated MOSFET is provided to operate at a current designed to eliminate temperature dependence of the device. Preferably, the MOSFET is rigidly mounted in the end of a miniature catheter and the catheter is implanted in the patient proximate the radiation source.
摘要翻译：用于体内辐射测量的方法和装置在具有高辐射灵敏度的MOSFET剂量计上继电，在被动模式下操作以提供积分剂量检测器和主动模式以提供辐射率检测器。提供具有匹配的未照射MOSFET的补偿电路，以在设计为消除器件的温度依赖性的电流下工作。优选地，MOSFET刚性地安装在微型导管的端部，并且将导管植入患者附近的辐射源。

4. 发明授权

US5187980A Method and apparatus for acoustic plate mode liquid-solid phase transition detection 失效
标题翻译：声板模式液 - 固相变检测方法与装置
公开(公告)号：US5187980A
公开(公告)日：1993-02-23
申请号：US531492
申请日：1990-05-31
申请人： Dianna S. Blair , Gregory C. Freye , Robert C. Hughes , Stephen J. Martin , Antonio J. Ricco
发明人： Dianna S. Blair , Gregory C. Freye , Robert C. Hughes , Stephen J. Martin , Antonio J. Ricco
IPC分类号： B64D15/20 , G01N29/02 , G01N29/11 , G08B19/02
CPC分类号： G01N29/11 , B64D15/20 , G01N29/022 , G01N2291/023 , G01N2291/0251 , G01N2291/0422 , G01N2291/0425
摘要： A method and apparatus for sensing a liquid-solid phase transition event is provided which comprises an acoustic plate mode detecting element placed in contact with a liquid or solid material which generates a high-frequency acoustic wave that is attenuated to an extent based on the physical state of the material is contact with the detecting element. The attenuation caused by the material in contact with the acoustic plate mode detecting element is used to determine the physical state of the material being detected. The method and device are particularly suited for detecting conditions such as the icing and deicing of wings of an aircraft. In another aspect of the present invention, a method is provided wherein the adhesion of a solid material to the detecting element can be measured using the apparatus of the invention.
摘要翻译：提供了一种用于感测液 - 液相变事件的方法和装置，其包括与液体或固体材料接触放置的声板模式检测元件，所述声板模式检测元件产生基于物理的一定程度衰减的高频声波材料的状态与检测元件接触。由与声板模式检测元件接触的材料引起的衰减用于确定被检测材料的物理状态。该方法和装置特别适用于检测诸如飞机机翼结冰和除冰等条件。在本发明的另一方面，提供了一种方法，其中可以使用本发明的装置测量固体材料对检测元件的粘附。

5. 发明申请

US20100054118A1 SELF-OPTIMIZATION AND SELF-HEALING OF VOICE QUALITY PROBLEMS UTILIZING SERVICE ORIENTED ARCHITECTURE 失效
标题翻译：使用面向服务架构的语音质量问题的自我优化和自我处理
公开(公告)号：US20100054118A1
公开(公告)日：2010-03-04
申请号：US12198446
申请日：2008-08-26
申请人： Robert C. Hughes , Andrew Liam Massey , William H. Tworek
发明人： Robert C. Hughes , Andrew Liam Massey , William H. Tworek
IPC分类号： G06F11/00
CPC分类号： G10L25/69 , H04L65/80 , H04L67/2809 , H04L69/40
摘要： A method and system for automatically resolving a voice transmission problem in real time in a communication system. Service oriented architecture (SOA)-based reporter services report voice transmission characteristic measurements. An enterprise service bus aggregates the measurements into a combination of measurements. An analyzer that is a SOA service provider determines that the combination of measurements indicates a voice transmission problem. The voice transmission problem determination includes identifying a match between the combination of measurements and a pattern of predefined conditions stored in a database. The database associates the pattern with one or more corrective actions. Using the database, the analyzer identifies the one or more corrective actions that are associated with the pattern of predefined conditions. SOA-based fixer services execute the corrective action(s) to resolve the voice transmission problem. As new voice transmission problems become known, the system expands to add reporting services and fixer services.
摘要翻译：一种在通信系统中实时自动解决语音传输问题的方法和系统。面向服务架构（SOA）的记者服务报告语音传输特性测量。企业服务总线将测量集合到测量的组合中。作为SOA服务提供商的分析器确定测量的组合表示语音传输问题。语音传输问题确定包括识别测量的组合与存储在数据库中的预定条件的模式之间的匹配。数据库将模式与一个或多个纠正措施相关联。使用数据库，分析器识别与预定义条件模式相关联的一个或多个校正动作。基于SOA的定位器服务执行纠正措施来解决语音传输问题。随着新的语音传输问题的出现，系统扩展到增加报告服务和定位服务。

6. 发明授权

US06290868B1 Field-structured material media and methods for synthesis thereof 有权
标题翻译：场结构材料介质及其合成方法
公开(公告)号：US06290868B1
公开(公告)日：2001-09-18
申请号：US09322068
申请日：1999-05-27
申请人： James E. Martin , Robert C. Hughes , Robert A. Anderson
发明人： James E. Martin , Robert C. Hughes , Robert A. Anderson
IPC分类号： H01R1113
CPC分类号： H01L21/288 , H01F1/083 , H01F1/28 , H01F1/442 , Y10S428/90 , Y10S428/928 , Y10T428/12465
摘要： The present application is directed to a new class of composite materials, called field-structured composite (FSC) materials, which comprise a oriented aggregate structure made of magnetic particles suspended in a nonmagnetic medium, and to a new class of processes for their manufacture. FSC materials have much potential for application, including use in chemical, optical, environmental, and mechanical sensors.
摘要翻译：本申请涉及一类称为场结构复合材料（FSC）的新型复合材料，其包括由悬浮在非磁性介质中的磁性颗粒制成的定向聚集体结构，以及一类新的制造方法。 FSC材料具有很大的应用潜力，包括在化学，光学，环境和机械传感器中的应用。

7. 发明授权

US06902701B1 Apparatus for sensing volatile organic chemicals in fluids 有权
标题翻译：用于检测流体中挥发性有机化学物质的装置
公开(公告)号：US06902701B1
公开(公告)日：2005-06-07
申请号：US09974327
申请日：2001-10-09
申请人： Robert C. Hughes , Ronald P. Manginell , Mark W. Jenkins , Richard Kottenstette , Sanjay V. Patel
发明人： Robert C. Hughes , Ronald P. Manginell , Mark W. Jenkins , Richard Kottenstette , Sanjay V. Patel
IPC分类号： G01N1/34 , G01N1/40 , G01N27/12 , G01N21/00 , G01N7/00 , G01N27/00 , G01N31/00 , G01N33/00
CPC分类号： G01N1/405 , G01N27/128 , Y10T29/49 , Y10T29/49002 , Y10T436/11 , Y10T436/25 , Y10T436/255
摘要： A chemical-sensing apparatus is formed from the combination of a chemical preconcentrator which sorbs and concentrates particular volatile organic chemicals (VOCs) and one or more chemiresistors that sense the VOCs after the preconcentrator has been triggered to release them in concentrated form. Use of the preconcentrator and chemiresistor(s) in combination allows the VOCs to be detected at lower concentration than would be possible using the chemiresistor(s) alone and further allows measurements to be made in a variety of fluids, including liquids (e.g. groundwater). Additionally, the apparatus provides a new mode of operation for sensing VOCs based on the measurement of decay time constants, and a method for background correction to improve measurement precision.
摘要翻译：化学感测装置由吸收和浓缩特定的挥发性有机化学品（VOC）的化学预浓缩器和在浓缩预浓缩器被触发释放它们之后感测VOC的一个或多个化学电阻器的组合形成。使用预浓缩器和化学电阻器组合使得可以以比单独使用化学电阻器可能的浓度更低的浓度检测VOC，并进一步允许在各种流体（包括液体（例如地下水））中进行测量，。此外，该装置提供了基于衰减时间常数的测量来检测VOC的新的操作模式，以及用于提高测量精度的背景校正方法。

8. 发明授权

US4622355A Radiation-hardened polymeric films 失效
标题翻译：辐射硬化聚合物膜
公开(公告)号：US4622355A
公开(公告)日：1986-11-11
申请号：US632347
申请日：1984-07-16
申请人： Charles Arnold, Jr. , Robert C. Hughes , R. Glen Kepler , Steven R. Kurtz
发明人： Charles Arnold, Jr. , Robert C. Hughes , R. Glen Kepler , Steven R. Kurtz
IPC分类号： C08J7/06 , H01B1/12
CPC分类号： C08J7/065 , H01B1/12
摘要： The radiation-induced conductivity of polymeric dielectrics with low electronic mobility is reduced by doping with electron donor or electron acceptor compounds at a level of 10.sup.15 to 10.sup.21 molecules of dopant/cm.sup.3. Polyesters, polyolefins, perfluoropolyolefins, vinyl polymers, vinylidene polymers, polycarbonates, polysulfones and polyimides can benefit from such a treatment. Usable dopants include 2,4,7-trinitro-9-fluorenone, tetracyanethylene, 7,7,8,8-tetracyanoquinodimethane, m-dinitrobenzene, 2-isopropylcarbazole, and triphenylamine.
摘要翻译：具有低电子迁移率的聚合物电介质的辐射诱导电导率通过以1015至1021分子掺杂剂/ cm 3的水平掺杂电子给体或电子受体化合物来降低。聚酯，聚烯烃，全氟聚烯烃，乙烯基聚合物，亚乙烯基聚合物，聚碳酸酯，聚砜和聚酰亚胺可以受益于这种处理。可用的掺杂剂包括2,4,7-三硝基-9-芴酮，四氰乙烯，7,7,8,8-四氰基醌二甲烷，间二硝基苯，2-异丙基咔唑和三苯胺。

9. 发明授权

US07122684B2 Process for preparing 1,2-diamino compounds 有权
标题翻译： 1,2-二氨基化合物的制备方法
公开(公告)号：US07122684B2
公开(公告)日：2006-10-17
申请号：US10388064
申请日：2003-03-13
申请人： Jack D. Brown , Peter J. Harrington , Robert C. Hughes
发明人： Jack D. Brown , Peter J. Harrington , Robert C. Hughes
IPC分类号： C07D203/26 , C07D209/56 , C07D209/38 , C07C69/74 , C07C213/00
CPC分类号： C07D303/02 , C07C233/52 , C07C2601/16 , C07D203/26
摘要： The invention provides a multi-step process for preparing 1,2-diamino compounds of formula wherein R1, R1′, R2, R2′, R3 and R4 have the meaning given in the specification and pharmaceutically acceptable addition salts thereof, from 1,2-epoxides of formula wherein R1, R1′, R2 and R2′ have the meaning given in the specification.
摘要翻译：本发明提供了制备下式的1,2-二氨基化合物的多步骤方法，其中R 1，R 2，R 2，R 2， R 2，R 3和R 4具有本说明书中给出的含义及其药学上可接受的加成盐，由1,2-环氧化物其中R 1，R 2，R 2，R 2和R 2'具有如下的含义：规范。

10. 发明授权

US6087818A Recreational vehicle voltage booster 有权
标题翻译：休闲车电压升压器
公开(公告)号：US6087818A
公开(公告)日：2000-07-11
申请号：US250219
申请日：1999-02-13
申请人： Robert C. Hughes
发明人： Robert C. Hughes
IPC分类号： G05F5/00 , H02M1/10
CPC分类号： H01F27/022 , H01F27/04 , H01F27/40 , H01F30/06
摘要： A voltage booster device for increasing the voltage level of power received by a recreational vehicle (RV) from a separate 120-volt power source includes an electrical box, a power cord and female outlet on the box, and an encapsulated transformer within the box. The transformer (e.g., an autotransformer) is adapted to increase the actual voltage level of the separate 120-volt power source a predetermined amount. A relay is provided for switching the transformer, the power cord, and the female outlet between (i) a first circuit configuration that couples power from the power cord to the female outlet via the transformer so that the transformer increases the voltage level by the predetermined amount, and (ii) a second circuit configuration that bypasses the transformer so that the transformer does not increase the voltage level by the predetermined amount. A control circuit controls the relay so that (i) the relay switches to the first circuit configuration when the actual voltage of the separate 120-volt power source falls below a predetermined first threshold level, and (ii) the relay switches to the second circuit configuration when the actual voltage rises above a predetermined second threshold level. One embodiment includes a mounting plate with a rounded end that functions as a handle, and a case-hardened steel loop that receives a security chain.
摘要翻译：用于增加娱乐车辆（RV）从单独的120伏电源接收的电力电压电平的升压装置包括箱子上的电箱，电源线和阴插座以及盒内的封装变压器。变压器（例如，自耦变压器）适于将单独120伏电源的实际电压电平增加预定量。提供继电器，用于在（i）第一电路配置之间切换变压器，电源线和母插座，该第一电路配置通过变压器将电力线从电源线耦合到母插座，使得变压器将电压电平提高预定量，以及（ii）绕过变压器使得变压器不将电压电平增加预定量的第二电路配置。控制电路控制继电器，使得（i）当分离的120伏电源的实际电压低于预定的第一阈值电平时，继电器切换到第一电路配置，以及（ii）继电器切换到第二电路当实际电压上升到高于预定的第二阈值电平时。一个实施例包括具有用作手柄的圆形端部的安装板和接收安全链的表壳硬化钢制环。

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