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1. 发明授权

US08554342B2 Neural stimulation lead fixation 失效
标题翻译：神经刺激铅固定
公开(公告)号：US08554342B2
公开(公告)日：2013-10-08
申请号：US13620138
申请日：2012-09-14
申请人： James R. Thacker , Michael S. Colvin , David K. L. Peterson , James P. McGivern
发明人： James R. Thacker , Michael S. Colvin , David K. L. Peterson , James P. McGivern
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译：具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。一个实施方案涉及脊髓刺激（SCS）引线。将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。气球充满空气，液体或柔顺材料。当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

2. 发明授权

US07099718B1 Neural stimulation lead fixation 失效
标题翻译：神经刺激铅固定
公开(公告)号：US07099718B1
公开(公告)日：2006-08-29
申请号：US10155146
申请日：2002-05-24
申请人： James R. Thacker , David K. L. Peterson , James P. McGivern , Michael S. Colvin
发明人： James R. Thacker , David K. L. Peterson , James P. McGivern , Michael S. Colvin
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/10
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. The pressure of the balloon is monitored or otherwise controlled during the filling process in order to determine at what point the filling process should be discontinued. An elastic aspect of the balloon serves as a contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译：具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。一个实施方案涉及脊髓刺激（SCS）引线。气球可以位于电极引线阵列上。气球充满空气，液体或柔顺材料。当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。在填充过程中监测或以其他方式控制气囊的压力，以便确定在何时应该停止填充过程。气囊的弹性方面用作包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

3. 发明授权

US08295945B1 Neural stimulation lead fixation 有权
标题翻译：神经刺激铅固定
公开(公告)号：US08295945B1
公开(公告)日：2012-10-23
申请号：US11464109
申请日：2006-08-11
申请人： James R. Thacker , Michael S Colvin , David K. L. Peterson , James P. McGivern
发明人： James R. Thacker , Michael S Colvin , David K. L. Peterson , James P. McGivern
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译：具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。一个实施方案涉及脊髓刺激（SCS）引线。将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。气球充满空气，液体或柔顺材料。当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

4. 发明授权

US07983766B1 Method of securing a neural stimulation lead 有权
标题翻译：确保神经刺激引线的方法
公开(公告)号：US07983766B1
公开(公告)日：2011-07-19
申请号：US11464128
申请日：2006-08-11
申请人： James R. Thacker , Michael S Colvin , David K. L. Peterson , James P. McGivern
发明人： James R. Thacker , Michael S Colvin , David K. L. Peterson , James P. McGivern
IPC分类号： A61N1/00
CPC分类号： A61N1/0558 , A61M25/10
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译：具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。一个实施方案涉及脊髓刺激（SCS）引线。将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。气球充满空气，液体或柔顺材料。当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

5. 发明授权

US07856277B1 Neural stimulation lead fixation 失效
标题翻译：神经刺激铅固定
公开(公告)号：US07856277B1
公开(公告)日：2010-12-21
申请号：US11464137
申请日：2006-08-11
申请人： James R. Thacker , Michael S Colvin , David K. L. Peterson , James P. McGivern
发明人： James R. Thacker , Michael S Colvin , David K. L. Peterson , James P. McGivern
IPC分类号： A61N1/372
CPC分类号： A61N1/0558 , A61M25/10
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as a contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译：具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。一个实施方案涉及脊髓刺激（SCS）引线。将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。气球充满空气，液体或柔顺材料。当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。气囊的弹性方面用作包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

6. 发明申请

US20130013044A1 NEURAL STIMULATION LEAD FIXATION 失效
标题翻译：神经刺激引线固定
公开(公告)号：US20130013044A1
公开(公告)日：2013-01-10
申请号：US13620138
申请日：2012-09-14
申请人： James R. Thacker , Michael S. Colvin , David K.L. Peterson , James P. McGivern
发明人： James R. Thacker , Michael S. Colvin , David K.L. Peterson , James P. McGivern
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译：具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。一个实施方案涉及脊髓刺激（SCS）引线。将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。气球充满空气，液体或柔顺材料。当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

7. 发明授权

US08934968B2 Neurostimulation and coronary artery disease treatment 有权
标题翻译：神经刺激和冠状动脉疾病治疗
公开(公告)号：US08934968B2
公开(公告)日：2015-01-13
申请号：US11779769
申请日：2007-07-18
申请人： Todd K. Whitehurst , James R. Thacker , James P. McGivern , Kelly H. McClure
发明人： Todd K. Whitehurst , James R. Thacker , James P. McGivern , Kelly H. McClure
IPC分类号： A61N1/362 , A61N1/36 , A61M5/142
CPC分类号： A61N1/36114 , A61M5/14276 , A61M2205/054 , A61M2205/3523 , A61M2205/8206 , A61M2230/06
摘要： A method for treating a patient may include treating coronary artery disease in combination with angina pectoris and/or the control of angina pain by delivering chemical and/or electrical stimulation pulses to the cardiac and/or nervous tissue of the patient in a coordinated manner. A system for treating a patient suffering from coronary artery disease and angina may include a stimulator that generates at least one pulse in accordance with prescribed parameters, a catheter, a lead, and/or a sensor.
摘要翻译：用于治疗患者的方法可以包括通过以协调的方式将化学和/或电刺激脉冲递送到患者的心脏和/或神经组织来治疗与心绞痛联合的冠状动脉疾病和/或控制心绞痛。用于治疗患有冠状动脉疾病和心绞痛的患者的系统可以包括根据规定参数产生至少一个脉冲的刺激器，导管，引线和/或传感器。

8. 发明授权

US09352161B2 Method of maintaining intensity output while adjusting pulse width or amplitude 有权
标题翻译：调整脉冲宽度或幅度时保持强度输出的方法
公开(公告)号：US09352161B2
公开(公告)日：2016-05-31
申请号：US11553447
申请日：2006-10-26
申请人： James R. Thacker , Harold Haut , Robert Nathan , David K. L. Peterson , Kerry Bradley
发明人： James R. Thacker , Harold Haut , Robert Nathan , David K. L. Peterson , Kerry Bradley
IPC分类号： A61N1/372 , A61N1/36
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36146 , A61N1/36171 , A61N1/36175
摘要： Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses.
摘要翻译：组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，用于传递由脉冲发生装置产生的电刺激脉冲的至少一个注入电极以及能够与脉冲发生装置通信的编程器。刺激脉冲可以由几个参数定义，例如脉冲宽度和幅度。在用刺激系统刺激组织的方法中，用户可以调整诸如脉冲宽度的参数之一。编程器可以响应于脉冲宽度的变化自动调节脉冲幅度，以便保持刺激脉冲的基本恒定的效果。

9. 发明授权

US06970741B1 Monitoring, preventing, and treating rejection of transplanted organs 失效
标题翻译：监测，预防和治疗移植器官的排斥
公开(公告)号：US06970741B1
公开(公告)日：2005-11-29
申请号：US10246554
申请日：2002-09-17
申请人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
发明人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
IPC分类号： A61M5/00 , A61M5/142 , A61M5/172 , A61N1/00 , A61N1/30 , A61N1/32
CPC分类号： A61B5/413 , A61B5/053 , A61B5/0538 , A61B5/41 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4244 , A61B2560/0219 , A61M5/14276 , A61M5/1723 , A61N1/30 , A61N1/32
摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.
摘要翻译：可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至患者。在某些实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

10. 发明授权

US08918174B2 Patient programmer for implantable devices 有权
标题翻译：用于可植入装置的患者程序员
公开(公告)号：US08918174B2
公开(公告)日：2014-12-23
申请号：US11625281
申请日：2007-01-19
申请人： Carla Mann Woods , James R. Thacker , David K. L. Peterson
发明人： Carla Mann Woods , James R. Thacker , David K. L. Peterson
IPC分类号： A61N1/378 , A61N1/05 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/36185 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37252 , A61N1/3787
摘要： An implantable medical device system, external programmer, and method of indicating the status of a power source in a medical device implanted within a patient. An actual status of the power source is maintained at the medical device. A status indicator of an external programmer indicates an estimated status of the power source, which can be reconciled with the actual status of the power source when the external programmer is placed in telecommunicative contact with the implantable medical device.
摘要翻译：一种植入式医疗装置系统，外部编程器和指示植入患者体内的医疗装置中的电源的状态的方法。在医疗设备上保持电源的实际状态。外部编程器的状态指示器指示当外部编程器与可植入医疗设备进行电话接触时可以与电源的实际状态对准的电源的估计状态。

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